{"id":"https://openalex.org/W2947799331","doi":"https://doi.org/10.1186/s13058-019-1147-7","title":"Rack1 mediates tyrosine phosphorylation of Anxa2 by Src and promotes invasion and metastasis in drug-resistant breast cancer cells","display_name":"Rack1 mediates tyrosine phosphorylation of Anxa2 by Src and promotes invasion and metastasis in drug-resistant breast cancer cells","publication_year":2019,"publication_date":"2019-05-22","ids":{"openalex":"https://openalex.org/W2947799331","doi":"https://doi.org/10.1186/s13058-019-1147-7","mag":"2947799331","pmid":"https://pubmed.ncbi.nlm.nih.gov/31113450","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6530024"},"language":"en","primary_location":{"id":"doi:10.1186/s13058-019-1147-7","doi":"https://doi.org/10.1186/s13058-019-1147-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13058-019-1147-7","pdf_url":"https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/s13058-019-1147-7","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2947799331"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/s13058-019-1147-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100525687","display_name":"Yanling Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanling Fan","raw_affiliation_strings":["Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080380278","display_name":"Weiyao Si","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiyao Si","raw_affiliation_strings":["Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101397423","display_name":"Wei Ji","orcid":"https://orcid.org/0009-0001-8162-6165","observed_orcids":["https://orcid.org/0009-0001-8162-6165"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Ji","raw_affiliation_strings":["Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443922","display_name":"Zhiyong Wang","orcid":"https://orcid.org/0000-0002-3574-6078","observed_orcids":["https://orcid.org/0000-0002-3574-6078"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyong Wang","raw_affiliation_strings":["Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103966759","display_name":"Zicong Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zicong Gao","raw_affiliation_strings":["Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046290843","display_name":"Ran Tian","orcid":"https://orcid.org/0000-0003-2637-6340","observed_orcids":["https://orcid.org/0000-0003-2637-6340","https://orcid.org/0000-0003-0103-6390"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ran Tian","raw_affiliation_strings":["Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101436741","display_name":"Weijie Song","orcid":"https://orcid.org/0000-0002-1041-4405","observed_orcids":["https://orcid.org/0000-0002-1041-4405"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijie Song","raw_affiliation_strings":["Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420122","display_name":"He Zhang","orcid":"https://orcid.org/0000-0002-3283-8620","observed_orcids":["https://orcid.org/0000-0002-3283-8620"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"He Zhang","raw_affiliation_strings":["Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","institution_ids":[]},{"raw_affiliation_string":"Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064802725","display_name":"Ruifang Niu","orcid":"https://orcid.org/0000-0002-8845-8838","observed_orcids":["https://orcid.org/0000-0002-8845-8838"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruifang Niu","raw_affiliation_strings":["Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China. rniu@tmu.edu.cn","Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China. rniu@tmu.edu.cn","Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China. rniu@tmu.edu.cn","Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China. rniu@tmu.edu.cn","Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China. rniu@tmu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China. rniu@tmu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China. rniu@tmu.edu.cn","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China. rniu@tmu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China","institution_ids":["https://openalex.org/I2802573037"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100412154","display_name":"Fei Zhang","orcid":"https://orcid.org/0000-0001-7434-7339","observed_orcids":["https://orcid.org/0000-0001-7434-7339"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fei Zhang","raw_affiliation_strings":["Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China. feizhang03@tmu.edu.cn","Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China. feizhang03@tmu.edu.cn","Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China. feizhang03@tmu.edu.cn","Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China. feizhang03@tmu.edu.cn","Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China"],"raw_orcid":"https://orcid.org/0000-0001-7434-7339","affiliations":[{"raw_affiliation_string":"Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin, 300060, China. feizhang03@tmu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China. feizhang03@tmu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China. feizhang03@tmu.edu.cn","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China. feizhang03@tmu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064802725","https://openalex.org/A5100412154"],"corresponding_institution_ids":["https://openalex.org/I2802573037"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":1.8851,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.86155987,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"21","issue":"1","first_page":"66","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rack1","display_name":"RACK1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/annexin-a2","display_name":"annexin