{"id":"https://openalex.org/W2946933450","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.3045","title":"Circulating bacterial DNA as a tool towards noninvasive biomarkers for colorectal adenocarcinoma and adenoma.","display_name":"Circulating bacterial DNA as a tool towards noninvasive biomarkers for colorectal adenocarcinoma and adenoma.","publication_year":2019,"publication_date":"2019-05-20","ids":{"openalex":"https://openalex.org/W2946933450","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.3045","mag":"2946933450"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2019.37.15_suppl.3045","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.3045","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.3045","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081262769","display_name":"Kefeng Ding","orcid":"https://orcid.org/0000-0002-2380-3717","observed_orcids":["https://orcid.org/0000-0002-2380-3717"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke-Feng Ding","raw_affiliation_strings":["Department of Surgical Oncology, Second Affiliated Hospital, and the Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, Second Affiliated Hospital, and the Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042121394","display_name":"Qian Xiao","orcid":"https://orcid.org/0000-0002-0120-2371","observed_orcids":["https://orcid.org/0000-0002-0120-2371"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Xiao","raw_affiliation_strings":["Department of Surgical Oncology, Second Affiliated Hospital, and the Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, Second Affiliated Hospital, and the Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101479008","display_name":"Xiangxing Kong","orcid":"https://orcid.org/0000-0001-8744-5421","observed_orcids":["https://orcid.org/0000-0001-8744-5421","https://orcid.org/0009-0001-4596-6808"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangxing Kong","raw_affiliation_strings":["Department of Surgical Oncology, Second Affiliated Hospital, and the Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, Second Affiliated Hospital, and the Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109297062","display_name":"Yeting Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yeting Hu","raw_affiliation_strings":["Department of Surgical Oncology, Second Affiliated Hospital, and the Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, Second Affiliated Hospital, and the Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100673138","display_name":"Wei L\u00fc","orcid":"https://orcid.org/0000-0001-6668-8432","observed_orcids":["https://orcid.org/0000-0001-6668-8432"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Lu","raw_affiliation_strings":["Department of Surgical Oncology, Second Affiliated Hospital, and the Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, Second Affiliated Hospital, and the Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100759964","display_name":"Ao Wang","orcid":"https://orcid.org/0009-0005-0310-5216","observed_orcids":["https://orcid.org/0009-0005-0310-5216","https://orcid.org/0009-0008-8905-5978"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ao Wang","raw_affiliation_strings":["Translational Medicine Research Institute, Geneseeq Technology Inc., Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine Research Institute, Geneseeq Technology Inc., Toronto, ON, Canada;","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kaihua Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaihua Liu","raw_affiliation_strings":["Nanjing Geneseeq Technology Inc., Nanjing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing Geneseeq Technology Inc., Nanjing, China;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085880746","display_name":"Hua Bao","orcid":"https://orcid.org/0000-0001-5774-8755","observed_orcids":["https://orcid.org/0000-0001-5774-8755"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Bao","raw_affiliation_strings":["Translational Medicine Research Institute, Geneseeq Technology Inc., Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine Research Institute, Geneseeq Technology Inc., Toronto, ON, Canada;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040527192","display_name":"Ying Yuan","orcid":"https://orcid.org/0000-0002-3922-9553","observed_orcids":["https://orcid.org/0000-0002-3922-9553","https://orcid.org/0000-0003-3163-480X"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Yuan","raw_affiliation_strings":["Department of Medical Oncology, Second Affiliated Hospital, and The Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Second Affiliated Hospital, and The Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434191","display_name":"Jiaqi Chen","orcid":"https://orcid.org/0000-0002-0252-7987","observed_orcids":["https://orcid.org/0000-0002-0252-7987","https://orcid.org/0009-0004-9390-0653"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaqi Chen","raw_affiliation_strings":["Department of Medical Oncology, Second Affiliated Hospital, and the Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Second Affiliated Hospital, and the Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Da Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Da Wang","raw_affiliation_strings":["Department of Surgical Oncology, Second Affiliated Hospital, and the Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, Second Affiliated Hospital, and the Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University College of Medicine, Hangzhou, China;","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410951","display_name":"Xiaonan Wang","orcid":"https://orcid.org/0000-0003-3759-778X","observed_orcids":["https://orcid.org/0000-0003-3759-778X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaonan Wang","raw_affiliation_strings":["Nanjing Geneseeq Technology Inc., Nanjing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing Geneseeq Technology Inc., Nanjing, China;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078555344","display_name":"Xue Zhen Wu","orcid":"https://orcid.org/0000-0002-4557-6236","observed_orcids":["https://orcid.org/0000-0002-4557-6236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xue Wu","raw_affiliation_strings":["Translational Medicine Research Institute, Geneseeq Technology Inc., Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine Research Institute, Geneseeq Technology Inc., Toronto, ON, Canada;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016008666","display_name":"Yang