{"id":"https://openalex.org/W2947508341","doi":"https://doi.org/10.1007/s10120-019-00974-4","title":"Differences in immune contextures among different molecular subtypes of gastric cancer and their prognostic impact","display_name":"Differences in immune contextures among different molecular subtypes of gastric cancer and their prognostic impact","publication_year":2019,"publication_date":"2019-05-31","ids":{"openalex":"https://openalex.org/W2947508341","doi":"https://doi.org/10.1007/s10120-019-00974-4","mag":"2947508341","pmid":"https://pubmed.ncbi.nlm.nih.gov/31152268"},"language":"en","primary_location":{"id":"doi:10.1007/s10120-019-00974-4","doi":"https://doi.org/10.1007/s10120-019-00974-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10120-019-00974-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10120-019-00974-4.pdf","source":{"id":"https://openalex.org/S145569942","display_name":"Gastric Cancer","issn_l":"1436-3291","issn":["1436-3291","1436-3305"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastric Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1007/s10120-019-00974-4.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100741459","display_name":"Joo Yeon Kim","orcid":"https://orcid.org/0000-0002-5563-4129","observed_orcids":["https://orcid.org/0000-0002-5563-4129"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]},{"id":"https://openalex.org/I4210102912","display_name":"Inje University Haeundae Paik Hospital","ror":"https://ror.org/019641589","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I104338594","https://openalex.org/I4210102912","https://openalex.org/I4405258751"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joo Yeon Kim","raw_affiliation_strings":["Department of Pathology, Haeundae Paik Hospital, College of Medicine, Inje University, Busan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Haeundae Paik Hospital, College of Medicine, Inje University, Busan, South Korea","institution_ids":["https://openalex.org/I104338594","https://openalex.org/I4210102912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022537060","display_name":"Woo Gyeong Kim","orcid":"https://orcid.org/0000-0003-1694-6602","observed_orcids":["https://orcid.org/0000-0003-1694-6602"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]},{"id":"https://openalex.org/I4210102912","display_name":"Inje University Haeundae Paik Hospital","ror":"https://ror.org/019641589","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I104338594","https://openalex.org/I4210102912","https://openalex.org/I4405258751"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woo Gyeong Kim","raw_affiliation_strings":["Department of Pathology, Haeundae Paik Hospital, College of Medicine, Inje University, Busan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Haeundae Paik Hospital, College of Medicine, Inje University, Busan, South Korea","institution_ids":["https://openalex.org/I104338594","https://openalex.org/I4210102912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041150612","display_name":"Chae Hwa Kwon","orcid":"https://orcid.org/0000-0003-2277-1570","observed_orcids":["https://orcid.org/0000-0003-2277-1570"]},"institutions":[{"id":"https://openalex.org/I4210115854","display_name":"Pusan National University Hospital","ror":"https://ror.org/027zf7h57","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210115854","https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Chae Hwa Kwon","raw_affiliation_strings":["BioMedical Research Institute, Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan, 49241, South Korea. chkwon@pusan.ac.kr","BioMedical Research Institute, Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan, 49241, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMedical Research Institute, Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan, 49241, South Korea. chkwon@pusan.ac.kr","institution_ids":["https://openalex.org/I4210115854"]},{"raw_affiliation_string":"BioMedical Research Institute, Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan, 49241, South Korea","institution_ids":["https://openalex.org/I4210115854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059888326","display_name":"Do Youn Park","orcid":"https://orcid.org/0000-0001-7641-1509","observed_orcids":["https://orcid.org/0000-0001-7641-1509"]},"institutions":[{"id":"https://openalex.org/I4210115854","display_name":"Pusan National University Hospital","ror":"https://ror.org/027zf7h57","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210115854","https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Do Youn Park","raw_affiliation_strings":["BioMedical Research Institute, Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan, 49241, South Korea. pdy220@pusan.ac.kr","Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan, South Korea. pdy220@pusan.ac.kr","BioMedical Research Institute, Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan, 49241, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMedical Research Institute, Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan, 49241, South Korea. pdy220@pusan.ac.kr","institution_ids":["https://openalex.org/I4210115854"]},{"raw_affiliation_string":"Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan, South Korea. pdy220@pusan.ac.kr","institution_ids":["https://openalex.org/I4210115854"]},{"raw_affiliation_string":"BioMedical Research Institute, Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan, 49241, South Korea","institution_ids":["https://openalex.org/I4210115854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5041150612","https://openalex.org/A5059888326"],"corresponding_institution_ids":["https://openalex.org/I4210115854"],"apc_list":{"value":3760,"currency":"USD","value_usd":3760},"apc_paid":null,"fwci":2.6959,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.91892858,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"6","first_page":"1164","last_page":"1175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5127000212669373,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5127000212669373,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.45969998836517334,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tumor-immune-contexture","display_name":"tumor