{"id":"https://openalex.org/W2945859424","doi":"https://doi.org/10.3390/ijms20102372","title":"A PTPmu Biomarker is Associated with Increased Survival in Gliomas","display_name":"A PTPmu Biomarker is Associated with Increased Survival in Gliomas","publication_year":2019,"publication_date":"2019-05-14","ids":{"openalex":"https://openalex.org/W2945859424","doi":"https://doi.org/10.3390/ijms20102372","mag":"2945859424","pmid":"https://pubmed.ncbi.nlm.nih.gov/31091655","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6566278"},"language":"en","primary_location":{"id":"doi:10.3390/ijms20102372","doi":"https://doi.org/10.3390/ijms20102372","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20102372","pdf_url":"https://www.mdpi.com/1422-0067/20/10/2372/pdf?version=1557808093","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/20/10/2372/pdf?version=1557808093","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029930573","display_name":"Mette L. Johansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mette L. Johansen","raw_affiliation_strings":["Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106-4960, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106-4960, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072775584","display_name":"Jason A. Vincent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Vincent","raw_affiliation_strings":["Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106-4960, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106-4960, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031363682","display_name":"Haley R Gittleman","orcid":"https://orcid.org/0000-0002-6976-8777","observed_orcids":["https://orcid.org/0000-0002-6976-8777"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haley Gittleman","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021259867","display_name":"Sonya Craig","orcid":"https://orcid.org/0000-0002-2535-4951","observed_orcids":["https://orcid.org/0000-0002-2535-4951"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonya E. L. Craig","raw_affiliation_strings":["Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106-4960, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106-4960, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069650895","display_name":"Marta Couce","orcid":"https://orcid.org/0000-0002-9595-2586","observed_orcids":["https://orcid.org/0000-0002-9595-2586"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210119077","display_name":"University Hospitals Seidman Cancer Center","ror":"https://ror.org/02kb97560","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210119077"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marta Couce","raw_affiliation_strings":["Department of Neurological Surgery, University Hospitals of Cleveland, Seidman Cancer Center and Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University Hospitals of Cleveland, Seidman Cancer Center and Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210119077","https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089511408","display_name":"Andrew Edward Sloan","orcid":"https://orcid.org/0000-0001-9607-5063","observed_orcids":["https://orcid.org/0000-0001-9607-5063"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210119077","display_name":"University Hospitals Seidman Cancer Center","ror":"https://ror.org/02kb97560","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210119077"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew E. Sloan","raw_affiliation_strings":["Department of Neurological Surgery, University Hospitals of Cleveland, Seidman Cancer Center and Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University Hospitals of Cleveland, Seidman Cancer Center and Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210119077","https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051948022","display_name":"Jill S. Barnholtz\u2010Sloan","orcid":"https://orcid.org/0000-0001-6190-9304","observed_orcids":["https://orcid.org/0000-0001-6190-9304"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill S. Barnholtz-Sloan","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065482075","display_name":"Susann M. Brady\u2010Kalnay","orcid":"https://orcid.org/0000-0003-4635-4093","observed_orcids":["https://orcid.org/0000-0003-4635-4093"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susann M. Brady-Kalnay","raw_affiliation_strings":["Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106-4960, USA","Department of Neurosciences, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA"],"raw_orcid":"https://orcid.org/0000-0003-4635-4093","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106-4960, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Neurosciences, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065482075"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":0.412,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.6049252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"20","issue":"10","first_page":"2372","last_page":"2372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.7319999933242798},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9419999718666077},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8149999976158142},{"id":"https://openalex.org/keywords/proteolytic-fragments","display_name":"proteolytic fragments","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8889999985694885},{"id":"https://openalex.org/keywords/astrocytic-tumors","display_name":"astrocytic tumors","score":0.6449999809265137},{"id":"https://openalex.org/keywords/oligodendroglioma","display_name":"oligodendroglioma","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.855746865272522},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.8410897254943848},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.5783553719520569},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.46654462814331055},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.44966354966163635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4161335825920105},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.39257174730300903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37709683179855347},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35657116770744324},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35073208808898926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054623","descriptor_name":"Receptor-Like Protein Tyrosine Phosphatases, Class 