{"id":"https://openalex.org/W2946828042","doi":null,"title":"Prokaryotic expression of the extracellular domain of porcine programmed death 1 (PD-1) and its ligand PD-L1 and identification of the binding with peripheral blood mononuclear cells in vitro.","display_name":"Prokaryotic expression of the extracellular domain of porcine programmed death 1 (PD-1) and its ligand PD-L1 and identification of the binding with peripheral blood mononuclear cells in vitro.","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W2946828042","mag":"2946828042","pmid":"https://pubmed.ncbi.nlm.nih.gov/28408783","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5370541"},"language":"en","primary_location":{"id":"pmid:28408783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28408783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5370541/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013412416","display_name":"Yanping Zhu","orcid":"https://orcid.org/0000-0002-2955-6585","observed_orcids":["https://orcid.org/0000-0002-2955-6585"]},"institutions":[{"id":"https://openalex.org/I4210163247","display_name":"Henan Institute of Science and Technology","ror":"https://ror.org/0578f1k82","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163247"]},{"id":"https://openalex.org/I4210165883","display_name":"Xinxiang University","ror":"https://ror.org/05qvskn85","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165883"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Ping Zhu","raw_affiliation_strings":["Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)","Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)","institution_ids":["https://openalex.org/I4210163247","https://openalex.org/I4210165883"]},{"raw_affiliation_string":"Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang)","institution_ids":["https://openalex.org/I4210165883"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Feng Yue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163247","display_name":"Henan Institute of Science and Technology","ror":"https://ror.org/0578f1k82","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163247"]},{"id":"https://openalex.org/I4210165883","display_name":"Xinxiang University","ror":"https://ror.org/05qvskn85","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165883"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Yue","raw_affiliation_strings":["Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)","College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)","institution_ids":["https://openalex.org/I4210163247","https://openalex.org/I4210165883"]},{"raw_affiliation_string":"College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)","institution_ids":["https://openalex.org/I4210163247"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yong He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163247","display_name":"Henan Institute of Science and Technology","ror":"https://ror.org/0578f1k82","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163247"]},{"id":"https://openalex.org/I4210165883","display_name":"Xinxiang University","ror":"https://ror.org/05qvskn85","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165883"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong He","raw_affiliation_strings":["Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)","institution_ids":["https://openalex.org/I4210163247","https://openalex.org/I4210165883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073589744","display_name":"Peng Li","orcid":"https://orcid.org/0009-0009-4457-3189","observed_orcids":["https://orcid.org/0009-0009-4457-3189"]},"institutions":[{"id":"https://openalex.org/I4210163247","display_name":"Henan Institute of Science and Technology","ror":"https://ror.org/0578f1k82","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163247"]},{"id":"https://openalex.org/I4210165883","display_name":"Xinxiang University","ror":"https://ror.org/05qvskn85","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165883"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Li","raw_affiliation_strings":["Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)","institution_ids":["https://openalex.org/I4210163247","https://openalex.org/I4210165883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102775452","display_name":"Yuan Yang","orcid":"https://orcid.org/0000-0003-2212-4023","observed_orcids":["https://orcid.org/0000-0003-2212-4023"]},"institutions":[{"id":"https://openalex.org/I4210163247","display_name":"Henan Institute of Science and Technology","ror":"https://ror.org/0578f1k82","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163247"]},{"id":"https://openalex.org/I4210165883","display_name":"Xinxiang University","ror":"https://ror.org/05qvskn85","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165883"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Yang","raw_affiliation_strings":["Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)","institution_ids":["https://openalex.org/I4210163247","https://openalex.org/I4210165883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059963751","display_name":"Yuting Han","orcid":"https://orcid.org/0000-0003-4868-3659","observed_orcids":["https://orcid.org/0000-0003-4868-3659"]},"institutions":[{"id":"https://openalex.org/I4210163247","display_name":"Henan Institute of Science and Technology","ror":"https://ror.org/0578f1k82","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163247"]},{"id":"https://openalex.org/I4210165883","display_name":"Xinxiang University","ror":"https://ror.org/05qvskn85","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165883"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Ting Han","raw_affiliation_strings":["Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)","institution_ids":["https://openalex.org/I4210163247","https://openalex.org/I4210165883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100749846","display_name":"Yanfang Zhang","orcid":"https://orcid.org/0000-0001-9309-7347","observed_orcids":["https://orcid.org/0000-0001-9309-7347","https://orcid.org/0000-0003-3610-033X"]},"institutions":[{"id":"https://openalex.org/I4210163247","display_name":"Henan Institute of Science and Technology","ror":"https://ror.org/0578f1k82","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163247"]},{"id":"https://openalex.org/I4210165883","display_name":"Xinxiang University","ror":"https://ror.org/05qvskn85","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165883"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Fang Zhang","raw_affiliation_strings":["Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)","institution_ids":["https://openalex.org/I4210163247","https://openalex.org/I4210165883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031631794","display_name":"Guopeng Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163247","display_name":"Henan Institute of Science and Technology","ror":"https://ror.org/0578f1k82","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163247"]},{"id":"https://openalex.org/I4210165883","display_name":"Xinxiang University","ror":"https://ror.org/05qvskn85","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165883"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guo-Peng Sun","raw_affiliation_strings":["Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)","institution_ids":["https://openalex.org/I4210163247","https://openalex.org/I4210165883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112184290","display_name":"Dongguang Guo","orcid":"https://orcid.org/0000-0003-4553-333X","observed_orcids":["https://orcid.org/0000-0003-4553-333X"]},"institutions":[{"id":"https://openalex.org/I4210163247","display_name":"Henan