{"id":"https://openalex.org/W2947922476","doi":null,"title":"Role of transforming growth factor-\u2203 in the progression of head and neck squamous cell carcinoma in a murine model.","display_name":"Role of transforming growth factor-\u2203 in the progression of head and neck squamous cell carcinoma in a murine model.","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W2947922476","mag":"2947922476"},"language":"en","primary_location":{"id":"mag:2947922476","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/67/9_Supplement/2165","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103635316","display_name":"Sunil K. Chatterjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunil K. Chatterjee","raw_affiliation_strings":["Univ. of Cincinnati, Cincinnati, OH, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Cincinnati, Cincinnati, OH, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109036736","display_name":"Malaya Bhattacharya\u2010Chatterjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malaya Bhattacharya\u2010Chatterjee","raw_affiliation_strings":["Univ. of Cincinnati, Cincinnati, OH, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Cincinnati, Cincinnati, OH, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053170957","display_name":"Benjamin A. Katchman","orcid":"https://orcid.org/0000-0002-7945-9943","observed_orcids":["https://orcid.org/0000-0002-7945-9943"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin A. Katchman","raw_affiliation_strings":["Univ. of Cincinnati, Cincinnati, OH, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":"https://orcid.org/0000-0002-7945-9943","affiliations":[{"raw_affiliation_string":"Univ. of Cincinnati, Cincinnati, OH, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040723719","display_name":"Asim Saha","orcid":"https://orcid.org/0000-0003-4721-2695","observed_orcids":["https://orcid.org/0000-0003-4721-2695"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asim Saha","raw_affiliation_strings":["Univ. of Cincinnati, Cincinnati, OH, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":"https://orcid.org/0000-0003-4721-2695","affiliations":[{"raw_affiliation_string":"Univ. of Cincinnati, Cincinnati, OH, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086418565","display_name":"Palash Mallick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Palash Mallick","raw_affiliation_strings":["Univ. of Cincinnati, Cincinnati, OH, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Cincinnati, Cincinnati, OH, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056527038","display_name":"John R. Pancoast","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Pancoast","raw_affiliation_strings":["Univ. of Cincinnati, Cincinnati, OH, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Cincinnati, Cincinnati, OH, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":null,"display_name":"Bert W. O\u2019Malley","orcid":"https://orcid.org/0000-0003-3332-1399","observed_orcids":["https://orcid.org/0000-0003-3332-1399"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bert W. O\u2019Malley","raw_affiliation_strings":["Univ. of Cincinnati, Cincinnati, OH, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":"https://orcid.org/0000-0003-3332-1399","affiliations":[{"raw_affiliation_string":"Univ. of Cincinnati, Cincinnati, OH, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":null,"first_page":"2165","last_page":"2165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.04560000076889992,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8820000290870667},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6819999814033508},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6119999885559082},{"id":"https://openalex.org/keywords/tgf-beta-receptor","display_name":"TGF-beta receptor","score":0.675000011920929},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6000000238418579},{"id":"https://openalex.org/keywords/vegf-secretion","display_name":"VEGF secretion","score":0.8230000138282776},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.6880000233650208},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7039999961853027},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.6570000052452087},{"id":"https://openalex.org/keywords/tumor-associated-neutrophils","display_name":"tumor-associated neutrophils","score":0.7200000286102295},{"id":"https://openalex.org/keywords/tumor-associated-dendritic-cells","display_name":"tumor-associated dendritic cells","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tumor-associated-t-cells","display_name":"tumor-associated T