{"id":"https://openalex.org/W2946639830","doi":"https://doi.org/10.1055/s-0039-1680344","title":"Enhancement of Platelet Activity by Inhibition of Adenylate Cyclase","display_name":"Enhancement of Platelet Activity by Inhibition of Adenylate Cyclase","publication_year":1977,"publication_date":"1977-01-01","ids":{"openalex":"https://openalex.org/W2946639830","doi":"https://doi.org/10.1055/s-0039-1680344","mag":"2946639830"},"language":"en","primary_location":{"id":"doi:10.1055/s-0039-1680344","doi":"https://doi.org/10.1055/s-0039-1680344","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0039-1680344","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1680344.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1680344.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114250240","display_name":"Edwin W. Salzman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"E. W. Salzman","raw_affiliation_strings":["Beth Israel Hospital, Harvard Medical School, Boston, Mass","Institute of Animal Physiology, Babraham","University Dept. of Pathology, Cambridge, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Hospital, Harvard Medical School, Boston, Mass","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Institute of Animal Physiology, Babraham","institution_ids":[]},{"raw_affiliation_string":"University Dept. of Pathology, Cambridge, England","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111202427","display_name":"D. Euan MacIntyre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"D. E. Macintyre","raw_affiliation_strings":["Beth Israel Hospital, Harvard Medical School, Boston, Mass","Institute of Animal Physiology, Babraham","University Dept. of Pathology, Cambridge, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Hospital, Harvard Medical School, Boston, Mass","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Institute of Animal Physiology, Babraham","institution_ids":[]},{"raw_affiliation_string":"University Dept. of Pathology, Cambridge, England","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036058874","display_name":"John L. Gordon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"J. L. Gordon","raw_affiliation_strings":["Beth Israel Hospital, Harvard Medical School, Boston, Mass","Institute of Animal Physiology, Babraham","University Dept. of Pathology, Cambridge, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Hospital, Harvard Medical School, Boston, Mass","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Institute of Animal Physiology, Babraham","institution_ids":[]},{"raw_affiliation_string":"University Dept. of Pathology, Cambridge, England","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089990723","display_name":"Michael L. Steer","orcid":"https://orcid.org/0000-0002-5365-8215","observed_orcids":["https://orcid.org/0000-0002-5365-8215"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"M. Steer","raw_affiliation_strings":["Beth Israel Hospital, Harvard Medical School, Boston, Mass","Institute of Animal Physiology, Babraham","University Dept. of Pathology, Cambridge, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Hospital, Harvard Medical School, Boston, Mass","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Institute of Animal Physiology, Babraham","institution_ids":[]},{"raw_affiliation_string":"University Dept. of Pathology, Cambridge, England","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.4235,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.9767712,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-function","display_name":"platelet function","score":0.7860000133514404},{"id":"https://openalex.org/keywords/adenylyl-cyclase-inhibition","display_name":"adenylate cyclase inhibition","score":0.9679999947547913},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.8399999737739563},{"id":"https://openalex.org/keywords/sq22536","display_name":"SQ22536","score":0.9639999866485596},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/serotonin-release","display_name":"serotonin release","score":0.9570000171661377},{"id":"https://openalex.org/keywords/adp","display_name":"ADP","score":0.7179999947547913},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9620000123977661},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.8550000190734863},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.5590000152587891},{"id":"https://openalex.org/keywords/platelet-agonists","display_name":"platelet