{"id":"https://openalex.org/W2945394243","doi":"https://doi.org/10.1186/s13148-019-0663-8","title":"Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells","display_name":"Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells","publication_year":2019,"publication_date":"2019-05-06","ids":{"openalex":"https://openalex.org/W2945394243","doi":"https://doi.org/10.1186/s13148-019-0663-8","mag":"2945394243","pmid":"https://pubmed.ncbi.nlm.nih.gov/31060628","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6501426"},"language":"en","primary_location":{"id":"doi:10.1186/s13148-019-0663-8","doi":"https://doi.org/10.1186/s13148-019-0663-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-019-0663-8","pdf_url":"https://clinicalepigeneticsjournal.biomedcentral.com/counter/pdf/10.1186/s13148-019-0663-8","source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://clinicalepigeneticsjournal.biomedcentral.com/counter/pdf/10.1186/s13148-019-0663-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026721434","display_name":"Clemens Zwergel","orcid":"https://orcid.org/0000-0002-3097-0003","observed_orcids":["https://orcid.org/0000-0002-3097-0003"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Clemens Zwergel","raw_affiliation_strings":["Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049285248","display_name":"Micha\u00ebl Schnekenburger","orcid":"https://orcid.org/0000-0003-0550-9538","observed_orcids":["https://orcid.org/0000-0003-0550-9538"]},"institutions":[{"id":"https://openalex.org/I4210095859","display_name":"H\u00f4pital Kirchberg","ror":"https://ror.org/00t1xpx62","country_code":"LU","type":"healthcare","lineage":["https://openalex.org/I4210095859"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Michael Schnekenburger","raw_affiliation_strings":["Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer, H\u00f4pital Kirchberg, 9 rue Edward Steichen, L-2540, Luxembourg City, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer, H\u00f4pital Kirchberg, 9 rue Edward Steichen, L-2540, Luxembourg City, Luxembourg","institution_ids":["https://openalex.org/I4210095859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031650006","display_name":"Federica Sarno","orcid":"https://orcid.org/0000-0003-1871-1807","observed_orcids":["https://orcid.org/0000-0003-1871-1807"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Sarno","raw_affiliation_strings":["Department of Medicine of Precision, University of Studi della Campania Luigi Vanvitelli, Vico L. De Crecchio 7, 80138, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine of Precision, University of Studi della Campania Luigi Vanvitelli, Vico L. De Crecchio 7, 80138, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065735989","display_name":"Cecilia Battistelli","orcid":"https://orcid.org/0000-0002-5611-7377","observed_orcids":["https://orcid.org/0000-0002-5611-7377"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cecilia Battistelli","raw_affiliation_strings":["Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025533934","display_name":"Maria Cristina Manara","orcid":"https://orcid.org/0000-0001-5686-720X","observed_orcids":["https://orcid.org/0000-0001-5686-720X"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Cristina Manara","raw_affiliation_strings":["Laboratory of Experimental Oncology, IRCCS - Istituto Ortopedico Rizzoli, via di Barbiano, 1/10, Bologna, 40136, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Oncology, IRCCS - Istituto Ortopedico Rizzoli, via di Barbiano, 1/10, Bologna, 40136, Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038329456","display_name":"Giulia Stazi","orcid":"https://orcid.org/0000-0002-8550-0850","observed_orcids":["https://orcid.org/0000-0002-8550-0850"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Stazi","raw_affiliation_strings":["Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017199888","display_name":"Roberta Mazzone","orcid":"https://orcid.org/0000-0002-7923-0268","observed_orcids":["https://orcid.org/0000-0002-7923-0268"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Mazzone","raw_affiliation_strings":["Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060116402","display_name":"Rossella Fioravanti","orcid":"https://orcid.org/0000-0002-9329-8234","observed_orcids":["https://orcid.org/0000-0002-9329-8234"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rossella Fioravanti","raw_affiliation_strings":["Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008644081","display_name":"Christina Gros","orcid":"https://orcid.org/0000-0001-8869-9028","observed_orcids":["https://orcid.org/0000-0001-8869-9028"]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christina Gros","raw_affiliation_strings":["Center for High-Throughput Chemical Biology, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for High-Throughput Chemical