{"id":"https://openalex.org/W2947710271","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e14180","title":"Quantitative assessment of immune cell populations and associations with clinical outcomes in African-American (AA) versus Caucasian triple-negative breast cancer (TNBC).","display_name":"Quantitative assessment of immune cell populations and associations with clinical outcomes in African-American (AA) versus Caucasian triple-negative breast cancer (TNBC).","publication_year":2019,"publication_date":"2019-05-20","ids":{"openalex":"https://openalex.org/W2947710271","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e14180","mag":"2947710271"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2019.37.15_suppl.e14180","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e14180","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.e14180","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033137375","display_name":"Tess A. O\u2019Meara","orcid":"https://orcid.org/0000-0002-4778-2842","observed_orcids":["https://orcid.org/0000-0002-4778-2842"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tess O'Meara","raw_affiliation_strings":["Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066080145","display_name":"Vesal Yaghoobi","orcid":"https://orcid.org/0000-0001-6534-1293","observed_orcids":["https://orcid.org/0000-0001-6534-1293"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vesal Yaghoobi","raw_affiliation_strings":["Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066496998","display_name":"Kim Blenman","orcid":"https://orcid.org/0000-0001-6070-0728","observed_orcids":["https://orcid.org/0000-0001-6070-0728"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim Blenman","raw_affiliation_strings":["Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091087835","display_name":"Vasiliki Pelekanou","orcid":"https://orcid.org/0000-0002-8431-1927","observed_orcids":["https://orcid.org/0000-0002-8431-1927"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vasiliki Pelekanou","raw_affiliation_strings":["Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039412967","display_name":"Andrea L.M. Silber","orcid":"https://orcid.org/0000-0002-3339-6959","observed_orcids":["https://orcid.org/0000-0002-3339-6959"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Silber","raw_affiliation_strings":["Yale Cancer Center, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Cancer Center, New Haven, CT;","institution_ids":["https://openalex.org/I2802730090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027326018","display_name":"David L. Rimm","orcid":"https://orcid.org/0000-0001-5820-4397","observed_orcids":["https://orcid.org/0000-0001-5820-4397"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Rimm","raw_affiliation_strings":["Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021113979","display_name":"Lajos Pusztai","orcid":"https://orcid.org/0000-0001-9632-6686","observed_orcids":["https://orcid.org/0000-0001-9632-6686"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lajos Pusztai","raw_affiliation_strings":["Yale Cancer Center, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Cancer Center, New Haven, CT;","institution_ids":["https://openalex.org/I2802730090"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"15_suppl","first_page":"e14180","last_page":"e14180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.05040000006556511,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/racial-disparities","display_name":"racial disparities","score":0.7820000052452087},{"id":"https://openalex.org/keywords/african-american-patients","display_name":"African American patients","score":0.7940000295639038},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cd68","display_name":"CD68","score":0.7990000247955322},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cytotoxic-cd8-t-cells","display_name":"CD8+ cytotoxic T lymphocytes","score":0.8880000114440918},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9589999914169312},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.7009999752044678},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.5929999947547913},{"id":"https://openalex.org/keywords/multiplex-immunofluorescence","display_name":"multiplex immunofluorescence","score":0.7749999761581421},{"id":"https://openalex.org/keywords/prognostic-score","display_name":"prognostic