{"id":"https://openalex.org/W2946320310","doi":"https://doi.org/10.1101/648592","title":"A cell-free DNA metagenomic sequencing assay that integrates the damage response to infection","display_name":"A cell-free DNA metagenomic sequencing assay that integrates the damage response to infection","publication_year":2019,"publication_date":"2019-05-24","ids":{"openalex":"https://openalex.org/W2946320310","doi":"https://doi.org/10.1101/648592","mag":"2946320310"},"language":"en","primary_location":{"id":"doi:10.1101/648592","doi":"https://doi.org/10.1101/648592","is_oa":true,"landing_page_url":"https://doi.org/10.1101/648592","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/05/24/648592.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2019/05/24/648592.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090404043","display_name":"Alexandre Pellan Cheng","orcid":"https://orcid.org/0000-0002-3667-0992","observed_orcids":["https://orcid.org/0000-0002-3667-0992"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandre Pellan Cheng","raw_affiliation_strings":["Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA","Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 4853, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 4853, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Philip Burnham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Burnham","raw_affiliation_strings":["Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA","Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 4853, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 4853, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101480458","display_name":"John R. Lee","orcid":"https://orcid.org/0000-0002-9612-5742","observed_orcids":["https://orcid.org/0000-0002-9612-5742"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Richard Lee","raw_affiliation_strings":["Department of Transplantation Medicine, NewYork-Presbyterian Hospital-Weill Cornell Medical Center, New York, 10065, USA","Division of Nephrology and Hypertensions, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation Medicine, NewYork-Presbyterian Hospital-Weill Cornell Medical Center, New York, 10065, USA","institution_ids":["https://openalex.org/I1340179700"]},{"raw_affiliation_string":"Division of Nephrology and Hypertensions, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033873670","display_name":"Matthew Pellan Cheng","orcid":"https://orcid.org/0000-0002-4867-2063","observed_orcids":["https://orcid.org/0000-0002-4867-2063"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Pellan Cheng","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA","Division of Infectious Diseases, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA","Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 0211, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Division of Infectious Diseases, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 0211, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073533672","display_name":"Manikkam Suthanthiran","orcid":"https://orcid.org/0000-0001-6894-0486","observed_orcids":["https://orcid.org/0000-0001-6894-0486"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manikkam Suthanthiran","raw_affiliation_strings":["Department of Transplantation Medicine, NewYork-Presbyterian Hospital-Weill Cornell Medical Center, New York, 10065, USA","Division of Nephrology and Hypertensions, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0001-6894-0486","affiliations":[{"raw_affiliation_string":"Department of Transplantation Medicine, NewYork-Presbyterian Hospital-Weill Cornell Medical Center, New York, 10065, USA","institution_ids":["https://openalex.org/I1340179700"]},{"raw_affiliation_string":"Division of Nephrology and Hypertensions, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068404213","display_name":"Darshana M. Dadhania","orcid":"https://orcid.org/0000-0002-7973-1521","observed_orcids":["https://orcid.org/0000-0002-7973-1521"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Darshana Dadhania","raw_affiliation_strings":["Department of Transplantation Medicine, NewYork-Presbyterian Hospital-Weill Cornell Medical Center, New York, 10065, USA","Division of Nephrology and Hypertensions, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation Medicine, NewYork-Presbyterian Hospital-Weill Cornell Medical Center, New York, 10065, USA","institution_ids":["https://openalex.org/I1340179700"]},{"raw_affiliation_string":"Division of Nephrology and Hypertensions, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027216516","display_name":"Iwijn De Vlaminck","orcid":"https://orcid.org/0000-0001-6085-7311","observed_orcids":["https://orcid.org/0000-0001-6085-7311"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Iwijn De Vlaminck","raw_affiliation_strings":["Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA","Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 4853, USA"],"raw_orcid":"https://orcid.org/0000-0001-6085-7311","affiliations":[{"raw_affiliation_string":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 4853, USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5027216516","https://openalex.org/A5068404213"],"corresponding_institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I205783295","https://openalex.org/I4387153466"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.4147999882698059,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.4147999882698059,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.093299999833107,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.08640000224113464,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.9549999833106995},{"id":"https://openalex.org/keywords/urinary-cell-free-dna","display_name":"urinary cell-free DNA","score":0.8059999942779541},{"id":"https://openalex.org/keywords/bisulfite-sequencing","display_name":"bisulfite sequencing","score":0.8289999961853027},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.925000011920929},{"id":"https://openalex.org/keywords/tissue-of-origin","display_name":"tissue of origin","score":0.6779999732971191},{"id":"https://openalex.org/keywords/kidney-transplant-recipients","display_name":"kidney transplant recipients","score":0.7459999918937683},{"id":"https://openalex.org/keywords/urinary-tract-infection","display_name":"urinary tract infection","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.8960000276565552},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.7409999966621399},{"id":"https://openalex.org/keywords/kidney-tissue-damage","display_name":"kidney tissue damage","score":0.699999988079071},{"id":"https://openalex.org/keywords/infection-diagnosis","display_name":"infection