{"id":"https://openalex.org/W2947088718","doi":"https://doi.org/10.21037/tau.2019.05.02","title":"Radium-223 plus abiraterone in metastatic castration-resistant prostate cancer: a cautionary tale","display_name":"Radium-223 plus abiraterone in metastatic castration-resistant prostate cancer: a cautionary tale","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2947088718","doi":"https://doi.org/10.21037/tau.2019.05.02","mag":"2947088718","pmid":"https://pubmed.ncbi.nlm.nih.gov/31392164","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6642951"},"language":"en","primary_location":{"id":"doi:10.21037/tau.2019.05.02","doi":"https://doi.org/10.21037/tau.2019.05.02","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tau.2019.05.02","pdf_url":"https://tau.amegroups.com/article/viewFile/26051/pdf","source":{"id":"https://openalex.org/S2754699985","display_name":"Translational Andrology and Urology","issn_l":"2223-4683","issn":["2223-4683","2223-4691"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Andrology and Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://tau.amegroups.com/article/viewFile/26051/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023971954","display_name":"Ramy Sedhom","orcid":"https://orcid.org/0000-0001-8937-0726","observed_orcids":["https://orcid.org/0000-0001-8937-0726"]},"institutions":[{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramy Sedhom","raw_affiliation_strings":["Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210150714","https://openalex.org/I4210164401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018645768","display_name":"Emmanuel S. Antonarakis","orcid":"https://orcid.org/0000-0003-0031-9655","observed_orcids":["https://orcid.org/0000-0003-0031-9655","https://orcid.org/0000-0003-3531-3851"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanuel S. Antonarakis","raw_affiliation_strings":["Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA","Genitourinary Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 401 N. Broadway, Baltimore, MD 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210150714","https://openalex.org/I4210164401"]},{"raw_affiliation_string":"Genitourinary Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 401 N. Broadway, Baltimore, MD 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714","https://openalex.org/I4210164401"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.531,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.53807922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"S3","first_page":"S341","last_page":"S345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radium-223-dichloride","display_name":"radium-223 dichloride","score":0.9610000252723694},{"id":"https://openalex.org/keywords/abiraterone-acetate","display_name":"abiraterone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6629999876022339},{"id":"https://openalex.org/keywords/skeletal-related-events","display_name":"skeletal-related events","score":0.7279999852180481},{"id":"https://openalex.org/keywords/androgen-receptor-targeted-therapy","display_name":"androgen receptor-targeted therapy","score":0.6679999828338623},{"id":"https://openalex.org/keywords/alpha-particle-therapy","display_name":"alpha therapy","score":0.6449999809265137},{"id":"https://openalex.org/keywords/treatment-sequencing","display_name":"treatment sequencing","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2780737065","wikidata":"https://www.wikidata.org/wiki/Q18888805","display_name":"Radium-223","level":5,"score":0.8943451642990112},{"id":"https://openalex.org/C2778971682","wikidata":"https://www.wikidata.org/wiki/Q412963","display_name":"Cabazitaxel","level":5,"score":0.8776550889015198},{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.8710674047470093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8692227602005005},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8607277274131775},{"id":"https://openalex.org/C2775832370","wikidata":"https://www.wikidata.org/wiki/Q27888393","display_name":"Abiraterone acetate","level":5,"score":0.8593292236328125},{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.7152045369148254},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.6696999073028564},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6163918375968933},{"id":"https://openalex.org/C2776421732","wikidata":"https://www.wikidata.org/wiki/Q27888393","display_name":"Abiraterone","level":5,"score":0.552021861076355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5354552268981934},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.42568567395210266},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3947848379611969},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.28181636333465576},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.21317827701568604},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.19389766454696655}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/tau.2019.05.02","doi":"https://doi.org/10.21037/tau.2019.05.02","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tau.2019.05.02","pdf_url":"https://tau.amegroups.com/article/viewFile/26051/pdf","source":{"id":"https://openalex.org/S2754699985","display_name":"Translational