A2","score":0.9070000052452087},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6069999933242798},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8690000176429749},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8859999775886536},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.7039999961853027},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.699999988079071},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.6958693265914917},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6737557649612427},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6375523805618286},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.6349260807037354},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.600584864616394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5166457295417786},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.47406142950057983},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4566859006881714},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38166600465774536},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27098652720451355},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24756813049316406},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075370","descriptor_name":"Receptors for Activated C Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017306","descriptor_name":"Annexin A2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13058-019-1147-7","doi":"https://doi.org/10.1186/s13058-019-1147-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13058-019-1147-7","pdf_url":"https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/s13058-019-1147-7","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},{"id":"pmid:31113450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31113450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast cancer research : BCR","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6530024","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6530024/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5da5976b75a24b60a7c5b9ad587940aa","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5da5976b75a24b60a7c5b9ad587940aa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Breast Cancer Research, Vol 21, Iss 1, Pp 1-16 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13058-019-1147-7","doi":"https://doi.org/10.1186/s13058-019-1147-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13058-019-1147-7","pdf_url":"https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/s13058-019-1147-7","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1738220293","display_name":null,"funder_award_id":"81472474","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1895617681","display_name":null,"funder_award_id":"IRT_14R40","funder_id":"https://openalex.org/F4320335000","funder_display_name":"Changjiang Scholar Program of Chinese Ministry of Education"},{"id":"https://openalex.org/G2883000058","display_name":null,"funder_award_id":"81661148051","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3753082043","display_name":null,"funder_award_id":"81772804","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4055107352","display_name":null,"funder_award_id":"81472474","funder_id":"https://openalex.org/F4320335577","funder_display_name":"Major Research Plan"},{"id":"https://openalex.org/G5493732304","display_name":null,"funder_award_id":"16JCYBJC25400","funder_id":"https://openalex.org/F4320326190","funder_display_name":"Tianjin Science and Technology Committee"},{"id":"https://openalex.org/G7521476461","display_name":null,"funder_award_id":"81772804","funder_id":"https://openalex.org/F4320335577","funder_display_name":"Major Research Plan"},{"id":"https://openalex.org/G7543333618","display_name":null,"funder_award_id":"16JCYBJC25400","funder_id":"https://openalex.org/F4320323993","funder_display_name":"Natural Science Foundation of Tianjin City"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323993","display_name":"Natural Science Foundation of Tianjin City","ror":null},{"id":"https://openalex.org/F4320326190","display_name":"Tianjin Science and Technology Committee","ror":"https://ror.org/03wb1xh22"},{"id":"https://openalex.org/F4320335000","display_name":"Changjiang Scholar Program of Chinese Ministry of Education","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320335577","display_name":"Major Research Plan","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2947799331.pdf","grobid_xml":"https://content.openalex.org/works/W2947799331.