{"id":"https://openalex.org/W2947579986","doi":"https://doi.org/10.1113/ep087253","title":"Suppressed baroreflex peripheral arc overwhelms augmented neural arc and incapacitates baroreflex function in rats with pulmonary arterial hypertension","display_name":"Suppressed baroreflex peripheral arc overwhelms augmented neural arc and incapacitates baroreflex function in rats with pulmonary arterial hypertension","publication_year":2019,"publication_date":"2019-05-29","ids":{"openalex":"https://openalex.org/W2947579986","doi":"https://doi.org/10.1113/ep087253","mag":"2947579986","pmid":"https://pubmed.ncbi.nlm.nih.gov/31140668"},"language":"en","primary_location":{"id":"doi:10.1113/ep087253","doi":"https://doi.org/10.1113/ep087253","is_oa":false,"landing_page_url":"https://doi.org/10.1113/ep087253","pdf_url":null,"source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110343455","display_name":"Masako Shinoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masako Shinoda","raw_affiliation_strings":["Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061041193","display_name":"Keita Saku","orcid":"https://orcid.org/0000-0001-9404-7069","observed_orcids":["https://orcid.org/0000-0001-9404-7069","https://orcid.org/0000-0002-6856-9362"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Keita Saku","raw_affiliation_strings":["Department of Advanced Risk Stratification for Cardiovascular Diseases, Center for Disruptive Cardiovascular Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9404-7069","affiliations":[{"raw_affiliation_string":"Department of Advanced Risk Stratification for Cardiovascular Diseases, Center for Disruptive Cardiovascular Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035618541","display_name":"Yasuhiro Oga","orcid":"https://orcid.org/0009-0005-8511-8431","observed_orcids":["https://orcid.org/0009-0005-8511-8431"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Oga","raw_affiliation_strings":["Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026341995","display_name":"Takeshi Tohyama","orcid":"https://orcid.org/0000-0002-7300-8180","observed_orcids":["https://orcid.org/0000-0002-7300-8180"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Tohyama","raw_affiliation_strings":["Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069176748","display_name":"Takuya Nishikawa","orcid":"https://orcid.org/0000-0002-4951-7831","observed_orcids":["https://orcid.org/0000-0002-4951-7831"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Nishikawa","raw_affiliation_strings":["Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4951-7831","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006874258","display_name":"Kohtaro Abe","orcid":"https://orcid.org/0000-0003-4131-5423","observed_orcids":["https://orcid.org/0000-0003-4131-5423"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohtaro Abe","raw_affiliation_strings":["Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014892153","display_name":"Keimei Yoshida","orcid":"https://orcid.org/0000-0001-5089-4047","observed_orcids":["https://orcid.org/0000-0001-5089-4047"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keimei Yoshida","raw_affiliation_strings":["Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110100083","display_name":"Yukimitsu Kuwabara","orcid":"https://orcid.org/0009-0007-4502-9383","observed_orcids":["https://orcid.org/0009-0007-4502-9383"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukimitsu Kuwabara","raw_affiliation_strings":["Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112311552","display_name":"Kana Fujii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kana Fujii","raw_affiliation_strings":["Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034063641","display_name":"Tomohito Ishikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohito Ishikawa","raw_affiliation_strings":["Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102768029","display_name":"Takuya Kishi","orcid":"https://orcid.org/0000-0001-5122-5793","observed_orcids":["https://orcid.org/0000-0001-5122-5793"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Kishi","raw_affiliation_strings":["Department of Advanced Risk Stratification for Cardiovascular Diseases, Center for Disruptive Cardiovascular Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Risk Stratification for Cardiovascular Diseases, Center for