Andrology and Urology","issn_l":"2223-4683","issn":["2223-4683","2223-4691"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Andrology and Urology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6642951","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6642951","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Androl Urol","raw_type":"Text"},{"id":"pmid:31392164","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31392164","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational andrology and urology","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.21037/tau.2019.05.02","doi":"https://doi.org/10.21037/tau.2019.05.02","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tau.2019.05.02","pdf_url":"https://tau.amegroups.com/article/viewFile/26051/pdf","source":{"id":"https://openalex.org/S2754699985","display_name":"Translational Andrology and Urology","issn_l":"2223-4683","issn":["2223-4683","2223-4691"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Andrology and Urology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4846955275","display_name":null,"funder_award_id":"W81XWH\u201016\u2010PCRP\u2010CCRSA","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8144833018","display_name":null,"funder_award_id":"W81XWH-16-PCRP-CCRSA","funder_id":"https://openalex.org/F4320338485","funder_display_name":"DOD Prostate Cancer Research Program"},{"id":"https://openalex.org/G9000891644","display_name":"Epidemiology and Biostatistics of Aging","funder_award_id":"T32AG000247","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000911005","display_name":"Regional Oncology Research Center","funder_award_id":"P30CA006973","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338485","display_name":"DOD Prostate Cancer Research Program","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2947088718.pdf","grobid_xml":"https://content.openalex.org/works/W2947088718.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1839255228","https://openalex.org/W1970345836","https://openalex.org/W2014574900","https://openalex.org/W2049366286","https://openalex.org/W2063171513","https://openalex.org/W2093941725","https://openalex.org/W2110534364","https://openalex.org/W2113701976","https://openalex.org/W2137467802","https://openalex.org/W2141454098","https://openalex.org/W2151759789","https://openalex.org/W2156422391","https://openalex.org/W2156923287","https://openalex.org/W2169737508","https://openalex.org/W2396720856","https://openalex.org/W2483834070","https://openalex.org/W2509917335","https://openalex.org/W2767227550","https://openalex.org/W2787956080","https://openalex.org/W2789294935","https://openalex.org/W2800630992","https://openalex.org/W2911490798","https://openalex.org/W4238920787","https://openalex.org/W6678109425"],"related_works":["https://openalex.org/W2999979765","https://openalex.org/W2981282955","https://openalex.org/W2943348499","https://openalex.org/W2608870902","https://openalex.org/W2218898199","https://openalex.org/W3164067785","https://openalex.org/W2925184412","https://openalex.org/W2994960678","https://openalex.org/W2911490798","https://openalex.org/W2313007927"],"abstract_inverted_index":{"Metastatic":[0],"castration-resistant":[1],"prostate":[2,110],"cancer":[3],"(mCRPC)":[4],"spreads":[5],"to":[6,10,86,115,123],"bone":[7],"in":[8,92],"up":[9],"90%":[11],"of":[12,27,102,120,128,137,149],"patients":[13,107],"and":[14,30,47,70,104,126],"can":[15],"be":[16],"associated":[17],"with":[18,25,108,152],"pain,":[19],"skeletal-related":[20],"events":[21],"(SREs),":[22],"reduced":[23],"mobility":[24],"quality":[26,127],"life":[28,129],"impairment,":[29],"shortened":[31],"overall":[32],"survival":[33,125],"(OS)":[34],"(1-4).":[35],"Over":[36],"the":[37,58,135,138],"past":[38],"several":[39],"years,":[40],"treatment":[41],"options":[42],"for":[43,106,117,130],"mCRPC":[44],"have":[45],"expanded,":[46],"now":[48],"include":[49],"cytotoxic":[50],"agents":[51,72,91],"(docetaxel,":[52],"cabazitaxel),":[53],"oral":[54],"hormonal":[55],"therapies":[56,122],"targeting":[57],"androgen":[59],"receptor":[60],"(abiraterone,":[61],"enzalutamide,":[62],"apalutamide),":[63],"targeted":[64],"alpha-particle":[65],"therapy":[66],"(radium-223),":[67],"immunotherapy":[68],"(sipuleucel-T),":[69],"bone-supportive":[71],"(zoledronate,":[73],"denosumab)":[74],"that":[75,144],"reduce":[76],"SREs":[77],"(5-7).":[78],"It":[79],"is":[80],"not":[81],"yet":[82],"clear,":[83],"however,":[84],"how":[85],"sequence":[87],"or":[88],"combine":[89],"available":[90],"routine":[93],"clinical":[94],"practice.":[95],"Bone":[96],"disease":[97],"remains":[98],"a":[99,142,146],"leading":[100],"contributor":[101],"morbidity":[103],"mortality":[105],"metastatic":[109],"cancer.":[111],"Researchers":[112],"thus":[113],"continue":[114],"search":[116],"novel":[118,147],"combinations":[119],"proven":[121],"improve":[124],"these":[131],"patients.":[132],"This":[133],"was":[134],"intention":[136],"ERA-223":[139],"study":[140],"(NCT02043678),":[141],"trial":[143],"investigated":[145],"combination":[148],"radium-223":[150],"dichloride":[151],"abiraterone":[153],"acetate.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-06-07T00:00:00"}