Institute of Science and Technology","ror":"https://ror.org/0578f1k82","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163247"]},{"id":"https://openalex.org/I4210165883","display_name":"Xinxiang University","ror":"https://ror.org/05qvskn85","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165883"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong-Guang Guo","raw_affiliation_strings":["Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)","institution_ids":["https://openalex.org/I4210163247","https://openalex.org/I4210165883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102204721","display_name":"Mei Yin","orcid":"https://orcid.org/0009-0006-3175-2469","observed_orcids":["https://orcid.org/0009-0006-3175-2469"]},"institutions":[{"id":"https://openalex.org/I4210163247","display_name":"Henan Institute of Science and Technology","ror":"https://ror.org/0578f1k82","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163247"]},{"id":"https://openalex.org/I4210165883","display_name":"Xinxiang University","ror":"https://ror.org/05qvskn85","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165883"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei Yin","raw_affiliation_strings":["Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)","institution_ids":["https://openalex.org/I4210163247","https://openalex.org/I4210165883"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004530231","display_name":"Xuannian Wang","orcid":"https://orcid.org/0009-0009-6948-2494","observed_orcids":["https://orcid.org/0009-0009-6948-2494"]},"institutions":[{"id":"https://openalex.org/I4210163247","display_name":"Henan Institute of Science and Technology","ror":"https://ror.org/0578f1k82","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163247"]},{"id":"https://openalex.org/I4210165883","display_name":"Xinxiang University","ror":"https://ror.org/05qvskn85","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165883"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan-Nian Wang","raw_affiliation_strings":["Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Center, School of Life Science and Technology, Xinxiang University, Xinxiang, Henan Province 453003, China (Zhu, Yue, He, Li, Yang, Han, Zhang, Sun, Guo, Wang); College of Veterinary and Animal Sciences, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China (Yang, Han, Yin, Wang)","institution_ids":["https://openalex.org/I4210163247","https://openalex.org/I4210165883"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2618,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57016989,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"81","issue":"2","first_page":"147","last_page":"154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.07190000265836716,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.8180000185966492},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pdcd1","display_name":"PDCD1","score":0.7310000061988831},{"id":"https://openalex.org/keywords/extracellular-domain","display_name":"extracellular domain","score":0.8140000104904175},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.8069999814033508},{"id":"https://openalex.org/keywords/soluble-pd-l1","display_name":"soluble PD-L1","score":0.6779999732971191},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pd-1-pd-l1-interaction","display_name":"PD-1/PD-L1 interaction","score":0.7620000243186951},{"id":"https://openalex.org/keywords/monoclonal-antibody-production","display_name":"monoclonal antibody production","score":0.7910000085830688},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.716310441493988},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.7106592655181885},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6815050840377808},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.6323322653770447},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5405946969985962},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5149694085121155},{"id":"https://openalex.org/C2777019933","wikidata":"https://www.wikidata.org/wiki/Q853845","display_name":"Fluorescein isothiocyanate","level":3,"score":0.49496692419052124},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.49222055077552795},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.49024468660354614},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.48985859751701355},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4429122805595398},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3809084892272949},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.28017687797546387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23477566242218018},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17311707139015198},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1049480140209198},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:28408783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28408783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5370541","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5370541/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Can J Vet Res","raw_type":"Text"},{"id":"mag:2946828042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28408783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5370541","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5370541/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Can J Vet Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1489480103","https://openalex.org/W1513178664","https://openalex.org/W1532380457","https://openalex.org/W1538902372","https://openalex.org/W1979571824","https://openalex.org/W1988474688","https://openalex.org/W1997152543","https://openalex.org/W1997910013","https://openalex.org/W2001287101","https://openalex.org/W2006365597","https://openalex.org/W2007771300","https://openalex.org/W2012070966","https://openalex.org/W2018478752","https://openalex.org/W2024662922","https://openalex.org/W2039765462","https://openalex.org/W2047475159","https://openalex.org/W2047502920","https://openalex.org/W2053677639","https://openalex.org/W2058798829","https://openalex.org/W2060473031","https://openalex.org/W2065386296","https://openalex.org/W2070631889","https://openalex.org/W2083025888","https://openalex.org/W2097855813","https://openalex.org/W2101990345","https://openalex.org/W2103532863","https://openalex.org/W2107752337","https://openalex.org/W2118098918","https://openalex.org/W2118471749","https://openalex.org/W2121498145","https://openalex.org/W2130030995","https://openalex.org/W2131633419","https://openalex.org/W2140369740","https://openalex.org/W2144547008","https://openalex.org/W2145871366","https://openalex.org/W2148022182","https://openalex.org/W2149121521","https://openalex.org/W2150640296","https://openalex.org/W2151469501","https://openalex.org/W2155464214","https://openalex.org/W2164456051","https://openalex.org/W2170715627"],"related_works":["https://openalex.org/W3142868295","https://openalex.org/W4400002629","https://openalex.org/W2410345148","https://openalex.org/W1469501108","https://openalex.org/W2360380664","https://openalex.org/W4386723855","https://openalex.org/W2360587303","https://openalex.org/W3088671915","https://openalex.org/W2995602860","https://openalex.org/W3038336355"],"abstract_inverted_index":{"PD-L1-FITC":[0],"were":[1],"greater":[2],"than":[3],"those":[4],"for":[5],"the":[6,13,26],"FITC":[7],"control.":[8],"These":[9],"results":[10],"suggest":[11],"that":[12],"soluble":[14],"recombinant":[15],"proteins":[16],"may":[17],"be":[18],"used":[19],"to":[20,24],"prepare":[21],"monoclonal":[22],"antibodies":[23],"block":[25],"PD-1/PD-L1":[27],"pathway.":[28]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2019-05-29T00:00:00"}