{"id":"https://openalex.org/W2946417044","doi":"https://doi.org/10.1055/s-0039-1680042","title":"Glucocorticoid-induced loss of cortical bone is exacerbated during cold-exposure in male mice","display_name":"Glucocorticoid-induced loss of cortical bone is exacerbated during cold-exposure in male mice","publication_year":2019,"publication_date":"2019-02-01","ids":{"openalex":"https://openalex.org/W2946417044","doi":"https://doi.org/10.1055/s-0039-1680042","mag":"2946417044"},"language":"en","primary_location":{"id":"doi:10.1055/s-0039-1680042","doi":"https://doi.org/10.1055/s-0039-1680042","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0039-1680042","pdf_url":null,"source":{"id":"https://openalex.org/S68901728","display_name":"Osteologie/Osteology","issn_l":"1019-1291","issn":["1019-1291","2567-5818"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313753","host_organization_name":"Schattauer Verlag","host_organization_lineage":["https://openalex.org/P4310313753","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Schattauer Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteologie","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058481548","display_name":"Manuel Gado","orcid":"https://orcid.org/0000-0001-9631-8694","observed_orcids":["https://orcid.org/0000-0001-9631-8694"]},"institutions":[{"id":"https://openalex.org/I4405266872","display_name":"Center for Regenerative Therapies Dresden","ror":"https://ror.org/00490nx58","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405266872","https://openalex.org/I4405279746","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Gado","raw_affiliation_strings":["Technische Universit\u00e4t Dresden, Center for Regenerative Therapies Dresden, Dresden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technische Universit\u00e4t Dresden, Center for Regenerative Therapies Dresden, Dresden","institution_ids":["https://openalex.org/I4405266872","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069963966","display_name":"Monique Noll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405266872","display_name":"Center for Regenerative Therapies Dresden","ror":"https://ror.org/00490nx58","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405266872","https://openalex.org/I4405279746","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Noll","raw_affiliation_strings":["Technische Universit\u00e4t Dresden, Center for Regenerative Therapies Dresden, Dresden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technische Universit\u00e4t Dresden, Center for Regenerative Therapies Dresden, Dresden","institution_ids":["https://openalex.org/I4405266872","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007912042","display_name":"Annett Heinrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405266872","display_name":"Center for Regenerative Therapies Dresden","ror":"https://ror.org/00490nx58","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405266872","https://openalex.org/I4405279746","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Heinrich","raw_affiliation_strings":["Technische Universit\u00e4t Dresden, Center for Regenerative Therapies Dresden, Dresden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technische Universit\u00e4t Dresden, Center for Regenerative Therapies Dresden, Dresden","institution_ids":["https://openalex.org/I4405266872","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056597436","display_name":"Martina Rauner","orcid":"https://orcid.org/0000-0002-4067-6799","observed_orcids":["https://orcid.org/0000-0002-4067-6799","https://orcid.org/0009-0001-9754-1334"]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Rauner","raw_affiliation_strings":["Technische Universit\u00e4t Dresden, Medizinische Klinik III, Dresden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technische Universit\u00e4t Dresden, Medizinische Klinik III, Dresden","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007702426","display_name":"Lorenz Christian Hofbauer","orcid":"https://orcid.org/0000-0002-8691-8423","observed_orcids":["https://orcid.org/0000-0002-8691-8423"]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"LC Hofbauer","raw_affiliation_strings":["Technische Universit\u00e4t Dresden, Medizinische Klinik III, Dresden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technische Universit\u00e4t Dresden, Medizinische Klinik III, Dresden","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035750809","display_name":"Holger