{"id":"https://openalex.org/W2946963404","doi":"https://doi.org/10.1093/omcr/omz041","title":"Secukinumab induced Beh\u00e7et\u2019s syndrome: a report of two cases","display_name":"Secukinumab induced Beh\u00e7et\u2019s syndrome: a report of two cases","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2946963404","doi":"https://doi.org/10.1093/omcr/omz041","mag":"2946963404","pmid":"https://pubmed.ncbi.nlm.nih.gov/31198577","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6544425"},"language":"en","primary_location":{"id":"doi:10.1093/omcr/omz041","doi":"https://doi.org/10.1093/omcr/omz041","is_oa":true,"landing_page_url":"https://doi.org/10.1093/omcr/omz041","pdf_url":null,"source":{"id":"https://openalex.org/S2734620550","display_name":"Oxford Medical Case Reports","issn_l":"2053-8855","issn":["2053-8855"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxford Medical Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/omcr/omz041","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048337949","display_name":"Elif Dincses","orcid":"https://orcid.org/0000-0002-7515-9927","observed_orcids":["https://orcid.org/0000-0002-7515-9927"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Elif Dincses","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, Cerrahpa\u015fa Medical Faculty, University of Istanbul-Cerrahpa\u015fa, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, Cerrahpa\u015fa Medical Faculty, University of Istanbul-Cerrahpa\u015fa, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085758606","display_name":"Berna Yurtta\u015f","orcid":"https://orcid.org/0000-0002-6096-0340","observed_orcids":["https://orcid.org/0000-0002-6096-0340"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Berna Yurttas","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, Cerrahpa\u015fa Medical Faculty, University of Istanbul-Cerrahpa\u015fa, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, Cerrahpa\u015fa Medical Faculty, University of Istanbul-Cerrahpa\u015fa, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014869164","display_name":"Sinem Nihal Esato\u011flu","orcid":"https://orcid.org/0000-0001-5414-7305","observed_orcids":["https://orcid.org/0000-0001-5414-7305"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sinem N Esatoglu","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, Cerrahpa\u015fa Medical Faculty, University of Istanbul-Cerrahpa\u015fa, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, Cerrahpa\u015fa Medical Faculty, University of Istanbul-Cerrahpa\u015fa, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081240145","display_name":"Melike Meliko\u011flu","orcid":"https://orcid.org/0000-0003-0253-8368","observed_orcids":["https://orcid.org/0000-0003-0253-8368"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Melike Melikoglu","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, Cerrahpa\u015fa Medical Faculty, University of Istanbul-Cerrahpa\u015fa, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, Cerrahpa\u015fa Medical Faculty, University of Istanbul-Cerrahpa\u015fa, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063297960","display_name":"Vedat Hamuryudan","orcid":"https://orcid.org/0000-0001-6625-1652","observed_orcids":["https://orcid.org/0000-0001-6625-1652"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Vedat Hamuryudan","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, Cerrahpa\u015fa Medical Faculty, University of Istanbul-Cerrahpa\u015fa, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, Cerrahpa\u015fa Medical Faculty, University of Istanbul-Cerrahpa\u015fa, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047872744","display_name":"Emire Seyahi","orcid":"https://orcid.org/0000-0003-4965-2918","observed_orcids":["https://orcid.org/0000-0003-4965-2918"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Emire Seyahi","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, Cerrahpa\u015fa Medical Faculty, University of Istanbul-Cerrahpa\u015fa, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, Cerrahpa\u015fa Medical Faculty, University of Istanbul-Cerrahpa\u015fa, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047872744"],"corresponding_institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"],"apc_list":{"value":1103,"currency":"USD","value_usd":1103},"apc_paid":{"value":1103,"currency":"USD","value_usd":1103},"fwci":5.1152,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.95765096,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"2019","issue":"5","first_page":"omz041","last_page":"omz041"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secukinumab","display_name":"secukinumab","score":1.0},{"id":"https://openalex.org/keywords/behcet-s-disease","display_name":"Beh\u00e7et's disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/il-17a-inhibition","display_name":"IL-17A inhibition","score":0.8389999866485596},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8889999985694885},{"id":"https://openalex.org/keywords/ankylosing-spondylitis","display_name":"ankylosing