{"id":"https://openalex.org/W2946938320","doi":"https://doi.org/10.12991/jrp.2019.142","title":"Effects of different sizes silica nanoparticle on the liver, kidney and brain in rats: Biochemical and histopathological evaluation","display_name":"Effects of different sizes silica nanoparticle on the liver, kidney and brain in rats: Biochemical and histopathological evaluation","publication_year":2019,"publication_date":"2019-05-15","ids":{"openalex":"https://openalex.org/W2946938320","doi":"https://doi.org/10.12991/jrp.2019.142","mag":"2946938320"},"language":"en","primary_location":{"id":"doi:10.12991/jrp.2019.142","doi":"https://doi.org/10.12991/jrp.2019.142","is_oa":true,"landing_page_url":"https://doi.org/10.12991/jrp.2019.142","pdf_url":"http://jrespharm.com/pdf.php?id=676","source":{"id":"https://openalex.org/S4210224330","display_name":"Journal of Research in Pharmacy","issn_l":"2630-6344","issn":["2630-6344"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Research in Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://jrespharm.com/pdf.php?id=676","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045101428","display_name":"\u00dclk\u00fc \u00c7\u00f6meleko\u011flu","orcid":"https://orcid.org/0000-0001-8060-6333","observed_orcids":["https://orcid.org/0000-0001-8060-6333"]},"institutions":[{"id":"https://openalex.org/I51780484","display_name":"Mersin \u00dcniversitesi","ror":"https://ror.org/04nqdwb39","country_code":"TR","type":"education","lineage":["https://openalex.org/I51780484"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"\u00dclk\u00fc \u00c7\u00d6MELEKO\u011eLU","raw_affiliation_strings":["Mersin University, Faculty of Medicine, Department of Biophysics, Mersin, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mersin University, Faculty of Medicine, Department of Biophysics, Mersin, Turkey","institution_ids":["https://openalex.org/I51780484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012195666","display_name":"Ebru Ball\u0131","orcid":"https://orcid.org/0000-0002-9950-5548","observed_orcids":["https://orcid.org/0000-0002-9950-5548"]},"institutions":[{"id":"https://openalex.org/I51780484","display_name":"Mersin \u00dcniversitesi","ror":"https://ror.org/04nqdwb39","country_code":"TR","type":"education","lineage":["https://openalex.org/I51780484"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ebru BALLI","raw_affiliation_strings":["Mersin University, Faculty of Medicine, Department of Histology and Embryology, Mersin, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mersin University, Faculty of Medicine, Department of Histology and Embryology, Mersin, Turkey","institution_ids":["https://openalex.org/I51780484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026955178","display_name":"Serap Yal\u0131n","orcid":"https://orcid.org/0000-0002-1286-2172","observed_orcids":["https://orcid.org/0000-0002-1286-2172"]},"institutions":[{"id":"https://openalex.org/I51780484","display_name":"Mersin \u00dcniversitesi","ror":"https://ror.org/04nqdwb39","country_code":"TR","type":"education","lineage":["https://openalex.org/I51780484"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Serap YALIN","raw_affiliation_strings":["Mersin University, Faculty of Pharmacy, Department of Biochemistry, Mersin, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mersin University, Faculty of Pharmacy, Department of Biochemistry, Mersin, Turkey","institution_ids":["https://openalex.org/I51780484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088109462","display_name":"Pelin Ero\u011flu","orcid":"https://orcid.org/0000-0002-6462-6841","observed_orcids":["https://orcid.org/0000-0002-6462-6841"]},"institutions":[{"id":"https://openalex.org/I51780484","display_name":"Mersin \u00dcniversitesi","ror":"https://ror.org/04nqdwb39","country_code":"TR","type":"education","lineage":["https://openalex.org/I51780484"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Pelin ERO\u011eLU","raw_affiliation_strings":["Mersin University, Faculty of Science and Literature, Department of Chemistry, Mersin, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mersin University, Faculty of Science and Literature, Department of