{"id":"https://openalex.org/W2946801038","doi":null,"title":"Understanding the Mechanism of Action of Copper-Tolfenamic Acid\u2019s Anti-cancer Activity in Pancreatic Cancer Cells","display_name":"Understanding the Mechanism of Action of Copper-Tolfenamic Acid\u2019s Anti-cancer Activity in Pancreatic Cancer Cells","publication_year":2019,"publication_date":"2019-03-05","ids":{"openalex":"https://openalex.org/W2946801038","mag":"2946801038"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.hsc.unt.edu:rad-2489","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.hsc.unt.edu/rad/RAD19/Cancer/13","pdf_url":null,"source":{"id":"https://openalex.org/S4406922508","display_name":"Digital Commons @ UNT Health Science Center","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Appreciation Day","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008012235","display_name":"Blair Levesque","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Levesque, Blair","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078516421","display_name":"L\u00e1szl\u00f3 Pr\u00f3kai","orcid":"https://orcid.org/0000-0002-4559-3458","observed_orcids":["https://orcid.org/0000-0002-4559-3458"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prokai, Laszlo, PhD","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Umesh, Sankpal T","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Umesh, Sankpal T","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007695569","display_name":"Riyaz M. Basha","orcid":"https://orcid.org/0000-0002-4071-0993","observed_orcids":["https://orcid.org/0000-0002-4071-0993","https://orcid.org/0000-0002-6955-5448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Basha, Riyaz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5026504263","display_name":"Myrna Hurtado","orcid":"https://orcid.org/0000-0003-0704-8384","observed_orcids":["https://orcid.org/0000-0003-0704-8384"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hurtado, Myrna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05785628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.18860000371932983,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tolfenamic-acid","display_name":"tolfenamic acid","score":0.9010000228881836},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.6859999895095825},{"id":"https://openalex.org/keywords/copper-complexes","display_name":"copper complexes","score":0.6240000128746033},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.5950000286102295},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.7870000004768372},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6909999847412109},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8579999804496765},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.7910000085830688},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.718999981880188},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9440000057220459},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5690000057220459},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.44999998807907104},{"id":"https://openalex.org/keywords/cenpf","display_name":"CENPF","score":0.7639999985694885},{"id":"https://openalex.org/keywords/skp2","display_name":"Skp2","score":0.9200000166893005},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6570761203765869},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.5916241407394409},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5768353343009949},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5212112665176392},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5073594450950623},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4437607228755951},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.4354328215122223},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4125867784023285},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35571807622909546},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3075241446495056},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3021851181983948},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17610260844230652},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16462764143943787},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.07039174437522888},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:digitalcommons.hsc.unt.edu:rad-2489","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.hsc.unt.edu/rad/RAD19/Cancer/13","pdf_url":null,"source":{"id":"https://openalex.org/S4406922508","display_name":"Digital Commons @ UNT Health Science