Biology, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031452617","display_name":"Fr\u00e9deric Ausseil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143394","display_name":"Pierre Fabre (France)","ror":"https://ror.org/04hdhz511","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210143394"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Ausseil","raw_affiliation_strings":["Pierre Fabre Laboratories, 3 Avenue Hubert Curien, Toulouse, 31100, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pierre Fabre Laboratories, 3 Avenue Hubert Curien, Toulouse, 31100, France","institution_ids":["https://openalex.org/I4210143394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039049846","display_name":"Cristina Florean","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095859","display_name":"H\u00f4pital Kirchberg","ror":"https://ror.org/00t1xpx62","country_code":"LU","type":"healthcare","lineage":["https://openalex.org/I4210095859"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Cristina Florean","raw_affiliation_strings":["Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer, H\u00f4pital Kirchberg, 9 rue Edward Steichen, L-2540, Luxembourg City, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer, H\u00f4pital Kirchberg, 9 rue Edward Steichen, L-2540, Luxembourg City, Luxembourg","institution_ids":["https://openalex.org/I4210095859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023140151","display_name":"Angela Nebbioso","orcid":"https://orcid.org/0000-0001-5374-3527","observed_orcids":["https://orcid.org/0000-0001-5374-3527"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angela Nebbioso","raw_affiliation_strings":["Department of Medicine of Precision, University of Studi della Campania Luigi Vanvitelli, Vico L. De Crecchio 7, 80138, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine of Precision, University of Studi della Campania Luigi Vanvitelli, Vico L. De Crecchio 7, 80138, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017097584","display_name":"Raffaele Strippoli","orcid":"https://orcid.org/0000-0003-3483-8381","observed_orcids":["https://orcid.org/0000-0003-3483-8381"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaele Strippoli","raw_affiliation_strings":["Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy","National Institute for Infectious Diseases L. Spallanzani, IRCCS, Via Portuense, 292, Rome, 00149, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"National Institute for Infectious Diseases L. Spallanzani, IRCCS, Via Portuense, 292, Rome, 00149, Italy","institution_ids":["https://openalex.org/I4210091493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073677729","display_name":"Toshikazu Ushijima","orcid":"https://orcid.org/0000-0003-3405-7817","observed_orcids":["https://orcid.org/0000-0003-3405-7817"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshikazu Ushijima","raw_affiliation_strings":["Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015636061","display_name":"Katia Scotlandi","orcid":"https://orcid.org/0000-0001-6114-9499","observed_orcids":["https://orcid.org/0000-0001-6114-9499"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Katia Scotlandi","raw_affiliation_strings":["Laboratory of Experimental Oncology, IRCCS - Istituto Ortopedico Rizzoli, via di Barbiano, 1/10, Bologna, 40136, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Oncology, IRCCS - Istituto Ortopedico Rizzoli, via di Barbiano, 1/10, Bologna, 40136, Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017329858","display_name":"Marco Tripodi","orcid":"https://orcid.org/0000-0001-6135-971X","observed_orcids":["https://orcid.org/0000-0001-6135-971X"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Tripodi","raw_affiliation_strings":["Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy","National Institute for Infectious Diseases L. Spallanzani, IRCCS, Via Portuense, 292, Rome, 00149, Italy","Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"National Institute for Infectious Diseases L. Spallanzani, IRCCS, Via Portuense, 292, Rome, 00149, Italy","institution_ids":["https://openalex.org/I4210091493"]},{"raw_affiliation_string":"Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy","institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031964935","display_name":"Paola Barbara Arimondo","orcid":"https://orcid.org/0000-0001-5175-4396","observed_orcids":["https://orcid.org/0000-0001-5175-4396"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4210162100","display_name":"Department of Genomes & Genetics","ror":"https://ror.org/05etkex69","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I157536573","https://openalex.org/I4210096427","https://openalex.org/I4210162100"]},{"id":"https://openalex.org/I4387154210","display_name":"Chimie Biologique pour le