{"id":"https://openalex.org/W2946320809","doi":"https://doi.org/10.1080/22221751.2019.1619485","title":"Robust in vitro assay for analyzing the neutralization activity of serum specimens against hepatitis B virus","display_name":"Robust in vitro assay for analyzing the neutralization activity of serum specimens against hepatitis B virus","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2946320809","doi":"https://doi.org/10.1080/22221751.2019.1619485","mag":"2946320809","pmid":"https://pubmed.ncbi.nlm.nih.gov/31130075","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6542156"},"language":"en","primary_location":{"id":"doi:10.1080/22221751.2019.1619485","doi":"https://doi.org/10.1080/22221751.2019.1619485","is_oa":true,"landing_page_url":"https://doi.org/10.1080/22221751.2019.1619485","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/22221751.2019.1619485?needAccess=true","source":{"id":"https://openalex.org/S2764760790","display_name":"Emerging Microbes & Infections","issn_l":"2222-1751","issn":["2222-1751"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Emerging Microbes &amp; Infections","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/22221751.2019.1619485?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100405862","display_name":"Yali Zhang","orcid":"https://orcid.org/0000-0002-2599-3710","observed_orcids":["https://orcid.org/0000-0002-2599-3710"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4405272336","display_name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","ror":"https://ror.org/040qz4226","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272336"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya-Li Zhang","raw_affiliation_strings":["School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]},{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074905580","display_name":"Ying Gao","orcid":"https://orcid.org/0000-0003-0696-7880","observed_orcids":["https://orcid.org/0000-0003-0696-7880","https://orcid.org/0009-0009-5600-9008"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4405272336","display_name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","ror":"https://ror.org/040qz4226","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272336"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Gao","raw_affiliation_strings":["Hainan Health Disseminate Centre","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","Hainan Health Disseminate Centre, Haikou, People's Republic of China","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan Health Disseminate Centre","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]},{"raw_affiliation_string":"Hainan Health Disseminate Centre, Haikou, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011509502","display_name":"Jiali Cao","orcid":"https://orcid.org/0009-0000-2806-0265","observed_orcids":["https://orcid.org/0009-0000-2806-0265"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4405272336","display_name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","ror":"https://ror.org/040qz4226","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272336"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-Li Cao","raw_affiliation_strings":["School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]},{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing-Hua Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Hua Zhao","raw_affiliation_strings":["Natural Medicine Institute of Zhejiang Yangshengtang","School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","Natural Medicine Institute of Zhejiang Yangshengtang, Hangzhou, People's Republic of China","School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Medicine Institute of Zhejiang Yangshengtang","institution_ids":[]},{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Natural Medicine Institute of Zhejiang Yangshengtang, Hangzhou, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000657358","display_name":"Tianying Zhang","orcid":"https://orcid.org/0000-0002-2477-329X","observed_orcids":["https://orcid.org/0000-0002-2477-329X","https://orcid.org/0000-0002-6601-9180"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4405272336","display_name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","ror":"https://ror.org/040qz4226","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272336"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian-Ying Zhang","raw_affiliation_strings":["School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111018867","display_name":"Chuanlai Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4405272336","display_name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","ror":"https://ror.org/040qz4226","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272336"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuan-Lai Yang","raw_affiliation_strings":["School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]},{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015835059","display_name":"Hualong Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4405272336","display_name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","ror":"https://ror.org/040qz4226","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272336"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua-Long Xiong","raw_affiliation_strings":["School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]},{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001741493","display_name":"Ying-Bin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4405272336","display_name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","ror":"https://ror.org/040qz4226","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272336"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying-Bin Wang","raw_affiliation_strings":["School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]},{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074106768","display_name":"Shan-Hai Ou","orcid":"https://orcid.org/0000-0002-0401-7809","observed_orcids":["https://orcid.org/0000-0002-0401-7809"]},"institutions":[{"id":"https://openalex.org/I4210162218","display_name":"Xiamen