{"id":"https://openalex.org/W2946720197","doi":"https://doi.org/10.11607/jomi.19suppl.g3","title":"The Effects of Systemic Diseases and Medications on Implant Osseointegration: A Systematic Review","display_name":"The Effects of Systemic Diseases and Medications on Implant Osseointegration: A Systematic Review","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2946720197","doi":"https://doi.org/10.11607/jomi.19suppl.g3","mag":"2946720197","pmid":"https://pubmed.ncbi.nlm.nih.gov/31116832"},"language":"en","primary_location":{"id":"doi:10.11607/jomi.19suppl.g3","doi":"https://doi.org/10.11607/jomi.19suppl.g3","is_oa":false,"landing_page_url":"https://doi.org/10.11607/jomi.19suppl.g3","pdf_url":null,"source":{"id":"https://openalex.org/S27890766","display_name":"The International Journal of Oral & Maxillofacial Implants","issn_l":"0882-2786","issn":["0882-2786","1086-6019","1942-4434"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4322696581","host_organization_name":"Quintessence Publishing Company","host_organization_lineage":["https://openalex.org/P4322696581"],"host_organization_lineage_names":["Quintessence Publishing Company"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Oral & Maxillofacial Implants","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003961812","display_name":"Tara L Aghaloo","orcid":"https://orcid.org/0000-0002-2079-5870","observed_orcids":["https://orcid.org/0000-0002-2079-5870"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tara Aghaloo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073198678","display_name":"Joan Pi\u2010Anfruns","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joan Pi-Anfruns","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014438006","display_name":"Alireza Moshaverinia","orcid":"https://orcid.org/0000-0002-1542-6202","observed_orcids":["https://orcid.org/0000-0002-1542-6202"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alireza Moshaverinia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Danielle Sim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danielle Sim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083311052","display_name":"Tristan Grogan","orcid":"https://orcid.org/0000-0001-9471-2938","observed_orcids":["https://orcid.org/0000-0001-9471-2938"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tristan Grogan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036237946","display_name":"Danny Hadaya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danny Hadaya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":17.2911,"has_fulltext":false,"cited_by_count":163,"citation_normalized_percentile":{"value":0.99586057,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"34","issue":null,"first_page":"s35","last_page":"s49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dental-implant-osseointegration","display_name":"dental implant osseointegration","score":0.921999990940094},{"id":"https://openalex.org/keywords/systemic-disease","display_name":"systemic disease","score":0.8820000290870667},{"id":"https://openalex.org/keywords/medication","display_name":"medication","score":0.5},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9409999847412109},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteonecrosis-of-the-jaw","display_name":"osteonecrosis of the jaw","score":0.9350000023841858},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9169999957084656},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":1.0},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.9670000076293945},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.703000009059906},{"id":"https://openalex.org/keywords/bone-complications","display_name":"bone complications","score":0.5379999876022339},{"id":"https://openalex.org/keywords/soft-tissue-complications","display_name":"soft tissue complications","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C101414908","wikidata":"https://www.wikidata.org/wiki/Q1541818","display_name":"Osseointegration","level":3,"score":0.910725474357605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8257249593734741},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6881340742111206},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5980252027511597},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46584638953208923},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.45228099822998047},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.4022579789161682},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.3964323103427887},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3596841096878052},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2732369899749756},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.20819321274757385},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06201496720314026}],"mesh":[{"descriptor_ui":"D000075202","descriptor_name":"Contraindications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003758","descriptor_name":"Dental