Vivant","ror":"https://ror.org/03cjyj977","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I157536573","https://openalex.org/I4387154210"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Paola B. Arimondo","raw_affiliation_strings":["Epigenetic Chemical Biology, Institut Pasteur, CNRS UMR3523, 28 rue du Docteur Roux, Paris, 75724, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epigenetic Chemical Biology, Institut Pasteur, CNRS UMR3523, 28 rue du Docteur Roux, Paris, 75724, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I157536573","https://openalex.org/I4210162100","https://openalex.org/I4387154210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039682482","display_name":"Lucia Altucci","orcid":"https://orcid.org/0000-0002-7312-5387","observed_orcids":["https://orcid.org/0000-0002-7312-5387"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia Altucci","raw_affiliation_strings":["Department of Medicine of Precision, University of Studi della Campania Luigi Vanvitelli, Vico L. De Crecchio 7, 80138, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine of Precision, University of Studi della Campania Luigi Vanvitelli, Vico L. De Crecchio 7, 80138, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018593253","display_name":"Marc F. Diederich","orcid":"https://orcid.org/0000-0003-0115-4725","observed_orcids":["https://orcid.org/0000-0003-0115-4725"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Marc Diederich","raw_affiliation_strings":["Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, 08826, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, 08826, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012839091","display_name":"Antonello Mai","orcid":"https://orcid.org/0000-0001-9176-2382","observed_orcids":["https://orcid.org/0000-0001-9176-2382"]},"institutions":[{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Antonello Mai","raw_affiliation_strings":["Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy. antonello.mai@uniroma1.it","Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy. antonello.mai@uniroma1.it","Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy. antonello.mai@uniroma1.it","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy. antonello.mai@uniroma1.it","institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy","institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084101516","display_name":"S\u00e9rgio Valente","orcid":"https://orcid.org/0000-0002-2241-607X","observed_orcids":["https://orcid.org/0000-0002-2241-607X"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Sergio Valente","raw_affiliation_strings":["Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy. sergio.valente@uniroma1.it","Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2241-607X","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy. sergio.valente@uniroma1.it","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5012839091","https://openalex.org/A5084101516"],"corresponding_institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":2.328,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.89760809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"68","last_page":"68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.765999972820282},{"id":"https://openalex.org/keywords/quinoline-compounds","display_name":"quinoline compounds","score":0.7419999837875366},{"id":"https://openalex.org/keywords/dna-demethylation","display_name":"DNA demethylation","score":0.800000011920929},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.781000018119812},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.925000011920929},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.4699999988079071},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.7089999914169312},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2779277951","wikidata":"https://www.wikidata.org/wiki/Q5255196","display_name":"Demethylating agent","level":5,"score":0.7074708342552185},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6134577393531799},{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.5274356007575989},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4968161880970001},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.49070918560028076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4816702604293823},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.42847931385040283},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41858386993408203},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4176870882511139},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4164542853832245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38774511218070984},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.20144322514533997},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1626284122467041},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14086991548538208},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08546179533004761},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015257","descriptor_name":"DNA-Cytosine