{"id":"https://openalex.org/W2947595033","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.2025","title":"Phase 1/2a study of once daily oral BAL101553, a novel tumor checkpoint controller (TCC), in adult patients with progressive or recurrent glioblastoma (GBM) or high-grade glioma.","display_name":"Phase 1/2a study of once daily oral BAL101553, a novel tumor checkpoint controller (TCC), in adult patients with progressive or recurrent glioblastoma (GBM) or high-grade glioma.","publication_year":2019,"publication_date":"2019-05-20","ids":{"openalex":"https://openalex.org/W2947595033","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.2025","mag":"2947595033"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2019.37.15_suppl.2025","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.2025","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.2025","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064237640","display_name":"Juanita Suzanne Lopez","orcid":"https://orcid.org/0000-0001-8321-4212","observed_orcids":["https://orcid.org/0000-0001-8321-4212"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Juanita Suzanne Lopez","raw_affiliation_strings":["Drug Development Unit-The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Development Unit-The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom;","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088144652","display_name":"Rebecca Sophie Kristeleit","orcid":"https://orcid.org/0000-0003-3825-1326","observed_orcids":["https://orcid.org/0000-0003-3825-1326"]},"institutions":[{"id":"https://openalex.org/I1289784979","display_name":"University College Hospital","ror":"https://ror.org/00wrevg56","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1289784979","https://openalex.org/I1340918713"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rebecca Sophie Kristeleit","raw_affiliation_strings":["University College London Hospitals, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London Hospitals, London, United Kingdom;","institution_ids":["https://openalex.org/I1289784979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091268040","display_name":"R. Rulach","orcid":"https://orcid.org/0000-0002-3148-0647","observed_orcids":["https://orcid.org/0000-0002-3148-0647"]},"institutions":[{"id":"https://openalex.org/I2800373718","display_name":"Beatson West of Scotland Cancer Centre","ror":"https://ror.org/03pp86w19","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800373718"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert Rulach","raw_affiliation_strings":["Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom;","institution_ids":["https://openalex.org/I2800373718"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109618350","display_name":"Noor Md Haris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Noor Md Haris","raw_affiliation_strings":["Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne, United Kingdom;","institution_ids":["https://openalex.org/I2801924861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014565080","display_name":"Mariana Scaranti","orcid":"https://orcid.org/0000-0001-7713-0100","observed_orcids":["https://orcid.org/0000-0001-7713-0100"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mariana Scaranti","raw_affiliation_strings":["The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom;","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050246084","display_name":"Paul James Mulholland","orcid":"https://orcid.org/0000-0002-7926-824X","observed_orcids":["https://orcid.org/0000-0002-7926-824X"]},"institutions":[{"id":"https://openalex.org/I1289784979","display_name":"University College Hospital","ror":"https://ror.org/00wrevg56","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1289784979","https://openalex.org/I1340918713"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul James Mulholland","raw_affiliation_strings":["University College London Hospitals, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London Hospitals, London, United Kingdom;","institution_ids":["https://openalex.org/I1289784979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111568289","display_name":"Donna Crawford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800373718","display_name":"Beatson West of Scotland Cancer Centre","ror":"https://ror.org/03pp86w19","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800373718"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Donna Crawford","raw_affiliation_strings":["Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom;","institution_ids":["https://openalex.org/I2800373718"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090242992","display_name":"Saira Bashir","orcid":"https://orcid.org/0000-0002-7016-2131","observed_orcids":["https://orcid.org/0000-0002-7016-2131"]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Saira Bashir","raw_affiliation_strings":["Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne, United Kingdom;","institution_ids":["https://openalex.org/I2801924861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033956695","display_name":"Caterina Aversa","orcid":"https://orcid.org/0000-0003-1972-7798","observed_orcids":["https://orcid.org/0000-0003-1972-7798"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Caterina Aversa","raw_affiliation_strings":["The Royal Marsden Hospital and The Institute of Cancer Research, Sutton, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Royal Marsden Hospital and The Institute of Cancer Research, Sutton, United Kingdom;","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089364285","display_name":"Alison