Henneicke","orcid":"https://orcid.org/0000-0003-1746-9369","observed_orcids":["https://orcid.org/0000-0003-1746-9369"]},"institutions":[{"id":"https://openalex.org/I4405266872","display_name":"Center for Regenerative Therapies Dresden","ror":"https://ror.org/00490nx58","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405266872","https://openalex.org/I4405279746","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Henneicke","raw_affiliation_strings":["Technische Universit\u00e4t Dresden, Center for Regenerative Therapies Dresden, Dresden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technische Universit\u00e4t Dresden, Center for Regenerative Therapies Dresden, Dresden","institution_ids":["https://openalex.org/I4405266872","https://openalex.org/I78650965"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9901,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.83569405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-induced-osteoporosis","display_name":"glucocorticoid-induced osteoporosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cold-exposure","display_name":"cold exposure","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cortical-bone-loss","display_name":"cortical bone loss","score":0.8270000219345093},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.8830000162124634},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.6230000257492065},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.6420000195503235},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.7229999899864197},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.972000002861023},{"id":"https://openalex.org/keywords/thermoneutrality","display_name":"thermoneutrality","score":0.7179999947547913},{"id":"https://openalex.org/keywords/femoral-bone","display_name":"femoral bone","score":0.4580000042915344},{"id":"https://openalex.org/keywords/trabecular-bone","display_name":"trabecular bone","score":0.7739999890327454},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.6570000052452087},{"id":"https://openalex.org/keywords/p1np","display_name":"P1NP","score":0.5320000052452087},{"id":"https://openalex.org/keywords/tracp-5b","display_name":"TRACP-5b","score":0.9940000176429749},{"id":"https://openalex.org/keywords/glucocorticoid-side-effects","display_name":"glucocorticoid adverse effects","score":0.6899999976158142},{"id":"https://openalex.org/keywords/secondary-osteoporosis","display_name":"secondary osteoporosis","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.7341947555541992},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7276948690414429},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.6920876502990723},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6064770221710205},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5966096520423889},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5540628433227539},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5379176139831543},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5104836225509644},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.4527946710586548},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4488424062728882},{"id":"https://openalex.org/C2781451080","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cortical bone","level":2,"score":0.41659682989120483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22695493698120117},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17583197355270386},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.09278371930122375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0039-1680042","doi":"https://doi.org/10.1055/s-0039-1680042","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0039-1680042","pdf_url":null,"source":{"id":"https://openalex.org/S68901728","display_name":"Osteologie/Osteology","issn_l":"1019-1291","issn":["1019-1291","2567-5818"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313753","host_organization_name":"Schattauer