diagnosis","score":0.5389999747276306},{"id":"https://openalex.org/keywords/metagenomics","display_name":"metagenomics","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.8522742986679077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7411218285560608},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.5170586705207825},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4810067117214203},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44988706707954407},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.43080294132232666},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.35367125272750854},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.32053834199905396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2352277934551239},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1875007152557373}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/648592","doi":"https://doi.org/10.1101/648592","is_oa":true,"landing_page_url":"https://doi.org/10.1101/648592","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/05/24/648592.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/648592","doi":"https://doi.org/10.1101/648592","is_oa":true,"landing_page_url":"https://doi.org/10.1101/648592","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/05/24/648592.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3146905352","display_name":"Precision monitoring of kidney transplants via single-cell and single-molecule sequencing","funder_award_id":"1dp2ai138242-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7285935397","display_name":"Graduate Reserach Fellowship Program (GRFP)","funder_award_id":"1144153","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7491476858","display_name":null,"funder_award_id":"DGE-1144153","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2946320310.pdf","grobid_xml":"https://content.openalex.org/works/W2946320310.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1270657610","https://openalex.org/W1496050929","https://openalex.org/W1509190140","https://openalex.org/W1745052598","https://openalex.org/W1859632889","https://openalex.org/W2000730994","https://openalex.org/W2010018187","https://openalex.org/W2012991226","https://openalex.org/W2014326574","https://openalex.org/W2035043466","https://openalex.org/W2038523604","https://openalex.org/W2048005397","https://openalex.org/W2049907774","https://openalex.org/W2055043387","https://openalex.org/W2067222383","https://openalex.org/W2084160423","https://openalex.org/W2099198339","https://openalex.org/W2100977485","https://openalex.org/W2101071606","https://openalex.org/W2102619694","https://openalex.org/W2103081012","https://openalex.org/W2106780559","https://openalex.org/W2108234281","https://openalex.org/W2110299641","https://openalex.org/W2124544563","https://openalex.org/W2126298009","https://openalex.org/W2131271579","https://openalex.org/W2132234884","https://openalex.org/W2137019479","https://openalex.org/W2139693494","https://openalex.org/W2151566934","https://openalex.org/W2153250619","https://openalex.org/W2157107905","https://openalex.org/W2166628353","https://openalex.org/W2169556367","https://openalex.org/W2170486072","https://openalex.org/W2170699755","https://openalex.org/W2186978757","https://openalex.org/W2202734965","https://openalex.org/W2222000795","https://openalex.org/W2239118478","https://openalex.org/W2247766769","https://openalex.org/W2273717373","https://openalex.org/W2298824325","https://openalex.org/W2337438739","https://openalex.org/W2436138214","https://openalex.org/W2479773785","https://openalex.org/W2549343567","https://openalex.org/W2553822231","https://openalex.org/W2589255237","https://openalex.org/W2593934358","https://openalex.org/W2734629565","https://openalex.org/W2786672974","https://openalex.org/W2805442283","https://openalex.org/W2807732072","https://openalex.org/W2889326414","https://openalex.org/W2890462206","https://openalex.org/W2900295924","https://openalex.org/W2911798461"],"related_works":["https://openalex.org/W2970394038","https://openalex.org/W2807732072","https://openalex.org/W6977351371","https://openalex.org/W3006410055","https://openalex.org/W3208366052","https://openalex.org/W2911798461","https://openalex.org/W4406949409","https://openalex.org/W7202190025","https://openalex.org/W4407693747","https://openalex.org/W4400380100"],"abstract_inverted_index":{"ABSTRACT":[0],"High-throughput":[1],"metagenomic":[2,15,168],"sequencing":[3,16,49,169],"offers":[4,199],"an":[5],"unbiased":[6],"approach":[7],"to":[8,29,36,56,70,81,145,157,166,197],"identify":[9],"pathogens":[10],"in":[11],"clinical":[12,173],"samples.":[13],"Conventional":[14],"however":[17],"does":[18],"not":[19],"integrate":[20],"information":[21],"about":[22],"the":[23,38,45,58,72,102,108,153,158,183,189,209,221],"host,":[24],"which":[25],"is":[26,195],"often":[27],"critical":[28],"distinguish":[30],"infection":[31,100,133],"from":[32,87,122],"infectious":[33],"disease,":[34],"and":[35,60,69,74,95,98,110,129,140,147,151,185,205,212],"assess":[37],"severity":[39],"of":[40,47,50,63,65,90,101,113,115,126,138,152,155,175,188,208,224],"disease.":[41],"Here,":[42],"we":[43,177],"explore":[44],"utility":[46],"high-throughput":[48],"cell-free":[51,67,117],"DNA":[52,118],"after":[53],"bisulfite":[54],"conversion":[55],"map":[57],"tissue":[59,111,142],"cell":[61,109],"types":[62,112],"origin":[64,114],"host-derived":[66],"DNA,":[68],"profile":[71,125],"bacterial":[73,97,148,184,204],"viral":[75,99,146,186,206],"metagenome.":[76],"We":[77,105,135],"applied":[78],"this":[79,179],"assay":[80,180,192],"51":[82],"urinary":[83,103,116,159,210],"cfDNA":[84],"isolates":[85],"collected":[86],"a":[88,200,218],"cohort":[89],"kidney":[91,139],"transplant":[92],"recipients":[93],"with":[94],"without":[96],"tract.":[104],"find":[106,136,178,214],"that":[107],"can":[119,213],"be":[120],"derived":[121],"its":[123],"genome-wide":[124],"methylation":[127],"marks,":[128],"strongly":[130],"depend":[131],"on":[132],"status.":[134],"evidence":[137],"bladder":[141],"damage":[143],"due":[144],"infection,":[149,176],"respectively,":[150],"recruitment":[154],"neutrophils":[156],"tract":[160],"during":[161],"infection.":[162],"Through":[163],"direct":[164],"comparison":[165],"conventional":[167],"as":[170,172,217],"well":[171],"tests":[174],"accurately":[181],"captures":[182],"composition":[187],"sample.":[190],"The":[191],"presented":[193],"here":[194],"straightforward":[196],"implement,":[198],"systems":[201],"view":[202],"into":[203],"infections":[207],"tract,":[211],"future":[215],"use":[216],"tool":[219],"for":[220],"differential":[222],"diagnosis":[223],"infections.":[225]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2019-05-29T00:00:00"}