Blood Center","ror":"https://ror.org/01rbbfm88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162218"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shan-Hai Ou","raw_affiliation_strings":["Xiamen Blood Service","Xiamen Blood Service, Xiamen, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiamen Blood Service","institution_ids":["https://openalex.org/I4210162218"]},{"raw_affiliation_string":"Xiamen Blood Service, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I4210162218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115604369","display_name":"Tong Cheng","orcid":"https://orcid.org/0000-0002-1638-6214","observed_orcids":["https://orcid.org/0000-0002-1638-6214","https://orcid.org/0000-0003-1251-8774"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4405272336","display_name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","ror":"https://ror.org/040qz4226","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272336"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong Cheng","raw_affiliation_strings":["School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-1638-6214","affiliations":[{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]},{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chang-Rong Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chang-Rong Chen","raw_affiliation_strings":["Xiamen Haicang Hospital","Xiamen Haicang Hospital, Xiamen, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiamen Haicang Hospital","institution_ids":[]},{"raw_affiliation_string":"Xiamen Haicang Hospital, Xiamen, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086740134","display_name":"Quan Yuan","orcid":"https://orcid.org/0000-0001-5487-561X","observed_orcids":["https://orcid.org/0000-0001-5487-561X"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4405272336","display_name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","ror":"https://ror.org/040qz4226","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272336"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Quan Yuan","raw_affiliation_strings":["School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-5487-561X","affiliations":[{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]},{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078732636","display_name":"Ningshao Xia","orcid":"https://orcid.org/0000-0003-0179-5266","observed_orcids":["https://orcid.org/0000-0003-0179-5266"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4405272336","display_name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","ror":"https://ror.org/040qz4226","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272336"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning-Shao Xia","raw_affiliation_strings":["School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0003-0179-5266","affiliations":[{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]},{"raw_affiliation_string":"School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, People's Republic of China","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074106768","https://openalex.org/A5086740134"],"corresponding_institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4210162218","https://openalex.org/I4405272336"],"apc_list":{"value":2155,"currency":"GBP","value_usd":2643},"apc_paid":{"value":2155,"currency":"GBP","value_usd":2643},"fwci":0.379,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.58613281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"724","last_page":"733"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9229999780654907},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.8270000219345093},{"id":"https://openalex.org/keywords/anti-hbs","display_name":"anti-HBs","score":0.6949999928474426},{"id":"https://openalex.org/keywords/anti-hbc","display_name":"anti-HBc","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hepatitis-b","display_name":"hepatitis B","score":0.3089999854564667},{"id":"https://openalex.org/keywords/protective-antibody-response","display_name":"protective antibody response","score":0.3409999907016754},{"id":"https://openalex.org/keywords/hepatitis-b-surface-antigen","display_name":"hepatitis B surface antigen","score":0.3070000112056732},{"id":"https://openalex.org/keywords/hbv-core-antigen","display_name":"HBV core antigen","score":0.6209999918937683},{"id":"https://openalex.org/keywords/hbv-e-antigen","display_name":"HBV e antigen","score":0.753000020980835},{"id":"https://openalex.org/keywords/cutoff-values","display_name":"cut-off values","score":0.36899998784065247},{"id":"https://openalex.org/keywords/doxycycline","display_name":"doxycycline","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.8038116693496704},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7389165759086609},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6529133915901184},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.48324093222618103},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.47260409593582153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3951323628425598},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.385730504989624},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32492515444755554},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12392494082450867}],"mesh":[{"descriptor_ui":"D006510","descriptor_name":"Hepatitis B Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044967","descriptor_name":"Serum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1080/22221751.2019.1619485","doi":"https://doi.org/10.1080/22221751.2019.1619485","is_oa":true,"landing_page_url":"https://doi.org/10.1080/22221751.2019.1619485","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/22221751.2019.1619485?needAccess=true","source":{"id":"https://openalex.org/S2764760790","display_name":"Emerging Microbes & Infections","issn_l":"2222-1751","issn":["2222-1751"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Emerging Microbes &amp; Infections","raw_type":"journal-article"},{"id":"pmid:31130075","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31130075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Emerging