{"id":"https://openalex.org/W2947574926","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e12521","title":"Efficacy of abemaciclib (abema) after palbociclib (palbo) in patients (pts) with metastatic breast cancer (MBC).","display_name":"Efficacy of abemaciclib (abema) after palbociclib (palbo) in patients (pts) with metastatic breast cancer (MBC).","publication_year":2019,"publication_date":"2019-05-20","ids":{"openalex":"https://openalex.org/W2947574926","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e12521","mag":"2947574926"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2019.37.15_suppl.e12521","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e12521","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.e12521","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055422485","display_name":"Veronica Mariotti","orcid":"https://orcid.org/0000-0001-8148-7866","observed_orcids":["https://orcid.org/0000-0001-8148-7866"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica Mariotti","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL;","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014744153","display_name":"Hung T. Khong","orcid":"https://orcid.org/0000-0001-8365-957X","observed_orcids":["https://orcid.org/0000-0001-8365-957X"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hung T. Khong","raw_affiliation_strings":["Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT;","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090789911","display_name":"Hatem Hussein Soliman","orcid":"https://orcid.org/0000-0001-6644-2264","observed_orcids":["https://orcid.org/0000-0001-6644-2264"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hatem Hussein Soliman","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006005284","display_name":"Ricardo Lima Barros Costa","orcid":"https://orcid.org/0000-0002-3303-3234","observed_orcids":["https://orcid.org/0000-0002-3303-3234"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricardo L Costa","raw_affiliation_strings":["H. Lee Moffitt Cancer Center, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center, Tampa, FL;","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072848912","display_name":"Shanel Fisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shanel Fisher","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL;","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087985396","display_name":"David C. Boulware","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Boulware","raw_affiliation_strings":["USF, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USF, Tampa, FL;","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059240684","display_name":"Hyo Sook Han","orcid":"https://orcid.org/0000-0002-0072-0257","observed_orcids":["https://orcid.org/0000-0002-0072-0257"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyo S. Han","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"15_suppl","first_page":"e12521","last_page":"e12521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abemaciclib","display_name":"abemaciclib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.9580000042915344},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hr-her2-breast-cancer","display_name":"hormone receptor-positive HER2-negative breast cancer","score":0.8830000162124634},{"id":"https://openalex.org/keywords/sequential-therapy","display_name":"sequential therapy","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cross-resistance","display_name":"cross-resistance","score":0.7269999980926514},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.906000018119812},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.8140000104904175},{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":0.953000009059906},{"id":"https://openalex.org/keywords/aromatase-inhibitors","display_name":"aromatase inhibitors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6639999747276306},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.8790000081062317},{"id":"https://openalex.org/keywords/heavily-pretreated-patients","display_name":"heavily pretreated patients","score":0.6639999747276306},{"id":"https://openalex.org/keywords/stable-disease","display_name":"stable disease","score":0.5730000138282776},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.48500001430511475},{"id":"https://openalex.org/keywords/survival-outcomes","display_name":"survival