{"id":"https://openalex.org/W2946693354","doi":"https://doi.org/10.1097/wad.0000000000000305","title":"Olfactory Impairment and Hippocampal Volume in a Chinese MCI Clinical Sample","display_name":"Olfactory Impairment and Hippocampal Volume in a Chinese MCI Clinical Sample","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2946693354","doi":"https://doi.org/10.1097/wad.0000000000000305","mag":"2946693354","pmid":"https://pubmed.ncbi.nlm.nih.gov/31094709"},"language":"en","primary_location":{"id":"doi:10.1097/wad.0000000000000305","doi":"https://doi.org/10.1097/wad.0000000000000305","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wad.0000000000000305","pdf_url":null,"source":{"id":"https://openalex.org/S107889856","display_name":"Alzheimer Disease & Associated Disorders","issn_l":"0893-0341","issn":["0893-0341","1546-4156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer Disease &amp; Associated Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100610660","display_name":"Hongli Yu","orcid":"https://orcid.org/0000-0003-4848-4756","observed_orcids":["https://orcid.org/0000-0003-4848-4756"]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-li Yu","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031809265","display_name":"Zhi-juan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-juan Chen","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083969121","display_name":"Jiwei Zhao","orcid":"https://orcid.org/0000-0002-9298-9412","observed_orcids":["https://orcid.org/0000-0002-9298-9412"]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-wei Zhao","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084343636","display_name":"Shurong Duan","orcid":"https://orcid.org/0000-0002-1574-6847","observed_orcids":["https://orcid.org/0000-0002-1574-6847"]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu-rong Duan","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084320586","display_name":"Jingkun Zhao","orcid":"https://orcid.org/0000-0003-4096-3373","observed_orcids":["https://orcid.org/0000-0003-4096-3373"]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-kun Zhao","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I4210156501"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210156501"],"apc_list":null,"apc_paid":null,"fwci":0.9952,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.69585366,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"33","issue":"2","first_page":"124","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.07620000094175339,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9210000038146973},{"id":"https://openalex.org/keywords/olfactory-dysfunction","display_name":"olfactory dysfunction","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hippocampal-volume","display_name":"hippocampal volume","score":0.9990000128746033},{"id":"https://openalex.org/keywords/upsit","display_name":"UPSIT","score":0.7080000042915344},{"id":"https://openalex.org/keywords/hippocampal-subfields","display_name":"hippocampal subfields","score":0.609000027179718},{"id":"https://openalex.org/keywords/brain-atrophy","display_name":"brain atrophy","score":0.6019999980926514},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.5870000123977661},{"id":"https://openalex.org/keywords/alzheimer-s-disease-risk","display_name":"Alzheimer's disease risk","score":0.6290000081062317},{"id":"https://openalex.org/keywords/neuroimaging-biomarkers","display_name":"neuroimaging biomarkers","score":0.6079999804496765},{"id":"https://openalex.org/keywords/sex-differences-in-olfaction","display_name":"sex differences in olfaction","score":0.47600001096725464},{"id":"https://openalex.org/keywords/anosmia","display_name":"anosmia","score":0.31299999356269836},{"id":"https://openalex.org/keywords/hyposmia","display_name":"hyposmia","score":0.6740000247955322},{"id":"https://openalex.org/keywords/hyperosmia","display_name":"hyperosmia","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.8673369288444519},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6488471031188965},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5750923752784729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5304305553436279},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4800502061843872},{"id":"https://openalex.org/C201792869","wikidata":"https://www.wikidata.org/wiki/Q1054094","display_name":"Olfactory