{"id":"https://openalex.org/W2946154731","doi":"https://doi.org/10.1055/s-0039-1683547","title":"Characterization of a glioma mouse model using multiparametric [18F]FET-PET-MRI","display_name":"Characterization of a glioma mouse model using multiparametric [18F]FET-PET-MRI","publication_year":2019,"publication_date":"2019-03-01","ids":{"openalex":"https://openalex.org/W2946154731","doi":"https://doi.org/10.1055/s-0039-1683547","mag":"2946154731"},"language":"en","primary_location":{"id":"doi:10.1055/s-0039-1683547","doi":"https://doi.org/10.1055/s-0039-1683547","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0039-1683547","pdf_url":null,"source":{"id":"https://openalex.org/S158897336","display_name":"Nuklearmedizin - NuclearMedicine","issn_l":"0029-5566","issn":["0029-5566","2567-6407"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310313753","host_organization_name":"Schattauer Verlag","host_organization_lineage":["https://openalex.org/P4310313753","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Schattauer Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuklearmedizin","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073646283","display_name":"S. Castaneda Vega","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Castaneda Vega","raw_affiliation_strings":["Uniklinikum T\u00fcbingen, Abteilung Nuklearmedizin und Klinische Molekulare Bildgebung, T\u00fcbingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinikum T\u00fcbingen, Abteilung Nuklearmedizin und Klinische Molekulare Bildgebung, T\u00fcbingen","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066583229","display_name":"Kristin Patzwaldt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K Patzwaldt","raw_affiliation_strings":["Uniklinikum T\u00fcbingen, Abteilung f\u00fcr Pr\u00e4klinischen Bildgebung und Radiopharmazie, T\u00fcbingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinikum T\u00fcbingen, Abteilung f\u00fcr Pr\u00e4klinischen Bildgebung und Radiopharmazie, T\u00fcbingen","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014119310","display_name":"Justyna Magdalena Przystal","orcid":"https://orcid.org/0000-0002-5574-8716","observed_orcids":["https://orcid.org/0000-0002-5574-8716"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Przystal","raw_affiliation_strings":["Uniklinikum T\u00fcbingen, Interdisziplin\u00e4re Sektion Neuroonkologie, T\u00fcbingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinikum T\u00fcbingen, Interdisziplin\u00e4re Sektion Neuroonkologie, T\u00fcbingen","institution_ids":["https://openalex.org/I4210094118","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Becker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Becker","raw_affiliation_strings":["Uniklinikum T\u00fcbingen, Interdisziplin\u00e4re Sektion Neuroonkologie, T\u00fcbingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinikum T\u00fcbingen, Interdisziplin\u00e4re Sektion Neuroonkologie, T\u00fcbingen","institution_ids":["https://openalex.org/I4210094118","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082667863","display_name":"FILIPPO C. MICHELOTTI","orcid":"https://orcid.org/0000-0002-2355-5119","observed_orcids":["https://orcid.org/0000-0002-2355-5119"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F Michelotti","raw_affiliation_strings":["Uniklinikum T\u00fcbingen, Abteilung f\u00fcr Pr\u00e4klinischen Bildgebung und Radiopharmazie, T\u00fcbingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinikum T\u00fcbingen, Abteilung f\u00fcr Pr\u00e4klinischen Bildgebung und Radiopharmazie, T\u00fcbingen","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073627821","display_name":"Andreas M. Schmid","orcid":"https://orcid.org/0000-0001-6483-8759","observed_orcids":["https://orcid.org/0000-0001-6483-8759"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Schmid","raw_affiliation_strings":["Uniklinikum T\u00fcbingen, Abteilung f\u00fcr Pr\u00e4klinischen Bildgebung und Radiopharmazie, T\u00fcbingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinikum T\u00fcbingen, Abteilung f\u00fcr Pr\u00e4klinischen Bildgebung und Radiopharmazie, T\u00fcbingen","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018788118","display_name":"Bernd J\u00fcrgen