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms20102372","doi":"https://doi.org/10.3390/ijms20102372","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20102372","pdf_url":"https://www.mdpi.com/1422-0067/20/10/2372/pdf?version=1557808093","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5547142","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6566278","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6566278","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6566278","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:31091655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31091655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b81bbe8048fd459e91641409df3dc99f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b81bbe8048fd459e91641409df3dc99f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 20, Iss 10, p 2372 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms20102372","doi":"https://doi.org/10.3390/ijms20102372","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20102372","pdf_url":"https://www.mdpi.com/1422-0067/20/10/2372/pdf?version=1557808093","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6399999856948853}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1137469073","display_name":"Hamamatsu Nanozoomer S60 Digital Whole Slide Scanner","funder_award_id":"1s10od024981-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1574313024","display_name":"A Novel Molecular Imaging Agent for Surgical Resection of Invasive Brain Tumors","funder_award_id":"R01CA217956","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2737633914","display_name":null,"funder_award_id":"P30 EY 11,373","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4918633610","display_name":"(PQC5) Detecting small clusters of tumor cells with a PTPmu probe","funder_award_id":"R01CA179956","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5713614895","display_name":"PTP mu Supresses Brain Tumor Cell Migration and Dispersal","funder_award_id":"R01NS051520","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6141520004","display_name":"Detecting invading glioma cells through in vivo molecular imaging of the cell sur","funder_award_id":"R01NS063971","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000862237","display_name":"Case Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA043703","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000887781","display_name":"CWRU NEI Vision Center Core Grant","funder_award_id":"P30EY011373","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306589","display_name":"Alex's Lemonade Stand Foundation for Childhood Cancer","ror":"https://ror.org/038ja4880"},{"id":"https://openalex.org/F4320311530","display_name":"Char and Chuck Fowler Family Foundation","ror":"https://ror.org/00wch0204"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2945859424.pdf","grobid_xml":"https://content.openalex.org/works/W2945859424.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W30336109","https://openalex.org/W1539113088","https://openalex.org/W1547034917","https://openalex.org/W1892053756","https://openalex.org/W1923635228","https://openalex.org/W1972922820","https://openalex.org/W1996908572","https://openalex.org/W2001247750","https://openalex.org/W2013563715","https://openalex.org/W2037492592","https://openalex.org/W2038964728","https://openalex.org/W2039512178","https://openalex.org/W2040827479","https://openalex.org/W2048796627","https://openalex.org/W2059452371","https://openalex.org/W2068480808","https://openalex.org/W2096287682","https://openalex.org/W2105528101","https://openalex.org/W2107007091","https://openalex.org/W2122157041","https://openalex.org/W2125372543","https://openalex.org/W2135465849","https://openalex.org/W2138137871","https://openalex.org/W2140292255","https://openalex.org/W2148977460","https://openalex.org/W2274473568","https://openalex.org/W2289602271","https://openalex.org/W2366536035","https://openalex.org/W2521224740","https://openalex.org/W2528360129","https://openalex.org/W2612175024","https://openalex.org/W2613341746","https://openalex.org/W2766456240","https://openalex.org/W2890863998","https://openalex.org/W2899135274","https://openalex.org/W4230172521","https://openalex.org/W6653785652","https://openalex.org/W6726068737"],"related_works":["https://openalex.org/W1923635228","https://openalex.org/W2162940190","https://openalex.org/W2081096522","https://openalex.org/W4200478028","https://openalex.org/W4288042289","https://openalex.org/W3158774833","https://openalex.org/W7214479158","https://openalex.org/W2338709534","https://openalex.org/W4399705658","https://openalex.org/W2417257317"],"abstract_inverted_index":{"An":[0],"integrated":[1],"approach":[2,17],"has":[3],"been":[4],"adopted":[5],"by":[6],"the":[7,20,51,72,83,98,102,107,140,155,198,202],"World":[8],"Health":[9],"Organization":[10],"(WHO)":[11],"for":[12,50,59,174],"diagnosing":[13],"brain":[14,39,78],"tumors.":[15,65],"This":[16],"relies":[18],"on":[19,177],"molecular":[21,219],"characterization":[22],"of":[23,54,85,97,117,154,162,193,197,208],"biopsied":[24],"tissue":[25,111],"in":[26,45,71,77,82,110,222],"conjunction":[27],"with":[28,146,159,167,170,211],"standard":[29],"histology.":[30],"Diffuse":[31],"gliomas":[32],"(grade":[33],"II":[34],"to":[35,57,91,200],"grade":[36,61],"IV":[37],"malignant":[38],"tumors)":[40],"have":[41],"a":[42,69,133,191],"wide":[43],"range":[44],"overall":[46],"survival,":[47],"from":[48],"months":[49,176],"worst":[52],"cases":[53],"glioblastoma":[55],"(GBM)":[56],"years":[58],"lower":[60],"astrocytic":[62],"and":[63,113,119,125,149,215],"oligodendroglial":[64],"We":[66,88,143],"previously":[67],"identified":[68],"change":[70],"cell":[73,94],"adhesion":[74],"molecule":[75],"PTPmu":[76,108,141,156,172,180,187,203],"tumors":[79],"that":[80,138,151],"results":[81],"generation":[84],"proteolytic":[86],"fragments.":[87],"developed":[89],"agents":[90],"detect":[92,201],"this":[93],"surface-associated":[95],"biomarker":[96,109,157,204],"tumor":[99,115],"microenvironment.":[100],"In":[101],"current":[103,218],"study,":[104],"we":[105],"evaluated":[106],"microarrays":[112],"individual":[114],"samples":[116],"adolescent":[118],"young":[120],"adult":[121,126],"(n":[122,127],"=":[123,128],"25)":[124],"69)":[129],"glioma":[130,163,209,223],"populations":[131],"using":[132],"fluorescent":[134],"histochemical":[135],"reagent,":[136],"SBK4-TR,":[137],"recognizes":[139],"biomarker.":[142],"correlated":[144],"staining":[145,189],"clinical":[147],"data":[148],"found":[150],"high":[152,171,188],"levels":[153],"correlate":[158],"increased":[160],"survival":[161,213],"patients,":[164],"including":[165],"those":[166],"GBM.":[168],"Patients":[169],"live":[173,183],"48":[175],"average,":[178],"whereas":[179],"low":[181],"patients":[182,210],"only":[184],"22":[185],"months.":[186],"indicates":[190],"doubling":[192],"patient":[194],"survival.":[195],"Use":[196],"agent":[199],"would":[205,216],"allow":[206],"differentiation":[207],"distinct":[212],"outcomes":[214],"complement":[217],"approaches":[220],"used":[221],"prognosis.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-05-29T00:00:00"}