{"id":"https://openalex.org/W2947960604","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e14645","title":"Real-world application of next generation sequencing to guide therapeutic options in lymphoma.","display_name":"Real-world application of next generation sequencing to guide therapeutic options in lymphoma.","publication_year":2019,"publication_date":"2019-05-20","ids":{"openalex":"https://openalex.org/W2947960604","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e14645","mag":"2947960604"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2019.37.15_suppl.e14645","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e14645","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.e14645","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003027916","display_name":"Molly C. Tokaz","orcid":"https://orcid.org/0000-0001-6371-4527","observed_orcids":["https://orcid.org/0000-0001-6371-4527"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molly Tokaz","raw_affiliation_strings":["University of Michigan Hospital, Ann Arbor, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Hospital, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045953567","display_name":"Anthony J. Scott","orcid":"https://orcid.org/0000-0003-0644-1790","observed_orcids":["https://orcid.org/0000-0003-0644-1790"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Scott","raw_affiliation_strings":["University of Michigan Medical Center, Ann Arbor, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical Center, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080068122","display_name":"Maryann M. Shango","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryann Shango","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047177351","display_name":"Sumana Devata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumana Devata","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073509371","display_name":"Shannon A. Carty","orcid":"https://orcid.org/0000-0003-2286-8014","observed_orcids":["https://orcid.org/0000-0003-2286-8014"]},"institutions":[{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Carty","raw_affiliation_strings":["Rogel Cancer Center, Ann Arbor, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rogel Cancer Center, Ann Arbor, MI;","institution_ids":["https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003311852","display_name":"Arul M. Chinnaiyan","orcid":"https://orcid.org/0000-0001-9282-3415","observed_orcids":["https://orcid.org/0000-0001-9282-3415"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arul Chinnaiyan","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080366682","display_name":"Mark Stefan Kaminski","orcid":"https://orcid.org/0000-0002-8712-2953","observed_orcids":["https://orcid.org/0000-0002-8712-2953"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Kaminski","raw_affiliation_strings":["University of Michigan Medical Center, Ann Arbor, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical Center, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062534813","display_name":"Tycel Jovelle Phillips","orcid":"https://orcid.org/0000-0003-2143-9672","observed_orcids":["https://orcid.org/0000-0003-2143-9672"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tycel Jovelle Phillips","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020537159","display_name":"Ryan A. Wilcox","orcid":"https://orcid.org/0000-0002-6420-0760","observed_orcids":["https://orcid.org/0000-0002-6420-0760"]},"institutions":[{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan A. Wilcox","raw_affiliation_strings":["University of Michigan Comprehensive Cancer Center, Dexter, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Comprehensive Cancer Center, Dexter, MI;","institution_ids":["https://openalex.org/I4390039285"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"15_suppl","first_page":"e14645","last_page":"e14645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.9629999995231628},{"id":"https://openalex.org/keywords/tumor-sequencing","display_name":"tumor sequencing","score":0.5929999947547913},{"id":"https://openalex.org/keywords/actionable-therapeutic-targets","display_name":"actionable targets","score":0.9629999995231628},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.796999990940094},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6930000185966492},{"id":"https://openalex.org/keywords/molecular-alterations","display_name":"molecular