{"id":"https://openalex.org/W2947758134","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.tps5087","title":"A phase Ib/II study of niraparib combination therapies for the treatment of metastatic castration-resistant prostate cancer (NCT03431350).","display_name":"A phase Ib/II study of niraparib combination therapies for the treatment of metastatic castration-resistant prostate cancer (NCT03431350).","publication_year":2019,"publication_date":"2019-05-20","ids":{"openalex":"https://openalex.org/W2947758134","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.tps5087","mag":"2947758134"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2019.37.15_suppl.tps5087","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.tps5087","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.tps5087","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021224140","display_name":"Sumit Kumar Subudhi","orcid":"https://orcid.org/0000-0001-5208-7732","observed_orcids":["https://orcid.org/0000-0001-5208-7732"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumit Kumar Subudhi","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021183845","display_name":"Ana M. Aparicio","orcid":"https://orcid.org/0000-0003-0900-0923","observed_orcids":["https://orcid.org/0000-0003-0900-0923"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Aparicio","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059272502","display_name":"Amado J. Zurita","orcid":"https://orcid.org/0000-0002-3805-7307","observed_orcids":["https://orcid.org/0000-0002-3805-7307"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amado J. Zurita","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108763096","display_name":"Bernard Doger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernard Doger","raw_affiliation_strings":["START Madrid Fundacion Jimenez Diaz, Madrid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"START Madrid Fundacion Jimenez Diaz, Madrid, Spain;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108511133","display_name":"William Kevin Kelly","orcid":"https://orcid.org/0000-0003-2629-672X","observed_orcids":["https://orcid.org/0000-0003-2629-672X"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Kevin Kelly","raw_affiliation_strings":["Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, PA;","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114046173","display_name":"Avivit Peer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Avivit Peer","raw_affiliation_strings":["Rambam Health Care Campus, Haifa, Israel;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rambam Health Care Campus, Haifa, Israel;","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002358672","display_name":"Dana E. Rathkopf","orcid":"https://orcid.org/0000-0002-4503-7582","observed_orcids":["https://orcid.org/0000-0002-4503-7582"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana E. Rathkopf","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024685539","display_name":"Lawrence Ivan Karsh","orcid":"https://orcid.org/0000-0002-3095-8303","observed_orcids":["https://orcid.org/0000-0002-3095-8303"]},"institutions":[{"id":"https://openalex.org/I4210088091","display_name":"The Urology Center of Colorado","ror":"https://ror.org/0008nva35","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210088091"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence Ivan Karsh","raw_affiliation_strings":["The Urology Center of Colorado, Denver, CO;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Urology Center of Colorado, Denver, CO;","institution_ids":["https://openalex.org/I4210088091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025347486","display_name":"Jeffrey J. Tryon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey J. Tryon","raw_affiliation_strings":["Janssen R&D, Oncology, Raritan, NJ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen R&D, Oncology, Raritan, NJ;","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113870041","display_name":"Nishi Kothari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nishi Kothari","raw_affiliation_strings":["Janssen Research and Development LLC, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development LLC, Los Angeles, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112914627","display_name":"Xin Yi Zhao","orcid":"https://orcid.org/0000-0002-8170-1583","observed_orcids":["https://orcid.org/0000-0002-8170-1583"]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Zhao","raw_affiliation_strings":["Janssen Research & Development, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, San Francisco, CA;","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109451502","display_name":"Eugene Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugene Zhu","raw_affiliation_strings":["Janssen, Raritan, NJ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen, Raritan, NJ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080782271","display_name":"Deborah Sokol Ricci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deborah S. Ricci","raw_affiliation_strings":["Janssen Research and Development, Spring House, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development, Spring House, PA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028207252","display_name":"NamPhuong Tran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Namphuong Tran","raw_affiliation_strings":["Janssen Research & Development, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, Los Angeles, CA;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072378199","display_name":"Johann Sebastian De Bono","orcid":"https://orcid.org/0000-0002-2034-595X","observed_orcids":["https://orcid.org/0000-0002-2034-595X"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Johann