{"id":"https://openalex.org/W2947653195","doi":"https://doi.org/10.1248/bpb.b18-00857","title":"The Effective Allergenic Reactivity of House Dust Mite Sublingual Immunotherapy Tablets Is Determined by Tablet Formulation","display_name":"The Effective Allergenic Reactivity of House Dust Mite Sublingual Immunotherapy Tablets Is Determined by Tablet Formulation","publication_year":2019,"publication_date":"2019-05-31","ids":{"openalex":"https://openalex.org/W2947653195","doi":"https://doi.org/10.1248/bpb.b18-00857","mag":"2947653195","pmid":"https://pubmed.ncbi.nlm.nih.gov/31155578"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.b18-00857","doi":"https://doi.org/10.1248/bpb.b18-00857","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b18-00857","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/42/6/42_b18-00857/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/bpb/42/6/42_b18-00857/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047679961","display_name":"Hirokazu Kito","orcid":"https://orcid.org/0009-0001-0582-7723","observed_orcids":["https://orcid.org/0009-0001-0582-7723"]},"institutions":[{"id":"https://openalex.org/I4405265357","display_name":"Torii Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/04jjqsg28","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265357"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirokazu Kito","raw_affiliation_strings":["Research Laboratory, Torii Pharmaceutical Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratory, Torii Pharmaceutical Co., Ltd","institution_ids":["https://openalex.org/I4405265357"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Weibin Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265357","display_name":"Torii Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/04jjqsg28","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265357"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Weibin Du","raw_affiliation_strings":["Research Laboratory, Torii Pharmaceutical Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratory, Torii Pharmaceutical Co., Ltd","institution_ids":["https://openalex.org/I4405265357"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroshi Nakazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265357","display_name":"Torii Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/04jjqsg28","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265357"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Nakazawa","raw_affiliation_strings":["Research Laboratory, Torii Pharmaceutical Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratory, Torii Pharmaceutical Co., Ltd","institution_ids":["https://openalex.org/I4405265357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004635365","display_name":"Kaare Lund","orcid":"https://orcid.org/0000-0002-3520-7744","observed_orcids":["https://orcid.org/0000-0002-3520-7744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaare Lund","raw_affiliation_strings":["Papermill Medical"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Papermill Medical","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082311245","display_name":"Katsuyo Ohashi\u2010Doi","orcid":"https://orcid.org/0000-0002-5104-6952","observed_orcids":["https://orcid.org/0000-0002-5104-6952"]},"institutions":[{"id":"https://openalex.org/I4405265357","display_name":"Torii Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/04jjqsg28","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265357"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuyo Ohashi-Doi","raw_affiliation_strings":["Research Laboratory, Torii Pharmaceutical Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratory, Torii Pharmaceutical Co., Ltd","institution_ids":["https://openalex.org/I4405265357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9111,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.70256304,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"42","issue":"6","first_page":"1030","last_page":"1033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/house-dust-mite-allergy","display_name":"house dust mite allergy","score":0.9020000100135803},{"id":"https://openalex.org/keywords/sublingual-immunotherapy","display_name":"sublingual immunotherapy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tablet-formulation","display_name":"tablet formulation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/freeze-dried-formulation","display_name":"freeze-dried formulation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.7210000157356262},{"id":"https://openalex.org/keywords/allergen-extracts","display_name":"allergen extracts","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2777037608","wikidata":"https://www.wikidata.org/wiki/Q1641412","display_name":"Sublingual immunotherapy","level":4,"score":0.8349167108535767},{"id":"https://openalex.org/C199215989","wikidata":"https://www.wikidata.org/wiki/Q79239196","display_name":"Slit","level":2,"score":0.8092440366744995},{"id":"https://openalex.org/C2778166374","wikidata":"https://www.wikidata.org/wiki/Q29938","display_name":"House