spondylitis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/uveitis","display_name":"uveitis","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2779786854","wikidata":"https://www.wikidata.org/wiki/Q7444755","display_name":"Secukinumab","level":4,"score":0.994953989982605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9329876899719238},{"id":"https://openalex.org/C2776260265","wikidata":"https://www.wikidata.org/wiki/Q511097","display_name":"Psoriatic arthritis","level":3,"score":0.7588430643081665},{"id":"https://openalex.org/C2777402515","wikidata":"https://www.wikidata.org/wiki/Q52849","display_name":"Ankylosing spondylitis","level":2,"score":0.6884268522262573},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.5933161377906799},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5836263298988342},{"id":"https://openalex.org/C2776194053","wikidata":"https://www.wikidata.org/wiki/Q280027","display_name":"Uveitis","level":2,"score":0.5792579054832458},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.4932085871696472},{"id":"https://openalex.org/C2779745271","wikidata":"https://www.wikidata.org/wiki/Q13574436","display_name":"Ixekizumab","level":5,"score":0.48509085178375244},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42888569831848145},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.41237717866897583}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1093/omcr/omz041","doi":"https://doi.org/10.1093/omcr/omz041","is_oa":true,"landing_page_url":"https://doi.org/10.1093/omcr/omz041","pdf_url":null,"source":{"id":"https://openalex.org/S2734620550","display_name":"Oxford Medical Case Reports","issn_l":"2053-8855","issn":["2053-8855"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxford Medical Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5537105","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6544425","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6544425","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6544425","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxf Med Case Reports","raw_type":"Text"},{"id":"pmid:31198577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31198577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxford medical case reports","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1093/omcr/omz041","doi":"https://doi.org/10.1093/omcr/omz041","is_oa":true,"landing_page_url":"https://doi.org/10.1093/omcr/omz041","pdf_url":null,"source":{"id":"https://openalex.org/S2734620550","display_name":"Oxford Medical Case Reports","issn_l":"2053-8855","issn":["2053-8855"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxford Medical Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2043198160","https://openalex.org/W2132784721","https://openalex.org/W2238339241","https://openalex.org/W2278932593","https://openalex.org/W2386234576","https://openalex.org/W2781701627","https://openalex.org/W2799570607","https://openalex.org/W2883819659","https://openalex.org/W2947737365"],"related_works":["https://openalex.org/W4281757895","https://openalex.org/W2610619451","https://openalex.org/W3016264928","https://openalex.org/W2891846602","https://openalex.org/W2799570607","https://openalex.org/W4385661788","https://openalex.org/W7119012127","https://openalex.org/W3094331073","https://openalex.org/W4399480355","https://openalex.org/W4412855694"],"abstract_inverted_index":{"Secukinumab":[0],"is":[1,114,137],"a":[2,130],"human":[3],"monoclonal":[4],"antibody":[5],"against":[6],"IL-17A":[7,113],"that":[8,67,126],"has":[9],"been":[10],"shown":[11],"to":[12,40,60,116,118],"be":[13,70],"effective":[14],"in":[15,27,74,102,110,144],"psoriasis,":[16],"psoriatic":[17],"arthritis":[18],"and":[19,37,53,104],"ankylosing":[20],"spondylitis":[21],"(AS).":[22],"On":[23],"the":[24,54,119,140],"other":[25],"hand,":[26],"randomized":[28],"controlled":[29],"trials":[30],"among":[31],"patients":[32,75,91],"with":[33,45,72,76,85,92,95,139],"Crohn\u2019s":[34],"disease":[35],"(CD)":[36],"uveitis":[38],"due":[39],"Beh\u00e7et\u2019s":[41],"syndrome":[42],"(BS)":[43],"treated":[44,94],"secukinumab,":[46],"primary":[47],"end":[48],"points":[49],"were":[50],"not":[51],"met":[52],"drug":[55,63],"caused":[56],"more":[57],"exacerbations":[58],"compared":[59],"placebo.":[61],"The":[62],"fact":[64],"sheet":[65],"states":[66],"secukinumab":[68],"should":[69],"used":[71],"caution":[73,136],"CD;":[77],"however,":[78],"there":[79],"are":[80],"no":[81],"warnings":[82],"for":[83],"those":[84],"BS.":[86,145],"Here,":[87],"we":[88,97,134],"present":[89],"two":[90],"AS":[93],"secukinumab;":[96],"observed":[98],"exacerbation":[99],"of":[100,106,121,142],"BS":[101,109],"one":[103],"emergence":[105],"de":[107],"novo":[108],"another.":[111],"Although":[112],"thought":[115],"contribute":[117],"pathogenesis":[120],"BS,":[122],"our":[123],"observations":[124],"suggest":[125,135],"it":[127],"might":[128],"have":[129],"protective":[131],"role.":[132],"Finally,":[133],"required":[138],"inhibition":[141],"IL-17":[143]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-07T00:00:00"}