Implantation, Endosseous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009140","descriptor_name":"Musculoskeletal Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015921","descriptor_name":"Dental Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016348","descriptor_name":"Osseointegration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016348","descriptor_name":"Osseointegration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019965","descriptor_name":"Neurocognitive Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D055553","descriptor_name":"Prescription Drugs","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.11607/jomi.19suppl.g3","doi":"https://doi.org/10.11607/jomi.19suppl.g3","is_oa":false,"landing_page_url":"https://doi.org/10.11607/jomi.19suppl.g3","pdf_url":null,"source":{"id":"https://openalex.org/S27890766","display_name":"The International Journal of Oral & Maxillofacial Implants","issn_l":"0882-2786","issn":["0882-2786","1086-6019","1942-4434"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4322696581","host_organization_name":"Quintessence Publishing Company","host_organization_lineage":["https://openalex.org/P4322696581"],"host_organization_lineage_names":["Quintessence Publishing Company"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Oral & Maxillofacial Implants","raw_type":"journal-article"},{"id":"pmid:31116832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31116832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of oral & maxillofacial implants","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310592","display_name":"Academy of Osseointegration","ror":"https://ror.org/0592g7p42"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4379519057","https://openalex.org/W7217131398","https://openalex.org/W4383823285","https://openalex.org/W7204084918","https://openalex.org/W1996320866","https://openalex.org/W4312732459","https://openalex.org/W7006320529","https://openalex.org/W2515664248","https://openalex.org/W1257017763","https://openalex.org/W4282940422"],"abstract_inverted_index":{"Since":[0],"their":[1],"development,":[2],"dental":[3],"implants":[4,25],"have":[5,61,154,219,239],"become":[6,26],"one":[7],"of":[8,69,78,96,148,191,223],"the":[9,30,76,94,128,146,187,192],"most":[10,139],"common":[11],"procedures":[12],"to":[13,42,74,92,171,186],"rehabilitate":[14],"patients":[15,184,197,208],"with":[16,58,198,209,255],"single":[17],"missing":[18],"teeth":[19],"or":[20,216,236],"fully":[21],"edentulous":[22],"jaws.":[23],"As":[24],"more":[27],"mainstream,":[28],"determining":[29],"factors":[31,40],"that":[32,56,133,207,231],"affect":[33,44],"osseointegration":[34,45,175,268],"is":[35,202],"extremely":[36],"important.":[37],"Medical":[38],"risk":[39,188],"identified":[41],"negatively":[43,135],"include":[46],"diabetes":[47,82,134],"and":[48,54,83,112,125,145,159,167,251,263,269,275],"osteoporosis.":[49],"However,":[50,177,226],"other":[51,97,264],"systemic":[52,79],"conditions":[53],"medications":[55,232],"interfere":[57],"wound":[59],"healing":[60],"not":[62,131],"been":[63],"as":[64,100,115,234],"widely":[65],"investigated.":[66],"The":[67,88],"aim":[68,89],"this":[70],"systematic":[71],"review":[72],"was":[73,90],"evaluate":[75,93],"effect":[77,95,242],"disorders":[80],"including":[81],"osteoporosis":[84],"on":[85,142,243],"implant":[86,137,224,244,267],"osseointegration.":[87,225,245],"also":[91,169,203],"diseases,":[98,102],"such":[99,114,233],"neurocognitive":[101],"cardiovascular":[103,211],"disease,":[104,212],"human":[105],"immunodeficiency":[106],"virus":[107],"(HIV),":[108],"hypothyroidism,":[109,215],"rheumatoid":[110,217],"arthritis,":[111],"medications,":[113,262],"selective":[116],"serotonin":[117],"reuptake":[118],"inhibitors":[119,123],"(SSRIs),":[120],"proton":[121],"pump":[122],"(PPIs),":[124],"antihypertensives.":[126],"Although":[127],"literature":[129],"does":[130],"demonstrate":[132,172],"affects":[136],"osseointegration,":[138],"studies":[140,153,166,247],"focus":[141],"well-controlled":[143],"diabetics":[144],"use":[147],"prophylactic":[149],"antibiotics.":[150],"In":[151],"addition,":[152],"shown":[155],"increased":[156],"long-term":[157],"bone":[158,199],"soft":[160],"tissue":[161],"complications.":[162],"For":[163],"osteoporosis,":[164],"recent":[165,250],"reviews":[168],"fail":[170],"a":[173,220,240],"lower":[174],"rate.":[176],"caution":[178],"must":[179,252,270],"be":[180,253],"exercised":[181],"in":[182,196],"these":[183],"due":[185],"for":[189],"osteonecrosis":[190],"jaws":[193],"(ONJ),":[194],"especially":[195],"malignancies.":[200],"There":[201],"no":[204],"direct":[205],"evidence":[206,229],"HIV,":[210],"neurologic":[213],"disorders,":[214],"arthritis":[218],"decreased":[221],"rate":[222],"some":[227],"preliminary":[228],"suggests":[230],"SSRIs":[235],"PPIs":[237],"may":[238],"negative":[241],"These":[246],"are":[248],"fairly":[249],"validated":[254],"continuous":[256],"research.":[257],"Moreover,":[258],"disease":[259],"control,":[260],"concomitant":[261],"comorbidities":[265],"complicate":[266],"guide":[271],"our":[272],"treatment":[273],"approaches":[274],"clinical":[276],"guidelines.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":36},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-05-29T00:00:00"}