immune contexture","score":0.7950000166893005},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.9210000038146973},{"id":"https://openalex.org/keywords/foxp3-regulatory-t-cells","display_name":"Foxp3+ regulatory T cells","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.921999990940094},{"id":"https://openalex.org/keywords/immune-subtypes","display_name":"immune subtypes","score":0.699999988079071},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8799999952316284},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.8629999756813049},{"id":"https://openalex.org/keywords/ebv-positive-gastric-cancer","display_name":"EBV-positive gastric cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9010000228881836},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.7648593187332153},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7126322984695435},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.6213417053222656},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5898003578186035},{"id":"https://openalex.org/C2777154038","wikidata":"https://www.wikidata.org/wiki/Q7168585","display_name":"Perineural invasion","level":3,"score":0.5846676826477051},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.5825086832046509},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5712041854858398},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5706133842468262},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.5635374784469604},{"id":"https://openalex.org/C2778740770","wikidata":"https://www.wikidata.org/wiki/Q6708283","display_name":"Lymphovascular invasion","level":4,"score":0.4728425145149231},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4711006283760071},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.4511486887931824},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4478166103363037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4308721721172333},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30570846796035767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2691158354282379},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.25580745935440063},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.25390493869781494},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10116755962371826},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.0},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053842","descriptor_name":"Microsatellite Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10120-019-00974-4","doi":"https://doi.org/10.1007/s10120-019-00974-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10120-019-00974-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10120-019-00974-4.pdf","source":{"id":"https://openalex.org/S145569942","display_name":"Gastric Cancer","issn_l":"1436-3291","issn":["1436-3291","1436-3305"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastric Cancer","raw_type":"journal-article"},{"id":"pmid:31152268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31152268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s10120-019-00974-4","doi":"https://doi.org/10.1007/s10120-019-00974-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10120-019-00974-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10120-019-00974-4.pdf","source":{"id":"https://openalex.org/S145569942","display_name":"Gastric Cancer","issn_l":"1436-3291","issn":["1436-3291","1436-3305"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastric Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1274657155","display_name":null,"funder_award_id":"NRF-2018R1C1B6004754","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321284","display_name":"Pusan National University","ror":"https://ror.org/01an57a31"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320324899","display_name":"Pusan National University Hospital","ror":"https://ror.org/027zf7h57"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2947508341.pdf","grobid_xml":"https://content.openalex.org/works/W2947508341.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1889335134","https://openalex.org/W1976269164","https://openalex.org/W1983928444","https://openalex.org/W1999075493","https://openalex.org/W2007631222","https://openalex.org/W2031681802","https://openalex.org/W2039155608","https://openalex.org/W2049491375","https://openalex.org/W2051929083","https://openalex.org/W2066671159","https://openalex.org/W2086595653","https://openalex.org/W2095724207","https://openalex.org/W2117692326","https://openalex.org/W2126547130","https://openalex.org/W2166626276","https://openalex.org/W2196944733","https://openalex.org/W2212189494","https://openalex.org/W2300582328","https://openalex.org/W2315980696","https://openalex.org/W2339303388","https://openalex.org/W2414672301","https://openalex.org/W2419439766","https://openalex.org/W2530724767","https://openalex.org/W2546425796","https://openalex.org/W2560348430","https://openalex.org/W2560367415","https://openalex.org/W2749878693","https://openalex.org/W2756207531","https://openalex.org/W2762052313"],"related_works":["https://openalex.org/W7124802218","https://openalex.org/W4393182986","https://openalex.org/W3087054038","https://openalex.org/W2905180339","https://openalex.org/W2794269769","https://openalex.org/W3008096828","https://openalex.org/W3032728980","https://openalex.org/W3096366699","https://openalex.org/W2908970744","https://openalex.org/W3176023012"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-06-07T00:00:00"}