{"id":"https://openalex.org/W2947836875","doi":null,"title":"Mechanotransduction and ion transport of the endothelial glycocalyx : a large-scale molecular dynamics study","display_name":"Mechanotransduction and ion transport of the endothelial glycocalyx : a large-scale molecular dynamics study","publication_year":2018,"publication_date":"2018-10-28","ids":{"openalex":"https://openalex.org/W2947836875","mag":"2947836875"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10058832","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10058832/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048680094","display_name":"Xi Zhuo Jiang","orcid":"https://orcid.org/0000-0002-1317-964X","observed_orcids":["https://orcid.org/0000-0002-1317-964X","https://orcid.org/0009-0004-0986-3280"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xizhuo Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5048680094"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.3752000033855438,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.3752000033855438,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.19290000200271606,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.09390000253915787,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-glycocalyx","display_name":"endothelial glycocalyx","score":1.0},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ion-transport","display_name":"ion transport","score":0.9679999947547913},{"id":"https://openalex.org/keywords/blood-flow","display_name":"blood flow","score":0.722000002861023},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.972000002861023},{"id":"https://openalex.org/keywords/endothelial-barrier-function","display_name":"endothelial barrier function","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C2780098789","wikidata":"https://www.wikidata.org/wiki/Q898356","display_name":"Glycocalyx","level":2,"score":0.9874687194824219},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.8064082860946655},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5868972539901733},{"id":"https://openalex.org/C21141959","wikidata":"https://www.wikidata.org/wiki/Q657936","display_name":"Shear stress","level":2,"score":0.5245097875595093},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4800925552845001},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.44508007168769836},{"id":"https://openalex.org/C131631996","wikidata":"https://www.wikidata.org/wiki/Q1141325","display_name":"Lumen (anatomy)","level":2,"score":0.411421000957489},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40230679512023926},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.32730790972709656},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.26564133167266846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23326769471168518},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18311822414398193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10121938586235046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10058832","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10058832/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:2947836875","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/id/eprint/10058832/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":137,"referenced_works":["https://openalex.org/W11810794","https://openalex.org/W75166960","https://openalex.org/W134700339","https://openalex.org/W200994553","https://openalex.org/W1510399576","https://openalex.org/W1570257195","https://openalex.org/W1840872282","https://openalex.org/W1879695632","https://openalex.org/W1936770188","https://openalex.org/W1967534316","https://openalex.org/W1968371127","https://openalex.org/W1969929083","https://openalex.org/W1971664858","https://openalex.org/W1976499671","https://openalex.org/W1976735940","https://openalex.org/W1977668366","https://openalex.org/W1978807770","https://openalex.org/W1980871054","https://openalex.org/W1982748428","https://openalex.org/W1985813959","https://openalex.org/W1987893498","https://openalex.org/W1987998019","https://openalex.org/W1991998048","https://openalex.org/W1992533883","https://openalex.org/W1996795546","https://openalex.org/W1997590090","https://openalex.org/W1997938471","https://openalex.org/W2000460436","https://openalex.org/W2000465700","https://openalex.org/W2002350611","https://openalex.org/W2003020475","https://openalex.org/W2009826592","https://openalex.org/W2013979082","https://openalex.org/W2017295052","https://openalex.org/W2019702170","https://openalex.org/W2020732104","https://openalex.org/W2021645853","https://openalex.org/W2024131229","https://openalex.org/W2027408247","https://openalex.org/W2028830247","https://openalex.org/W2029667189","https://openalex.org/W2030216347","https://openalex.org/W2031272029","https://openalex.org/W2033093592","https://openalex.org/W2034248554","https://openalex.org/W2035266068","https://openalex.org/W2040064797","https://openalex.org/W2040138930","https://openalex.org/W2041902442","https://openalex.org/W2044592960","https://openalex.org/W2044652637","https://openalex.org/W2047136147","https://openalex.org/W2049718632","https://openalex.org/W2051596663","https://openalex.org/W2054512362","https://openalex.org/W2055375869","https://openalex.org/W2057918301","https://openalex.org/W2058064653","https://openalex.org/W2058172582","https://openalex.org/W2058912578","https://openalex.org/W2060079863","https://openalex.org/W2063922196","https://openalex.org/W2067174909","https://openalex.org/W2068834294","https://openalex.org/W2069443069","https://openalex.org/W2070244277","https://openalex.org/W2071010874","https://openalex.org/W2071145526","https://openalex.org/W2073019678","https://openalex.org/W2080151529","https://openalex.org/W2084652263","https://openalex.org/W2086381852","https://openalex.org/W2086946136","https://openalex.org/W2093221728","https://openalex.org/W2098539467","