Pichler","orcid":"https://orcid.org/0000-0001-6784-5524","observed_orcids":["https://orcid.org/0000-0001-6784-5524"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B Pichler","raw_affiliation_strings":["Uniklinikum T\u00fcbingen, Abteilung f\u00fcr Pr\u00e4klinischen Bildgebung und Radiopharmazie, T\u00fcbingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinikum T\u00fcbingen, Abteilung f\u00fcr Pr\u00e4klinischen Bildgebung und Radiopharmazie, T\u00fcbingen","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091648075","display_name":"Ghazaleh Tabatabai","orcid":"https://orcid.org/0000-0002-3542-8782","observed_orcids":["https://orcid.org/0000-0002-3542-8782"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G Tabatabai","raw_affiliation_strings":["Uniklinikum T\u00fcbingen, Interdisziplin\u00e4re Sektion Neuroonkologie, T\u00fcbingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinikum T\u00fcbingen, Interdisziplin\u00e4re Sektion Neuroonkologie, T\u00fcbingen","institution_ids":["https://openalex.org/I4210094118","https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025657000","display_name":"Christian la Foug\u00e8re","orcid":"https://orcid.org/0000-0001-7519-0417","observed_orcids":["https://orcid.org/0000-0001-7519-0417"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C la Foug\u00e8re","raw_affiliation_strings":["Uniklinikum T\u00fcbingen, Abteilung Nuklearmedizin und Klinische Molekulare Bildgebung, T\u00fcbingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinikum T\u00fcbingen, Abteilung Nuklearmedizin und Klinische Molekulare Bildgebung, T\u00fcbingen","institution_ids":["https://openalex.org/I4210094118"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14751358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7324000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7324000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.20640000700950623,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/18f-fet-pet","display_name":"18F-FET PET","score":0.8289999961853027},{"id":"https://openalex.org/keywords/pet-mri","display_name":"PET/MRI","score":0.8579999804496765},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.4189999997615814},{"id":"https://openalex.org/keywords/gadolinium-enhancement","display_name":"gadolinium enhancement","score":0.656000018119812},{"id":"https://openalex.org/keywords/apparent-diffusion-coefficient","display_name":"apparent diffusion coefficient","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tumor-vascularization","display_name":"tumor vascularization","score":0.8209999799728394},{"id":"https://openalex.org/keywords/tumor-permeability","display_name":"tumor permeability","score":0.8220000267028809},{"id":"https://openalex.org/keywords/tumor-volume","display_name":"tumor volume","score":0.30300000309944153},{"id":"https://openalex.org/keywords/longitudinal-tumor-imaging","display_name":"longitudinal tumor imaging","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.769910454750061},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.6548020243644714},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49475306272506714},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.4920803904533386},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4845663607120514},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4762601852416992},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.4669422209262848},{"id":"https://openalex.org/C3017724952","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Pet imaging","level":3,"score":0.4316096901893616},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41096287965774536},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37143027782440186},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.3118963837623596},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.29611074924468994},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.19882172346115112},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16181737184524536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14027687907218933}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0039-1683547","doi":"https://doi.org/10.1055/s-0039-1683547","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0039-1683547","pdf_url":null,"source":{"id":"https://openalex.org/S158897336","display_name":"Nuklearmedizin - NuclearMedicine","issn_l":"0029-5566","issn":["0029-5566","2567-6407"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310313753","host_organization_name":"Schattauer Verlag","host_organization_lineage":["https://openalex.org/P4310313753","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Schattauer Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuklearmedizin","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7128681298","https://openalex.org/W2427680455","https://openalex.org/W2002509827","https://openalex.org/W4366485639","https://openalex.org/W2319226765","https://openalex.org/W4307263738","https://openalex.org/W3195677305","https://openalex.org/W2162272725","https://openalex.org/W2151806077","https://openalex.org/W2768054837"],"abstract_inverted_index":{"Ziel/Aim:":[0],"Glioblastoma":[1],"(GBM)":[2],"is":[3,242],"the":[4,10,29,43,57,61,72,134,139,154,180,197,235,240,264,272],"most":[5],"aggressive":[6],"malignant":[7],"tumor":[8,18,32,36,135,168,181,207],"of":[9,31,100,106,129,175,186,196,204,213,228,259,268],"brain":[11],"with":[12,85,167,271],"remarkably":[13],"reduced":[14],"survival.":[15],"Many":[16],"animal":[17],"models":[19],"have":[20],"been":[21],"designed":[22],"to":[23],"understand":[24],"glioma":[25],"development.":[26],"PET-MRI":[27],"allows":[28],"evaluation":[30,258],"progression":[33],"and":[34,56,69,104,115,136,170,230,234,245],"intrinsic":[35],"tissue":[37,261],"characteristics":[38],"in":[39,60,67,153,179,183,220,263],"vivoand":[40],"longitudinally.":[41],"Understanding":[42],"dependencies":[44],"between":[45],"multiple":[46],"imaging":[47],"parameters":[48],"provides":[49],"useful":[50],"information":[51],"regarding":[52],"early":[53],"therapy":[54],"response":[55],"time-dependent":[58],"changes":[59],"tumor.":[62,265],"Here,":[63],"we":[64],"modeled":[65],"GBM":[66,214,276],"mice":[68],"longitudinally":[70],"characterized":[71],"tumors":[73,146],"using":[74,90,125,215],"[":[75,91,119,176,187,231],"18":[76,92,120,177,188,232],"F]FET-PET-MRI.":[77],"Methodik/Methods:":[78],"Mice":[79],"(n":[80],"=":[81],"8)":[82],"intracranially":[83],"induced":[84],"Glioblastom":[86],"were":[87,123,131],"measured":[88],"weekly":[89],"F]FET-PET-MRI":[93],"(6":[94],"weeks).":[95],"The":[96,217,266],"acquisition":[97],"protocol":[98],"consisted":[99],"T1-weighted":[101],"images":[102],"pre-":[103],"post-administration":[105],"Gadovist,":[107],"T2-weighted":[108],"images,":[109],"Apparent":[110],"Diffusion":[111],"Coefficient":[112],"(ADC)":[113],"maps":[114],"dynamic":[116],"(45":[117],"min)":[118],"F]FET-PET.":[121],"Images":[122],"analyzed":[124],"Pmod":[126],"software.":[127],"Regions":[128],"interest":[130],"drawn":[132],"on":[133,138],"overlaid":[137],"coregistered":[140],"PET/MRI.":[141],"Ergebnisse/Results:":[142],"We":[143,210],"successfully":[144],"identified":[145],"4":[147,224],"weeks":[148],"post-injection.":[149],"Tumor":[150],"volumes":[151],"increased":[152,182],"following":[155],"2":[156],"weeks.":[157],"There":[158],"was":[159,190],"a":[160],"consistent":[161,218],"concentration":[162],"Gadovist":[163],"increment":[164,219],"that":[165,239],"correlated":[166],"growth":[169],"time.":[171,184],"Likewise,":[172],"%":[173],"ID/cc":[174],"F]FET":[178,189,233],"Deposition":[185],"also":[191],"confirmed":[192],"by":[193],"autoradiography.":[194],"Histology":[195],"surviving":[198],"animals":[199],"showed":[200],"permeability":[201],"through":[202],"identification":[203],"IgG":[205],"inside":[206],"vessels.":[208],"Schlussfolgerungen/Conclusions:":[209],"evaluated":[211],"development":[212],"PET-MRI.":[216],"volume":[221],"starting":[222],"at":[223],"weeks,":[225],"increasing":[226],"deposition":[227],"gadolinium":[229],"histological":[236],"results,":[237],"indicate":[238],"model":[241,270],"well":[243],"vascularized":[244,274],"highly":[246,273],"permeable.":[247],"Further":[248],"voxelwise":[249],"analysis":[250],"(including":[251],"ADC":[252],"maps)":[253],"will":[254],"likely":[255],"permit":[256],"further":[257],"different":[260],"populations":[262],"similarity":[267],"this":[269],"human":[275],"shows":[277],"potential":[278],"for":[279],"machine":[280],"learning":[281],"evaluations.":[282]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-05-29T00:00:00"}