L. Hannah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alison L. Hannah","raw_affiliation_strings":["Consultant, Sebastopol, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant, Sebastopol, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057841016","display_name":"Stephanie Anderson","orcid":"https://orcid.org/0000-0001-9304-6419","observed_orcids":["https://orcid.org/0000-0001-9304-6419"]},"institutions":[{"id":"https://openalex.org/I4210141406","display_name":"Basilea Pharmaceutica (Switzerland)","ror":"https://ror.org/04n4q2213","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210141406"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stephanie Anderson","raw_affiliation_strings":["Basilea Pharmaceutica International Ltd, Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basilea Pharmaceutica International Ltd, Basel, Switzerland;","institution_ids":["https://openalex.org/I4210141406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044733396","display_name":"Marc Frederick Engelhardt","orcid":"https://orcid.org/0000-0003-2432-0212","observed_orcids":["https://orcid.org/0000-0003-2432-0212"]},"institutions":[{"id":"https://openalex.org/I4210141406","display_name":"Basilea Pharmaceutica (Switzerland)","ror":"https://ror.org/04n4q2213","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210141406"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marc Engelhardt","raw_affiliation_strings":["Basilea Pharmaceutica International Ltd., Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basilea Pharmaceutica International Ltd., Basel, Switzerland;","institution_ids":["https://openalex.org/I4210141406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040288354","display_name":"Thomas Kaindl","orcid":"https://orcid.org/0000-0001-9640-7937","observed_orcids":["https://orcid.org/0000-0001-9640-7937"]},"institutions":[{"id":"https://openalex.org/I4210141406","display_name":"Basilea Pharmaceutica (Switzerland)","ror":"https://ror.org/04n4q2213","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210141406"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas Kaindl","raw_affiliation_strings":["Basilea Pharmaceutica International Ltd, Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basilea Pharmaceutica International Ltd, Basel, Switzerland;","institution_ids":["https://openalex.org/I4210141406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055037319","display_name":"Patrice J. Larger","orcid":"https://orcid.org/0000-0002-4508-4741","observed_orcids":["https://orcid.org/0000-0002-4508-4741"]},"institutions":[{"id":"https://openalex.org/I4210141406","display_name":"Basilea Pharmaceutica (Switzerland)","ror":"https://ror.org/04n4q2213","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210141406"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Patrice Larger","raw_affiliation_strings":["Basilea Pharmaceutica International Ltd, Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basilea Pharmaceutica International Ltd, Basel, Switzerland;","institution_ids":["https://openalex.org/I4210141406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069633002","display_name":"Phil McKernan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141406","display_name":"Basilea Pharmaceutica (Switzerland)","ror":"https://ror.org/04n4q2213","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210141406"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Phil McKernan","raw_affiliation_strings":["Basilea Pharmaceutica International Ltd, Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basilea Pharmaceutica International Ltd, Basel, Switzerland;","institution_ids":["https://openalex.org/I4210141406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108485804","display_name":"TR Jeffry Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800373718","display_name":"Beatson West of Scotland Cancer Centre","ror":"https://ror.org/03pp86w19","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800373718"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"TR Jeffry Evans","raw_affiliation_strings":["Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom;","institution_ids":["https://openalex.org/I2800373718"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033962986","display_name":"Elizabeth Ruth Plummer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth Plummer","raw_affiliation_strings":["Freeman Hospital Newcastle, Newcastle, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Freeman Hospital Newcastle, Newcastle, United Kingdom;","institution_ids":["https://openalex.org/I2801924861"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"15_suppl","first_page":"2025","last_page":"2025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spindle-assembly-checkpoint","display_name":"spindle assembly checkpoint","score":0.8349999785423279},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9810000061988831},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.9369999766349792},{"id":"https://openalex.org/keywords/recurrent-glioma","display_name":"recurrent glioma","score":0.7049999833106995},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.7509999871253967},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7919999957084656},{"id":"https://openalex.org/keywords/oral-prodrug","display_name":"oral prodrug","score":0.6909999847412109},{"id":"https://openalex.org/keywords/brain-penetration","display_name":"brain