system","level":2,"score":0.43718957901000977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40082791447639465},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3235633373260498},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.17706671357154846},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0994059145450592}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000857","descriptor_name":"Olfaction Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012903","descriptor_name":"Smell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/wad.0000000000000305","doi":"https://doi.org/10.1097/wad.0000000000000305","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wad.0000000000000305","pdf_url":null,"source":{"id":"https://openalex.org/S107889856","display_name":"Alzheimer Disease & Associated Disorders","issn_l":"0893-0341","issn":["0893-0341","1546-4156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer Disease &amp; Associated Disorders","raw_type":"journal-article"},{"id":"pmid:31094709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31094709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer disease and associated disorders","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1512500939","https://openalex.org/W1963487177","https://openalex.org/W1967449362","https://openalex.org/W1970198304","https://openalex.org/W1990300073","https://openalex.org/W1994790739","https://openalex.org/W2023253889","https://openalex.org/W2036663662","https://openalex.org/W2038003677","https://openalex.org/W2049771698","https://openalex.org/W2059483016","https://openalex.org/W2065056564","https://openalex.org/W2085329193","https://openalex.org/W2088269376","https://openalex.org/W2100223163","https://openalex.org/W2107218654","https://openalex.org/W2114811717","https://openalex.org/W2119016770","https://openalex.org/W2125879914","https://openalex.org/W2133703021","https://openalex.org/W2141073802","https://openalex.org/W2157110881","https://openalex.org/W2164876002","https://openalex.org/W2167840686","https://openalex.org/W2174497040","https://openalex.org/W2511297184","https://openalex.org/W2521766691"],"related_works":["https://openalex.org/W2409448311","https://openalex.org/W7163037152","https://openalex.org/W2142146020","https://openalex.org/W3205884569","https://openalex.org/W3154254886","https://openalex.org/W2163923034","https://openalex.org/W601049529","https://openalex.org/W3096003683","https://openalex.org/W2999528626","https://openalex.org/W3190844506"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,46,65,83,205],"aim":[2],"of":[3,29,67,80,85,135],"this":[4],"study":[5],"was":[6,73,191,208],"to":[7,60,75],"evaluate":[8,76],"the":[9,62,77,136,183],"relationship":[10],"between":[11,193],"olfactory":[12,78,130,176,197,203],"function":[13,79,177,238],"and":[14,33,56,91,113,152,187,199,229],"hippocampal":[15,63,89,92,119,139,146,153,156,164,184,188,214,219,224,231,242],"volume":[16,90,94,186,190,215,220,226,233,243],"in":[17,182],"patients":[18,32,104,128,195,245],"with":[19,88,122,129,172,174,196,201,212,241,246],"mild":[20],"cognitive":[21],"impairment":[22],"(MCI).":[23],"METHODS:":[24],"We":[25],"enrolled":[26],"a":[27],"total":[28],"31":[30],"MCI":[31,81,103,194],"9":[34],"normal":[35,123,175,202],"control":[36],"subjects.":[37],"All":[38],"participants":[39],"underwent":[40],"3.0":[41],"T-magnetic":[42],"resonance":[43],"imaging":[44],"scanning.":[45],"scan":[47],"results":[48],"were":[49,95],"processed":[50],"using":[51],"GE":[52],"ADW4.6":[53],"processing":[54],"software":[55],"V0xar":[57],"3D":[58],"workstation":[59],"acquire":[61],"volume.":[64],"University":[66],"Pennsylvania":[68],"Smell":[69],"Identification":[70],"Test":[71],"(UPSIT)":[72],"used":[74],"patients.":[82],"correlations":[84],"UPSIT":[86,206],"score":[87,207],"head":[93,154,157,165,225,232],"evaluated":[96],"by":[97],"Pearson":[98],"correlation":[99],"coefficient":[100],"analysis.":[101],"RESULTS:":[102],"had":[105,132],"significantly":[106,209],"smaller":[107,133],"left":[108,213,223],"(2.78\u00b10.50":[109],"vs.":[110,116,142,149,160,168],"3.19\u00b10.31":[111],"cm(3))":[112,118,151,170],"right":[114,145,163,218,230],"(2.97\u00b10.42":[115],"3.31\u00b10.25":[117],"volumes":[120,134],"compared":[121,171],"controls":[124],"(P<0.05).":[125,178],"In":[126],"addition,":[127],"dysfunction":[131],"hippocampus":[137],"(left":[138,155],"volume,":[140,147,158,166],"2.57\u00b10.39":[141],"3.23\u00b10.40":[143],"cm(3);":[144,162],"2.86\u00b10.43":[148],"3.22\u00b10.30":[150],"1.18\u00b10.16":[159],"1.53\u00b10.25":[161],"1.25\u00b10.22":[167],"1.54\u00b10.22":[169],"those":[173,200],"No":[179],"significant":[180],"difference":[181],"body":[185],"tail":[189],"found":[192],"loss":[198],"function.":[204],"positively":[210],"correlated":[211],"(r=0.55,":[216],"P<0.05),":[217,222,228],"(r=0.42,":[221],"(r=0.53,":[227],"(r=0.45,":[234],"P<0.05).":[235],"CONCLUSIONS:":[236],"Olfactory":[237],"correlates":[239],"well":[240],"among":[244],"MCI.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-05-29T00:00:00"}