{"id":"https://openalex.org/W2946874716","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e20048","title":"Mutational landscape of early-stage non-small cell lung cancer patients using a 451 gene panel.","display_name":"Mutational landscape of early-stage non-small cell lung cancer patients using a 451 gene panel.","publication_year":2019,"publication_date":"2019-05-20","ids":{"openalex":"https://openalex.org/W2946874716","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e20048","mag":"2946874716"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2019.37.15_suppl.e20048","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e20048","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.e20048","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061644593","display_name":"Guanxian Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanxian Mao","raw_affiliation_strings":["Peking University Shenzhen Hospital, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University Shenzhen Hospital, Shenzhen, China;","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057147638","display_name":"Xuxing Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Xuxing","raw_affiliation_strings":["Peking University Shenzhen Hospital, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University Shenzhen Hospital, Shenzhen, China;","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101578944","display_name":"Hao Wu","orcid":"https://orcid.org/0000-0003-1579-2138","observed_orcids":["https://orcid.org/0000-0003-1579-2138"]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wu Hao","raw_affiliation_strings":["Peking University Shenzhen Hospital, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University Shenzhen Hospital, Shenzhen, China;","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wang Junbing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang Junbing","raw_affiliation_strings":["Peking University Shenzhen Hospital, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University Shenzhen Hospital, Shenzhen, China;","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017694119","display_name":"Suyue Liu","orcid":"https://orcid.org/0009-0000-6610-5591","observed_orcids":["https://orcid.org/0009-0000-6610-5591"]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liu Suyue","raw_affiliation_strings":["Peking University Shenzhen Hospital, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University Shenzhen Hospital, Shenzhen, China;","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068836221","display_name":"Qiang Wu","orcid":"https://orcid.org/0000-0003-3841-3591","observed_orcids":["https://orcid.org/0000-0003-3841-3591"]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wu Qiang","raw_affiliation_strings":["Peking University Shenzhen Hospital, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University Shenzhen Hospital, Shenzhen, China;","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108122416","display_name":"Liu Ying","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu Ying","raw_affiliation_strings":["HaploX Biotechnology, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HaploX Biotechnology, Shenzhen, China;","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qiang Ren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiang Ren","raw_affiliation_strings":["HaploX Biotechnology, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HaploX Biotechnology, Shenzhen, China;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102951018","display_name":"Jixian Liu","orcid":"https://orcid.org/0000-0001-6184-6905","observed_orcids":["https://orcid.org/0000-0001-6184-6905"]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jixian Liu","raw_affiliation_strings":["Peking University, Shenzhen Hospital, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University, Shenzhen Hospital, Shenzhen, China;","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051788322","display_name":"Charles E. Melan\u00e7on","orcid":"https://orcid.org/0000-0002-4236-3868","observed_orcids":["https://orcid.org/0000-0002-4236-3868"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles E. Melan\u00e7on","raw_affiliation_strings":["HaploX Biotechnology, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HaploX Biotechnology, Shenzhen, China;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"15_suppl","first_page":"e20048","last_page":"e20048"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.1264999955892563,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9390000104904175},{"id":"https://openalex.org/keywords/early-stage-lung-cancer","display_name":"early-stage lung cancer","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mutational-landscape","display_name":"mutational landscape","score":0.6660000085830688},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tumor-dna","display_name":"tumor DNA","score":0.6100000143051147},{"id":"https://openalex.org/keywords/driver-mutations","display_name":"driver