S. De Bono","raw_affiliation_strings":["The Institute of Cancer Research and The Royal Marsden Hospital, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research and The Royal Marsden Hospital, London, United Kingdom;","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210121186"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"15_suppl","first_page":"TPS5087","last_page":"TPS5087"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.384799987077713,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/niraparib","display_name":"niraparib","score":0.9929999709129333},{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.968999981880188},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.8230000138282776},{"id":"https://openalex.org/keywords/anti-pd-1-monoclonal-antibody","display_name":"anti-PD-1 monoclonal antibody","score":0.9710000157356262},{"id":"https://openalex.org/keywords/abiraterone-acetate","display_name":"abiraterone","score":0.9300000071525574},{"id":"https://openalex.org/keywords/prednisone","display_name":"prednisone","score":0.9470000267028809},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8809999823570251},{"id":"https://openalex.org/keywords/master-protocols","display_name":"master protocols","score":0.7730000019073486},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9220825433731079},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7513373494148254},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6229354739189148},{"id":"https://openalex.org/C2775832370","wikidata":"https://www.wikidata.org/wiki/Q27888393","display_name":"Abiraterone acetate","level":5,"score":0.5807089805603027},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5384078025817871},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.49685052037239075},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48963719606399536},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.46605050563812256},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4222235679626465},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.3816506862640381}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2019.37.15_suppl.tps5087","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.tps5087","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.tps5087","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6399999856948853}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3008866163","https://openalex.org/W4248868233","https://openalex.org/W3008375418","https://openalex.org/W3008112021","https://openalex.org/W4361245262","https://openalex.org/W2898234056","https://openalex.org/W4212903168","https://openalex.org/W3137618571","https://openalex.org/W2534152141","https://openalex.org/W2892180740"],"abstract_inverted_index":{"TPS5087":[0],"Background:":[1],"Assessing":[2],"multiple":[3],"therapies":[4],"in":[5,54,123,183,237],"a":[6,32,76,82],"single":[7],"clinical":[8,69],"trial":[9,241],"can":[10],"facilitate":[11],"the":[12,19,88,127,162,188,208,238],"rapid":[13],"identification":[14],"of":[15,21,92,126,150,177,190,207],"new":[16],"agents":[17],"for":[18,145,155],"treatment":[20],"patients":[22,134,210],"with":[23,37,57,79,135,160],"metastatic":[24],"castration-resistant":[25],"prostate":[26],"cancer":[27],"(mCRPC).":[28],"Niraparib":[29],"(Nirap)":[30],"is":[31,73,117,132,235],"highly":[33],"selective":[34],"PARP":[35,48],"inhibitor,":[36],"potent":[38],"activity":[39],"against":[40],"PARP-1":[41],"and":[42,68,90,108,131,194],"PARP-2":[43],"deoxyribonucleic":[44],"acid":[45],"(DNA)-repair":[46],"polymerases.":[47],"inhibition":[49],"may":[50],"be":[51,168,198],"especially":[52],"lethal":[53],"tumor":[55],"cells":[56],"genetic":[58],"DNA":[59],"damage":[60],"response":[61],"deficits":[62],"(DRD).":[63],"Based":[64],"on":[65,140,187],"promising":[66],"preclinical":[67],"data,":[70],"this":[71],"study":[72,116,231],"designed":[74],"as":[75,81],"master":[77],"protocol":[78],"nirap":[80,93,104,169,178],"backbone":[83],"therapy.":[84],"Combination":[85,101],"1":[86,185],"assesses":[87,103],"safety":[89],"efficacy":[91],"plus":[94,105,179,218],"JNJ-63723283":[95],"(JNJ-283),":[96],"an":[97],"anti-PD-1":[98],"monoclonal":[99],"antibody.":[100],"2":[102,206,234],"abiraterone":[106],"acetate":[107],"prednisone":[109],"(AA-P).":[110],"Methods:":[111],"This":[112],"multicenter,":[113],"global,":[114],"open-label":[115],"currently":[118],"open":[119],"at":[120,148],"18":[121],"sites":[122],"5":[124],"countries":[125],"planned":[128],"XX":[129],"sites,":[130],"enrolling":[133],"mCRPC":[136],"who":[137],"have":[138],"progressed":[139],"\u22651":[141],"androgen-receptor":[142],"targeted":[143],"therapy":[144],"mCRPC.":[146],"Enrollment":[147],"time":[149],"abstract":[151],"submission":[152],"was":[153,181],"25":[154],"combination":[156],"1.":[157],"When":[158],"combined":[159],"AA-P,":[161],"RP2D":[163],"has":[164],"been":[165],"determined":[166,182],"to":[167,197,213],"200":[170],"mg.":[171],"The":[172],"recommended":[173],"phase-2":[174],"dose":[175],"(RP2D)":[176],"JNJ-283":[180,219],"Part":[184,205,233],"based":[186],"incidence":[189],"specified":[191],"adverse":[192],"events":[193],"PK":[195],"data":[196],"480":[199],"mg":[200],"every":[201,222],"4":[202],"weeks.":[203],"For":[204],"study,":[209],"are":[211],"assigned":[212],"receive":[214],"oral":[215],"niraparib":[216],"daily":[217],"infusions":[220],"once":[221],"four":[223],"weeks":[224],"until":[225],"disease":[226],"progression,":[227],"unacceptable":[228],"toxicity,":[229],"death,":[230],"termination.":[232],"described":[236],"table.":[239],"Clinical":[240],"information:":[242],"NCT03431350.":[243],"[Table:":[244],"see":[245],"text]":[246]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2019-06-07T00:00:00"}