Chemistry, Mersin, Turkey","institution_ids":["https://openalex.org/I51780484"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032956786","display_name":"G\u00fcl\u015fen Bayrak","orcid":"https://orcid.org/0000-0002-1397-7203","observed_orcids":["https://orcid.org/0000-0002-1397-7203"]},"institutions":[{"id":"https://openalex.org/I51780484","display_name":"Mersin \u00dcniversitesi","ror":"https://ror.org/04nqdwb39","country_code":"TR","type":"education","lineage":["https://openalex.org/I51780484"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G\u00fclsen BAYRAK","raw_affiliation_strings":["Mersin University, Faculty of Medicine, Department of Histology and Embryology, Mersin, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mersin University, Faculty of Medicine, Department of Histology and Embryology, Mersin, Turkey","institution_ids":["https://openalex.org/I51780484"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045101428"],"corresponding_institution_ids":["https://openalex.org/I51780484"],"apc_list":null,"apc_paid":null,"fwci":0.5934,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.56972133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"23","issue":"3","first_page":"344","last_page":"353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silica-nanoparticles","display_name":"silica nanoparticles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nanoparticle-size","display_name":"nanoparticle size","score":0.8360000252723694},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.5249999761581421},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":1.0},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.902999997138977},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8659999966621399},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":1.0},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.777999997138977},{"id":"https://openalex.org/keywords/nerve-fiber-degeneration","display_name":"nerve fiber degeneration","score":0.75}],"concepts":[{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5839716196060181},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.46249130368232727},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4090474247932434},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3623308539390564},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.27208971977233887},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2550152540206909},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24072563648223877},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.24023091793060303}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.12991/jrp.2019.142","doi":"https://doi.org/10.12991/jrp.2019.142","is_oa":true,"landing_page_url":"https://doi.org/10.12991/jrp.2019.142","pdf_url":"http://jrespharm.com/pdf.php?id=676","source":{"id":"https://openalex.org/S4210224330","display_name":"Journal of Research in Pharmacy","issn_l":"2630-6344","issn":["2630-6344"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Research in Pharmacy","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/1689122","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/en/pub/jrespharm/article/1689122","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.12991/jrp.2019.142","doi":"https://doi.org/10.12991/jrp.2019.142","is_oa":true,"landing_page_url":"https://doi.org/10.12991/jrp.2019.142","pdf_url":"http://jrespharm.com/pdf.php?id=676","source":{"id":"https://openalex.org/S4210224330","display_name":"Journal of Research in Pharmacy","issn_l":"2630-6344","issn":["2630-6344"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Research in Pharmacy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2946938320.pdf","grobid_xml":"https://content.openalex.org/works/W2946938320.