https://openalex.org/W2099598754","https://openalex.org/W2100833559","https://openalex.org/W2103945336","https://openalex.org/W2104052152","https://openalex.org/W2105415261","https://openalex.org/W2105534832","https://openalex.org/W2111800573","https://openalex.org/W2113427441","https://openalex.org/W2114952318","https://openalex.org/W2118335680","https://openalex.org/W2119802842","https://openalex.org/W2123681603","https://openalex.org/W2124745044","https://openalex.org/W2127785449","https://openalex.org/W2132703750","https://openalex.org/W2134621426","https://openalex.org/W2135962807","https://openalex.org/W2143697649","https://openalex.org/W2143965055","https://openalex.org/W2145156849","https://openalex.org/W2146403956","https://openalex.org/W2147604745","https://openalex.org/W2148910661","https://openalex.org/W2150561062","https://openalex.org/W2150981663","https://openalex.org/W2152252241","https://openalex.org/W2152543475","https://openalex.org/W2152678130","https://openalex.org/W2156014566","https://openalex.org/W2156156866","https://openalex.org/W2157195892","https://openalex.org/W2160373069","https://openalex.org/W2162303223","https://openalex.org/W2165130888","https://openalex.org/W2166841168","https://openalex.org/W2177224260","https://openalex.org/W2231875798","https://openalex.org/W2300722342","https://openalex.org/W2302303317","https://openalex.org/W2302884879","https://openalex.org/W2318347990","https://openalex.org/W2320656688","https://openalex.org/W2328490316","https://openalex.org/W2333729563","https://openalex.org/W2341655097","https://openalex.org/W2501078658","https://openalex.org/W2514965278","https://openalex.org/W2527154400","https://openalex.org/W2553936717","https://openalex.org/W2557726663","https://openalex.org/W2573771003","https://openalex.org/W2580325886","https://openalex.org/W2581888819","https://openalex.org/W2594335097","https://openalex.org/W2615108024","https://openalex.org/W2706450057","https://openalex.org/W2714824404","https://openalex.org/W2772181290","https://openalex.org/W2791160082","https://openalex.org/W2791748439","https://openalex.org/W2803134496","https://openalex.org/W2805171242"],"related_works":["https://openalex.org/W2772181290","https://openalex.org/W2921542650","https://openalex.org/W6902268031","https://openalex.org/W2896604346","https://openalex.org/W2941927952","https://openalex.org/W7215027943","https://openalex.org/W2973222431","https://openalex.org/W2791160082","https://openalex.org/W2034248554","https://openalex.org/W2757782906"],"abstract_inverted_index":{"In":[0,68],"our":[1],"vessels,":[2],"the":[3,7,15,18,23,39,63,85,102,114,117,133,140,148,154,158,165,196,201,209,228,231,244,279,288,297,307],"endothelial":[4,25,86,129,210],"glycocalyx":[5,26,87,115,130,134,162,202,211],"is":[6,94,106,221],"first":[8],"and":[9,49,51,54,58,119,128,137,191,254,266],"foremost":[10],"barrier":[11,36],"directly":[12],"exposed":[13],"to":[14,37,56,66,80,269,296],"blood":[16,43,64,217],"in":[17,98,101,294],"lumen.":[19],"The":[20,123,144,161,214,260,271,282],"functions":[21],"of":[22,42,73,84,113,126,147,167,185,198,200,208,230,237,239,246,274,284,310],"normal":[24],"under":[27],"physiological":[28,304],"conditions":[29],"are":[30,290],"widely":[31],"accepted":[32],"as":[33,150],"a":[34,52,71,95,151,183,224,303],"physical":[35],"prevent":[38],"abnormal":[40],"transportation":[41],"components":[44],"(e.g.":[45],"ions,":[46],"proteins,":[47],"albumin":[48],"etc.)":[50],"mechanosensor":[53],"mechanotransducer":[55],"sense":[57],"transmit":[59],"mechanical":[60],"signals":[61],"from":[62,182,216],"flow":[65,100,127,141,155,172,192,218,247,261,285,305],"cytoplasm.":[67],"this":[69],"study,":[70],"series":[72,184],"large-scale":[74],"molecular":[75],"dynamics":[76,125,197],"simulations":[77],"were":[78],"undertaken":[79],"study":[81,97],"atomic":[82],"events":[83],"layers":[88],"interacting":[89],"with":[90,116,187,234,316],"flow.":[91],"This":[92],"research":[93],"pioneer":[96],"which":[99],"physiologically":[103],"relevant":[104],"range":[105],"accomplished":[107],"based":[108,179],"on":[109,174,180,195,249,287],"an":[110,235],"atomistic":[111],"model":[112],"to-date":[118],"detailed":[120],"structural":[121],"information.":[122],"coupled":[124],"show":[131],"that":[132,302],"constituents":[135],"swing":[136],"swirl":[138],"when":[139],"passes":[142],"by.":[143],"active":[145],"motion":[146,226],"glycocalyx,":[149],"result,":[152],"disturbs":[153],"by":[156,313],"modifying":[157],"velocity":[159,286],"distributions.":[160],"also":[163],"controls":[164],"emergence":[166],"strong":[168],"shear":[169,219],"stresses.":[170],"Moreover,":[171],"regime":[173],"complex":[175],"surface":[176,189],"was":[177,212,252,258],"proposed":[178],"results":[181],"cases":[186],"varying":[188],"configurations":[190],"velocities.":[193],"Based":[194],"subdomains":[199],"core":[203,232],"protein,":[204],"mechanism":[205,245],"for":[206],"mechanotransduction":[207],"established.":[213],"force":[215],"stress":[220],"transmitted":[222],"via":[223],"scissor-like":[225],"alongside":[227],"bending":[229],"protein":[233],"order":[236],"magnitude":[238],"10~":[240],"100":[241],"pN.":[242],"Finally,":[243],"impact":[248],"ion":[250],"transport":[251,312],"investigated":[253],"improved":[255,298],"Starling":[256,299],"principle":[257,300],"proposed.":[259],"modifies":[262],"sugar":[263,275],"chain":[264],"conformations":[265],"transfers":[267],"momentum":[268],"ions.":[270],"conformational":[272],"changes":[273,306],"chains":[276],"then":[277],"affect":[278],"Na+/sugar-chain":[280],"interactions.":[281],"effects":[283],"interactions":[289],"non-linear.":[291],"An":[292],"estimation":[293],"accordance":[295],"suggests":[301],"osmotic":[308],"part":[309],"Na+":[311],"8%":[314],"compared":[315],"stationary":[317],"transport.":[318]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-06-07T00:00:00"}