agonists","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.7310171127319336},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7224767208099365},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.6955897212028503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5760934948921204},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.5647134780883789},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5568116903305054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5248123407363892},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.4851311147212982},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.4250746965408325},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.3596500754356384},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35444772243499756},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2810773253440857},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21879908442497253},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12290588021278381},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07614666223526001}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0039-1680344","doi":"https://doi.org/10.1055/s-0039-1680344","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0039-1680344","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1680344.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1055/s-0039-1680344","doi":"https://doi.org/10.1055/s-0039-1680344","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0039-1680344","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1680344.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2946639830.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2092842832","https://openalex.org/W2945241243","https://openalex.org/W2114632037","https://openalex.org/W2027241860","https://openalex.org/W2170920264","https://openalex.org/W1896310453","https://openalex.org/W983833456","https://openalex.org/W4237379435","https://openalex.org/W59385160","https://openalex.org/W61035730"],"abstract_inverted_index":{"Induction":[0],"of":[1,18,30,44,50,77,106,136,151,213,220,228,236],"the":[2,42,75,92,102,176,190,206,211,226],"platelet":[3,45,51,96,107,137,170,198],"response":[4],"to":[5,161],"ADP":[6,111],"and":[7,47,62,67,73,112,114,118,131],"many":[8],"other":[9],"agonists":[10],"is":[11,144,159,200],"accompanied":[12,201],"by":[13,53,81,121,139,172,202,233],"reduction":[14,219],"from":[15],"basal":[16,66,78,85],"level":[17],"cyclic":[19,187],"AMP":[20],"(cAMP)":[21],".":[22],"The":[23],"Squibb":[24],"compound":[25],"22536":[26],"(9-(tetrahydro-2-furyl)-adenine),":[27],"an":[28],"inhibitor":[29],"lung":[31],"adenylate":[32,57,70],"cyclase":[33,71],"(Harris":[34],"et":[35],"al.":[36],"Fed.":[37],"Proc.":[38],"34:617,":[39],"1975),":[40],"reverses":[41],"inhibition":[43,76],"function":[46],"prevents":[48],"elevation":[49],"cAMP":[52,86,105,221],"drugs":[54],"that":[55,218],"stimulate":[56],"cyclase,":[58],"including":[59,238],"PGE1,":[60],"PGD2":[61],"adenosine.":[63],"It":[64,98],"reduces":[65,84],"PGE1-or":[68],"NaF-stimulated":[69],"activity":[72,79,138],"enhances":[74,115],"induced":[80,120],"epinephrine.":[82],"SQ22536":[83,140,166],"levels":[87],"but":[88],"does":[89,167],"not":[90,168,209],"initiate":[91],"release":[93,117,158,204,229],"reaction":[94],"or":[95,175],"aggregation.":[97,240],"does,":[99],"however,":[100],"increase":[101],"effect":[103],"on":[104],"stimulants":[108],"such":[109],"as":[110],"epinephrine":[113],"serotonin":[116,203],"aggregation":[119,156,163,199],"ADP,":[122],"epinephrine,":[123],"collagen,":[124],"thrombin,":[125],"arachidonic":[126],"acid,":[127],"endoperoxide":[128],"PGG2,":[129],"centrifugation,":[130],"rewarming":[132],"after":[133],"chilling.":[134],"Enhancement":[135],"in":[141,205,210,225,230],"citrated":[142],"PRP":[143],"demonstrable":[145],"only":[146],"over":[147],"a":[148,234],"narrow":[149],"range":[150],"agonist":[152],"concentrations":[153],"where":[154],"primary":[155,239],"without":[157,185],"transformed":[160],"complete":[162],"with":[164],"release.":[165],"enhance":[169],"stimulation":[171],"vasopressin,":[173],"serotonin,":[174],"calcium":[177],"ionophore":[178],"Lilly":[179],"A23187;":[180],"these":[181],"substances":[182],"activate":[183],"platelets":[184,231],"lowering":[186],"AMP,":[188],"unlike":[189],"stimuli":[191],"listed":[192],"above.":[193],"In":[194],"heparinized":[195],"PRP,":[196],"ADP-induced":[197],"presence":[207],"(but":[208],"absence)":[212],"SQ22536.":[214],"These":[215],"results":[216],"suggest":[217],"may":[222],"be":[223],"involved":[224],"initiation":[227],"conditioned":[232],"variety":[235],"phenomena,":[237]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2019-05-29T00:00:00"}
