{"id":"https://openalex.org/W2948126643","doi":null,"title":"Organoid technology: an identification and evaluation of the ethical challenges","display_name":"Organoid technology: an identification and evaluation of the ethical challenges","publication_year":2019,"publication_date":"2019-05-16","ids":{"openalex":"https://openalex.org/W2948126643","mag":"2948126643"},"language":"en","primary_location":{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/380204","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/380204","pdf_url":"https://dspace.library.uu.nl/handle/1874/380204","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/380204","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080096898","display_name":"Sarah N. Boers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sarah N. Boers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080096898"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/2910","display_name":"Issues, ethics and legal aspects"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/2910","display_name":"Issues, ethics and legal aspects"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.11460000276565552,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13147","display_name":"Ethics and bioethics in healthcare","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organoids","display_name":"organoids","score":0.9750000238418579},{"id":"https://openalex.org/keywords/organoid-biobank","display_name":"organoid biobank","score":0.7210000157356262},{"id":"https://openalex.org/keywords/donor-consent","display_name":"donor consent","score":0.7720000147819519},{"id":"https://openalex.org/keywords/biobank-governance","display_name":"biobank governance","score":0.843999981880188},{"id":"https://openalex.org/keywords/pediatric-clinical-trials","display_name":"pediatric clinical trials","score":0.6759999990463257},{"id":"https://openalex.org/keywords/risk-benefit-assessment","display_name":"risk-benefit assessment","score":0.7369999885559082},{"id":"https://openalex.org/keywords/animal-studies","display_name":"animal studies","score":0.4970000088214874},{"id":"https://openalex.org/keywords/organoid-transplantation","display_name":"organoid transplantation","score":0.5519999861717224},{"id":"https://openalex.org/keywords/stem-cell-ethics","display_name":"stem cell research ethics","score":0.5540000200271606},{"id":"https://openalex.org/keywords/privacy-by-design","display_name":"privacy by design","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.9041849374771118},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.8764970302581787},{"id":"https://openalex.org/C2776050585","wikidata":"https://www.wikidata.org/wiki/Q7439360","display_name":"Scrutiny","level":2,"score":0.4936162233352661},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.4342612028121948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3205913305282593},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.26353925466537476},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.21373659372329712},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1961701512336731},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1582280397415161},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.14559006690979004}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/380204","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/380204","pdf_url":"https://dspace.library.uu.nl/handle/1874/380204","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:oai:dspace.library.uu.nl:1874/380204","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/380204","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2948126643","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/380204","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/380204","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/380204","pdf_url":"https://dspace.library.uu.nl/handle/1874/380204","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2948126643.pdf","grobid_xml":"https://content.openalex.org/works/W2948126643.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1966840659","https://openalex.org/W2058571677","https://openalex.org/W2085630475","https://openalex.org/W2111744339","https://openalex.org/W2461088337","https://openalex.org/W2530055419","https://openalex.org/W2580761472"],"related_works":["https://openalex.org/W4213091526","https://openalex.org/W3177318533","https://openalex.org/W4286762037","https://openalex.org/W2898319603","https://openalex.org/W2429685958","https://openalex.org/W4246944776","https://openalex.org/W4406781637","https://openalex.org/W7073679293","https://openalex.org/W7161758822","https://openalex.org/W2576832945"],"abstract_inverted_index":{"Recent":[0],"advances":[1],"in":[2,15,43,87,132,162,182,242,357,395,398