{"id":"https://openalex.org/W2946079822","doi":"https://doi.org/10.1186/s12944-019-1044-1","title":"Plasmalogens and Alzheimer\u2019s disease: a review","display_name":"Plasmalogens and Alzheimer\u2019s disease: a review","publication_year":2019,"publication_date":"2019-04-16","ids":{"openalex":"https://openalex.org/W2946079822","doi":"https://doi.org/10.1186/s12944-019-1044-1","mag":"2946079822","pmid":"https://pubmed.ncbi.nlm.nih.gov/30992016","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6466717"},"language":"en","primary_location":{"id":"doi:10.1186/s12944-019-1044-1","doi":"https://doi.org/10.1186/s12944-019-1044-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12944-019-1044-1","pdf_url":"https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-019-1044-1","source":{"id":"https://openalex.org/S188748365","display_name":"Lipids in Health and Disease","issn_l":"1476-511X","issn":["1476-511X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids in Health and Disease","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-019-1044-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053436130","display_name":"Xiao Qun Su","orcid":"https://orcid.org/0000-0001-8178-406X","observed_orcids":["https://orcid.org/0000-0001-8178-406X"]},"institutions":[{"id":"https://openalex.org/I71270174","display_name":"Victoria University","ror":"https://ror.org/04j757h98","country_code":"AU","type":"education","lineage":["https://openalex.org/I71270174"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Xiao Q. Su","raw_affiliation_strings":["Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC, 8001, Australia. xiao.su@vu.edu.au","Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC, 8001, Australia"],"raw_orcid":"https://orcid.org/0000-0001-8178-406X","affiliations":[{"raw_affiliation_string":"Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC, 8001, Australia. xiao.su@vu.edu.au","institution_ids":["https://openalex.org/I71270174"]},{"raw_affiliation_string":"Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC, 8001, Australia","institution_ids":["https://openalex.org/I71270174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101541205","display_name":"Junming Wang","orcid":"https://orcid.org/0000-0002-2563-5200","observed_orcids":["https://orcid.org/0000-0002-2563-5200"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junming Wang","raw_affiliation_strings":["Department of Pathology, University of Mississippi Medical Centre, Jackson, MS, 39213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Mississippi Medical Centre, Jackson, MS, 39213, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018868735","display_name":"Andrew James Sinclair","orcid":"https://orcid.org/0000-0002-9515-9721","observed_orcids":["https://orcid.org/0000-0002-9515-9721"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew J. Sinclair","raw_affiliation_strings":["Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, VIC, 3800, Australia","Faculty of Health, Deakin University, Geelong, VIC, 3217, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, VIC, 3800, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Faculty of Health, Deakin University, Geelong, VIC, 3217, Australia","institution_ids":["https://openalex.org/I149704539"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5053436130"],"corresponding_institution_ids":["https://openalex.org/I71270174"],"apc_list":{"value":2040,"currency":"USD","value_usd":2040},"apc_paid":{"value":2040,"currency":"USD","value_usd":2040},"fwci":1.9897,"has_fulltext":true,"cited_by_count":177,"citation_normalized_percentile":{"value":0.89684625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"18","issue":"1","first_page":"100","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmalogens","display_name":"plasmalogens","score":0.972000002861023},{"id":"https://openalex.org/keywords/ethanolamine-plasmalogen","display_name":"ethanolamine plasmalogen","score":0.9419999718666077},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/phospholipids","display_name":"phospholipids","score":0.9089999794960022},{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.7160000205039978},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7760000228881836},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.7570000290870667},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/orphan-gpcrs","display_name":"orphan G protein-coupled