{"id":"https://openalex.org/W2947996391","doi":null,"title":"Metabolic trafficking between astrocytes and neurons under hyperammonemia and manganism: Nitrogen- and Carbon metabolism","display_name":"Metabolic trafficking between astrocytes and neurons under hyperammonemia and manganism: Nitrogen- and Carbon metabolism","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2947996391","mag":"2947996391"},"language":"en","primary_location":{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-013528173","doi":null,"is_oa":false,"landing_page_url":"http://elib.suub.uni-bremen.de/publications/diss/html/E-Diss1199_HTML.html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://media.suub.uni-bremen.de/handle/elib/2088","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063217812","display_name":"Touraj Shokati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Touraj Shokati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063217812"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperammonemia","display_name":"hyperammonemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/manganism","display_name":"manganism","score":0.9470000267028809},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8370000123977661},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ammonia-detoxification","display_name":"ammonia detoxification","score":0.7020000219345093},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.9150000214576721},{"id":"https://openalex.org/keywords/glutamine-synthetase","display_name":"glutamine synthetase","score":0.8669999837875366},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.6209999918937683},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.9290000200271606},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/anaplerosis","display_name":"anaplerosis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/aminotransferases","display_name":"transaminases","score":0.8040000200271606},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.6119999885559082},{"id":"https://openalex.org/keywords/oxaloacetate","display_name":"oxaloacetate","score":0.8040000200271606},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.9900000095367432},{"id":"https://openalex.org/keywords/nitrogen-metabolism","display_name":"nitrogen metabolism","score":0.6610000133514404},{"id":"https://openalex.org/keywords/carbon-metabolism","display_name":"carbon metabolism","score":0.8899999856948853},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C2781099255","wikidata":"https://www.wikidata.org/wiki/Q1640868","display_name":"Hyperammonemia","level":2,"score":0.9323704242706299},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.541702926158905},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5045212507247925},{"id":"https://openalex.org/C140205800","wikidata":"https://www.wikidata.org/wiki/Q5860","display_name":"Carbon fibers","level":3,"score":0.4293251633644104},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.41338488459587097},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3542439341545105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35335326194763184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30216723680496216},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.12982982397079468},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.09966284036636353},{"id":"https://openalex.org/C104779481","wikidata":"https://www.wikidata.org/wiki/Q50707","display_name":"Composite number","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-013528173","doi":null,"is_oa":false,"landing_page_url":"http://elib.suub.uni-bremen.de/publications/diss/html/E-Diss1199_HTML.html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"},{"id":"pmh:oai:elib.suub.uni-bremen.de:DISS/00001199","doi":null,"is_oa":false,"landing_page_url":"http://elib.suub.uni-bremen.de/peid=D00001199","pdf_url":null,"source":{"id":"https://openalex.org/S7407064325","display_name":"State and University Library Bremen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nbn-resolving.de/<identifier