mutations","score":0.906000018119812},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.7110000252723694},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.8920000195503235},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.7300000190734863},{"id":"https://openalex.org/keywords/braf","display_name":"BRAF","score":0.8450000286102295},{"id":"https://openalex.org/keywords/anaplastic-lymphoma-kinase","display_name":"anaplastic lymphoma kinase","score":0.8360000252723694},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.7979999780654907},{"id":"https://openalex.org/keywords/ret","display_name":"RET","score":0.8429999947547913},{"id":"https://openalex.org/keywords/notch3","display_name":"Notch3","score":0.8240000009536743},{"id":"https://openalex.org/keywords/atm","display_name":"ATM","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.8690000176429749},{"id":"https://openalex.org/keywords/kmt2b","display_name":"KMT2B","score":0.9589999914169312},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.5820000171661377},{"id":"https://openalex.org/keywords/mutation-frequency","display_name":"mutation frequency","score":0.36399999260902405}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8657783269882202},{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.8355609178543091},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6448882222175598},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6076108813285828},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5302654504776001},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5149086713790894},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48576095700263977},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48564091324806213},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47924330830574036},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45711541175842285},{"id":"https://openalex.org/C160136775","wikidata":"https://www.wikidata.org/wiki/Q74081","display_name":"Transfer DNA","level":5,"score":0.4375944137573242},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4315766990184784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2136532962322235},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.196946382522583},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.14279219508171082},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.0},{"id":"https://openalex.org/C2776162087","wikidata":"https://www.wikidata.org/wiki/Q131472","display_name":"Agrobacterium tumefaciens","level":4,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2019.37.15_suppl.e20048","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e20048","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.e20048","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4379338190","https://openalex.org/W2549595418","https://openalex.org/W2890804071","https://openalex.org/W3107430277","https://openalex.org/W3014052445","https://openalex.org/W2947025618","https://openalex.org/W3022801864","https://openalex.org/W4221061124","https://openalex.org/W2907122585","https://openalex.org/W3109175465"],"abstract_inverted_index":{"e20048":[0],"Background:":[1],"Many":[2,34],"studies":[3,35],"have":[4,36],"reported":[5,37],"mutation":[6,27,38,59],"landscapes":[7,39],"of":[8,16,29,40,48,61,77,96,121,128,188,207,232,239],"non-small":[9,41],"cell":[10,42],"lung":[11,43],"cancer":[12,44],"(NSCLC),":[13,45],"but":[14,46],"most":[15,47],"the":[17,26,49,58,93,115,118,204,226,229],"data":[18,50],"were":[19,51,73,80,100,114,184,191,211,225],"from":[20,52],"advanced-stage":[21,53],"patients.":[22,32,54,64],"This":[23,55],"study":[24,56],"reports":[25,57],"landscape":[28,60],"early-stage":[30,62],"NSCLC":[31,63],"Methods:":[33],"Results:":[65],"In":[66,177],"all,":[67,178],"74":[68,179],"tDNA":[69,85,99,132,180,196,210,243],"and":[70,86,107,133,139,146,153,160,165,171,181,197,218,244,250,257,264,271,277,284],"ctDNA":[71,182],"samples":[72,183],"analyzed.":[74,185],"A":[75,186],"total":[76,187],"285":[78,189],"mutations":[79,97,122,130,190,208,233,241],"identified,":[81,192],"including":[82,193],"174":[83,194],"in":[84,88,98,123,131,195,199,209,234,242],"111":[87,198],"plasma":[89,200],"ctDNA.":[90,124,201,235],"Genes":[91,202],"with":[92,117,203,228],"highest":[94,119,205,230],"-frequencies":[95,206],"EGFR,":[101,110,143,212,221,254],"TP53,":[102,109,213,220],"KMT2B,":[103,214],"BRAF,":[104,215],"PIK3CA,":[105,112,216,223],"CDKN2A,":[106,217],"KRAS,while":[108,219],"NOTCH3,":[111,222],"andATM":[113,224],"genes":[116,227],"frequencies":[120,231],"The":[125,236],"detection":[126,237],"rate":[127,238],"driver":[129,240],"ctDNA,":[134,245],"respectively,":[135,246],"were:":[136,247],"42.9%":[137,248],"(15/35)":[138,249],"12.8%":[140,251],"(5/39)":[141,252],"for":[142,149,156,162,167,174,253,260,267,274,280,287],"5.7%":[144,151,255,262],"(2/35)":[145,152,164,256,263,276],"2.6%":[147,154,258,265],"(1/39)":[148,155,259,266],"ALK,":[150,261],"ERBB2,":[157,268],"11.4%":[158,269],"(4/35)":[159,270],"0%)0/39)":[161,166],"BRAF,5.7%":[163,275],"RET,":[168,281],"37%":[169,282],"(13/35)":[170,283],"23.1%":[172,285],"(9/39)":[173,286],"TP53.":[175,288],"Conclusions:":[176],"0%":[272,278],")0/39)":[273,279]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2019-06-07T00:00:00"}
