{"id":"https://openalex.org/W2946896889","doi":"https://doi.org/10.1186/s13223-019-0344-3","title":"Sublingual immunotherapy tablet for the treatment of house dust mite allergic rhinitis in Canada: an alternative to minimize treatment costs?","display_name":"Sublingual immunotherapy tablet for the treatment of house dust mite allergic rhinitis in Canada: an alternative to minimize treatment costs?","publication_year":2019,"publication_date":"2019-04-27","ids":{"openalex":"https://openalex.org/W2946896889","doi":"https://doi.org/10.1186/s13223-019-0344-3","mag":"2946896889","pmid":"https://pubmed.ncbi.nlm.nih.gov/31061666","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6487002"},"language":"en","primary_location":{"id":"doi:10.1186/s13223-019-0344-3","doi":"https://doi.org/10.1186/s13223-019-0344-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13223-019-0344-3","pdf_url":"https://aacijournal.biomedcentral.com/track/pdf/10.1186/s13223-019-0344-3","source":{"id":"https://openalex.org/S658968","display_name":"Allergy Asthma and Clinical Immunology","issn_l":"1710-1484","issn":["1710-1484","1710-1492"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy, Asthma & Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacijournal.biomedcentral.com/track/pdf/10.1186/s13223-019-0344-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016112377","display_name":"Anne K. Ellis","orcid":"https://orcid.org/0000-0002-0725-2353","observed_orcids":["https://orcid.org/0000-0002-0725-2353"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Anne K. Ellis","raw_affiliation_strings":["1Division of Allergy and Immunology, Department of Medicine, Queen's University, Kingston, ON Canada","Division of Allergy and Immunology, Department of Medicine, Queen's University, Kingston, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Allergy and Immunology, Department of Medicine, Queen's University, Kingston, ON Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Division of Allergy and Immunology, Department of Medicine, Queen's University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110840076","display_name":"R\u00e9mi Gagnon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093650","display_name":"Centre hospitalier universitaire de Qu\u00e9bec","ror":"https://ror.org/006a7pj43","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210093650","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R\u00e9mi Gagnon","raw_affiliation_strings":["2Service d'Allergie et Immunologie, D\u00e9partement de m\u00e9decine, CHU de Qu\u00e9bec, Quebec, Canada","Service d'Allergie et Immunologie, D\u00e9partement de m\u00e9decine, CHU de Qu\u00e9bec, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Service d'Allergie et Immunologie, D\u00e9partement de m\u00e9decine, CHU de Qu\u00e9bec, Quebec, Canada","institution_ids":["https://openalex.org/I4210093650"]},{"raw_affiliation_string":"Service d'Allergie et Immunologie, D\u00e9partement de m\u00e9decine, CHU de Qu\u00e9bec, Quebec, Canada","institution_ids":["https://openalex.org/I4210093650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014000262","display_name":"Eva Hammerby","orcid":"https://orcid.org/0000-0001-9418-264X","observed_orcids":["https://orcid.org/0000-0001-9418-264X"]},"institutions":[{"id":"https://openalex.org/I4210127808","display_name":"ALK-Abell\u00f3 (Denmark)","ror":"https://ror.org/03gyzpb04","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210127808"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Eva Hammerby","raw_affiliation_strings":["3ALK-Abello A/S, H\u00f8rsholm, Denmark","ALK-Abello A/S, H\u00f8rsholm, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-9418-264X","affiliations":[{"raw_affiliation_string":"3ALK-Abello A/S, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210127808"]},{"raw_affiliation_string":"ALK-Abello A/S, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210127808"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103364504","display_name":"Andrea Lau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Lau","raw_affiliation_strings":["PDCI Market Access Inc., Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PDCI Market Access