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W32161370","https://openalex.org/W1580655877","https://openalex.org/W1777529877","https://openalex.org/W1848812244","https://openalex.org/W1887866454","https://openalex.org/W1904639086","https://openalex.org/W1974069587","https://openalex.org/W1982414245","https://openalex.org/W1983065127","https://openalex.org/W1990893849","https://openalex.org/W2000436863","https://openalex.org/W2004839771","https://openalex.org/W2014504800","https://openalex.org/W2020736422","https://openalex.org/W2024681421","https://openalex.org/W2031220858","https://openalex.org/W2033041256","https://openalex.org/W2033355502","https://openalex.org/W2040285331","https://openalex.org/W2041280565","https://openalex.org/W2047172303","https://openalex.org/W2048181989","https://openalex.org/W2056772956","https://openalex.org/W2058468989","https://openalex.org/W2065629669","https://openalex.org/W2066509081","https://openalex.org/W2066823227","https://openalex.org/W2070595880","https://openalex.org/W2071501137","https://openalex.org/W2074241794","https://openalex.org/W2074740400","https://openalex.org/W2079323943","https://openalex.org/W2081593861","https://openalex.org/W2082345666","https://openalex.org/W2082743261","https://openalex.org/W2085002181","https://openalex.org/W2087160148","https://openalex.org/W2097136004","https://openalex.org/W2101844105","https://openalex.org/W2105260702","https://openalex.org/W2118165245","https://openalex.org/W2132117256","https://openalex.org/W2138640452","https://openalex.org/W2142655978","https://openalex.org/W2142807621","https://openalex.org/W2145249666","https://openalex.org/W2150322923","https://openalex.org/W2157923000","https://openalex.org/W2169105660","https://openalex.org/W2216993934","https://openalex.org/W2277277686","https://openalex.org/W2278900005","https://openalex.org/W2346420742","https://openalex.org/W2522149547","https://openalex.org/W2529918369","https://openalex.org/W2531986769","https://openalex.org/W2598530115","https://openalex.org/W2598984757","https://openalex.org/W2604267877","https://openalex.org/W2605999118","https://openalex.org/W2610294225","https://openalex.org/W2728674371","https://openalex.org/W2742157864","https://openalex.org/W2750470970","https://openalex.org/W2751239073","https://openalex.org/W2751602291","https://openalex.org/W2774736917","https://openalex.org/W2781501555","https://openalex.org/W2803250303","https://openalex.org/W2809187265","https://openalex.org/W2884209032","https://openalex.org/W2886256853","https://openalex.org/W2888310730","https://openalex.org/W2895739306","https://openalex.org/W2903136739"],"related_works":["https://openalex.org/W6939854978","https://openalex.org/W6958697254","https://openalex.org/W2005243343","https://openalex.org/W2610294225","https://openalex.org/W2117447637","https://openalex.org/W7099397858","https://openalex.org/W2344031044","https://openalex.org/W2027247168","https://openalex.org/W4405530935","https://openalex.org/W2116980560"],"abstract_inverted_index":{"BACKGROUND:":[0],"Acquirement":[1],"of":[2,12,37,64,83,97,111,115,139,147,155,200,242],"resistance":[3,30,250,267,290],"is":[4,23,42,66,90,182,192,260],"always":[5],"associated":[6],"with":[7],"a":[8,24,45,216,238],"highly":[9,46],"aggressive":[10,47],"phenotype":[11,96],"tumor":[13],"cells.":[14,60,159,274],"Recent":[15],"studies":[16],"have":[17],"revealed":[18],"that":[19,27,178,212],"Annexin":[20],"A2":[21],"(Anxa2)":[22],"key":[25],"protein":[26],"links":[28],"drug":[29,249,266,289],"and":[31,87,126,141,149,152,165,189,197,219,225,251,258,268,291],"cancer":[32,40,59,158,187,203,252,273,292],"metastasis.":[33,190],"A":[34],"high":[35],"level":[36],"Anxa2":[38,50,65,84,148,166,179,207,229,257],"in":[39,56,127,167,245,271],"tissues":[41],"correlated":[43],"to":[44,53,134],"phenotype.":[48],"Increased":[49],"expression":[51],"appears":[52],"be":[54],"specific":[55],"many":[57],"drug-resistant":[58,98,156,168,201],"The":[61,160,254],"functional":[62,137,286],"activity":[63],"regulated":[67],"by":[68,172,231],"tyrosine":[69,85,145],"phosphorylation":[70,86,89,146,181,230],"at":[71],"the":[72,76,81,93,136,144,150,195,221,246,263,282,285],"Tyr23":[73,180],"site.":[74],"Nevertheless,":[75],"accurate":[77],"molecular":[78],"mechanisms":[79],"underlying":[80,284],"regulation":[82],"whether":[88],"necessary":[91,183],"for":[92,184,194,262],"enhanced":[94],"invasive":[95,196],"cells":[99,169,204],"remain":[100],"unknown.":[101],"METHODS:":[102],"Small":[103],"interfering":[104],"RNAs,":[105],"small":[106],"molecule":[107],"inhibitors,":[108],"overexpression,":[109],"loss":[110],"function":[112],"or":[113],"gain":[114],"function,":[116],"rescue":[117],"experiments,":[118],"Western":[119],"blot,":[120],"wound":[121],"healing":[122],"assays,":[123,125],"transwell":[124],"vivo":[128],"metastasis":[129],"mice":[130],"models":[131],"were":[132],"used":[133],"investigate":[135],"effects":[138],"Rack1":[140,191,213],"Src":[142,224,232],"on":[143,281],"invasion":[151,188],"metastatic":[153,198],"potential":[154,199,270],"breast":[157,186,202,272],"interaction":[161,222,255],"among":[162],"Rack1,":[163],"Src,":[164],"was":[170],"verified":[171],"co-immunoprecipitation":[173],"assay.":[174],"RESULTS:":[175],"We":[176,209],"demonstrated":[177],"multidrug-resistant":[185],"required":[193],"through":[205],"modulating":[206],"phosphorylation.":[208],"provided":[210],"evidence":[211],"acts":[214],"as":[215],"signal":[217],"hub":[218],"mediates":[220],"between":[223,248,256,265,288],"Anxa2,":[226],"thereby":[227],"facilitating":[228],"kinase.":[233],"CONCLUSIONS:":[234],"Our":[235],"findings":[236,277],"suggest":[237],"convergence":[239],"point":[240],"role":[241],"Rack1/Src/Anxa2":[243],"complex":[244],"crosstalk":[247],"aggressiveness.":[253,293],"Rack1/Src":[259],"responsible":[261],"association":[264],"invasive/metastatic":[269],"Thus,":[275],"our":[276],"provide":[278],"novel":[279],"insights":[280],"mechanism":[283],"linkage":[287]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-06-07T00:00:00"}