receptor","score":0.8360000252723694},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.8619999885559082},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":1.0},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.8209999799728394},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.8960000276565552},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5264438390731812},{"id":"https://openalex.org/C39920043","wikidata":"https://www.wikidata.org/wiki/Q786278","display_name":"Neurochemistry","level":3,"score":0.5022082328796387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.496368944644928},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4907902181148529},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.46649953722953796},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4590195417404175},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.44641223549842834},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4305693507194519},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.427510142326355},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.39968258142471313},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.3608750104904175},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34458795189857483},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3305298686027527},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.29755425453186035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28552424907684326},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25836730003356934}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010955","descriptor_name":"Plasmalogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010955","descriptor_name":"Plasmalogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1186/s12944-019-1044-1","doi":"https://doi.org/10.1186/s12944-019-1044-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12944-019-1044-1","pdf_url":"https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-019-1044-1","source":{"id":"https://openalex.org/S188748365","display_name":"Lipids in Health and Disease","issn_l":"1476-511X","issn":["1476-511X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids in Health and Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5458333","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6466717","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6466717","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6466717","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids Health Dis","raw_type":"Text"},{"id":"pmid:30992016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30992016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids in health and disease","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.vu.edu.au:38387","doi":null,"is_oa":true,"landing_page_url":"https://vuir.vu.edu.au/38387/","pdf_url":"https://vuir.vu.edu.au/38387/","source":{"id":"https://openalex.org/S4306400215","display_name":"Victoria University Research Repository (Victoria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I41156924","host_organization_name":"Victoria University of Wellington","host_organization_lineage":["https://openalex.org/I41156924"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:dro.deakin.edu.au:DU:30153678","doi":null,"is_oa":false,"landing_page_url":"http://elements.deakin.edu.au/viewobject.html?id=239098&cid=1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401102","display_name":"Own your potential (DEAKIN)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149704539","host_organization_name":"Deakin University","host_organization_lineage":["https://openalex.org/I149704539"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:monash.edu:openaire/bbb21ee3-e053-4fc5-8cfd-f23b228390c3","doi":null,"is_oa":true,"landing_page_url":"https://research.monash.edu/en/publications/bbb21ee3-e053-4fc5-8cfd-f23b228390c3","pdf_url":null,"source":{"id":"https://openalex.org/S4306402625","display_name":"Monash University Research Portal (Monash University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I56590836","host_organization_name":"Monash University","host_organization_lineage":["https://openalex.org/I56590836"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Su, X Q, Wang, J & Sinclair, A J 2019, 'Plasmalogens and Alzheimer's disease : A review', Lipids in Health and Disease, vol. 18, no. 1, 100. https://doi.org/10.1186/s12944-019-1044-1","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:doaj.org/article:bb4bc6ffb1e44359a73308b75fc85c42","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bb4bc6ffb1e44359a73308b75fc85c42","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-10 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/20759971","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Plasmalogens_and_Alzheimer_s_disease_A_review/20759971","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12944-019-1044-1","doi":"https://doi.org/10.1186/s12944-019-1044-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12944-019-1044-1","pdf_url":"https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-019-1044-1","source":{"id":"https://openalex.org/S188748365","display_name":"Lipids in Health and Disease","issn_l":"1476-511X","issn":["1476-511X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids in Health and Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320976","display_name":"Victoria University","ror":"https://ror.org/04j757h98"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2946079822.pdf","grobid_xml":"https://content.openalex.org/works/W2946079822.