Methylases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s13148-019-0663-8","doi":"https://doi.org/10.1186/s13148-019-0663-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-019-0663-8","pdf_url":"https://clinicalepigeneticsjournal.biomedcentral.com/counter/pdf/10.1186/s13148-019-0663-8","source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},{"id":"pmid:31060628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31060628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical epigenetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6501426","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6501426/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Epigenetics","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-02383678v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-02383678","pdf_url":"https://hal.science/hal-02383678/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Epigenetics, 2019, 11 (1), pp.68. ⟨10.1186/s13148-019-0663-8⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1265927","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/1265927","pdf_url":"http://hdl.handle.net/11573/1265927","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unicampania.it:11591/406430","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/406430","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/153911","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/153911","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/s13148-019-0663-8","doi":"https://doi.org/10.1186/s13148-019-0663-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-019-0663-8","pdf_url":"https://clinicalepigeneticsjournal.biomedcentral.com/counter/pdf/10.1186/s13148-019-0663-8","source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1932638011","display_name":"Histone Lysine deMethylation: Structures, Inhibitions and Mechanisms","funder_award_id":"R01GM114306","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G727116197","display_name":null,"funder_award_id":"GCRC (2011-0030001)","funder_id":"https://openalex.org/F4320321292","funder_display_name":"Seoul National University"}],"funders":[{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321292","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322750","display_name":"Istituto Pasteur-Fondazione Cenci Bolognetti","ror":"https://ror.org/051v7w268"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320324022","display_name":"Action LIONS Vaincre le Cancer","ror":"https://ror.org/02cmtcb39"},{"id":"https://openalex.org/F4320326415","display_name":"Een H\u00e4erz fir kriibskrank Kanner","ror":"https://ror.org/04vn83f14"},{"id":"https://openalex.org/F4320326760","display_name":"Recherches Scientifiques Luxembourg","ror":"https://ror.org/0333e3w09"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2945394243.pdf","grobid_xml":"https://content.openalex.org/works/W2945394243.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1027568982","https://openalex.org/W1172536215","https://openalex.org/W1492602108","https://openalex.org/W1662652967","https://openalex.org/W1699926620","https://openalex.org/W1836388061","https://openalex.org/W1839314511","https://openalex.org/W1920034616","https://openalex.org/W1972019985","https://openalex.org/W1972635017","https://openalex.org/W1976273278","https://openalex.org/W1989175027","https://openalex.org/W1997109671","https://openalex.org/W2006500779","https://openalex.org/W2012601402","https://openalex.org/W2013154874","https://openalex.org/W2018366426","https://openalex.org/W2032743020","https://openalex.org/W2041231836","https://openalex.org/W2048389974","https://openalex.org/W2053213384","https://openalex.org/W2055770867","https://openalex.org/W2057602048","https://openalex.org/W2061819850","https://openalex.org/W2067126902","https://openalex.org/W2076333986","https://openalex.org/W2081052876","https://openalex.org/W2100645337","https://openalex.org/W2101292434","https://openalex.org/W2114127218","https://openalex.org/W2125126707","https://openalex.org/W2128188406","https://openalex.org/W2141419938","https://openalex.org/W2281539095","https://openalex.org/W2519953954","https://openalex.org/W2563296381","https://openalex.org/W2572628969","https://openalex.org/W2607048704","https://openalex.org/W2610682583","https://openalex.org/W2624193974","https://openalex.org/W2810908878","https://openalex.org/W2889989054"],"related_works":["https://openalex.org/W3006157349","https://openalex.org/W4416140746","https://openalex.org/W1172536215","https://openalex.org/W2941293438","https://openalex.org/W2901092878","https://openalex.org/W2225193452","https://openalex.org/W1023473612","https://openalex.org