outcomes","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9485573172569275},{"id":"https://openalex.org/C2780482068","wikidata":"https://www.wikidata.org/wiki/Q5508491","display_name":"Fulvestrant","level":5,"score":0.8879626989364624},{"id":"https://openalex.org/C2779744173","wikidata":"https://www.wikidata.org/wiki/Q15269707","display_name":"Palbociclib","level":5,"score":0.848212718963623},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.688232958316803},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6461759209632874},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5141899585723877},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5027000904083252},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.44105860590934753},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.4395903944969177},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4377061426639557},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.367687463760376},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3468467593193054},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2307661771774292},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.17214033007621765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2019.37.15_suppl.e12521","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e12521","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.e12521","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3005667647","https://openalex.org/W2943341596","https://openalex.org/W3137868312","https://openalex.org/W2947876005","https://openalex.org/W4398171679","https://openalex.org/W4408376357","https://openalex.org/W7165401544","https://openalex.org/W2947864495","https://openalex.org/W4283713831","https://openalex.org/W4210295521"],"abstract_inverted_index":{"e12521":[0],"Background:":[1],"CDK":[2,21],"4/6":[3,22],"inhibitors":[4,23,160],"(Abema":[5],"and":[6,24,95,119,158,212,216,286],"Palbo)":[7],"have":[8],"shown":[9],"efficacy":[10],"in":[11,56,149,156,162,179,188,201,206,258,276],"patients":[12,104],"with":[13,59,151,190,203,289],"HR+/HER2-":[14],"MBC.":[15],"Abema":[16,53,74,115,124,169,198,229,245,252,273,308],"is":[17,33],"distinct":[18],"from":[19,75],"other":[20,121],"was":[25,47,193,199,232,253,265],"approved":[26,84],"after":[27,77,309],"the":[28,50,120,166,305],"approval":[29],"of":[30,44,111,141,168,186,228,280,292],"Palbo.":[31,63,81],"There":[32],"limited":[34],"data":[35],"on":[36,114,244],"sequential":[37],"use":[38],"or":[39,262],"cross":[40],"resistance.":[41],"The":[42,128,181,225],"aim":[43],"this":[45],"study":[46],"to":[48,52,62,108,126,247,256,284,302,307,311],"analyze":[49],"response":[51,264,275,306],"based":[54,170,230],"therapy":[55,153,192,205,231],"MBC":[57],"pts":[58,71,100,131,157,208,210,214,218,238,281],"prior":[60,80,143,248],"exposure":[61,310],"Methods:":[64],"We":[65],"queried":[66],"our":[67],"EMR":[68],"database":[69],"for":[70,116,294],"who":[72],"received":[73,79,138,219],"9/2017-9/2018":[76],"having":[78],"Under":[82],"IRB":[83],"protocol":[85],"we":[86],"retrospectively":[87],"collected":[88],"demographics,":[89],"tumor":[90],"characteristics,":[91],"disease":[92],"status,":[93],"toxicities":[94,257],"survival.":[96],"Results:":[97],"23":[98],"female":[99],"were":[101],"identified.":[102],"Four":[103,237],"discontinued":[105,123,254],"Palbo":[106,148,187,249,285],"due":[107,125,255],"toxicities:":[109],"two":[110],"them":[112],"remained":[113],"8":[117,194],"months":[118,195,234],"2":[122],"toxicities.":[127],"remaining":[129],"19":[130],"(median":[132],"age":[133],"57":[134],"years,":[135],"range":[136],"39-76)":[137],"a":[139,222,241,277],"mean":[140],"5.6":[142],"therapies":[144],"(range":[145,196,235],"(1-11)":[146],"including":[147,176],"combination":[150,189,202],"endocrine":[152,191,204],"(fulvestrant":[154],"9":[155],"Aromatase":[159],"(AI)":[161],"10":[163],"pts)":[164],"at":[165],"time":[167],"therapy.":[171],"73.6%":[172],"had":[173,240,269],"visceral":[174],"involvement":[175],"brain":[177],"metastasis":[178],"26%.":[180],"median":[182,226],"progression-free":[183],"survival":[184],"(PFS)":[185],"2.3-14.3).":[197],"given":[200],"15":[207],"(9":[209],"fulvestrant":[211],"6":[213],"AI)":[215],"4":[217],"it":[220],"as":[221],"single":[223],"agent.":[224],"PFS":[227,243,250],"7.0":[233],"1.8-12.1).":[236],"(21%)":[239],"longer":[242],"compared":[246],"(table).":[251],"15.7%.":[259],"No":[260],"partial":[261],"complete":[263],"observed":[266],"but":[267],"33%":[268],"stable":[270],"disease.":[271,297],"Conclusions:":[272],"showed":[274],"significant":[278],"number":[279],"previously":[282],"exposed":[283],"heavily":[287],"treated":[288],"multiple":[290],"lines":[291],"chemotherapy":[293],"widespread":[295],"metastatic":[296],"Prospective":[298],"studies":[299],"are":[300],"warranted":[301],"better":[303],"assess":[304],"CDK4/6":[312],"inhibitors.":[313],"[Table:":[314],"see":[315],"text]":[316]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2019-06-07T00:00:00"}
