{"id":"https://openalex.org/W2946575355","doi":"https://doi.org/10.1021/acsbiomaterials.9b00270","title":"Surface Modification by Divalent Main-Group-Elemental Ions for Improved Bone Remodeling To Instruct Implant Biofabrication","display_name":"Surface Modification by Divalent Main-Group-Elemental Ions for Improved Bone Remodeling To Instruct Implant Biofabrication","publication_year":2019,"publication_date":"2019-05-23","ids":{"openalex":"https://openalex.org/W2946575355","doi":"https://doi.org/10.1021/acsbiomaterials.9b00270","mag":"2946575355","pmid":"https://pubmed.ncbi.nlm.nih.gov/33405574"},"language":"en","primary_location":{"id":"doi:10.1021/acsbiomaterials.9b00270","doi":"https://doi.org/10.1021/acsbiomaterials.9b00270","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.9b00270","pdf_url":null,"source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science &amp; Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001827987","display_name":"Jiaxing Gong","orcid":"https://orcid.org/0000-0001-6454-5956","observed_orcids":["https://orcid.org/0000-0001-6454-5956"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210121744","display_name":"Zhejiang University Medical College Affiliated Stomatological Hospital","ror":"https://ror.org/02yk7ya44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121744"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jiaxing Gong","raw_affiliation_strings":["Division of Engineering in Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, Massachusetts 02139, United States","Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Engineering in Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","institution_ids":[]},{"raw_affiliation_string":"The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China","institution_ids":["https://openalex.org/I4210121744","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016390421","display_name":"Miao Sun","orcid":"https://orcid.org/0000-0002-9445-0007","observed_orcids":["https://orcid.org/0000-0002-9445-0007"]},"institutions":[{"id":"https://openalex.org/I4210121744","display_name":"Zhejiang University Medical College Affiliated Stomatological Hospital","ror":"https://ror.org/02yk7ya44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121744"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miao Sun","raw_affiliation_strings":["Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","institution_ids":[]},{"raw_affiliation_string":"The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China","institution_ids":["https://openalex.org/I4210121744","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066330368","display_name":"Shaolong Wang","orcid":"https://orcid.org/0000-0001-9711-5688","observed_orcids":["https://orcid.org/0000-0001-9711-5688"]},"institutions":[{"id":"https://openalex.org/I4210121744","display_name":"Zhejiang University Medical College Affiliated Stomatological Hospital","ror":"https://ror.org/02yk7ya44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121744"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaolong Wang","raw_affiliation_strings":["Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","institution_ids":[]},{"raw_affiliation_string":"The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China","institution_ids":["https://openalex.org/I4210121744","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086877435","display_name":"Jianxiang He","orcid":"https://orcid.org/0009-0006-5078-8387","observed_orcids":["https://orcid.org/0009-0006-5078-8387"]},"institutions":[{"id":"https://openalex.org/I4210121744","display_name":"Zhejiang University Medical College Affiliated Stomatological Hospital","ror":"https://ror.org/02yk7ya44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121744"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxiang He","raw_affiliation_strings":["Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","institution_ids":[]},{"raw_affiliation_string":"The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China","institution_ids":["https://openalex.org/I4210121744","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100445141","display_name":"Yu Wang","orcid":"https://orcid.org/0000-0002-0305-9759","observed_orcids":["https://orcid.org/0000-0002-0305-9759"]},"institutions":[{"id":"https://openalex.org/I4210121744","display_name":"Zhejiang University Medical College Affiliated Stomatological Hospital","ror":"https://ror.org/02yk7ya44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121744"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Wang","raw_affiliation_strings":["Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","institution_ids":[]},{"raw_affiliation_string":"The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China","institution_ids":["https://openalex.org/I4210121744","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057720547","display_name":"Ying Qian","orcid":"https://orcid.org/0000-0002-0825-9880","observed_orcids":["https://orcid.org/0000-0002-0825-9880"]},"institutions":[{"id":"https://openalex.org/I4210121744","display_name":"Zhejiang University Medical College Affiliated Stomatological