{"id":"https://openalex.org/W2945575889","doi":"https://doi.org/10.1055/s-0039-1687347","title":"The Relationship of the Quaternary Structure of Factor VIII to its Biological Activities","display_name":"The Relationship of the Quaternary Structure of Factor VIII to its Biological Activities","publication_year":1979,"publication_date":"1979-01-01","ids":{"openalex":"https://openalex.org/W2945575889","doi":"https://doi.org/10.1055/s-0039-1687347","mag":"2945575889"},"language":"en","primary_location":{"id":"doi:10.1055/s-0039-1687347","doi":"https://doi.org/10.1055/s-0039-1687347","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0039-1687347","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111695595","display_name":"Richard B. Counts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799735646","display_name":"Bloodworks Northwest","ror":"https://ror.org/00ek9j693","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799735646"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. B. Counts","raw_affiliation_strings":["Puget Sound Blood Center and University of Washington, Seattle, Washington, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Puget Sound Blood Center and University of Washington, Seattle, Washington, U.S.A","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I2799735646"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004243880","display_name":"Stefan L. Paskell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799735646","display_name":"Bloodworks Northwest","ror":"https://ror.org/00ek9j693","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799735646"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.L. Paskell","raw_affiliation_strings":["Puget Sound Blood Center and University of Washington, Seattle, Washington, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Puget Sound Blood Center and University of Washington, Seattle, Washington, U.S.A","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I2799735646"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23515982,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.1940000057220459,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-viii","display_name":"factor VIII","score":0.9980000257492065},{"id":"https://openalex.org/keywords/quaternary-structure","display_name":"quaternary structure","score":0.9629999995231628},{"id":"https://openalex.org/keywords/multimers","display_name":"multimers","score":0.7170000076293945},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.8500000238418579},{"id":"https://openalex.org/keywords/von-willebrand-factor-activity","display_name":"von Willebrand factor activity","score":0.6589999794960022},{"id":"https://openalex.org/keywords/clotting-activity","display_name":"clotting activity","score":0.6620000004768372},{"id":"https://openalex.org/keywords/antibody-mediated-inhibition","display_name":"antibody inhibition","score":0.5649999976158142},{"id":"https://openalex.org/keywords/platelet-binding","display_name":"platelet binding","score":0.7570000290870667},{"id":"https://openalex.org/keywords/ristocetin","display_name":"ristocetin","score":0.8740000128746033},{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.8970000147819519},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/protein-reduction","display_name":"protein reduction","score":0.6069999933242798},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C2776057759","wikidata":"https://www.wikidata.org/wiki/Q904599","display_name":"Ristocetin","level":4,"score":0.941780686378479},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.812076210975647},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7642104029655457},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.6868358850479126},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.602059543132782},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.552737295627594},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5292505621910095},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.501866340637207},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.484599232673645},{"id":"https://openalex.org/C7927669","wikidata":"https://www.wikidata.org/wiki/Q898529","display_name":"Protein quaternary structure","level":4,"score":0.4419032633304596},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.4384479820728302},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4181615114212036},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2240070402622223},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14072582125663757},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0039-1687347","doi":"https://doi.org/10.1055/s-0039-1687347","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0039-1687347","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2883404100","https://openalex.org/W2050166343","https://openalex.org/W7098981789","https://openalex.org/W6922309933","https://openalex.org/W1570269678","https://openalex.org/W2396817272","https://openalex.org/W2204334573","https://openalex.org/W2462325359","https://openalex.org/W2124357175","https://openalex.org/W2011210722"],"abstract_inverted_index":{"Purified":[0],"factor":[1,145,150,181],"VIII":[2,99,146,151,182],"exists":[3],"as":[4],"a":[5,16,162],"homologous":[6],"series":[7],"of":[8,18,32,57,64,88,110,137,159,164,180],"multimers":[9,58],"in":[10,107,156],"which":[11],"the":[12,19,33,37,55,65,85,89,108,115,157,177],"protomeric":[13],"unit":[14],"is":[15,51,60,79,92,120,128,183],"dimer":[17],"basic":[20],"subunit.":[21],"On":[22,135],"reduction":[23],"by":[24,94,141],"2-mercaptoethanol,":[25],"clotting":[26],"activity":[27,35,49,67,87,188],"(VIII:C)":[28],"persists":[29],"at":[30],"90%":[31],"initial":[34],"when":[36,68],"only":[38,69],"species":[39],"present":[40],"are":[41],"monomers":[42,70],"and":[43,59,71],"dimers.":[44],"In":[45],"contrast,":[46],"Von":[47],"Willebrand":[48],"(VIII:VWF)":[50],"lost":[52,81],"concurrently":[53],"with":[54,76,161],"disaggregation":[56],"decreased":[61],"to":[62,101,154,192],"5%":[63],"starting":[66],"dimers":[72],"remain.":[73],"VIII:Ag":[74],"reactivity":[75],"rabbit":[77],"antibody":[78],"Likewise":[80],"on":[82,130],"reduction,":[83],"but":[84,167,194],"VIII:C":[86,187],"reduced":[90],"protein":[91],"inhibitable":[93],"hemophilic":[95],"a-VIII":[96],"antibodies.":[97],"Unreduced":[98],"binds":[100,153],"fresh":[102],"or":[103,112,133,139],"formalin":[104],"fixed":[105],"platelets":[106,155,193],"presence":[109,158],"ristocetin":[111,138,160],"vancomycin.":[113],"Although":[114],"apparent":[116],"Ka":[117,163],"for":[118,186,190,198],"binding":[119,127,191],"high,":[121],"approximately":[122,165],"5":[123],"x":[124],"108":[125],"M-1,":[126],"dependent":[129],"an":[131],"excess":[132],"ristocetin.":[134],"removal":[136],"vancomycin":[140],"serial":[142],"dilution,":[143],"platelet-bound":[144],"readily":[147],"dissociates.":[148],"Reduced":[149],"also":[152],"108M-1,":[166],"does":[168],"not":[169,184],"cause":[170],"platelet":[171],"aggregation.":[172],"These":[173],"data":[174],"suggest":[175],"that":[176],"multimeric":[178],"structure":[179],"necessary":[185],"nor":[189],"may":[195],"be":[196],"important":[197],"VWF":[199],"platelet-aggregating":[200],"activity.":[201]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2019-05-29T00:00:00"}