score","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8021308779716492},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.6917985677719116},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6048601269721985},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.5870877504348755},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5759605169296265},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5501469373703003},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5085223913192749},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.490621954202652},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4660217761993408},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.45050859451293945},{"id":"https://openalex.org/C2776460901","wikidata":"https://www.wikidata.org/wiki/Q21109693","display_name":"CD68","level":3,"score":0.43376386165618896},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39057934284210205},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.37280797958374023},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36980700492858887},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30971264839172363}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2019.37.15_suppl.e14180","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e14180","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.e14180","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0},{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7130096090","https://openalex.org/W2912346810","https://openalex.org/W4226255293","https://openalex.org/W2804513975","https://openalex.org/W2953675030","https://openalex.org/W2610557075","https://openalex.org/W4285726351","https://openalex.org/W4322771529","https://openalex.org/W3082802647","https://openalex.org/W2891362037"],"abstract_inverted_index":{"e14180":[0],"Background:":[1],"Tumor":[2],"infiltrating":[3],"lymphocytes":[4],"(TILs)":[5],"are":[6],"powerful":[7],"prognostic":[8],"and":[9,40,47,54,65,75,85,106,114,141,148,158,164,179,234,242,263,302,312,318,326],"predictive":[10],"factors":[11],"in":[12,19,28,37,45,110,161,188,218,251,264,298,334],"TNBC.":[13],"We":[14,33],"hypothesized":[15],"that":[16],"survival":[17,56],"differences":[18,27,36,50],"TNBC":[20,46,63,307],"by":[21,26,82,212,238],"race":[22,266,336],"may":[23],"be":[24],"caused":[25],"the":[29,38,111,162,252],"tumor":[30,113,222],"immune":[31,43],"microenvironment.":[32],"assessed":[34,90],"racial":[35],"extent":[39],"composition":[41],"of":[42,127,146,196,205,288],"infiltration":[44],"correlated":[48],"these":[49],"with":[51,248,274,331],"clinical":[52,66,142],"characteristics":[53],"disease-free":[55],"(DFS).":[57],"Methods:":[58],"Formalin":[59],"fixed":[60],"paraffin":[61],"embedded":[62],"samples":[64],"information":[67],"were":[68,89,132,151,156,186,246,329],"collected":[69],"for":[70,119],"n":[71,76],"=":[72,77,177,184,232,261,283,296],"43":[73,78],"AA":[74,147,163,189,197,306],"Caucasian":[79,149,165,192],"cases,":[80],"matched":[81],"diagnosis":[83],"date":[84],"stage.":[86],"Stromal":[87],"TILs":[88],"on":[91],"H&E-stained":[92],"slides.":[93],"Multiplexed":[94],"immunofluorescence":[95],"was":[96,122,210,216,271],"performed":[97],"to":[98,134,191,221,300,322],"quantify":[99],"CD68":[100,181,269,303,313,325],"(macrophage),":[101],"CD8":[102,208,317],"(cytotoxic":[103],"T":[104],"cell)":[105],"PD-L1":[107,214,244,301,319,327],"protein":[108],"expression":[109,118,182,209,215,245,270,314,320,328],"whole-section,":[112],"stromal":[115,243],"compartments.":[116],"Average":[117],"each":[120,265],"marker":[121],"calculated":[123],"over":[124],"all":[125,224],"fields":[126],"view.":[128],"Cox":[129],"proportional":[130],"hazards":[131],"used":[133],"assess":[135],"associations":[136],"between":[137],"DFS,":[138,289],"staining":[139],"markers":[140],"variables.":[143],"Results:":[144],"Characteristics":[145],"cases":[150,198],"not":[152,236],"significantly":[153],"different.":[154],"There":[155],"14":[157],"8":[159],"recurrences":[160],"cohorts,":[166],"respectively":[167],"(median":[168,226,255,277],"follow-up":[169],"8.7":[170],"vs":[171,228,257,279],"9.4":[172],"yrs).":[173],"TIL":[174,200,310],"counts":[175,311],"(p":[176,183,295],"0.031)":[178],"overall":[180,241],"0.005)":[185],"higher":[187,217,309],"compared":[190,220,321],"patients.":[193],"21%":[194],"percent":[195],"had":[199,308],"predominant":[201],"phenotype":[202],"versus":[203],"3%":[204],"Caucasians,":[206],"but":[207,315],"similar":[211,316],"race.":[213,239],"stroma":[219],"across":[223],"patients":[225],"401":[227],"267":[229],"au,":[230],"p":[231,260,282],"0.002)":[233,297],"did":[235],"differ":[237],"Higher":[240,268],"associated":[247,273,330],"better":[249,275,332],"DFS":[250,276,333],"entire":[253],"population":[254],"3501":[256],"1895":[258],"days,":[259,281],"0.0009)":[262],"separately.":[267],"also":[272],"3015":[278],"2111":[280],"0.0004).":[284],"In":[285],"multivariate":[286],"analysis":[287],"stage":[290],"at":[291],"presentation":[292],"remained":[293],"significant":[294],"addition":[299],"expression.":[304],"Conclusions:":[305],"Caucasians.":[323],"High":[324],"both":[335],"cohorts.":[337]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-06-07T00:00:00"}