{"id":"https://openalex.org/W2947579323","doi":"https://doi.org/10.4187/respcare.06544","title":"Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction","display_name":"Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction","publication_year":2019,"publication_date":"2019-05-28","ids":{"openalex":"https://openalex.org/W2947579323","doi":"https://doi.org/10.4187/respcare.06544","mag":"2947579323","pmid":"https://pubmed.ncbi.nlm.nih.gov/31138736"},"language":"en","primary_location":{"id":"doi:10.4187/respcare.06544","doi":"https://doi.org/10.4187/respcare.06544","is_oa":false,"landing_page_url":"https://doi.org/10.4187/respcare.06544","pdf_url":null,"source":{"id":"https://openalex.org/S744042","display_name":"Respiratory Care","issn_l":"0020-1324","issn":["0020-1324","1943-3654"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316455","host_organization_name":"American Association for Respiratory Care","host_organization_lineage":["https://openalex.org/P4310316455"],"host_organization_lineage_names":["American Association for Respiratory Care"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047535051","display_name":"Alexander Papolos","orcid":"https://orcid.org/0000-0001-6045-5988","observed_orcids":["https://orcid.org/0000-0001-6045-5988"]},"institutions":[{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander I Papolos","raw_affiliation_strings":["University of California San Francisco Medical Center at Parnassus, Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco Medical Center at Parnassus, Department of Medicine","institution_ids":["https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044541484","display_name":"Nelson B. Schiller","orcid":"https://orcid.org/0000-0001-5489-4378","observed_orcids":["https://orcid.org/0000-0001-5489-4378"]},"institutions":[{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nelson B Schiller","raw_affiliation_strings":["University of California San Francisco Medical Center at Parnassus, Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco Medical Center at Parnassus, Department of Medicine","institution_ids":["https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008630478","display_name":"Annika Belzer","orcid":"https://orcid.org/0000-0003-2228-4107","observed_orcids":["https://orcid.org/0000-0003-2228-4107"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annika Belzer","raw_affiliation_strings":["School of Medicine at Yale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine at Yale University","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109425107","display_name":"Hanjing Zhuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanjing Zhuo","raw_affiliation_strings":["University of California San Francisco Medical Center at Parnassus, Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco Medical Center at Parnassus, Department of Medicine","institution_ids":["https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050732719","display_name":"Jeffery E Gotts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffery E Gotts","raw_affiliation_strings":["University of California San Francisco Medical Center at Parnassus, Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco Medical Center at Parnassus, Department of Medicine","institution_ids":["https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018136738","display_name":"Dwight Bibby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dwight Bibby","raw_affiliation_strings":["University of California San Francisco Medical Center at Parnassus, Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco Medical Center at Parnassus, Department of Medicine","institution_ids":["https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062212651","display_name":"Carolyn S. Calfee","orcid":"https://orcid.org/0000-0001-9208-6865","observed_orcids":["https://orcid.org/0000-0001-9208-6865"]},"institutions":[{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn S Calfee","raw_affiliation_strings":["University of California San Francisco Medical Center at Parnassus, Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco Medical Center at Parnassus, Department of Medicine","institution_ids":["https://openalex.org/I4210110664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052576862","display_name":"Michael A. Matthay","orcid":"https://orcid.org/0000-0003-3039-8155","observed_orcids":["https://orcid.org/0000-0003-3039-8155"]},"institutions":[{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Matthay","raw_affiliation_strings":["University of California San Francisco Medical Center at Parnassus, Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco Medical Center at Parnassus, Department of Medicine","institution_ids":["https://openalex.org/I4210110664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5508,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.68632775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"64","issue":"9","first_page":"1101","last_page":"1108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9900000095367432},{"id":"https://openalex.org/keywords/right-ventricular-dysfunction","display_name":"right ventricular dysfunction","score":0.9240000247955322},{"id":"https://openalex.org/keywords/pulmonary-vascular-resistance","display_name":"pulmonary vascular resistance","score":0.7289999723434448},{"id":"https://openalex.org/keywords/tricuspid-regurgitation","display_name":"tricuspid regurgitation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cor-pulmonale","display_name":"cor pulmonale","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pulmonary-hemodynamics","display_name":"pulmonary hemodynamics","score":0.9359999895095825},{"id":"https://openalex.org/keywords/right-ventricular-afterload","display_name":"right ventricular