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W167281892","https://openalex.org/W1775749144","https://openalex.org/W1950590558","https://openalex.org/W1973681903","https://openalex.org/W1983937216","https://openalex.org/W1985722254","https://openalex.org/W1986505213","https://openalex.org/W1996697333","https://openalex.org/W1997889992","https://openalex.org/W2004010748","https://openalex.org/W2004906357","https://openalex.org/W2011482088","https://openalex.org/W2018392526","https://openalex.org/W2020915539","https://openalex.org/W2034476799","https://openalex.org/W2044708797","https://openalex.org/W2046553143","https://openalex.org/W2062437431","https://openalex.org/W2068303118","https://openalex.org/W2070032426","https://openalex.org/W2070634315","https://openalex.org/W2099412187","https://openalex.org/W2111423624","https://openalex.org/W2131536155","https://openalex.org/W2137260452","https://openalex.org/W2139980848","https://openalex.org/W2143376609","https://openalex.org/W2144546631","https://openalex.org/W2159305277","https://openalex.org/W2169601928","https://openalex.org/W2292175732","https://openalex.org/W2294597441","https://openalex.org/W2316223368","https://openalex.org/W2352361607","https://openalex.org/W2395200037","https://openalex.org/W2609654853","https://openalex.org/W2749570678","https://openalex.org/W2767542665","https://openalex.org/W2789636102","https://openalex.org/W2800406647","https://openalex.org/W2801513163","https://openalex.org/W2803365970","https://openalex.org/W2804901001","https://openalex.org/W2810068188","https://openalex.org/W2811244359","https://openalex.org/W2884063232"],"related_works":["https://openalex.org/W4416642205","https://openalex.org/W3088995862","https://openalex.org/W3128258726","https://openalex.org/W2399604854","https://openalex.org/W4364359281","https://openalex.org/W2789636102","https://openalex.org/W4366087785","https://openalex.org/W2804901001","https://openalex.org/W4212791193","https://openalex.org/W2292175732"],"abstract_inverted_index":{"Silica":[0],"is":[1],"among":[2],"the":[3,12,25,29,35,91,125,137,140,146,153,159,164,173,179,198,205,216,242,264,284],"most":[4],"popular":[5],"nanoparticles.Large-scale":[6],"production":[7],"and":[8,32,79,97,100,107,118,148,166,168,182,188,209,213,218,224,228,245,249,258,273,287],"use":[9],"have":[10],"increased":[11,144,177,214],"risk":[13],"of":[14,34,129,163,172,247],"human":[15],"exposure":[16,269],"to":[17,23,270],"silica":[18],"nanoparticles":[19],"(SiO2NPs).This":[20],"study":[21],"aimed":[22],"investigate":[24],"toxic":[26,281],"effects":[27,282],"on":[28],"kidney,":[30,98],"liver":[31,99,165,199,223,229],"brain":[33,101,187,225],"SiO2NPs.Twenty":[36],"eight":[37],"male":[38],"Wistar":[39],"albino":[40],"rats":[41,94],"were":[42,95,103,122,131,239],"divided":[43],"into":[44],"four":[45],"groups":[46,171,185,212,221,262],"(n=7":[47],"rats)":[48],"as":[49],"control":[50],"(1":[51],"mL/day":[52],"physiological":[53],"saline":[54],"administration":[55],"for":[56,66,76,87,105],"28":[57,67,77,88],"day),":[58,68],"6":[59,147,160,208,254],"nm":[60,70,81,150,161,170,184,211,220,275],"SiO2NP":[61,71,82,261],"(6":[62],"nm,":[63,73,84],"150":[64,74,85],"\u03bcg/mL/day":[65,75,86],"20":[69,167,181,217,256,272],"(20":[72],"day)":[78,89],"50":[80,149,169,183,210,219,259,274],"(50":[83],"groups.After":[90],"last":[92],"administration,":[93],"sacrificed":[96],"samples":[102],"taken":[104],"biochemical":[106],"histological":[108],"investigation.In":[109],"all":[110,236],"groups,":[111,151],"malondialdehyde":[112],"(MDA)":[113],"levels,":[114],"superoxide":[115],"dismutase":[116],"(SOD)":[117],"catalase":[119],"(CAT)":[120],"activities":[121],"measured":[123],"using":[124,133],"spectrophotometric":[126],"methods.Ultrastructural":[127],"changes":[128,238],"tissues":[130,230],"evaluated":[132],"transmission":[134],"electron":[135],"microscopy.In":[136],"kidney":[138,189,227,286],"tissue,":[139],"MDA":[141],"level":[142],"significantly":[143,176],"in":[145,158,178,186,197,204,215,222,235,241,253,263,283],"while":[152],"similar":[154],"increase":[155],"was":[156,195],"observed":[157,196,240],"group":[162],"brain.SOD":[174],"activity":[175,202],"6,":[180,271],"tissues,":[190],"but":[191],"no":[192],"significant":[193],"change":[194],"tissue":[200],"groups.Catalase":[201],"decreased":[203],"kidneys":[206],"at":[207],"tissues.Ultrastructurally,":[226],"had":[231],"normal":[232],"morphological":[233],"features":[234],"groups.Degenerative":[237],"nerve":[243,251],"fibers":[244,252],"axoplasm":[246],"myelinated":[248],"unmyelinated":[250],"nM,":[255],"nM":[257,260],"brain.These":[265],"findings":[266],"showed":[267],"that":[268],"sizes":[276],"SiO2":[277],"NPs":[278],"may":[279],"cause":[280],"liver,":[285],"brain.":[288]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-06-07T00:00:00"}