{"id":"https://openalex.org/W2948243161","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.602.10","title":"A kinetic model of endothelial dysfunction from the NOS NO synthesis biochemical pathway","display_name":"A kinetic model of endothelial dysfunction from the NOS NO synthesis biochemical pathway","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2948243161","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.602.10","mag":"2948243161"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.24.1_supplement.602.10","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.602.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.602.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053177689","display_name":"Saptarshi Kar","orcid":"https://orcid.org/0000-0002-3788-372X","observed_orcids":["https://orcid.org/0000-0002-3788-372X"]},"institutions":[{"id":"https://openalex.org/I78715868","display_name":"University of Arkansas at Fayetteville","ror":"https://ror.org/05jbt9m15","country_code":"US","type":"education","lineage":["https://openalex.org/I78715868"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saptarshi Kar","raw_affiliation_strings":["Biomedical Engineering, University of Arkansas, Fayetteville, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, University of Arkansas, Fayetteville, AR","institution_ids":["https://openalex.org/I78715868"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065731677","display_name":"Mahendra Kavdia","orcid":"https://orcid.org/0009-0004-8458-9592","observed_orcids":["https://orcid.org/0009-0004-8458-9592"]},"institutions":[{"id":"https://openalex.org/I78715868","display_name":"University of Arkansas at Fayetteville","ror":"https://ror.org/05jbt9m15","country_code":"US","type":"education","lineage":["https://openalex.org/I78715868"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahendra Kavdia","raw_affiliation_strings":["Biomedical Engineering, University of Arkansas, Fayetteville, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, University of Arkansas, Fayetteville, AR","institution_ids":["https://openalex.org/I78715868"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78715868"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42747626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8629999756813049},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9620000123977661},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.6570000052452087},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.9760000109672546},{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.9350000023841858},{"id":"https://openalex.org/keywords/tetrahydrobiopterin","display_name":"tetrahydrobiopterin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/dihydrobiopterin","display_name":"dihydrobiopterin","score":0.925000011920929},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.6100000143051147},{"id":"https://openalex.org/keywords/kinetic-modeling","display_name":"kinetic modeling","score":0.7310000061988831},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.972000002861023},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8209999799728394},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.8999767899513245},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.818665623664856},{"id":"https://openalex.org/C2776145790","wikidata":"https://www.wikidata.org/wiki/Q419808","display_name":"Tetrahydrobiopterin","level":4,"score":0.8066908717155457},{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.7490997314453125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6646780371665955},{"id":"https://openalex.org/C2777451243","wikidata":"https://www.wikidata.org/wiki/Q408256","display_name":"Biopterin","level":5,"score":0.6592669486999512},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5697315335273743},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5352426767349243},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.4819905161857605},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4756062626838684},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4617718458175659},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.46089544892311096},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4451754689216614},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.44131791591644287},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4312276840209961},{"id":"https://openalex.org/C2779698670","wikidata":"https://www.wikidata.org/wiki/Q408853","display_name":"Endothelial NOS","level":5,"score":0.4227627217769623},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20579364895820618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18418800830841064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15918123722076416},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.24.1_supplement.602.10","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.602.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.602.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7798775006","display_name":"Nitric Oxide-Superoxide Interactions in Endothelial Cell Dysfunction","funder_award_id":"R01HL084337","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2073963062","https://openalex.org/W1545448131","https://openalex.org/W2736229017","https://openalex.org/W2165073849","https://openalex.org/W3138098186","https://openalex.org/W116914182","https://openalex.org/W2148390554","https://openalex.org/W2122028544","https://openalex.org/W2278320363","https://openalex.org/W1989080390"],"abstract_inverted_index":{"Endothelial":[0],"nitric":[1,20],"oxide":[2,21],"synthase":[3],"(enos)":[4],"under":[5],"the":[6,18,42,46,94,103,166],"influence":[7],"of":[8,34,41,48,53,86,102,131,137,147,168],"shear":[9],"stress":[10],"due":[11],"to":[12,37,60,125],"blood":[13],"flow":[14],"and":[15,26,30,96,107,133,139,171],"agonist":[16],"produces":[17,31],"vasorelaxant":[19],"(NO).":[22],"In":[23,76,160],"hyperglycemia,":[24],"hypertension":[25],"hypercholesterolemia,":[27],"enos":[28,54,87],"uncouples":[29],"superoxide":[32,138,157,162,170],"instead":[33],"NO,":[35,169],"leading":[36],"endothelial":[38,49,97],"dysfunction.":[39],"One":[40],"key":[43],"events":[44],"in":[45,121,129,135],"process":[47],"dysfunction":[50],"involves":[51],"reduction":[52,70],"co\u2010factor":[55],"tetrahydrobiopterin":[56],"(BH4)":[57],"with":[58],"respect":[59],"dihydrobiopterin":[61],"(BH2).":[62],"However,":[63],"it":[64],"is":[65],"not":[66],"known":[67],"how":[68],"this":[69,77],"affects":[71,165],"NO/superoxide":[72,111],"synthesis":[73,112],"by":[74,185],"enos.":[75],"study,":[78],"a":[79,126,145],"mathematical":[80],"kinetic":[81,108,148],"model":[82,142],"for":[83,92,150,177],"biochemical":[84,152],"pathways":[85,153],"was":[88,113],"developed":[89],"that":[90,118],"accounts":[91],"both":[93],"normal":[95],"dysfunctional":[98],"state.":[99],"The":[100,115,141],"effect":[101],"biopterin":[104],"ratio":[105,123],"(BH2:BH4)":[106],"parameters":[109,149],"on":[110],"analyzed.":[114],"results":[116,174],"predicted":[117],"an":[119],"increase":[120,134],"BH2:BH4":[122],"leads":[124],"significant":[127,156],"decrease":[128],"production":[130,136],"NO":[132],"peroxynitrite.":[140,172],"also":[143],"provides":[144],"range":[146],"NOS":[151,179],"over":[154],"which":[155],"formation":[158],"occurs.":[159],"addition,":[161],"dismutase":[163],"significantly":[164],"concentrations":[167],"These":[173],"have":[175],"implications":[176],"understanding":[178],"uncoupling":[180],"related":[181],"oxidative":[182],"stress.":[183],"Supported":[184],"NIH":[186],"R01":[187],"HL084337.":[188]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-06-14T00:00:00"}