{"id":"https://openalex.org/W29456049","doi":null,"title":"Regression of aggressive laryngeal papillomatosis with 13-cis-retinoic acid (accutane).","display_name":"Regression of aggressive laryngeal papillomatosis with 13-cis-retinoic acid (accutane).","publication_year":1986,"publication_date":"1986-04-01","ids":{"openalex":"https://openalex.org/W29456049","mag":"29456049","pmid":"https://pubmed.ncbi.nlm.nih.gov/3461133"},"language":"en","primary_location":{"id":"pmid:3461133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3461133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological response modifiers","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.escholarship.org/uc/item/7kj5v81f","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109356977","display_name":"David Samuel Alberts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D S Alberts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071856123","display_name":"Stanley W. Coulthard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S W Coulthard","raw_affiliation_strings":["University of Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060872059","display_name":"Frank Louis Meyskens","orcid":"https://orcid.org/0000-0002-8827-4334","observed_orcids":["https://orcid.org/0000-0002-8827-4334"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F L Meyskens","raw_affiliation_strings":["University of Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.4709,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.93173913,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"5","issue":"2","first_page":"124","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laryngeal-papillomatosis","display_name":"recurrent respiratory papillomatosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/isotretinoin","display_name":"isotretinoin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/antiproliferative-therapy","display_name":"antiproliferative therapy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/treatment-side-effects","display_name":"treatment side effects","score":0.652999997138977},{"id":"https://openalex.org/keywords/laser-surgery","display_name":"laser surgery","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.7827309370040894},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6315949559211731},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.5400389432907104},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.438234806060791},{"id":"https://openalex.org/C2777063820","wikidata":"https://www.wikidata.org/wiki/Q1223924","display_name":"Papillomatosis","level":2,"score":0.43761226534843445},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41201138496398926},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.39760714769363403},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32563257217407227},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32520490884780884},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26990649104118347},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23877683281898499},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08734175562858582},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07461932301521301}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010212","descriptor_name":"Papilloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010212","descriptor_name":"Papilloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010212","descriptor_name":"Papilloma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015474","descriptor_name":"Isotretinoin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053685","descriptor_name":"Laser Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:3461133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3461133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological response modifiers","raw_type":"Case Reports"},{"id":"pmh:qt7kj5v81f","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/7kj5v81f","pdf_url":"http://www.escholarship.org/uc/item/7kj5v81f","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alberts, DS; Coulthard, SW; & Meyskens, FL. (1986). Regression of aggressive laryngeal papillomatosis with 13-cis-retinoic acid (accutane).. J Biol Response Mod, 5(2), 124 - 128. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7kj5v81f","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt7kj5v81f","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7kj5v81f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of biological response modifiers, vol 5, iss 2","raw_type":"article"},{"id":"mag:29456049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3461133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:qt7kj5v81f","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/7kj5v81f","pdf_url":"http://www.escholarship.org/uc/item/7kj5v81f","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alberts, DS; Coulthard, SW; & Meyskens, FL. (1986). Regression of aggressive laryngeal papillomatosis with 13-cis-retinoic acid (accutane).. J Biol Response Mod, 5(2), 124 - 128. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7kj5v81f","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W29456049.pdf"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1693459658","https://openalex.org/W1702536112","https://openalex.org/W1930352112","https://openalex.org/W1983603085","https://openalex.org/W1990686237","https://openalex.org/W1999461060","https://openalex.org/W2014691397","https://openalex.org/W2050835301","https://openalex.org/W2089231734","https://openalex.org/W2096389716","https://openalex.org/W2098428600","https://openalex.org/W2112392941","https://openalex.org/W2115824015","https://openalex.org/W2122667446","https://openalex.org/W2126183519","https://openalex.org/W2128614409","https://openalex.org/W2129438524","https://openalex.org/W2151177248","https://openalex.org/W2153407613","https://openalex.org/W2157474179","https://openalex.org/W2275737843","https://openalex.org/W2292688512","https://openalex.org/W2296446840","https://openalex.org/W2322651497","https://openalex.org/W2592310224","https://openalex.org/W2596970432"],"related_works":["https://openalex.org/W2068308242","https://openalex.org/W1994627048","https://openalex.org/W5466098","https://openalex.org/W2005531922","https://openalex.org/W2468524888","https://openalex.org/W2318022518","https://openalex.org/W2410129655","https://openalex.org/W3091196724","https://openalex.org/W2013802037","https://openalex.org/W1981233673"],"abstract_inverted_index":{"Laryngeal":[0],"papillomatosis":[1],"often":[2],"involves":[3],"a":[4,82],"relentless":[5],"growth":[6],"of":[7,22,49,62,74],"papillomas":[8],"on":[9,26],"the":[10,63],"vocal":[11],"cords,":[12],"requiring":[13],"repeated":[14],"excisions":[15],"to":[16],"maintain":[17],"an":[18],"adequate":[19],"airway.":[20],"Because":[21],"its":[23],"antiproliferative":[24],"effects":[25,73],"epithelial":[27],"tissues,":[28],"13-cis-retinoic":[29],"acid":[30],"(0.5-2.0":[31],"mg/kd/day":[32],"p.o.)":[33],"was":[34,41],"used":[35],"in":[36,60,85],"five":[37],"patients":[38],"whose":[39],"disease":[40,50],"poorly":[42],"controlled":[43],"by":[44],"laser":[45],"beam":[46],"surgery.":[47],"Control":[48],"for":[51],"24+,":[52],"5+,":[53],"and":[54,68,78],"12":[55],"months":[56],"has":[57],"been":[58],"achieved":[59],"three":[61],"patients,":[64],"with":[65],"two":[66],"complete":[67],"one":[69],"partial":[70],"responses.":[71],"Side":[72],"treatment":[75],"were":[76],"mild":[77],"rapidly":[79],"reversible,":[80],"following":[81],"25-50%":[83],"reduction":[84],"drug":[86],"dose.":[87]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}