,425,430,442],"the":[3,63,73,80,93,108,127,139,152,157,172,177,217,254,272,291,312,324,353,414,431],"stem":[4],"cell":[5],"field":[6,434],"make":[7],"it":[8],"possible":[9],"to":[10,33,156,187,195,203,248,296,332,390,419],"culture":[11],"three-dimensional":[12],"human":[13,145,211,275,278,318,437],"tissues":[14,276],"a":[16,168,303,358,387],"dish":[17],"called":[18],"organoids.":[19],"These":[20,55,234],"organoids":[21,42,142,161,189,226,247,315],"have":[22],"promising":[23],"scientific":[24],"and":[25,37,50,53,70,110,118,143,148,197,205,214,219,223,256,260,269,281,290,316,344,393,407],"clinical":[26,120,158],"applications":[27],"that":[28,103,192,230,265,352,374],"range":[29],"from":[30,210,328],"disease":[31],"modelling":[32],"(personalized)":[34],"drug":[35],"development":[36],"organoid":[38,85,164,361,426],"transplantation.":[39],"Storage":[40],"of":[41,72,101,113,130,141,160,171,180,246,258,274,287,314,355,401],"living":[44],"biobanks":[45],"enables":[46],"long-term,":[47],"international,":[48],"academic":[49],"commercial":[51,232],"distribution":[52],"use.":[54],"promises":[56],"are":[57,208,227,294,382,411,440],"paired":[58],"with":[59,84,380],"ethical":[60,74,81,94,153,267,325,345],"challenges.":[61],"In":[62,122,321,347],"thesis":[64,417],"entitled":[65],"\u2018Organoid":[66],"technology:":[67],"an":[68,443],"identification":[69],"evaluation":[71],"challenges\u2019,":[75],"Sarah":[76],"Boers":[77,125,185,301,350,385],"pro-actively":[78],"examines":[79,126],"challenges":[82,102,154],"associated":[83],"technology":[86],"four":[88,99],"parts.":[89],"Part":[90,123,133,149,183,262,348],"I":[91],"sets":[92],"research":[95,379],"agenda":[96],"through":[97],"mapping":[98],"clusters":[100],"require":[104],"pro-active":[105],"scrutiny,":[106],"namely:":[107],"moral":[109,128,178],"legal":[111],"status":[112,129,179],"organoids,":[114,131,181],"consent,":[115,285],"biobank":[116],"governance,":[117],"responsible":[119,378,421],"translation.":[121],"II":[124,134,184],"she":[135],"formulates":[136],"conditions":[137,268,376],"for":[138,271,305,311,377],"exchange":[140,273,313],"related":[144,155,317],"tissue":[146,212,279,288,319,438],"products,":[147],"IV":[150,349],"evaluates":[151],"translation":[159],"first-in-human":[163,359,396],"trials.":[165],"Here":[166],"follows":[167],"short":[169],"summary":[170],"most":[173],"important":[174],"findings.":[175],"Regarding":[176],"proposes":[186,302,386],"recognize":[188],"as":[190,200,202,308],"hybrids":[191],"ambiguously":[193],"relate":[194],"persons":[196],"their":[198,220],"bodies":[199],"well":[201],"technologies":[204],"markets.":[206],"Organoids":[207],"grown":[209],"samples":[213],"they":[215],"represent":[216],"donors":[218,259],"bodies,":[221],"identity":[222],"values.":[224],"Simultaneously,":[225],"(bio)technological":[228],"instruments":[229],"bear":[231],"value.":[233],"different":[235],"values":[236,255],"can":[237,369],"conflict.":[238],"The":[239],"challenge":[240],"lies":[241],"enabling":[243],"(partial)":[244],"commercialization":[245],"stimulate":[249],"biomedical":[250],"innovation,":[251,422],"while":[252],"respecting":[253],"interests":[257],"society.":[261],"III":[263],"contends":[264],"current":[266],"safeguards":[270],"(or":[277],"banking":[280],"research),":[282],"i.e.":[283],"donor":[284,330],"anonymization":[286],"samples,":[289],"non-commercialization":[292],"principle,":[293],"inapt":[295],"meet":[297],"this":[298,322],"challenge.":[299],"Alternatively,":[300],"\u2018consent":[304],"governance":[306,334],"model\u2019":[307],"leading":[309],"paradigm":[310],"products.":[320],"model":[323],"emphasis":[326],"shifts":[327],"initial":[329],"consent":[331],"ongoing":[333],"obligations,":[335],"including":[336],"privacy":[337],"by":[338],"design,":[339],"participant":[340],"engagement,":[341],"benefit":[342],"sharing,":[343],"oversight.":[346],"argues":[351],"inclusion":[354],"children":[356,381],"live":[360],"trial":[362],"is":[363],"only":[364,424],"justified":[365],"if":[366],"direct":[367],"benefits":[368,394],"be":[370],"reasonably":[371],"expected,":[372],"provided":[373],"other":[375],"met.":[383],"Furthermore,":[384],"novel":[388],"approach":[389],"evaluate":[391],"risks":[392],"trials":[397],"which":[399],"estimates":[400],"efficacy":[402],"based":[403],"on":[404],"animal":[405],"studies":[406],"reference":[408],"class":[409],"evidence":[410],"integrated":[412],"into":[413],"assessment.":[415],"This":[416],"contributes":[418],"morally":[420],"not":[423],"technology,":[427],"but":[428],"also":[429],"broader":[432],"biotechnological":[433],"where":[435],"sophisticated":[436],"products":[439],"exchanged":[441],"increasingly":[444],"complex":[445],"global":[446],"market.":[447]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-06-14T00:00:00"}