Disruptive Cardiovascular Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007483946","display_name":"Kenji Sunagawa","orcid":"https://orcid.org/0000-0003-0365-4619","observed_orcids":["https://orcid.org/0000-0003-0365-4619"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Sunagawa","raw_affiliation_strings":["Department of Therapeutic Regulation of Cardiovascular Homeostasis, Center for Disruptive Cardiovascular Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Therapeutic Regulation of Cardiovascular Homeostasis, Center for Disruptive Cardiovascular Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091849037","display_name":"Hiroyuki Tsutsui","orcid":"https://orcid.org/0000-0002-5291-2875","observed_orcids":["https://orcid.org/0000-0002-5291-2875"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Tsutsui","raw_affiliation_strings":["Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061041193"],"corresponding_institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":null,"fwci":0.1793,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.52940278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"104","issue":"8","first_page":"1164","last_page":"1178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.6875,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.6875,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.24549999833106995,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/baroreflex-function","display_name":"baroreflex function","score":0.8479999899864197},{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.9860000014305115},{"id":"https://openalex.org/keywords/monocrotaline","display_name":"monocrotaline","score":0.8180000185966492},{"id":"https://openalex.org/keywords/sympathetic-nerve-activity","display_name":"sympathetic activity","score":0.7400000095367432},{"id":"https://openalex.org/keywords/baroreflex-gain","display_name":"baroreflex gain","score":0.7699999809265137},{"id":"https://openalex.org/keywords/carotid-sinus-pressure","display_name":"carotid sinus pressure","score":0.7730000019073486},{"id":"https://openalex.org/keywords/plasma-norepinephrine","display_name":"plasma norepinephrine","score":0.9089999794960022},{"id":"https://openalex.org/keywords/blood-pressure-regulation","display_name":"blood pressure regulation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.5740000009536743},{"id":"https://openalex.org/keywords/celiac-ganglion","display_name":"celiac ganglion","score":0.6230000257492065},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.503000020980835},{"id":"https://openalex.org/keywords/baroreflex-sensitivity","display_name":"baroreflex sensitivity","score":0.4350000023841858},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.4390000104904175},{"id":"https://openalex.org/keywords/plasma-angiotensin-ii","display_name":"plasma angiotensin II","score":0.7540000081062317},{"id":"https://openalex.org/keywords/plasma-aldosterone-concentration","display_name":"plasma aldosterone","score":0.7390000224113464},{"id":"https://openalex.org/keywords/plasma-vasopressin","display_name":"plasma vasopressin","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C191237925","wikidata":"https://www.wikidata.org/wiki/Q808725","display_name":"Baroreflex","level":4,"score":0.8711808919906616},{"id":"https://openalex.org/C83415579","wikidata":"https://www.wikidata.org/wiki/Q161973","display_name":"Arc (geometry)","level":2,"score":0.7096496820449829},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.6959667801856995},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6828340291976929},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6551382541656494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5984710454940796},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4621015787124634},{"id":"https://openalex.org/C2984127161","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neural activity","level":2,"score":0.41331666707992554},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.2677803337574005},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18498483300209045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10858699679374695},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.057293713092803955},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000081029","descriptor_name":"Pulmonary