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W7449367","https://openalex.org/W1491619276","https://openalex.org/W1560871346","https://openalex.org/W1564394754","https://openalex.org/W1716249017","https://openalex.org/W1799953022","https://openalex.org/W1846679411","https://openalex.org/W1966692685","https://openalex.org/W1966833346","https://openalex.org/W1967190893","https://openalex.org/W1967786181","https://openalex.org/W1967818306","https://openalex.org/W1968112386","https://openalex.org/W1982959887","https://openalex.org/W1985113736","https://openalex.org/W1986724957","https://openalex.org/W1993160420","https://openalex.org/W1993630867","https://openalex.org/W1994717869","https://openalex.org/W2000631247","https://openalex.org/W2002082959","https://openalex.org/W2002498042","https://openalex.org/W2010048722","https://openalex.org/W2016926967","https://openalex.org/W2025783037","https://openalex.org/W2025880887","https://openalex.org/W2029432224","https://openalex.org/W2034147064","https://openalex.org/W2034365997","https://openalex.org/W2038924076","https://openalex.org/W2041241825","https://openalex.org/W2053377648","https://openalex.org/W2056785199","https://openalex.org/W2064032283","https://openalex.org/W2068394909","https://openalex.org/W2068764038","https://openalex.org/W2071676030","https://openalex.org/W2075180304","https://openalex.org/W2079604770","https://openalex.org/W2084121214","https://openalex.org/W2086931624","https://openalex.org/W2087747373","https://openalex.org/W2089198803","https://openalex.org/W2113121774","https://openalex.org/W2113370504","https://openalex.org/W2117388188","https://openalex.org/W2118782534","https://openalex.org/W2124956869","https://openalex.org/W2128846833","https://openalex.org/W2137014450","https://openalex.org/W2137905820","https://openalex.org/W2140066914","https://openalex.org/W2142409356","https://openalex.org/W2144822024","https://openalex.org/W2145447463","https://openalex.org/W2147613942","https://openalex.org/W2155109894","https://openalex.org/W2166628970","https://openalex.org/W2166772109","https://openalex.org/W2176882881","https://openalex.org/W2235461737","https://openalex.org/W2299963540","https://openalex.org/W2335948454","https://openalex.org/W2409743725","https://openalex.org/W2471367613","https://openalex.org/W2524225904","https://openalex.org/W2529201238","https://openalex.org/W2591489876","https://openalex.org/W2765180668","https://openalex.org/W2800789084","https://openalex.org/W2802245552"],"related_works":["https://openalex.org/W2620145446","https://openalex.org/W2000631247","https://openalex.org/W7101042812","https://openalex.org/W2155109894","https://openalex.org/W1499036764","https://openalex.org/W7145678951","https://openalex.org/W3044563286","https://openalex.org/W1564394754","https://openalex.org/W2776408819","https://openalex.org/W2802676780"],"abstract_inverted_index":{"Growing":[0],"evidence":[1,91],"suggests":[2],"that":[3,77,94],"ethanolamine":[4],"plasmalogens":[5,47,167],"(PlsEtns),":[6],"a":[7,12,84,182],"subtype":[8],"of":[9,21,38,62,72,81,86,103,111,128,137,153],"phospholipids,":[10],"have":[11,23,121,175],"close":[13],"association":[14],"with":[15,33,46,156,166],"Alzheimer's":[16],"disease":[17],"(AD).":[18],"Decreased":[19],"levels":[20],"PlsEtns":[22,63,95,120,154],"been":[24,122],"commonly":[25],"found":[26,123],"in":[27,49,53,89,170],"AD":[28,50,65,188],"patients,":[29],"and":[30,36,52,105,139,190],"were":[31],"correlated":[32],"cognition":[34],"deficit":[35],"severity":[37],"disease.":[39],"Limited":[40],"studies":[41],"showed":[42,93],"positive":[43],"therapeutic":[44,184],"outcomes":[45],"interventions":[48],"subjects":[51],"rodents.":[54],"The":[55],"potential":[56,160,177],"mechanisms":[57],"underlying":[58],"the":[59,70,79,109,126,135,149,176],"beneficial":[60],"effects":[61],"on":[64],"may":[66,174],"be":[67,179],"related":[68],"to":[69,124,147,178,186],"reduction":[71],"\u03b3-secretase":[73],"activity,":[74],"an":[75],"enzyme":[76],"catalyzes":[78],"synthesis":[80],"\u03b2-amyloid":[82],"(A\u03b2),":[83],"hallmark":[85],"AD.":[87],"Emerging":[88],"vitro":[90],"also":[92],"prevented":[96],"neuronal":[97,132],"cell":[98],"death":[99,127],"by":[100],"enhancing":[101],"phosphorylation":[102],"AKT":[104],"ERK":[106],"signaling":[107],"through":[108,134],"activation":[110],"orphan":[112],"G-protein":[113],"coupled":[114],"receptor":[115],"(GPCR)":[116],"proteins.":[117],"In":[118],"addition,":[119],"suppress":[125],"primary":[129],"mouse":[130],"hippocampal":[131],"cells":[133],"inhibition":[136],"caspase-9":[138],"caspase-3":[140],"cleavages.":[141],"Further":[142],"in-depth":[143],"investigations":[144],"are":[145],"required":[146],"determine":[148],"signature":[150],"molecular":[151],"species":[152],"associated":[155],"AD,":[157],"hence":[158],"their":[159],"role":[161],"as":[162],"biomarkers.":[163],"Clinical":[164],"intervention":[165],"is":[168],"still":[169],"its":[171],"infancy":[172],"but":[173],"explored":[180],"for":[181],"novel":[183],"approach":[185],"correct":[187],"pathology":[189],"neural":[191],"function.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":27},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":30},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-05-29T00:00:00"}