Hospital","ror":"https://ror.org/02yk7ya44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121744"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Qian","raw_affiliation_strings":["Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","institution_ids":[]},{"raw_affiliation_string":"The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China","institution_ids":["https://openalex.org/I4210121744","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345666","display_name":"Yu Liu","orcid":"https://orcid.org/0000-0001-8723-1896","observed_orcids":["https://orcid.org/0000-0001-8723-1896"]},"institutions":[{"id":"https://openalex.org/I4210121744","display_name":"Zhejiang University Medical College Affiliated Stomatological Hospital","ror":"https://ror.org/02yk7ya44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121744"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Liu","raw_affiliation_strings":["Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","institution_ids":[]},{"raw_affiliation_string":"The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China","institution_ids":["https://openalex.org/I4210121744","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062318629","display_name":"Lingqing Dong","orcid":"https://orcid.org/0000-0002-2203-3212","observed_orcids":["https://orcid.org/0000-0002-2203-3212"]},"institutions":[{"id":"https://openalex.org/I4210121744","display_name":"Zhejiang University Medical College Affiliated Stomatological Hospital","ror":"https://ror.org/02yk7ya44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121744"]},{"id":"https://openalex.org/I4391767789","display_name":"State Key Laboratory of Silicon Materials","ror":"https://ror.org/02dmmay61","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767789","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingqing Dong","raw_affiliation_strings":["Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China","The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China"],"raw_orcid":"https://orcid.org/0000-0002-2203-3212","affiliations":[{"raw_affiliation_string":"Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","institution_ids":[]},{"raw_affiliation_string":"School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China","institution_ids":["https://openalex.org/I4391767789","https://openalex.org/I76130692"]},{"raw_affiliation_string":"The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China","institution_ids":["https://openalex.org/I4210121744","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100637356","display_name":"Liang Ma","orcid":"https://orcid.org/0000-0002-6242-1850","observed_orcids":["https://orcid.org/0000-0002-6242-1850"]},"institutions":[{"id":"https://openalex.org/I4391767679","display_name":"State Key Laboratory Fluid Power and Mechatronic Systems","ror":"https://ror.org/01h0g5x34","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767679","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Ma","raw_affiliation_strings":["State Key Laboratory of Fluid Power & Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Fluid Power & Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China","institution_ids":["https://openalex.org/I4391767679","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085227348","display_name":"Kui Cheng","orcid":"https://orcid.org/0000-0003-4828-6450","observed_orcids":["https://orcid.org/0000-0003-4828-6450"]},"institutions":[{"id":"https://openalex.org/I4391767789","display_name":"State Key Laboratory of Silicon Materials","ror":"https://ror.org/02dmmay61","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767789","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kui Cheng","raw_affiliation_strings":["School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China"],"raw_orcid":"https://orcid.org/0000-0003-4828-6450","affiliations":[{"raw_affiliation_string":"School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China","institution_ids":["https://openalex.org/I4391767789","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028417681","display_name":"Wenjian Weng","orcid":"https://orcid.org/0000-0002-9373-7284","observed_orcids":["https://orcid.org/0000-0002-9373-7284"]},"institutions":[{"id":"https://openalex.org/I4391767789","display_name":"State Key Laboratory of Silicon Materials","ror":"https://ror.org/02dmmay61","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767789","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjian Weng","raw_affiliation_strings":["School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China"],"raw_orcid":"https://orcid.org/0000-0002-9373-7284","affiliations":[{"raw_affiliation_string":"School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China","institution_ids":["https://openalex.org/I4391767789","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007197560","display_name":"Mengfei Yu","orcid":"https://orcid.org/0000-0002-7700-4697","observed_orcids":["https://orcid.org/0000-0002-7700-4697"]},"institutions":[{"id":"https://openalex.org/I4210121744","display_name":"Zhejiang University Medical College Affiliated Stomatological Hospital","ror":"https://ror.org/02yk7ya44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121744"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mengfei