microbes & infections","raw_type":"Evaluation Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:6542156","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6542156/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Emerg Microbes Infect","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:aab120e57e3549738fd6c1a9194fa490","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/aab120e57e3549738fd6c1a9194fa490","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Emerging Microbes and Infections, Vol 8, Iss 1, Pp 724-733 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/22221751.2019.1619485","doi":"https://doi.org/10.1080/22221751.2019.1619485","is_oa":true,"landing_page_url":"https://doi.org/10.1080/22221751.2019.1619485","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/22221751.2019.1619485?needAccess=true","source":{"id":"https://openalex.org/S2764760790","display_name":"Emerging Microbes & Infections","issn_l":"2222-1751","issn":["2222-1751"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Emerging Microbes &amp; Infections","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2946320809.pdf"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1975436361","https://openalex.org/W2000984427","https://openalex.org/W2038452027","https://openalex.org/W2063948876","https://openalex.org/W2088160623","https://openalex.org/W2090710125","https://openalex.org/W2099753264","https://openalex.org/W2120426460","https://openalex.org/W2131134210","https://openalex.org/W2143233396","https://openalex.org/W2163147639","https://openalex.org/W2168630917","https://openalex.org/W2175342091","https://openalex.org/W2462489090","https://openalex.org/W2520996611","https://openalex.org/W2521381331","https://openalex.org/W2565679138","https://openalex.org/W2567418439","https://openalex.org/W2615881027","https://openalex.org/W2791705633","https://openalex.org/W2801666689","https://openalex.org/W3144051925"],"related_works":["https://openalex.org/W4362558312","https://openalex.org/W2004646253","https://openalex.org/W2367345573","https://openalex.org/W2391028415","https://openalex.org/W2028775797","https://openalex.org/W2626522750","https://openalex.org/W1764314633","https://openalex.org/W348336412","https://openalex.org/W2560261955","https://openalex.org/W2151819117"],"abstract_inverted_index":{"Anti-HBs":[0],"is":[1,12],"a":[2,95,192,280],"well-known":[3],"marker":[4],"of":[5,41,44,57,79,97,127,143,273,305],"protective":[6],"capability":[7],"against":[8,170],"HBV.":[9],"However,":[10],"little":[11],"known":[13],"about":[14],"the":[15,18,24,42,63,69,85,106,111,123,128,149,158,183,187,197,286,302,308],"association":[16],"between":[17],"qAnti-HBs":[19,112,129],"determined":[20],"by":[21,175],"immunoassays":[22],"and":[23],"neutralization":[25,243],"activity":[26],"(NAT)":[27],"derived":[28,262],"from":[29],"functional":[30],"assays.":[31],"We":[32],"developed":[33],"an":[34,54,141],"in":[35],"vitro":[36,89],"assay":[37,49,190],"for":[38,62,94],"direct":[39],"measurement":[40],"NAT":[43,90,107,133,159],"human":[45],"sera.":[46],"The":[47,102],"new":[48,188],"was":[50,82,137,151],"highly":[51],"sensitive,":[52],"with":[53,110,140,157],"analytical":[55],"sensitivity":[56],"9.6":[58],"\u00b1":[59],"1.3":[60],"mIU/mL":[61],"HBIG":[64],"standard.":[65],"For":[66],"serum":[67],"detection,":[68],"maximum":[70,309],"fold":[71,310],"dilution":[72,311],"required":[73,312],"to":[74,130,182,195,313],"produce":[75,314],"\u226550%":[76,315],"inhibition":[77],"(MDF50)":[78],"HBV":[80,172,177],"infection":[81],"used":[83],"as":[84],"quantitative":[86,225,231,237],"index.":[87],"In":[88,185],"evaluations":[91],"were":[92],"conducted":[93],"cohort":[96],"164":[98],"HBV-free":[99],"healthy":[100],"individuals.":[101],"results":[103],"demonstrated":[104],"that":[105,122,148,168,284],"positively":[108,155],"correlated":[109],"(R2":[113,160],"=":[114,161],"0.473,":[115],"p":[116,163],"<":[117,164],"0.001).":[118],"ROC":[119],"analysis":[120],"indicated":[121],"optimal":[124],"cutoff":[125],"value":[126],"discriminate":[131],"significant":[132],"(MDF50":[134],"\u2265":[135],"8)":[136],"62.9":[138],"mIU/mL,":[139],"AUROC":[142],"0.920.":[144],"Additionally,":[145],"we":[146],"found":[147],"qAnti-HBc":[150],"another":[152],"independent":[153],"parameter":[154],"associated":[156],"0.300,":[162],"0.001),":[165],"which":[166],"suggested":[167],"antibodies":[169],"other":[171],"proteins":[173],"generated":[174],"previous":[176],"exposure":[178],"possibly":[179],"also":[180],"contribute":[181],"NAT.":[184],"summary,":[186],"cell-based":[189],"provides":[191],"robust":[193],"tool":[194],"analyse":[196],"anti-HBV":[198],"NAT.Abbreviations:":[199],"HBV:":[200],"Hepatitis":[201,205,210,215,220],"B":[202,206,211,216,221,227,233,239,247,264],"virus;":[203,265],"HBsAg:":[204],"surface":[207,212,228],"antigen;":[208,218,241],"Anti-HBs:":[209],"antibody;":[213,223,229,235],"HBeAg:":[214],"e":[217,240],"Anti-HBc:":[219],"core":[222,234],"qAnti-HBs:":[224],"hepatitis":[226,232,238,246,263],"qAnti-HBc:":[230],"qHBeAg:":[236],"NAT:":[242],"activity;":[244],"HBIG:":[245],"immune":[248],"globulin;":[249],"NTCP:":[250],"Na+-taurocholate":[251],"cotransporting":[252],"polypeptide;":[253],"IRES:":[254],"internal":[255],"ribosome":[256],"entry":[257],"site;":[258],"ccHBV:":[259],"cell":[260,282],"culture":[261],"GE/cell:":[266],"genome":[267],"equivalent":[268],"per":[269],"cell;":[270],"MOI:":[271],"multiplicity":[272],"infection;":[274,278],"Dpi:":[275],"day":[276],"post":[277],"HepG2-TetOn:":[279],"HepG2-derived":[281],"line":[283],"expresses":[285],"doxycycline-regulated":[287],"transactivator;":[288],"ROC:":[289],"receiver":[290,297],"operating":[291,298],"characteristic":[292,299],"curve;":[293,300],"AUROC:":[294],"area":[295],"under":[296],"LLOQ:":[301],"lower":[303],"limits":[304],"quantification;":[306],"MDF50:":[307],"inhibition;":[316],"IC50:":[317],"half":[318],"maximal":[319],"inhibitory":[320],"concentration":[321]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-05-29T00:00:00"}