Inc., Ottawa, ON, Canada","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014000262"],"corresponding_institution_ids":["https://openalex.org/I4210127808"],"apc_list":{"value":2145,"currency":"USD","value_usd":2145},"apc_paid":{"value":2145,"currency":"USD","value_usd":2145},"fwci":1.8339,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.82549784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"15","issue":"1","first_page":"27","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sublingual-immunotherapy","display_name":"sublingual immunotherapy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/house-dust-mite-allergy","display_name":"house dust mite allergy","score":0.9490000009536743},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/subcutaneous-immunotherapy","display_name":"subcutaneous immunotherapy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cost-minimization-analysis","display_name":"cost-minimization analysis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/treatment-costs","display_name":"treatment costs","score":0.8040000200271606},{"id":"https://openalex.org/keywords/productivity-loss","display_name":"productivity loss","score":0.6919999718666077},{"id":"https://openalex.org/keywords/ontario","display_name":"Ontario","score":0.6370000243186951},{"id":"https://openalex.org/keywords/quebec","display_name":"Quebec","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2777037608","wikidata":"https://www.wikidata.org/wiki/Q1641412","display_name":"Sublingual immunotherapy","level":4,"score":0.7429096102714539},{"id":"https://openalex.org/C2778166374","wikidata":"https://www.wikidata.org/wiki/Q29938","display_name":"House dust mite","level":4,"score":0.7383812069892883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7084974646568298},{"id":"https://openalex.org/C2779787640","wikidata":"https://www.wikidata.org/wiki/Q1641412","display_name":"Allergen immunotherapy","level":4,"score":0.5323866605758667},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.49873900413513184},{"id":"https://openalex.org/C199215989","wikidata":"https://www.wikidata.org/wiki/Q79239196","display_name":"Slit","level":2,"score":0.47737476229667664},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.2102811336517334},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16408592462539673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13223-019-0344-3","doi":"https://doi.org/10.1186/s13223-019-0344-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13223-019-0344-3","pdf_url":"https://aacijournal.biomedcentral.com/track/pdf/10.1186/s13223-019-0344-3","source":{"id":"https://openalex.org/S658968","display_name":"Allergy Asthma and Clinical Immunology","issn_l":"1710-1484","issn":["1710-1484","1710-1492"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy, Asthma & Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:31061666","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31061666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6487002","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6487002/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy Asthma Clin Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b7b9201ad7674f5f9967a2861288de51","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b7b9201ad7674f5f9967a2861288de51","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Allergy, Asthma & Clinical Immunology, Vol 15, Iss 1, Pp 1-9 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13223-019-0344-3","doi":"https://doi.org/10.1186/s13223-019-0344-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13223-019-0344-3","pdf_url":"https://aacijournal.biomedcentral.com/track/pdf/10.1186/s13223-019-0344-3","source":{"id":"https://openalex.org/S658968","display_name":"Allergy Asthma and Clinical Immunology","issn_l":"1710-1484","issn":["1710-1484","1710-1492"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy, Asthma & Clinical Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2946896889.pdf","grobid_xml":"https://content.openalex.org/works/W2946896889.