{"id":"https://openalex.org/W2946194992","doi":"https://doi.org/10.1055/s-0039-1680831","title":"Measurement of Amount of Invaginated Membrane in Mammalian Platelets by Osmotically-Induced Spherocyte Formation","display_name":"Measurement of Amount of Invaginated Membrane in Mammalian Platelets by Osmotically-Induced Spherocyte Formation","publication_year":1977,"publication_date":"1977-01-01","ids":{"openalex":"https://openalex.org/W2946194992","doi":"https://doi.org/10.1055/s-0039-1680831","mag":"2946194992"},"language":"en","primary_location":{"id":"doi:10.1055/s-0039-1680831","doi":"https://doi.org/10.1055/s-0039-1680831","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0039-1680831","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1680831.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1680831.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078550670","display_name":"JOHN G. MILTON","orcid":"https://orcid.org/0000-0001-5037-2548","observed_orcids":["https://orcid.org/0000-0001-5037-2548"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John G. Milton","raw_affiliation_strings":["Department of Physiology, McGill University, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109096367","display_name":"M M Frojmovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M.M. Frojmovic","raw_affiliation_strings":["Department of Physiology, McGill University, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50780142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-swelling","display_name":"platelet swelling","score":0.8059999942779541},{"id":"https://openalex.org/keywords/osmotic-stress","display_name":"osmotic stress","score":0.7979999780654907},{"id":"https://openalex.org/keywords/lactate-dehydrogenase-release","display_name":"lactate dehydrogenase release","score":0.8930000066757202},{"id":"https://openalex.org/keywords/human-platelets","display_name":"human platelets","score":0.6520000100135803},{"id":"https://openalex.org/keywords/rabbit-platelets","display_name":"rabbit platelets","score":1.0}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.8381543159484863},{"id":"https://openalex.org/C117277713","wikidata":"https://www.wikidata.org/wiki/Q925744","display_name":"Tonicity","level":2,"score":0.654934823513031},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.6469042301177979},{"id":"https://openalex.org/C2779429693","wikidata":"https://www.wikidata.org/wiki/Q274959","display_name":"Distilled water","level":2,"score":0.589394211769104},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5682892203330994},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.542577862739563},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5410609841346741},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.5155934691429138},{"id":"https://openalex.org/C190481736","wikidata":"https://www.wikidata.org/wiki/Q6803639","display_name":"Mean platelet volume","level":3,"score":0.4749082326889038},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.32345855236053467},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27077221870422363},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.24771025776863098},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23294755816459656},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.22330856323242188},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.12751325964927673},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11418846249580383},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0039-1680831","doi":"https://doi.org/10.1055/s-0039-1680831","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0039-1680831","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1680831.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1055/s-0039-1680831","doi":"https://doi.org/10.1055/s-0039-1680831","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0039-1680831","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1680831.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2946194992.pdf","grobid_xml":"https://content.openalex.org/works/W2946194992.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2413799144","https://openalex.org/W4231047095","https://openalex.org/W4401241716","https://openalex.org/W946408251","https://openalex.org/W2288079052","https://openalex.org/W2946727057","https://openalex.org/W3004160978","https://openalex.org/W4234662952","https://openalex.org/W2009975603","https://openalex.org/W2025832700"],"abstract_inverted_index":{"Invaginated":[0],"membrane":[1,104],"of":[2,8,39,60,67,76,83,86,123,150,158,193,206,223],"the":[3,9,19,68,84,124,148,151,159,164,191,204,207,224],"surface-connected":[4],"canalicular":[5],"system":[6],"(SCCS)":[7],"resting":[10,208],"platelet":[11,179,209],"can":[12,210],"be":[13,211],"potentially":[14],"externalized.":[15],"We":[16],"have":[17],"estimated":[18,71,107,146],"SCCS":[20,194,205,225],"surface":[21,165,226],"area":[22,166],"by":[23,34,57,62,169],"carefully":[24],"swelling":[25,180],"platelets":[26,69],"in":[27,53],"hypotonic":[28],"media.":[29],"Platelets":[30],"were":[31,70,173],"osmotically":[32,182],"stressed":[33],"either":[35],"interfacing":[36],"a":[37,47,54,73,220],"drop":[38],"platelet-rich":[40],"plasma":[41],"(PRP)":[42],"with":[43,190],"distilled":[44],"water":[45],"on":[46],"siliconized":[48],"glass":[49],"slide":[50],"or":[51],"directly":[52],"test":[55],"tube":[56],"careful":[58],"additions":[59],"60-80%":[61],"volume":[63,149],"water.":[64],"Surface":[65],"areas":[66],"from":[72,108],"cinematographic":[74],"analysis":[75],"freely":[77],"rotating":[78],"platelets.":[79,177],"Within":[80],"five":[81],"minutes":[82],"addition":[85],"water,":[87],"large":[88,188],"smooth":[89],"spheres":[90,189],"(spherocytes)":[91],"are":[92],"formed.":[93],"Soluble,":[94],"cytoplasmic":[95],"lactate":[96],"dehydrogenase":[97],"activity":[98],"is":[99,145,153,200],"not":[100,113,137],"released":[101],"and":[102,135,162,214],"visible":[103],"damage":[105],"as":[106],"dark-field":[109],"microscopy":[110],"observations":[111],"does":[112],"occur":[114],"for":[115,175],"at":[116],"least":[117],"one":[118],"hour.":[119],"The":[120],"mean":[121],"value":[122],"spherocyte":[125,152,217],"diameters":[126],"was":[127],"3.9":[128],"\u00b1":[129],"0.6":[130],"um":[131],"(3":[132],"human":[133],"donors)":[134],"did":[136],"change":[138],"over":[139],"5":[140],"-":[141],"60":[142],"minutes.":[143],"It":[144],"that":[147,157,163],"~550%":[154],"greater":[155],"than":[156],"original":[160],"disc":[161],"has":[167,183],"increased":[168],"~300%.":[170],"Similar":[171],"results":[172],"obtained":[174],"rabbit":[176],"Since":[178],"induced":[181],"been":[184],"shown":[185],"to":[186],"yield":[187],"disappearance":[192],"(J.G.":[195],"White,":[196],"personal":[197],"communication),":[198],"it":[199],"concluded":[201],"that:":[202],"1)":[203],"easily":[212],"externalized,":[213],"2)":[215],"osmotic":[216],"formation":[218],"allows":[219],"quantitative":[221],"estimation":[222],"area.":[227]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-05-29T00:00:00"}