Shao","orcid":"https://orcid.org/0000-0002-8491-3610","observed_orcids":["https://orcid.org/0000-0002-8491-3610"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Shao","raw_affiliation_strings":["Translational Medicine Research Institute, Geneseeq Technology Inc., Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine Research Institute, Geneseeq Technology Inc., Toronto, ON, Canada;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"15_suppl","first_page":"3045","last_page":"3045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.13600000739097595,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-adenocarcinoma","display_name":"colorectal adenocarcinoma","score":0.8960000276565552},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/colorectal-neoplasms","display_name":"colorectal neoplasia","score":0.8190000057220459},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7770000100135803},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.9120000004768372},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.8379999995231628},{"id":"https://openalex.org/keywords/random-forest","display_name":"random forest","score":0.5730000138282776},{"id":"https://openalex.org/keywords/flavobacterium","display_name":"Flavobacterium","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ruminococcus-torques","display_name":"Ruminococcus torques","score":0.9860000014305115},{"id":"https://openalex.org/keywords/metagenomics","display_name":"metagenomics","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7044431567192078},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6694169640541077},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5674240589141846},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5650905966758728},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5422713160514832},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5357024073600769},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.5211656093597412},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.507445752620697},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5066564679145813},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.45882678031921387},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3227490186691284},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3052002489566803},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23062995076179504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21681609749794006},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17079806327819824},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12600454688072205},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1257861852645874},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10121423006057739}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2019.37.15_suppl.3045","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.3045","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.3045","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2945412259","https://openalex.org/W3110220548","https://openalex.org/W3191731681","https://openalex.org/W3112094687","https://openalex.org/W3016523455","https://openalex.org/W4312218828","https://openalex.org/W3164037858","https://openalex.org/W7126151058","https://openalex.org/W7155467428","https://openalex.org/W4414765490"],"abstract_inverted_index":{"3045":[0],"Background:":[1],"The":[2,173],"gut":[3,170],"microbiota":[4,39],"is":[5,257],"closely":[6],"associated":[7],"with":[8,124,163,211,268,293],"the":[9,86,104,130,184,201,225,239,258],"progression":[10],"of":[11,66,198,228,280,314],"colorectal":[12,25,315],"neoplasia.":[13,316],"While":[14],"most":[15,205],"metagenomics":[16],"studies":[17],"utilized":[18],"fecal":[19],"samples,":[20],"circulating":[21,263],"bacteria":[22,264,305],"DNA":[23,40,265],"in":[24,41,85,103,117,139,152,167,200,208,266,277],"adenocarcinoma":[26],"(ADC)":[27],"or":[28],"adenoma":[29],"(ADM)":[30],"patients":[31,267],"remain":[32],"unexplored.":[33],"This":[34,255],"study":[35,256],"aimed":[36],"to":[37,142,236,261],"characterize":[38,262],"plasma":[42,67],"samples":[43,68],"and":[44,51,76,91,94,109,119,126,144,158,169,194,216,238,250,270,287,300],"build":[45],"a":[46,97],"machine-learning":[47],"model":[48,99,178,240,291],"for":[49,121,311],"ADC":[50,71,90,108,125,140,215,249,269,299],"ADM":[52,74,118,209,251,286,301],"early":[53,312],"detection.":[54],"Methods:":[55],"In":[56,129],"this":[57,229],"proof-of-concept":[58],"study,":[59],"we":[60],"performed":[61],"whole":[62],"genome":[63],"sequencing":[64,231],"(~30X)":[65],"from":[69,183,220,252,302],"25":[70],"patients,":[72,75,210],"10":[73],"22":[77],"healthy":[78],"controls":[79],"(HC).":[80],"Significant":[81],"biomarkers":[82,113,306],"were":[83,114,161,218,233],"identified":[84],"discovery":[87,131,185],"cohort":[88,106,186],"(12":[89],"11":[92,110],"HC)":[93],"built":[95],"into":[96],"random-forest":[98],"which":[100],"was":[101],"tested":[102,120],"validation":[105,202],"(13":[107],"HC).":[111],"These":[112],"further":[115,223],"examined":[116],"abundance":[122,138,212,279],"difference":[123,276],"HP.":[127],"Results:":[128],"cohort,":[132],"111":[133],"species":[134,146,154,182,207,283],"had":[135,147],"increased":[136],"relative":[137,149,278],"compared":[141],"HC":[143],"165":[145],"decreased":[148],"abundance.":[150],"Alteration":[151],"several":[153,281],"such":[155],"as":[156],"Flavobacterium":[157],"Ruminococcus":[159],"torques":[160],"consistent":[162],"previously":[164],"published":[165],"results":[166],"faecal":[168],"microbiome":[171],"samples.":[172],"random":[174],"forest-recursive":[175],"feature":[176],"elimination":[177],"selected":[179,294],"28":[180],"significant":[181,275],"(mean":[187],"AUC":[188,197],"=":[189,245],"0.98,":[190],"repeated":[191],"2-fold":[192],"cross-validation)":[193],"yielded":[195],"an":[196],"1":[199],"cohort.":[203],"Interestingly,":[204],"biomarker":[206],"intermediate":[213],"between":[214,284],"HC,":[217],"distinguished":[219,298],"HC.":[221,253,288,303],"To":[222],"test":[224],"clinical":[226],"utility":[227],"model,":[230],"data":[232],"randomly":[234],"down-sampled":[235],"1X":[237],"performance":[241],"remained":[242],"robust":[243],"(AUC":[244],"1)":[246],"at":[247],"distinguishing":[248],"Conclusions:":[254],"first":[259],"effort":[260],"ADM.":[271],"Our":[272],"findings":[273],"revealed":[274],"bacterial":[282],"ADC,":[285],"A":[289],"predictive":[290],"constructed":[292],"microbial":[295],"features":[296],"accurately":[297],"Circulating":[304],"represent":[307],"potential":[308],"non-invasive":[309],"tools":[310],"diagnosis":[313]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2019-06-07T00:00:00"}