Center","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Appreciation Day","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2986591745","https://openalex.org/W2954902550","https://openalex.org/W2886423465","https://openalex.org/W2991365718","https://openalex.org/W2574076446","https://openalex.org/W2807602776","https://openalex.org/W4409690527","https://openalex.org/W2741093502","https://openalex.org/W2805000505","https://openalex.org/W2605653536"],"abstract_inverted_index":{"Purpose:":[0],"\\nNon-steroidal":[1],"anti-inflammatory":[2],"(NSAID)":[3],"agents":[4,22],"have":[5,9],"been":[6,68],"proven":[7],"to":[8,23,35,52,122,130,166,195,209,234],"anti-cancer":[10,38,54,74,138,370],"activity.":[11],"Our":[12],"group":[13],"is":[14,50,82,129,306,355],"investigating":[15],"the":[16,31,46,90,93,107,132,168,172,199,213,216,219,235,273,363],"use":[17,24],"of":[18,33,87,96,126,171,218,237,269,287,365],"NSAIDs":[19,55,88],"as":[20,333,367],"sensitizing":[21],"alongside":[25],"standard":[26],"chemotherapy.":[27],"This":[28,361],"combination":[29],"increases":[30],"efficacy":[32],"chemotherapy":[34],"accomplish":[36],"higher":[37],"activity":[39,75,95,139],"at":[40,308],"relatively":[41],"low":[42,57],"doses,":[43],"thereby":[44],"reducing":[45],"side":[47],"effects.":[48],"It":[49,282],"desirable":[51],"find":[53],"with":[56,148,345,359],"Inhibitory":[58],"concentration":[59],"(IC50)":[60],"values.":[61],"The":[62,124,176,336],"NSAID,":[63],"tolfenamic":[64],"acid":[65,98],"(TA),":[66],"has":[67],"tested":[69],"in":[70,140,215,222,239],"preclinical":[71],"studies":[72,227],"for":[73,249],"against":[76],"pancreatic":[77],"cancer":[78,102],"(PaCa).":[79],"Recently,":[80],"it":[81],"shown":[83],"that":[84,106,304,340,353],"metal":[85],"complexes":[86],"enhances":[89],"efficacy.\\nMethods:\\nWe":[91],"investigated":[92],"anti-proliferative":[94],"copper-tolfenamic":[97],"(Cu-TA)":[99],"using":[100,230],"12":[101],"cells":[103,145],"and":[104,115,154,188,190,203,211,264,267,298,314,321,338],"reported":[105],"Cu-TA":[108,136,151,200,305,346,354,366],"complex":[109],"had":[110],"a":[111,244,309],"stronger":[112],"therapeutic":[113],"response":[114],"lower":[116,310],"IC50":[117],"values":[118],"by":[119,134,156,182,198,278,285,324,343],"30-80%":[120],"compared":[121],"TA.":[123],"goal":[125],"this":[127,240,327],"investigation":[128],"determine":[131,167],"mechanism":[133],"which":[135],"induces":[137],"PaCa":[141,223],"cell":[142,246,348],"lines.":[143],"MIAPaCa2":[144,231,334],"were":[146,180,193,207,228,272,341],"treated":[147],"vehicle":[149],"or":[150,350],"(IC50":[152],"value)":[153],"processed":[155],"Next":[157],"Generation":[158],"Sequencing":[159],"(NGS).":[160],"Ingenuity":[161,315],"Pathway":[162,316],"Analysis":[163],"was":[164,283],"used":[165,208,243],"functional":[169],"significance":[170],"altered":[173,342],"gene":[174],"expression.":[175],"top":[177,274],"upstream":[178,275],"regulators":[179,276],"confirmed":[181,277],"Western":[183,204,279],"blot":[184,205,280],"analysis.\\nResults:\\nSeveral":[185],"networks,":[186],"regulators,":[187],"molecular":[189],"cellular":[191],"functions":[192],"found":[194],"be":[196],"affected":[197],"treatment.":[201],"qPCR":[202,286],"analysis":[206,317],"assess":[210],"confirm":[212],"alterations":[214],"expression":[217],"candidate":[220],"markers":[221],"cells.":[224,232,335],"Previously,":[225],"confirmatory":[226],"performed":[229],"Due":[233],"heterogeneity":[236],"PaCa,":[238],"study":[241],"we":[242],"second":[245],"line":[247],"PANC1":[248,329],"similar":[250,331],"experiments.":[251],"Tumor":[252],"protein":[253,262,291,302],"p53,":[254],"human":[255],"epidermal":[256],"receptor":[257],"growth":[258],"factor":[259],"2,":[260],"Specificity":[261],"1":[263],"signal":[265],"transducer":[266],"activator":[268],"transcription":[270],"3":[271,297],"analysis.":[281],"demonstrated":[284],"selected":[288],"genes,":[289],"Centromere":[290],"F,":[292],"DNA":[293],"damage":[294],"inducible":[295],"transcript":[296],"S-phase":[299],"kinase":[300],"associated":[301,358],"2":[303],"efficacious":[307],"dose":[311],"than":[312],"TA.\\nConclusion:\\nNGS":[313],"identified":[318],"important":[319],"pathways":[320,339],"genes":[322,337,357],"effected":[323],"Cu-TA.":[325],"In":[326],"investigation,":[328],"showed":[330],"results":[332],"treatment":[344],"involved":[347],"survival":[349],"apoptosis":[351],"demonstrating":[352],"modulating":[356],"cancer.":[360],"identifies":[362],"potential":[364],"an":[368],"effective":[369],"agent.":[371]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}