Verlag","host_organization_lineage":["https://openalex.org/P4310313753","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Schattauer Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteologie","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2052379922","https://openalex.org/W3022774686","https://openalex.org/W2943852876","https://openalex.org/W1999744701","https://openalex.org/W40652775","https://openalex.org/W2327224766","https://openalex.org/W2074971805","https://openalex.org/W2937550989","https://openalex.org/W1992295729","https://openalex.org/W2058566062"],"abstract_inverted_index":{"Introduction:":[0],"Despite":[1],"their":[2,16],"desired":[3],"immunosuppressive":[4],"properties,":[5],"glucocorticoids":[6],"(GCs)":[7],"are":[8,378],"associated":[9],"with":[10,280,344],"multiple":[11],"adverse":[12],"effects":[13,86,375],"severely":[14],"limiting":[15],"clinical":[17],"use.":[18],"Patients":[19],"receiving":[20,121],"continuous":[21],"GC":[22,76,157,183,209,274,299,307,390],"therapy":[23],"frequently":[24],"suffer":[25],"from":[26],"a":[27,32,58,67,79,130,189,196,236,345,385],"reduced":[28],"bone":[29,62,138,154,163,239,244,292,314,337],"mass":[30],"and":[31,75,145,225,294,357,365,392],"high":[33],"propensity":[34],"for":[35,83,129,238],"spinal":[36],"fractures,":[37],"rendering":[38],"glucocorticoid-induced":[39],"osteoporosis":[40],"(GIO)":[41],"the":[42,71,88,93,96,126,166,169,214,332,339,372,393,396],"most":[43],"common":[44],"form":[45],"of":[46,61,95,133,153,175,182,228,243,263,289,306,335,376,395],"secondary":[47],"osteoporosis.":[48],"The":[49],"sympathetic":[50,72,97,397],"nervous":[51,73,98,398],"system":[52,74,99,399],"has":[53],"been":[54],"shown":[55],"to":[56,319],"be":[57],"potent":[59],"regulator":[60],"metabolism.":[63],"Here":[64],"we":[65],"examine":[66],"possible":[68],"interaction":[69],"between":[70,388],"exposure":[77,158,210,308],"as":[78,148,150,247,258,260,298],"potential":[80],"underlying":[81],"reason":[82],"GCs":[84,281,377],"site-specific":[85],"throughout":[87],"skeleton.":[89],"Methods:":[90],"To":[91],"modulate":[92],"outflow":[94],"8-month-old":[100],"C57BL/6NRj":[101],"male":[102],"mice":[103,187,279],"were":[104,271],"housed":[105],"at":[106,185,211,276,282,301,309,325,362],"either":[107],"29":[108],"\u00b0C":[109,112,117],"(thermoneutrality),":[110],"22":[111],"(room/ambient":[113],"temperature)":[114],"or":[115,123,168],"13":[116],"(cold),":[118],"while":[119],"simultaneously":[120],"corticosterone":[122],"placebo":[124,324],"via":[125,142],"drinking":[127],"water":[128],"total":[131],"duration":[132],"6":[134,180,304],"weeks.":[135],"After":[136,303],"sacrifice,":[137],"quality":[139],"was":[140,316,342,360],"examined":[141],"micro-CT,":[143],"static":[144],"dynamic":[146],"histomorphometry":[147],"well":[149,259],"serum":[151,226,261],"markers":[152],"turnover.":[155],"Results:":[156],"did":[159],"not":[160],"alter":[161],"trabecular":[162],"structure":[164],"in":[165,191,199,286,338,348],"vertebra":[167],"femur":[170],"across":[171],"experimental":[172],"groups":[173],"regardless":[174],"thermal":[176],"condition.":[177],"However,":[178],"following":[179,400],"weeks":[181,305],"treatment":[184,275,300],"thermoneutrality,":[186],"showed":[188],"loss":[190,293,315,334],"cortical":[192,201,215,291,313,336],"bone,":[193],"reflected":[194],"by":[195,273],"significant":[197,386],"decrease":[198],"femoral":[200,290,312],"thickness":[202],"(-11%":[203],"vs.":[204,220,231,253,266,323,351],"placebo;":[205,221,232,254,267,352],"p":[206,222,233,255,268,328,353],"<":[207,223,234,256,269,329,354],"0.01).":[208,330],"thermoneutrality":[212],"decreased":[213],"osteoblast":[216],"perimeter":[217],"(Ob.Pm.)":[218],"(-40%":[219],"0.01)":[224,257,270,355],"levels":[227,262,288],"PINP":[229],"(-58%":[230],"0.01),":[235],"marker":[237],"formation.":[240],"Conversely,":[241],"indicators":[242],"resorption":[245],"such":[246],"osteoclast":[248],"surface/bone":[249],"surface":[250],"(Oc.S./B.S.)":[251],"(+49%":[252],"TRAP5b":[264],"(+53%":[265],"increased":[272,333],"thermoneutrality.":[277,302,366],"Treating":[278],"room":[283],"temperature":[284,311,364],"resulted":[285],"similar":[287],"concomitant":[295],"cellular":[296],"changes":[297],"cold":[310,326,340,381,401],"exacerbated":[317,379],"compared":[318],"higher":[320],"temperatures":[321],"(-17%":[322],"temperature;":[327],"Interestingly,":[331],"environment":[341],"correlated":[343],"GC-induced":[346],"increase":[347],"Oc.S/B.S.":[349],"(+67%":[350],"above":[356],"beyond":[358],"what":[359],"observed":[361],"ambient":[363],"Discussion:":[367],"These":[368],"results":[369],"suggest":[370],"that":[371],"deleterious":[373],"skeletal":[374],"during":[380],"exposure;":[382],"potentially":[383],"indicating":[384],"interplay":[387],"local":[389],"action":[391],"activation":[394],"exposure.":[402]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2019-05-29T00:00:00"}