afterload","score":0.7559999823570251},{"id":"https://openalex.org/keywords/echocardiographic-monitoring","display_name":"echocardiographic monitoring","score":0.6309999823570251},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9814416170120239},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.8465511798858643},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5612465143203735},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4435611069202423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3802381157875061},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.24311068654060364}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011660","descriptor_name":"Pulmonary Heart Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012126","descriptor_name":"Respiratory Dead Space","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018497","descriptor_name":"Ventricular Dysfunction, Right","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4187/respcare.06544","doi":"https://doi.org/10.4187/respcare.06544","is_oa":false,"landing_page_url":"https://doi.org/10.4187/respcare.06544","pdf_url":null,"source":{"id":"https://openalex.org/S744042","display_name":"Respiratory Care","issn_l":"0020-1324","issn":["0020-1324","1943-3654"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316455","host_organization_name":"American Association for Respiratory Care","host_organization_lineage":["https://openalex.org/P4310316455"],"host_organization_lineage_names":["American Association for Respiratory Care"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Care","raw_type":"journal-article"},{"id":"pmid:31138736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31138736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory care","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1542340631","https://openalex.org/W1803784511","https://openalex.org/W1826133152","https://openalex.org/W1970966681","https://openalex.org/W1973897024","https://openalex.org/W1976726694","https://openalex.org/W1981598317","https://openalex.org/W1994386449","https://openalex.org/W2002603912","https://openalex.org/W2027211149","https://openalex.org/W2027812057","https://openalex.org/W2033161102","https://openalex.org/W2043912534","https://openalex.org/W2051137983","https://openalex.org/W2065503072","https://openalex.org/W2068854215","https://openalex.org/W2085634565","https://openalex.org/W2112861506","https://openalex.org/W2123227952","https://openalex.org/W2141654397","https://openalex.org/W2145613376","https://openalex.org/W2187630416","https://openalex.org/W2208635741","https://openalex.org/W2259004039","https://openalex.org/W2626332159","https://openalex.org/W4244976753"],"related_works":["https://openalex.org/W4239749724","https://openalex.org/W2360649637","https://openalex.org/W7171868134","https://openalex.org/W2512716318","https://openalex.org/W4406028438","https://openalex.org/W2043208721","https://openalex.org/W3176457114","https://openalex.org/W2589859245","https://openalex.org/W23758576","https://openalex.org/W1973792320"],"abstract_inverted_index":{"BACKGROUND:":[0],"ARDS":[1,23,93,258],"is":[2],"a":[3,32,37,85,120,127,251],"highly":[4],"morbid":[5],"condition":[6],"characterized":[7],"by":[8,55,154,173],"diffuse":[9],"pulmonary":[10,62,72,80,99,104,123,130,150,190,198],"inflammation,":[11],"which":[12,228],"results":[13],"in":[14,36,51,71,79,122,129,189,196,207,241],"hypoxemic":[15],"respiratory":[16],"failure.":[17],"Approximately":[18],"25%":[19],"of":[20,40,89,98,235,261],"patients":[21,256],"with":[22,28,60,92,204,257],"develop":[24],"right":[25,43,138,214,237,263],"ventricular":[26,44,52,139,215,238,264],"dysfunction,":[27],"cor":[29,268],"pulmonale":[30],"being":[31],"common":[33],"final":[34],"pathway":[35],"significant":[38],"number":[39],"non-survivors.":[41],"ARDS-related":[42,236],"dysfunction":[45,239,265],"occurs":[46],"due":[47],"to":[48,114,137,213,231,254],"acute":[49,267],"elevation":[50],"afterload":[53],"caused":[54],"mechanisms":[56],"that":[57,69],"are":[58],"associated":[59,203],"increased":[61,153,172],"dead":[63,73,100,124,191,199,245],"space":[64,74,101,125,192,200,246],"fraction.":[65,193],"Thus,":[66],"we":[67],"hypothesized":[68],"changes":[70,78],"fraction":[75,102,201],"may":[76,248],"reflect":[77],"hemodynamics.":[81,131],"METHODS:":[82],"This":[83],"was":[84,112],"prospective":[86],"single-center":[87],"study":[88],"21":[90],"subjects":[91],"who":[94],"underwent":[95],"serial":[96],"determination":[97],"and":[103,126,166,222,266],"hemodynamics":[105],"via":[106],"transthoracic":[107],"echocardiography.":[108],"Linear":[109],"mixed-effects":[110],"modeling":[111],"performed":[113],"test":[115],"for":[116,149,185],"an":[117,146],"association":[118],"between":[119],"change":[121,128],"RESULTS:":[132],"The":[133],"tricuspid":[134,168,210,224],"regurgitation":[135,169,211,225],"velocity":[136,142,212,218],"outflow":[140,216],"track":[141,217],"time":[143,219],"integral":[144,220],"ratio,":[145],"echocardiographic":[147],"surrogate":[148],"vascular":[151],"resistance,":[152],"0.16":[155],"Wood":[156],"units":[157],"(Coefficient":[158,177],"0.16,":[159],"95%":[160,179],"CI":[161,180],"0.09\u20130.23;":[162],"P":[163,182],"<":[164,183],".001),":[165],"the":[167,197,209,223,232],"pressure":[170,226],"gradient":[171],"3.7":[174],"mm":[175],"Hg":[176],"3.7,":[178],"1.74\u20135.63,":[181],".001)":[184],"every":[186],"10%":[187],"increase":[188],"CONCLUSIONS:":[194],"Increases":[195],"were":[202],"relative":[205],"increases":[206],"both":[208],"ratio":[221],"gradient,":[227],"likely":[229],"contributed":[230],"high":[233],"incidence":[234],"encountered":[240],"clinical":[242,252],"practice.":[243],"Pulmonary":[244],"monitoring":[247],"serve":[249],"as":[250],"indicator":[253],"identify":[255],"at":[259],"risk":[260],"developing":[262],"pulmonale.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-06-07T00:00:00"}