cells","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6264857649803162},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.555338442325592},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5472511649131775},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5177828073501587},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.4668847620487213},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.4457651376724243},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.4433711767196655},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3665326237678528},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3079891800880432},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.2285672128200531},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17838069796562195},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.0940292477607727},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2947922476","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/67/9_Supplement/2165","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2030564965","https://openalex.org/W1980802790","https://openalex.org/W12241887","https://openalex.org/W2022857324","https://openalex.org/W2028183553","https://openalex.org/W2152142084","https://openalex.org/W2886048619","https://openalex.org/W2002201590","https://openalex.org/W2000547121","https://openalex.org/W1019023126"],"abstract_inverted_index":{"2165":[0],"In":[2,44],"an":[3],"orthotopic":[4],"model":[5,333],"of":[6,24,51,63,82,99,101,104,114,124,144,149,155,158,181,186,194,217,224,259,270,275,289,298,310,316,324,342],"head":[7],"and":[8,41,61,68,77,118,147,163,226,244,273,293],"neck":[9],"squamous":[10],"cell":[11],"carcinoma":[12],"(HNSCC)":[13],"in":[14,54,74,92,95,108,166,197,208,214,247,267,278,283,302,331,344,348],"immunocompetent":[15],"mice":[16,151,219,235],"(SCC":[17],"VII/SF),":[18],"we":[19,47],"determined":[20,58],"the":[21,49,59,122,130,184,209,215,221,268,287,290,295,299,308,321,340],"vaccine":[22,35],"efficiency":[23,36],"recombinant":[25],"vaccinia":[26],"virus":[27],"expressing":[28],"IL-2":[29],"(rvv-IL-2).":[30],"Despite":[31],"significant":[32],"tumor":[33,109,139,248,279,284,291,303,345],"regression,":[34],"was":[37,126,170],"restricted":[38],"by":[39,318,350],"recurrence":[40],"loco-regional":[42],"metastasis.":[43],"this":[45,55,96,332],"study":[46],"examined":[48],"mechanism":[50],"immune":[52,69,93,105,245,300],"escape":[53],"model.":[56,97],"We":[57,252],"frequency":[60],"activities":[62,223,240,297,323],"CD4+/CD25+":[64],"regulatory":[65],"T":[66,225],"cells":[67,73,84,134,169,196,205,246,265,292,301],"suppressive":[70],"myeloid":[71],"CD11b+/CD31+/Gr-1+":[72],"rvv-IL-2":[75,233],"vaccinated":[76,234],"control":[78],"mice.":[79],"These":[80],"populations":[81],"suppressor":[83],"do":[85],"not":[86,136],"appear":[87],"to":[88,174,242,338],"have":[89],"any":[90],"role":[91],"suppression":[94],"Assay":[98],"expression":[100,113,123],"a":[102],"number":[103],"modulatory":[106],"molecules":[107],"lesions":[110],"demonstrated":[111],"high":[112,142,153],"TGF-\u03b2,":[115,138],"IL-10,":[116],"GM-CSF":[117],"iNOS.":[119],"Among":[120],"these,":[121],"TGF-\u03b2":[125,146,159,182,191,201,212,260,271,277,282,306,319,343],"most":[127],"abundant.":[128],"Although":[129],"cultured":[131,187],"SCC":[132,167,188,203,263,311,325],"VII/SF":[133,168,189,204,264,312,326],"did":[135],"express":[137,141],"tissues":[140],"levels":[143,154],"activated":[145,276],"sera":[148,216],"tumor-bearing":[150,218],"had":[152],"TGF-\u03b2.":[156],"Expression":[157],"receptors,":[160],"(TGFBR":[161],"I":[162],"TGFBR":[164],"II)":[165],"significantly":[171],"lower":[172,238],"compared":[173,241],"normal":[175],"mouse":[176],"epithelial":[177],"cells.":[178,190,228,313,327],"Low":[179],"concentrations":[180],"stimulated":[183,192,307],"growth":[185,288],"invasion":[193,309],"SCCVII/SF":[195],"Matrigel":[198],"Invasion":[199],"Chambers.":[200],"treated":[202],"secreted":[206],"VEGF":[207,317],"culture":[210],"media.":[211],"present":[213],"inhibited":[220],"biological":[222,239,296],"NK":[227],"Tumor":[229],"infiltrating":[230],"lymphocytes":[231],"from":[232,254,262],"also":[236],"showed":[237],"splenocytes":[243],"draining":[249],"lymph":[250],"nodes.":[251],"concluded":[253],"these":[255],"data":[256],"that":[257],"loss":[258],"receptors":[261],"resulted":[266],"disruption":[269],"signaling":[272],"accumulation":[274],"microenvironment.":[280,304,346],"Accumulated":[281],"microenvironment":[285],"promoted":[286],"disrupted":[294],"Moreover,":[305],"Increased":[314],"secretion":[315],"augmented":[320],"metastatic":[322],"For":[328],"successful":[329],"immunotherapy":[330],"it":[334],"would":[335],"be":[336],"necessary":[337],"reduce":[339],"level":[341],"Supported":[347],"part":[349],"NIH":[351],"grant":[352],"RO1":[353],"CA":[354],"89748.":[355]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2019-06-07T00:00:00"}