Arterial Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017704","descriptor_name":"Baroreflex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062186","descriptor_name":"Arterial Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1113/ep087253","doi":"https://doi.org/10.1113/ep087253","is_oa":false,"landing_page_url":"https://doi.org/10.1113/ep087253","pdf_url":null,"source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},{"id":"pmid:31140668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31140668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental physiology","raw_type":"Journal Article"},{"id":"pmh:oai:catalog.lib.kyushu-u.ac.jp:2324/2556283","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2324/2556283","pdf_url":null,"source":{"id":"https://openalex.org/S4306400832","display_name":"Kyushu University Institutional Repository (QIR) (Kyushu University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135598925","host_organization_name":"Kyushu University","host_organization_lineage":["https://openalex.org/I135598925"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},{"id":"mag:3189987745","doi":null,"is_oa":false,"landing_page_url":"https://api.lib.kyushu-u.ac.jp/opac_download_md/2556283/med2758_abstract.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2837782432","display_name":"The role of inflammation on the development of occlusive lesions in pulmonary arterial hypertension","funder_award_id":"17K09591","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3315602216","display_name":"Personalized optimization of interatrial shunt device to prevent heart failure","funder_award_id":"19K20690","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5211718276","display_name":"\u8840\u5727\u5909\u52d5\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3057\u305f\u81ea\u5f8b\u7684\u7d4c\u795e\u7d4c\u8840\u5727\u5236\u5fa1\u30c7\u30d0\u30a4\u30b9\u306e\u958b\u767a","funder_award_id":"18he1902003h0001","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6116418362","display_name":null,"funder_award_id":"JP18he1102003","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G7832144653","display_name":"The development of neuro-mechanical unloading therapy for myocardial infarction","funder_award_id":"18K15893","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G809509027","display_name":"\u5fc3\u7b4b\u6897\u585e\u5f8c\u5fc3\u4e0d\u5168\u3092\u9632\u3050\u8ff7\u8d70\u795e\u7d4c\u523a\u6fc0\u30ab\u30c6\u30fc\u30c6\u30eb\u88c5\u7f6e\u958b\u767a","funder_award_id":"18hm0102041h0003","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W114168622","https://openalex.org/W155312217","https://openalex.org/W1983303212","https://openalex.org/W1993537235","https://openalex.org/W1994283109","https://openalex.org/W1999629141","https://openalex.org/W2004082022","https://openalex.org/W2016305001","https://openalex.org/W2025593289","https://openalex.org/W2025717255","https://openalex.org/W2037012175","https://openalex.org/W2050506828","https://openalex.org/W2052744648","https://openalex.org/W2061689246","https://openalex.org/W2071857547","https://openalex.org/W2074248400","https://openalex.org/W2076687508","https://openalex.org/W2078614037","https://openalex.org/W2088136863","https://openalex.org/W2098368231","https://openalex.org/W2099549518","https://openalex.org/W2107771085","https://openalex.org/W2109070559","https://openalex.org/W2109805789","https://openalex.org/W2112569130","https://openalex.org/W2115605234","https://openalex.org/W2117339256","https://openalex.org/W2124484106","https://openalex.org/W2125378109","https://openalex.org/W2126548892","https://openalex.org/W2130668388","https://openalex.org/W2138428172","https://openalex.org/W2140319297","https://openalex.org/W2147229303","https://openalex.org/W2158195504","https://openalex.org/W2163403433","https://openalex.org/W2166224440","https://openalex.org/W2167985345","https://openalex.org/W2169255927","https://openalex.org/W2169482291","https://openalex.org/W2170194742","https://openalex.org/W2201970982","https://openalex.org/W2279860619","https://openalex.org/W2304371460","https://openalex.org/W2412131839","https://openalex.org/W2562291689","https://openalex.org/W2607288225","https://openalex.org/W2614800967","https://openalex.org/W2755231255","https://openalex.org/W2768652998","https://openalex.org/W2900537098"],"related_works":["https://openalex.org/W4389