scheme=\"urn:nbn:de\">urn:nbn:de:gbv:46-diss000011995</identifier>","raw_type":null},{"id":"pmh:oai:media.suub.uni-bremen.de:elib/2088","doi":null,"is_oa":true,"landing_page_url":"https://media.suub.uni-bremen.de/handle/elib/2088","pdf_url":null,"source":{"id":"https://openalex.org/S4306402486","display_name":"Media (https://www.suub.uni-bremen.de/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I180437899","host_organization_name":"University of Bremen","host_organization_lineage":["https://openalex.org/I180437899"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2947996391","doi":null,"is_oa":false,"landing_page_url":"http://elib.suub.uni-bremen.de/peid=D00001199","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:media.suub.uni-bremen.de:elib/2088","doi":null,"is_oa":true,"landing_page_url":"https://media.suub.uni-bremen.de/handle/elib/2088","pdf_url":null,"source":{"id":"https://openalex.org/S4306402486","display_name":"Media (https://www.suub.uni-bremen.de/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I180437899","host_organization_name":"University of Bremen","host_organization_lineage":["https://openalex.org/I180437899"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":218,"referenced_works":["https://openalex.org/W13199988","https://openalex.org/W16603568","https://openalex.org/W34251905","https://openalex.org/W35676459","https://openalex.org/W47059509","https://openalex.org/W48848062","https://openalex.org/W67995918","https://openalex.org/W80831769","https://openalex.org/W92689579","https://openalex.org/W108170107","https://openalex.org/W111736103","https://openalex.org/W125509774","https://openalex.org/W139231123","https://openalex.org/W142757994","https://openalex.org/W149315073","https://openalex.org/W157175025","https://openalex.org/W166813605","https://openalex.org/W186464998","https://openalex.org/W204348490","https://openalex.org/W593073923","https://openalex.org/W1043684383","https://openalex.org/W1275454548","https://openalex.org/W1505560697","https://openalex.org/W1541747283","https://openalex.org/W1542443723","https://openalex.org/W1557387148","https://openalex.org/W1585218706","https://openalex.org/W1663649587","https://openalex.org/W1752444028","https://openalex.org/W1772857860","https://openalex.org/W1775749144","https://openalex.org/W1799449456","https://openalex.org/W1888519824","https://openalex.org/W1938553409","https://openalex.org/W1942398216","https://openalex.org/W1948027812","https://openalex.org/W1954425429","https://openalex.org/W1964063902","https://openalex.org/W1965095530","https://openalex.org/W1965448509","https://openalex.org/W1965857385","https://openalex.org/W1966838176","https://openalex.org/W1967558353","https://openalex.org/W1968179612","https://openalex.org/W1968419639","https://openalex.org/W1968807182","https://openalex.org/W1969454688","https://openalex.org/W1971347536","https://openalex.org/W1971368452","https://openalex.org/W1974329567","https://openalex.org/W1975350144","https://openalex.org/W1975759372","https://openalex.org/W1976474638","https://openalex.org/W1977891134","https://openalex.org/W1981319871","https://openalex.org/W1982272512","https://openalex.org/W1983718136","https://openalex.org/W1984089779","https://openalex.org/W1984771893","https://openalex.org/W1989066796","https://openalex.org/W1989087051","https://openalex.org/W1989249456","https://openalex.org/W1989528677","https://openalex.org/W1991366776","https://openalex.org/W1991772978","https://openalex.org/W1992525412","https://openalex.org/W1993823258","https://openalex.org/W1995227276","https://openalex.org/W1997536241","https://openalex.org/W1998416188","https://openalex.org/W1999631359","https://openalex.org/W2000791013","https://openalex.org/W2001402717","https://openalex.org/W2002562482","https://openalex.org/W2003123169","https://openalex.org/W2003188525","https://openalex.org/W2003410399","https://openalex.org/W2004060692","https://openalex.org/W2004240389","https://openalex.org/W2004406347","https://openalex.org/W2004993911","https://openalex.org/W2005441705","https://openalex.org/W2005925597","https://openalex.org/W2008072540","https://openalex.org/W2013653760","https://openalex.org/W2013887112","https://openalex.org/W2015858981","https://openalex.org/W2017725789","https://openalex.org/W2018736934","https://openalex.org/W2018750514","https://openalex.org/W2019008972","https://openalex.org/W2019250628","https://openalex.org/W2019535483","https://openalex.org/W2019558153","https://openalex.org/W2022188529","https://openalex.org/W2023174772","https://openalex.org/W2023798788","https://openalex.org/W2024717575","https://openalex.org/W2025502483","https://openalex.org/W2026105737","https://openalex.org/W2027795947","https://openalex.org/W2027894979","https://openalex.org/W2028075356","https://openalex.org/W2029584072","https://openalex.org/W2030219424","https://openalex.org/W2030814758","https://openalex.org/W2030833898","https://openalex.org/W2033476668","https://openalex.org/W2034335770","https://openalex.org/W2034623287","https://openalex.org/W2035162752","https://openalex.org/W2035183926","https://openalex.org/W2037393813","https://openalex.org/W2038112426","https://openalex.org/W2039142811","https://openalex.org/W2039385640","https://openalex.org/W2042422091","https://openalex.org/W2042530953","https://openalex.org/W2043305007","https://openalex.org/W2043830216","https://openalex.org/W2044091266","https://openalex.org/W2045849369","https://openalex.org/W2047699315","https://openalex.org/W2048005373","https://openalex.org/W2048420531","https://openalex.org/W2048498676","https://openalex.org/W2048960021","https://openalex.org/W2049017691","https://openalex.org/W2049382869","https://openalex.org/W2050437049","https://openalex.org/W2051638758","https://openalex.org/W2054683291","https://openalex.org/W2055390759","https://openalex.org/W2055670306","https://openalex.org/W2055852420","https://openalex.org/W2056409947","https://openalex.org/W2057418199","https://openalex.org/W2059994807","https://openalex.org/W2060302535","https://openalex.org/W2060311284","https://openalex.org/W2061656366","https://openalex.org/W2064182395","https://openalex.org/W2067055660","https://openalex.org/W2067261800","https://openalex.org/W2067990182","https://openalex.org/W2068898323","https://openalex.org/W2072304064","https://openalex.org/W2073218335","https://openalex.org/W2073850907","https://openalex.org/W2075204863","https://openalex.org/W2075888943","https://openalex.org/W2075902432","https://openalex.org/W2076206894","https://openalex.org/W2076521884","https://openalex.org/W2077714930","https://openalex.org/W2078241081","https://openalex.org/W2078926626","https://openalex.org/W2079930410","https://openalex.org/W2079938883","https://openalex.org/W2081499598","https://openalex.org/W2082249282","https://openalex.org/W2082809972","https://openalex.org/W2083362231","https://openalex.org/W2091241793","https://openalex.org/W2091364185","https://openalex.org/W2091490498","https://openalex.org/W2092507269","https://openalex.org/W2092635505","https://openalex.org/W2093225320","https://openalex.org/W2093538602","https://openalex.org/W2095341170","https://openalex.org/W2095485695","https://openalex.org/W2095920121","https://openalex.org/W2096198884","https://openalex.org/W2106804169","https://openalex.org/W2108856110","https://openalex.org/W2111039706","https://openalex.org/W2112017685","https://openalex.org/W2115721699","https://openalex.org/W2120746654","https://openalex.org/W2131059399","https://openalex.org/W2132135875","https://openalex.org/W2138408590","https://openalex.org/W2138554096","https://openalex.org/W2139155172","https://openalex.org/W2140494844","https://openalex.org/W2141182992","https://openalex.org/W2141946911","https://openalex.org/W2142918026","https://openalex.org/W2147687590","https://openalex.org/W2151818004","https://openalex.org/W2153883114","https://openalex.org/W2156877875","https://openalex.org/W2164855749","https://openalex.org/W2169054484","https://openalex.org/W2169566293","https://openalex.org/W2170974856","https://openalex.org