alterations","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.859673261642456},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5927964448928833},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.5140343904495239},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.44216105341911316},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4303479492664337},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42624741792678833},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4018707275390625},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3722130060195923},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15556907653808594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2019.37.15_suppl.e14645","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e14645","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.e14645","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.550000011920929}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200407670","https://openalex.org/W3037909725","https://openalex.org/W4252478283","https://openalex.org/W4312815657","https://openalex.org/W4323912214","https://openalex.org/W3014749029","https://openalex.org/W4388011470","https://openalex.org/W4280635227","https://openalex.org/W1501007924","https://openalex.org/W3097361656"],"abstract_inverted_index":{"e14645":[0],"Background:":[1],"Despite":[2],"the":[3,39,68,81,89,125,172,194,209,224,232,293],"increasing":[4,280],"availability":[5,225,275],"of":[6,13,42,64,84,108,134,200,211,226,234,260],"targeted":[7,227],"and":[8,115,181,197,220,237,272],"novel":[9],"therapies,":[10],"successful":[11,40],"treatment":[12,139,150,162,179],"many":[14],"relapsed/refractory":[15,285],"lymphomas":[16],"remains":[17,35,263],"a":[18,46,189,198,250,264,297],"challenge.":[19,265],"Tumor":[20],"sequencing":[21,63,112,191,219,247,271],"is":[22,249,289],"becoming":[23],"an":[24,106],"increasingly":[25],"available":[26,201],"technique":[27],"to":[28,71,152,222,291,295],"identify":[29,72],"potential":[30],"therapeutic":[31,74,282],"targets;":[32],"however,":[33],"there":[34],"considerable":[36],"uncertainty":[37],"about":[38],"application":[41,233,259],"this":[43],"data":[44,213,236],"in":[45,193,240,279],"\u201creal":[47],"world\u201d":[48],"clinical":[49,82,202,215,241,258],"setting.":[50],"Methods:":[51],"Herein,":[52],"we":[53],"describe":[54],"91":[55,90],"lymphoma":[56],"patients":[57,91,97,128,146],"who":[58],"underwent":[59,105],"DNA":[60],"&":[61],"RNA":[62],"tumor":[65],"biopsies":[66],"via":[67],"MIONCOSEQ":[69,85,142,212],"protocol":[70],"actionable":[73,131],"targets.":[75],"Their":[76],"charts":[77],"were":[78,92,204],"reviewed":[79],"for":[80,177,208,253,284],"use":[83],"recommendations.":[86,143],"Results:":[87],"Among":[88],"13":[93],"Lymphoma":[94],"subtypes.":[95],"Most":[96],"had":[98,116,130],"Stage":[99],"III/IV":[100],"disease":[101,195],"(68%)":[102],"at":[103,171],"diagnosis,":[104],"average":[107],"4":[109],"treatments":[110,185],"before":[111],"(range":[113,122],"0-16)":[114],"approximately":[117],"47":[118],"distinct":[119],"molecular":[120],"alterations":[121],"2-447).":[123],"Of":[124],"cohort,":[126],"60":[127],"(65%)":[129],"targets":[132],"identified":[133,205],"which":[135,296],"11":[136],"ultimately":[137],"received":[138],"based":[140],"on":[141,158,183],"The":[144],"remaining":[145],"did":[147],"not":[148,160],"receive":[149],"due":[151],"multiple":[153],"reasons:":[154],"prior":[155],"CR":[156],"or":[157],"surveillance":[159],"requiring":[161],"(10);":[163],"death":[164],"(12);":[165],"trial":[166,169,274],"ineligibility":[167],"(4);":[168],"unavailability":[170],"institution":[173],"(8);":[174],"patient":[175],"preference":[176],"local":[178],"(6);":[180],"already":[182],"alternative":[184],"(9).":[186],"Taken":[187],"as":[188,206],"whole,":[190],"late":[192],"course":[196],"lack":[199],"trials":[203],"barriers":[207],"incorporation":[210],"into":[214],"practice.":[216,242],"Therefore,":[217],"earlier":[218],"strategies":[221],"bolster":[223],"therapies":[228],"may":[229],"significantly":[230],"increase":[231],"genomic":[235],"precision":[238,255],"medicine":[239],"Conclusions:":[243],"While":[244],"next":[245],"generation":[246],"(NGS)":[248],"powerful":[251],"tool":[252],"advancing":[254],"medicine,":[256],"meaningful":[257],"these":[261],"results":[262],"Our":[266],"study":[267],"indicates":[268],"that":[269],"early":[270],"improved":[273],"could":[276],"be":[277],"beneficial":[278],"real-world":[281],"options":[283],"lymphoma.":[286],"Further":[287],"research":[288],"needed":[290],"determine":[292],"extent":[294],"personalized":[298],"approach,":[299],"informed":[300],"by":[301],"NGS":[302],"data,":[303],"improves":[304],"outcomes.":[305]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}