028294","https://openalex.org/W2513588859","https://openalex.org/W4405884478","https://openalex.org/W4403911357","https://openalex.org/W2786045180","https://openalex.org/W7145636805","https://openalex.org/W3002375826","https://openalex.org/W2931495349","https://openalex.org/W4411875373","https://openalex.org/W3175677746"],"abstract_inverted_index":{"New":[0],"Findings":[1],"What":[2,36],"is":[3,37,56,67,123],"the":[4,26,38,47,52,74,83,98,120,124,134,206,217,238,250,254,259,301,311,318,322,337,342,345,363,369,377,380,385,389],"central":[5],"question":[6],"of":[7,12,46,73,82,93,129,157,253,284,321,344,379,388],"this":[8,146],"study?":[9],"The":[10,44],"impact":[11],"pulmonary":[13,63,103,115],"arterial":[14,31,64,94,104,116,121,210],"hypertension":[15,117],"on":[16],"open\u2010loop":[17,151],"baroreflex":[18,27,48,53,75,122,140,150,219,255,323,346,365],"function,":[19,55,220],"which":[20,137,383],"determines":[21,384],"how":[22],"powerfully":[23],"and":[24,41,78,197,209,230,237,309],"rapidly":[25],"operates":[28],"to":[29,90,167,235,241,304],"regulate":[30],"pressure,":[32],"remains":[33,142],"poorly":[34,143],"understood.":[35,144],"main":[39,125],"finding":[40],"its":[42],"importance?":[43],"gain":[45,252,320,378],"total":[49,256,324,381],"arc,":[50,382],"indicating":[51],"pressure\u2010stabilizing":[54,386],"markedly":[57,278],"attenuated":[58],"in":[59,102,111,136,153,374],"rats":[60,160,359],"with":[61,113,163,263,290,360],"monocrotaline\u2010induced":[62],"hypertension.":[65,105],"This":[66],"caused":[68],"by":[69,97,286,294],"a":[70,79,154,179,305],"rightward":[71],"shift":[72,81],"neural":[76,302,371],"arc":[77,257,303,313,325,367,372],"downward":[80],"peripheral":[84,312,366],"arc.":[85],"These":[86],"findings":[87],"contribute":[88],"greatly":[89],"our":[91],"understanding":[92],"pressure":[95,199,211],"regulation":[96],"sympathetic":[99,130],"nervous":[100],"system":[101],"Abstract":[106],"Sympathoexcitation":[107],"has":[108],"been":[109],"documented":[110],"patients":[112],"established":[114],"(PAH).":[118],"Although":[119],"negative":[126],"feedback":[127],"regulator":[128],"nerve":[131],"activity":[132],"(SNA),":[133],"way":[135],"PAH":[138,169],"impacts":[139],"function":[141],"In":[145,358],"study,":[147],"we":[148],"conducted":[149],"analysis":[152],"rat":[155],"model":[156],"PAH.":[158],"Sprague\u2013Dawley":[159],"were":[161,195,213,245],"injected":[162],"monocrotaline":[164],"(MCT)":[165],"s.c.":[166],"induce":[168],"(60":[170],"mg":[171],"kg\u22121;":[172],"n":[173,183],"=":[174,184],"11)":[175],"or":[176],"saline":[177],"as":[178],"control":[180],"group":[181],"(CTL;":[182],"8).":[185],"At":[186],"3.5":[187],"weeks":[188],"after":[189],"MCT":[190,277,299],"injection,":[191],"bilateral":[192],"carotid":[193],"sinuses":[194],"isolated,":[196],"intrasinus":[198],"(CSP)":[200],"was":[201,222],"controlled":[202],"while":[203,225,336],"SNA":[204,231,242,293,307],"at":[205,258],"coeliac":[207],"ganglia":[208],"(AP)":[212],"recorded.":[214],"To":[215],"examine":[216],"static":[218,251],"CSP":[221,236],"increased":[223,279],"stepwise":[224],"steady\u2010state":[226],"AP":[227,239,261],"(total":[228],"arc)":[229,233,244],"(neural":[232],"responses":[234],"response":[240],"(peripheral":[243],"measured.":[246],"Monocrotaline":[247,315],"significantly":[248],"decreased":[249,317],"operating":[260],"compared":[262,289],"CTL":[264],"(\u22120.80":[265],"\u00b1":[266,270,327,331,350,354],"0.31":[267],"versus":[268,329,352],"\u22120.22":[269],"0.22,":[271],"P":[272,333],"<":[273,334],"0.05).":[274],"Given":[275],"that":[276,298,340],"plasma":[280,295],"noradrenaline,":[281],"an":[282],"index":[283],"SNA,":[285],"approximately":[287],"3.6\u2010fold":[288],"CTL,":[291],"calibrating":[292],"noradrenaline":[296],"revealed":[297],"shifted":[300,310],"higher":[306],"level":[308],"downwards.":[314],"also":[316],"dynamic":[319],"(\u22120.79":[326],"0.16":[328],"\u22120.35":[330],"0.17,":[332],"0.05),":[335],"corner":[338],"frequencies":[339],"reflect":[341],"speed":[343],"remained":[347],"unchanged":[348],"(0.06":[349],"0.02":[351,355],"0.08":[353],"Hz,":[356],"n.s.).":[357],"MCT\u2010induced":[361],"PAH,":[362],"suppressed":[364],"overwhelms":[368],"augmented":[370],"and,":[373],"turn,":[375],"attenuates":[376],"capacity":[387],"baroreflex.":[390]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-07T00:00:00"}