/W2208762294","https://openalex.org/W2215413276","https://openalex.org/W2219432952","https://openalex.org/W2227670160","https://openalex.org/W2275513263","https://openalex.org/W2324446066","https://openalex.org/W2398137194","https://openalex.org/W2401172749","https://openalex.org/W2401790577","https://openalex.org/W2408958446","https://openalex.org/W2417129789","https://openalex.org/W2417687935","https://openalex.org/W2418425878","https://openalex.org/W2419319620","https://openalex.org/W2419603248","https://openalex.org/W2428045570","https://openalex.org/W2470016997","https://openalex.org/W2470951531","https://openalex.org/W2484613043","https://openalex.org/W2490281677","https://openalex.org/W2614218613"],"related_works":["https://openalex.org/W7002116106","https://openalex.org/W173633881","https://openalex.org/W2036537718","https://openalex.org/W2074216751","https://openalex.org/W2032773883","https://openalex.org/W7099360753","https://openalex.org/W1964052519","https://openalex.org/W2056409947","https://openalex.org/W7042736263","https://openalex.org/W2031312860"],"abstract_inverted_index":{"Hyperammonemia":[0],"is":[1,9,239],"defined":[2],"as":[3,124],"an":[4,12,99,125,269],"elevated":[5],"ammonia":[6,19,39,62,97,146,251,278],"concentration,":[7],"which":[8],"caused":[10],"by":[11,103,140],"impairment":[13],"of":[14,30,38,55,60,90,105,159,167,178,199,206,222,259,272,277,282],"liver":[15],"function.":[16],"The":[17,88,157,197],"increased":[18,100],"concentrations":[20],"in":[21,40,110,149,155,170,193,213,229,263,274],"the":[22,34,43,53,58,91,130,160,164,168,176,200,214,225,232,236,275,280,283],"brain":[23],"exert":[24],"toxic":[25],"effects":[26,59],"on":[27,33,65,181,224],"neural":[28,182],"cells.Despite":[29],"intensive":[31],"investigations":[32],"role":[35,221,271],"and":[36,63,84,107,113,138,186,252,279],"importance":[37],"cerebral":[41,66],"metabolism,":[42,183],"exact":[44],"molecular":[45,78],"mechanism":[46],"could":[47,117],"not":[48,240],"be":[49,118],"yet":[50],"clarified.":[51],"In":[52,128],"line":[54],"this":[56,71],"thesis,":[57],"extracellular":[61,179,207,253],"glutamine":[64,121,153,180,208,223,254,260],"metabolism":[67,102,228],"were":[68,86,188],"investigated.":[69],"For":[70],"purpose,":[72],"apart":[73],"form":[74],"multinuclear":[75],"NMR":[76],"spectroscopy,":[77],"biological":[79],"methods,":[80],"e.g.":[81],"Western":[82,243],"Blotting,":[83],"RT-PCR":[85],"used.":[87],"data":[89,198],"present":[92,161,201],"study":[93,162,175,202],"clearly":[94],"show":[95,203],"that":[96,120,204,235,249],"causes":[98],"glucose":[101],"stimulation":[104],"glycolytic-":[106],"TCA":[108,216],"cycle-activity":[109],"both":[111,250],"astrocytes":[112,171,185],"neurons.":[114],"Furthermore,":[115,231],"it":[116,246],"shown":[119,248],"was":[122,134,247],"utilized":[123],"anaplerotic":[126],"substrate.":[127],"addition,":[129],"nitrogen":[131],"from":[132],"glutamate":[133],"transferred":[135],"to":[136,144,152,172,210,268],"oxaloacetate":[137],"pyruvate":[139],"aminotransferase.":[141],"This":[142,265],"indicates":[143,267],"alternative":[145],"detoxification":[147],"processes":[148],"neurons,":[150],"compared":[151],"synthesis":[154],"astrocytes.":[156,264],"results":[158,233],"confirm":[163],"higher":[165],"susceptibility":[166],"energy-status":[169],"ammonia.":[173],"To":[174],"effect":[177],"primary":[184],"neurons":[187,230],"incubated":[189],"for":[190],"24":[191],"hours":[192],"a":[194,211,219,256],"glutamine-containing":[195],"medium.":[196],"deprivation":[205],"leads":[209],"disturbance":[212],"neuronal":[215],"cycle,":[217],"demonstrating":[218],"crucial":[220],"normal,":[226],"physiological":[227],"prove":[234],"glutamine-glutamate":[237,284],"cycle":[238],"stochiometric.":[241],"Using":[242],"blot":[244],"analysis,":[245],"cause":[255],"remarkably":[257],"increase":[258],"synthetase":[261],"expression":[262],"finding":[266],"important":[270],"GS":[273],"elimination":[276],"regulation":[281],"cycle.":[285]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-07T00:00:00"}