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1132113666","https://openalex.org/W1548476693","https://openalex.org/W1969524066","https://openalex.org/W1982085915","https://openalex.org/W2005917183","https://openalex.org/W2022429437","https://openalex.org/W2117488028","https://openalex.org/W2140866288","https://openalex.org/W2150203626","https://openalex.org/W2166534739","https://openalex.org/W2167675381","https://openalex.org/W2202332854","https://openalex.org/W2316752415","https://openalex.org/W2476084013","https://openalex.org/W2511719925","https://openalex.org/W2781626918","https://openalex.org/W2916610774","https://openalex.org/W3192241548","https://openalex.org/W4253311735","https://openalex.org/W4253944279"],"related_works":["https://openalex.org/W2289898917","https://openalex.org/W2601816089","https://openalex.org/W2588294353","https://openalex.org/W2540965933","https://openalex.org/W3134483919","https://openalex.org/W2900458765","https://openalex.org/W2509833579","https://openalex.org/W4250717332","https://openalex.org/W4416225095","https://openalex.org/W2427095088"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1,58,80,99,147],"cost-minimization":[2],"analysis":[3],"(CMA)":[4],"was":[5,60,64,83,104,152],"performed":[6,178],"to":[7,77,107,186,234,304],"estimate":[8],"the":[9,14,32,67,70,86,157,170,173,191,194,231,235,240],"economic":[10],"impact":[11,189],"of":[12,34,91,112,150,172,193,246,274,281],"introducing":[13],"SQ":[15,71,206,243,282,297],"house":[16,44],"dust":[17,45],"mite":[18,46],"sublingual":[19],"immunotherapy":[20,48],"(SQ":[21],"HDM":[22,72,78,207,213,244,260,283,286,298,305],"SLIT)-tablet":[23],"marketed":[24],"as":[25],"ACARIZAX\u2122":[26],"(regulatory":[27],"approval":[28],"May":[29],"2017)":[30],"for":[31,160,183,201,212,215,239,248,252],"treatment":[33,55,110,199,204,241],"HDM-induced":[35],"allergic":[36],"rhinitis":[37],"in":[38,85,136,139,142,154,164,279,288,313],"Canada":[39],"(Ontario":[40],"and":[41,63,96,117,126,128,141,162,219,222,226,250,267,272,315],"Quebec),":[42],"where":[43,124,145],"subcutaneous":[47],"(HDM":[49],"SCIT)":[50],"is":[51],"already":[52],"an":[53],"available":[54],"option.":[56],"METHODS:":[57],"CMA":[59,294],"deemed":[61],"appropriate":[62],"based":[65,120],"on":[66,121,190],"assumption":[68],"that":[69,296],"SLIT-tablet":[73],"has":[74],"comparable":[75],"efficacy":[76],"SCIT.":[79],"societal":[81,311],"perspective":[82,312],"adopted":[84],"model,":[87,236],"including":[88],"relevant":[89],"costs":[90,118,200,233],"medications,":[92],"health":[93],"care":[94],"services":[95],"productivity":[97],"loss.":[98],"3":[100],"year":[101],"time":[102],"horizon":[103],"used":[105],"corresponding":[106],"a":[108,131,202,301,310],"recommended":[109],"course":[111],"allergy":[113],"immunotherapy.":[114],"Resource":[115],"use":[116],"were":[119,177,209,254],"published":[122],"sources,":[123],"possible,":[125],"validated":[127],"complemented":[129],"by":[130,179],"Canadian":[132,158],"specialist":[133],"clinician":[134],"(allergist)":[135],"active":[137],"practice":[138],"Ontario":[140,218,249,314],"Quebec,":[143],"respectively,":[144],"applicable.":[146],"discount":[148,264],"rate":[149],"1.5%":[151],"applied":[153],"accordance":[155],"with":[156,205,242,258],"Agency":[159],"Drugs":[161],"Technologies":[163],"Health":[165],"(CADTH)":[166],"guidelines.":[167],"To":[168],"assess":[169],"robustness":[171],"results,":[174],"sensitivity":[175],"analyses":[176,257],"testing":[180],"alternative":[181,303],"assumptions":[182],"selected":[184],"parameters,":[185],"understand":[187],"their":[188],"results":[192],"analysis.":[195],"RESULTS:":[196],"The":[197,293],"direct":[198],"3-year":[203],"SLIT-tablets":[208,245,284,299],"higher":[210],"than":[211],"SCIT":[214,261,287,306],"both":[216],"provinces,":[217],"Quebec":[220,253],"($4732.12":[221],"$4829.03":[223],"vs.":[224],"$3434.51":[225],"$2987.74).":[227],"However,":[228],"when":[229,307],"adding":[230],"indirect":[232],"total":[237],"savings":[238,280],"$1833.00":[247],"$769.03":[251],"observed.":[255],"Sensitivity":[256],"varying":[259],"resource":[262],"use,":[263],"rates,":[265],"titration":[266],"maintenance":[268],"injections,":[269],"nurse":[270],"time,":[271],"number":[273],"injections":[275],"per":[276],"vial":[277],"resulted":[278],"over":[285],"all":[289],"scenarios":[290],"analysed.":[291],"CONCLUSIONS:":[292],"indicates":[295],"are":[300],"cost-minimizing":[302],"considered":[308],"from":[309],"Quebec.":[316]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-06-07T00:00:00"}