/W6940094946","https://openalex.org/W2087360288","https://openalex.org/W2006500779"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"DNA":[2],"methyltransferases":[3],"(DNMTs)":[4],"are":[5,49,63],"epigenetic":[6],"enzymes":[7],"involved":[8,415],"in":[9,33,104,117,122,130,164,259,288,321,355,382,405,416],"embryonic":[10],"development,":[11],"cell":[12,200,223,264,301,306,356,385,388,408],"differentiation,":[13],"epithelial":[14],"to":[15,108,217,221,253,317,339],"mesenchymal":[16],"transition,":[17],"and":[18,36,46,57,66,96,120,182,193,202,230,262,285,290,331,362,378,390,395],"control":[19],"of":[20,54,75,86,98,150,178,208,271,298,329,337,366,413],"gene":[21,115],"expression,":[22],"whose":[23],"overexpression":[24],"or":[25,233],"enhanced":[26,110],"catalytic":[27],"activity":[28,139,381],"has":[29],"been":[30],"widely":[31],"reported":[32],"cancer":[34,145,179,384],"initiation":[35],"progression.":[37],"To":[38],"date,":[39],"two":[40],"DNMT":[41,166],"inhibitors":[42],"(DNMTi),":[43],"5-azacytidine":[44],"(5-AZA)":[45],"5-aza-2\u2032-deoxycytidine":[47],"(DAC),":[48],"approved":[50],"for":[51,69],"the":[52,73,84,244,255,272,333,367,411],"treatment":[53,151,209],"myelodysplastic":[55],"syndromes":[56],"acute":[58,184],"myeloid":[59,185],"leukemia.":[60],"Nevertheless,":[61],"they":[62],"chemically":[64],"instable":[65],"quite":[67],"toxic":[68],"healthy":[70,222],"cells;":[71],"thus,":[72],"discovery":[74],"novel":[76,350],"DNMTi":[77,351],"is":[78],"urgent.":[79],"Results":[80],"Here,":[81],"we":[82],"report":[83],"identification":[85],"a":[87,93,123,136,161,175,296,349,353],"new":[88],"quinoline-based":[89],"molecule,":[90],"MC3353,":[91],"as":[92,335,348],"non-nucleoside":[94],"inhibitor":[95],"downregulator":[97],"DNMT.":[99],"This":[100],"compound":[101,159,268,401],"was":[102,171,250],"able,":[103],"promoter":[105],"demethylating":[106,357],"assays,":[107],"induce":[109],"green":[111],"fluorescence":[112],"protein":[113,257,286],"(EGFP)":[114],"expression":[116,328],"HCT116":[118,143,168,261,291],"cells":[119,146,180],"transcription":[121],"cytomegalovirus":[124],"(CMV)":[125],"promoter-driven":[126],"luciferase":[127],"reporter":[128],"system":[129],"KG-1":[131,231],"cells.":[132,169,292],"Moreover,":[133],"MC3353":[134,170,225,249,303,325,347,375],"displayed":[135,376],"strong":[137],"antiproliferative":[138,380],"when":[140],"tested":[141,294],"on":[142,174,295],"colon":[144],"after":[147,205],"48":[148,206],"h":[149,207],"at":[152,238],"0.5":[153],"\u03bcM.":[154,219,319],"At":[155],"higher":[156],"doses,":[157],"this":[158,267,400],"provided":[160,269],"cytotoxic":[162],"effect":[163],"double":[165],"knockout":[167],"also":[172,251],"screened":[173],"different":[176],"panel":[177,297],"(KG-1":[181],"U-937":[183,229],"leukemia,":[186],"RAJI":[187,236],"Burkitt\u2019s":[188],"lymphoma,":[189],"PC-3":[190,263,289],"prostate":[191],"cancer,":[192],"MDA-MB-231":[194],"breast":[195],"cancer),":[196],"where":[197],"it":[198],"arrested":[199],"proliferation":[201],"reduced":[203],"viability":[204],"with":[210,243,308],"IC":[211,312],"50":[212,313],"values":[213],"ranging":[214,314],"from":[215,315],"0.3":[216],"0.9":[218],"Compared":[220],"models,":[224,409],"induced":[226,326],"apoptosis":[227],"(e.g.,":[228,235],"cells)":[232,237],"necrosis":[234],"lower":[239],"concentrations.":[240],"Importantly,":[241],"together":[242],"main":[245],"DNMT3A":[246,256],"enzyme":[247],"inhibition,":[248],"able":[252],"downregulate":[254],"level":[258],"selected":[260],"lines.":[265],"Additionally,":[266],"impairment":[270],"epithelial-to-mesenchymal":[273],"transition":[274],"(EMT)":[275],"by":[276],"inducing":[277,387],"E-cadherin":[278,394],"while":[279],"reducing":[280],"matrix":[281,334],"metalloproteinase":[282],"(MMP2)":[283],"mRNA":[284],"levels":[287],"Last,":[293],"primary":[299,406],"osteosarcoma":[300,323,338,407],"lines,":[302],"markedly":[304],"inhibited":[305],"growth":[307],"low":[309],"single-digit":[310],"micromolar":[311],"1.1":[316],"2.4":[318],"Interestingly,":[320],"Saos-2":[322],"cells,":[324],"both":[327,360],"genes":[330,414],"mineralized":[332],"evidence":[336],"osteoblast":[340,417],"differentiation.":[341,418],"Conclusions":[342],"The":[343],"present":[344],"work":[345],"describes":[346],"displaying":[352],"stronger":[354],"ability":[358],"than":[359],"5-AZA":[361],"DAC,":[363],"providing":[364],"re-activation":[365],"silenced":[368],"ubiquitin":[369],"C-terminal":[370],"hydrolase":[371],"L1":[372],"(UCHL1)":[373],"gene.":[374],"dose-":[377],"time-dependent":[379],"several":[383],"types,":[386],"death":[389],"affecting":[391],"EMT":[392],"through":[393,410],"MMP2":[396],"modulation.":[397],"In":[398],"addition,":[399],"proved":[402],"efficacy":[403],"even":[404],"modulation":[412]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-05-29T00:00:00"}