penetration","score":0.6539999842643738},{"id":"https://openalex.org/keywords/hyponatremia","display_name":"hyponatremia","score":0.7649999856948853},{"id":"https://openalex.org/keywords/hallucinations","display_name":"hallucinations","score":0.4099999964237213},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":0.6349999904632568},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.9300000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8843721151351929},{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.7874433398246765},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6968998908996582},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.5717836618423462},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5534635782241821},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5047520399093628},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.4881480634212494},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.48572784662246704},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41870319843292236},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.41767317056655884},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.41627979278564453},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.39074599742889404},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.13823407888412476}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2019.37.15_suppl.2025","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.2025","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.2025","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2780145751","https://openalex.org/W2891929650","https://openalex.org/W2699630253","https://openalex.org/W2742097381","https://openalex.org/W2891619027","https://openalex.org/W2778353074","https://openalex.org/W2479616000","https://openalex.org/W2721855883","https://openalex.org/W14082197","https://openalex.org/W2399550623"],"abstract_inverted_index":{"2025":[0],"Background:":[1],"BAL101553":[2,67,144,220,327],"(prodrug":[3],"of":[4,77,82,105,183,203,211,225,347],"BAL27862)":[5],"is":[6,22,328],"a":[7,23,102,148,280],"novel":[8],"TCC":[9],"that":[10,326],"promotes":[11],"tumor":[12,169,259],"cell":[13],"death":[14],"by":[15,100,163,171],"modulating":[16],"the":[17,32,96,154,190,335],"spindle":[18],"assembly":[19],"checkpoint.":[20],"BAL27862":[21],"lipophilic,":[24],"small":[25],"molecule":[26],"shown":[27],"in":[28,42,50,71,147,251,261,311,318,338],"rodents":[29],"to":[30,152],"penetrate":[31],"brain":[33],"(brain/plasma":[34],"ratio":[35],"around":[36],"unity),":[37],"with":[38,52,55,74,107,125,131,241,276,320,340],"promising":[39],"antitumor":[40],"activity":[41],"orthotopic":[43],"preclinical":[44],"GBM":[45,111,127,252,278,321],"models":[46],"as":[47],"monotherapy":[48],"or":[49,56,109,112,128,133,216,322],"combination":[51],"radiotherapy":[53],"(RT)":[54],"without":[57],"temozolomide.":[58],"In":[59,189],"this":[60],"ongoing":[61,191],"study":[62,97,291],"(NCT02490800,":[63],"CDI-CS-002),":[64],"daily":[65],"oral":[66,143,219],"was":[68,98,254,309],"initially":[69],"examined":[70],"solid-tumor":[72],"patients,":[73,260],"an":[75],"MTD":[76,336],"16":[78],"mg/d":[79,270],"and":[80,85,168,186,229,238,245,265,288,295,344],"DLTs":[81],"G4":[83],"hyponatremia":[84],"G2":[86,227],"hallucinations":[87],"(Lopez":[88],"2018,":[89,92,120],"JCO":[90,118],"36,":[91],"suppl.":[93,121],"A2530).":[94],"Subsequently":[95],"expanded":[99],"including":[101],"separate":[103],"cohort":[104],"patients":[106,253,319,339],"progressive":[108,132],"recurrent":[110,134],"high-grade":[113,129,323],"glioma":[114,324],"(Ingles":[115],"Garces":[116],"2017,":[117],"35,":[119],"TPS2601).":[122],"Methods:":[123],"Patients":[124],"histologically-confirmed":[126],"glioma,":[130],"disease":[135,300,308],"after":[136],"prior":[137,204],"RT":[138],"with/without":[139],"chemotherapy,":[140],"received":[141,209],"once-daily":[142],"(28-day":[145],"cycles)":[146],"3+3":[149],"dose-escalation":[150],"design":[151],"determine":[153],"maximum":[155],"tolerated":[156,330],"dose":[157,242,332],"(MTD).":[158],"Adverse":[159],"events":[160],"were":[161,178],"assessed":[162],"CTCAE":[164],"v4.03":[165],"grade":[166],"(G),":[167],"response":[170,282],"RANO":[172],"every":[173],"two":[174],"cycles.":[175],"Pharmacokinetics":[176],"(PK)":[177],"evaluated":[179],"on":[180,290],"Day":[181],"1":[182,185],"Cycles":[184],"2.":[187],"Results:":[188],"study,":[192],"23":[193],"pts":[194],"(13M/10F;":[195],"median":[196,200],"age":[197],"50":[198],"y),":[199],"(min\u2013max)":[201],"number":[202],"regimens":[205],"=":[206,272],"2":[207],"(1\u20135),":[208],"doses":[210],"8,":[212],"15,":[213],"20,":[214],"25":[215,266,269],"30":[217,246],"mg":[218],"once":[221],"daily.":[222],"One":[223],"DLT":[224],"reversible":[226],"depression":[228],"fatigue":[230],"occurred":[231],"at":[232,263,331],"20":[233,264],"mg.":[234,247,267],"Both":[235],"mean":[236],"Cmax":[237],"AUC":[239],"increased":[240],"between":[243],"8":[244,293],"The":[248,315],"PK":[249],"exposure":[250],"lower":[255],"than":[256],"for":[257,301],"solid":[258,342],"particular":[262],"At":[268,304],"(n":[271],"3),":[273],"one":[274],"patient":[275,297],"IDH-mutated":[277],"had":[279,298],"partial":[281],"(63%":[283],"area":[284],"reduction":[285],"per":[286],"RANO)":[287],"continues":[289],">":[292],"months,":[294],"another":[296],"stable":[299,307],"5":[302],"months.":[303],"15\u201320":[305],"mg/d,":[306],"observed":[310],"3/10":[312],"patients.":[313],"Conclusions:":[314],"current":[316],"data":[317],"suggest":[325],"well":[329],"levels":[333],"above":[334],"established":[337],"advanced":[341],"tumors,":[343],"shows":[345],"indications":[346],"clinical":[348],"activity.":[349],"Clinical":[350],"trial":[351],"information:":[352],"02490800.":[353]},"counts_by_year":[{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-06-07T00:00:00"}