dust mite","level":4,"score":0.6585108041763306},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.5982828140258789},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.5899549126625061},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5666160583496094},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.4609193801879883},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4533601701259613},{"id":"https://openalex.org/C2779673145","wikidata":"https://www.wikidata.org/wiki/Q7263653","display_name":"Pyroglyphidae","level":5,"score":0.4190558195114136},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32981276512145996},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1839067041873932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1353277862071991},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D039741","descriptor_name":"Antigens, Dermatophagoides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D039981","descriptor_name":"Pyroglyphidae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D063729","descriptor_name":"Sublingual Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1248/bpb.b18-00857","doi":"https://doi.org/10.1248/bpb.b18-00857","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b18-00857","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/42/6/42_b18-00857/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:31155578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31155578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/bpb.b18-00857","doi":"https://doi.org/10.1248/bpb.b18-00857","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b18-00857","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/42/6/42_b18-00857/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2947653195.pdf","grobid_xml":"https://content.openalex.org/works/W2947653195.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2030046937","https://openalex.org/W2141856163","https://openalex.org/W2150203626","https://openalex.org/W2154185834","https://openalex.org/W2155645788","https://openalex.org/W2302277303","https://openalex.org/W2346674349","https://openalex.org/W2554771773","https://openalex.org/W2760148976","https://openalex.org/W2794407266"],"related_works":["https://openalex.org/W2760148976","https://openalex.org/W2921288370","https://openalex.org/W2788120876","https://openalex.org/W7160602635","https://openalex.org/W4283316230","https://openalex.org/W3047122035","https://openalex.org/W2174237155","https://openalex.org/W1525527590","https://openalex.org/W4405954556","https://openalex.org/W2784211463"],"abstract_inverted_index":{"House":[0],"dust":[1],"mite":[2],"(HDM)":[3],"sublingual":[4,60,82],"immunotherapy":[5,27],"(SLIT)":[6],"in":[7,45,47,150,162],"the":[8,38,55,59,64,81,87,110,131,153,158,164,168,183,186,197,207,221],"form":[9],"of":[10,58,63,73,92,144,167,185],"SLIT-tablets":[11,94],"is":[12,123,133,179],"now":[13],"an":[14],"established":[15],"treatment":[16],"option":[17],"for":[18],"HDM":[19,93,102,107,139,188,193,211],"allergy":[20],"and":[21,35,146,161,217],"HDM-induced":[22],"allergic":[23],"asthma.":[24],"In":[25],"SLIT-tablet":[26,189],"allergen":[28],"extracts":[29,103,140],"are":[30,95],"formulated":[31],"as":[32,109,119],"dry":[33,198],"tablets":[34],"administered":[36],"under":[37],"tongue":[39],"where":[40],"it":[41],"must":[42,66],"be":[43,50],"solubilized":[44],"saliva":[46],"order":[48],"to":[49,52,117,181,191],"able":[51],"interact":[53],"with":[54,115],"immune":[56],"system":[57],"mucosa.":[61],"Solubilization":[62],"extract":[65],"occur":[67],"within":[68],"a":[69,126,136,142,171],"short":[70],"time":[71,84],"span":[72],"about":[74],"one":[75,120],"minute":[76],"after":[77],"administration,":[78],"determined":[79],"by":[80,86],"holding":[83],"recommended":[85],"manufacturer.":[88],"Currently,":[89],"two":[90,105,187],"types":[91,99,190],"available.":[96],"Both":[97],"tablet":[98,121,128,199],"contain":[100,141],"natural":[101],"from":[104,196],"common":[106],"species":[108],"active":[111],"ingredient,":[112],"but":[113],"differ":[114],"regard":[116],"formulation":[118,129,209],"type":[122],"based":[124,134],"on":[125,135],"freeze-dried":[127,208],"while":[130],"other":[132],"compressed":[137,222],"formulation.":[138,223],"number":[143],"major":[145],"minor":[147],"allergens,":[148],"which":[149],"combination":[151],"provide":[152],"allergenic":[154,194,212],"activity":[155,213],"that":[156,206],"drives":[157],"immunological":[159],"response":[160],"turn":[163],"clinical":[165],"efficacy":[166],"tablets.":[169],"Here,":[170],"biologically":[172],"relevant":[173],"human":[174],"immunoglobulin":[175],"E":[176],"(IgE)-based":[177],"assay":[178],"used":[180],"compare":[182],"ability":[184],"deliver":[192],"reactivity":[195],"into":[200,214],"soluble":[201],"form.":[202],"The":[203],"experiments":[204],"demonstrate":[205],"delivers":[210],"solution":[215],"faster":[216],"more":[218],"efficiently":[219],"than":[220]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-07T00:00:00"}