Yu","raw_affiliation_strings":["Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China"],"raw_orcid":"https://orcid.org/0000-0002-7700-4697","affiliations":[{"raw_affiliation_string":"Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","institution_ids":[]},{"raw_affiliation_string":"The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China","institution_ids":["https://openalex.org/I4210121744","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067842712","display_name":"Yu Shrike Zhang","orcid":"https://orcid.org/0000-0002-0045-0808","observed_orcids":["https://orcid.org/0000-0002-0045-0808","https://orcid.org/0000-0002-2291-2022"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yu Shrike Zhang","raw_affiliation_strings":["Division of Engineering in Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":"https://orcid.org/0000-0002-0045-0808","affiliations":[{"raw_affiliation_string":"Division of Engineering in Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115588114","display_name":"Huiming Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121744","display_name":"Zhejiang University Medical College Affiliated Stomatological Hospital","ror":"https://ror.org/02yk7ya44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121744"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huiming Wang","raw_affiliation_strings":["Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Oral Biomedical Research of Zhejiang Province, 268 Kaixuan Road, Hangzhou 310029, China","institution_ids":[]},{"raw_affiliation_string":"The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, 395 Yanan Road, Hangzhou 310003, China","institution_ids":["https://openalex.org/I4210121744","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5007197560","https://openalex.org/A5067842712","https://openalex.org/A5115588114"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210121744","https://openalex.org/I76130692"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.9385,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.69774563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"7","first_page":"3311","last_page":"3324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11442","display_name":"Titanium Alloys Microstructure and Properties","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13470","display_name":"Surface Treatment and Coatings","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/strontium-ions","display_name":"strontium ions","score":0.7089999914169312},{"id":"https://openalex.org/keywords/surface-modification","display_name":"surface modification","score":0.6880000233650208},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.7480000257492065},{"id":"https://openalex.org/keywords/osseointegration","display_name":"osseointegration","score":0.9829999804496765},{"id":"https://openalex.org/keywords/titanium-implants","display_name":"titanium implants","score":0.6370000243186951},{"id":"https://openalex.org/keywords/hydrothermal-treatment","display_name":"hydrothermal treatment","score":0.6990000009536743},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.9520000219345093},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/bone-implant-interface","display_name":"bone-implant interface","score":0.5799999833106995},{"id":"https://openalex.org/keywords/removal-torque","display_name":"removal torque","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C101414908","wikidata":"https://www.wikidata.org/wiki/Q1541818","display_name":"Osseointegration","level":3,"score":0.951424241065979},{"id":"https://openalex.org/C74884574","wikidata":"https://www.wikidata.org/wiki/Q171407","display_name":"Divalent","level":2,"score":0.6504483819007874},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5447583198547363},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.5237005949020386},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.4703117907047272},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.456853449344635},{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.4412325620651245},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.437777042388916},{"id":"https://openalex.org/C2781201070","wikidata":"https://www.wikidata.org/wiki/Q2790033","display_name":"Bioceramic","level":2,"score":0.41764047741889954},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3820047974586487},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.37809932231903076},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.19718211889266968},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10511475801467896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09889119863510132},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.09193038940429688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09035590291023254},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.05639541149139404},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acsbiomaterials.9b00270","doi":"https://doi.org/10.1021/acsbiomaterials.9b00270","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.9b00270","pdf_url":null,"source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science &amp; Engineering","raw_type":"journal-article"},{"id":"pmid:33405574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33405574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS biomaterials science & engineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2221215123","display_name":null,"funder_award_id":"81670972","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4156698323","display_name":null,"funder_award_id":"81600838","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4252500354","display_name":null,"funder_award_id":"2017M621923","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G6587614904","display_name":null,"funder_award_id":"51502262","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1828403781","https://openalex.org/W1965517432","https://openalex.org/W1969202083","https://openalex.org/W1969540263","https://openalex.org/W1975682654","https://openalex.org/W1977087650","https://openalex.org/W1979432868","https://openalex.org/W1984284007","https://openalex.org/W1987301228","https://openalex.org/W1991053758","https://openalex.org/W1996608840","https://openalex.org/W2001203834","https://openalex.org/W2006851263","https://openalex.org/W2007322941","https://openalex.org/W2007605247","https://openalex.org/W2009756491","https://openalex.org/W2010473896","https://openalex.org/W2014932842","https://openalex.org/W2015005969","https://openalex.org/W2019199574","https://openalex.org/W2035127714","https://openalex.org/W2053995348","https://openalex.org/W2055364274","https://openalex.org/W2061790220","https://openalex.org/W2065242899","https://openalex.org/W2067493579","https://openalex.org/W2087153492","https://openalex.org/W2093252878","https://openalex.org/W2093712902","https://openalex.org/W2096735953","https://openalex.org/W2119062112","https://openalex.org/W2120555029","https://openalex.org/W2135799879","https://openalex.org/W2145272279","https://openalex.org/W2152233267","https://openalex.org/W2152840234","https://openalex.org/W2161531696","https://openalex.org/W2161988995","https://openalex.org/W2186588920","https://openalex.org/W2215626906","https://openalex.org/W2290087407","https://openalex.org/W2290282561","https://openalex.org/W2310263653","https://openalex.org/W2327420122","https://openalex.org/W2328033143","https://openalex.org/W2396951247","https://openalex.org/W2516845446","https://openalex.org/W2538332725","https://openalex.org/W2626727929","https://openalex.org/W2780315214","https://openalex.org/W2792560436","https://openalex.org/W2794435788","https://openalex.org/W2808727261","https://openalex.org/W2887512683","https://openalex.org/W4320581076"],"related_works":["https://openalex.org/W2293095610","https://openalex.org/W2911849347","https://openalex.org/W4296095315","https://openalex.org/W6941105918","https://openalex.org/W4408523296","https://openalex.org/W3099117778","https://openalex.org/W1912221974","https://openalex.org/W2512827953","https://openalex.org/W2977170934","https://openalex.org/W2799815794"],"abstract_inverted_index":{"Divalent":[0],"main-group-elemental":[1,58,121,192],"ions":[2,59,122],"are":[3,26],"widely":[4],"used":[5,208],"to":[6,209],"improve":[7],"osteogenic":[8,112],"capacity":[9],"of":[10,30,87,103,111,137,147,157,172,180,212,215],"implants":[11,95,139,174,221],"biofabricated":[12,216],"from":[13,45],"Ti":[14],"and":[15,24,74,85,89,101,135,151,159,219],"its":[16],"alloys.":[17],"However,":[18],"the":[19,31,39,51,77,99,109,132,155,164,169,178,213,223],"conclusions":[20],"regarding":[21],"their":[22],"osseointegration":[23,171],"immunogenicity":[25],"always":[27],"inconsistent":[28],"because":[29],"multiple":[32],"bone":[33,79,149,203],"remodeling":[34,80],"processes":[35],"as":[36,38,161,163,175,177],"well":[37,162,176],"distinct":[40],"material":[41],"surface":[42,54],"features":[43],"arising":[44],"processing.":[46],"Here":[47],"we":[48],"successfully":[49],"manufactured":[50],"porous":[52],"micro/nanostructured":[53],"topography":[55],"with":[56,115],"divalent":[57,120,191],"(Mg":[60,123],"2+,":[61,63,65,124,126],"Ca":[62,125],"Sr":[64,194],"Ba":[66,127],"2+":[67,128,195],")":[68],"on":[69],"substrates":[70,88],"through":[71],"hydrothermal":[72],"treatment":[73],"comprehensively":[75],"evaluated":[76],"complex":[78],"processes,":[81],"including":[82],"osseointegration,":[83],"immunogenicity,":[84,134,181],"fibrosis":[86,136],"implants.":[90],"We":[91],"found":[92],"that":[93,188],"Sr-modified":[94,138,173],"not":[96],"only":[97],"upregulated":[98],"adhesion":[100],"proliferation":[102],"mesenchymal":[104],"stem":[105],"cells":[106],"but":[107],"also":[108,141],"differentiation":[110],"markers":[113],"compared":[114],"those":[116],"modified":[117],"by":[118],"other":[119],").":[129],"More":[130],"importantly,":[131],"osteoclastogenesis,":[133],"were":[140],"significantly":[142],"downregulated.":[143],"In":[144],"vivo,":[145],"evaluations":[146],"new":[148],"formation":[150],"histological":[152],"morphology":[153],"at":[154],"interface":[156],"implant":[158],"host":[160],"removal":[165],"torque":[166],"similarly":[167],"indicated":[168],"improved":[170],"absence":[179],"fibrosis,":[182],"or":[183],"necrosis.":[184],"Our":[185],"results":[186],"suggested":[187],"among":[189],"various":[190],"ions,":[193],"might":[196],"be":[197,207],"a":[198],"promising":[199],"one":[200],"for":[201],"enhancing":[202],"remodeling,":[204],"which":[205],"can":[206],"instruct":[210],"functionalization":[211],"surfaces":[214],"Ti-based":[217],"orthopedic":[218],"dental":[220],"in":[222],"future.":[224]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-05-29T00:00:00"}
