{"id":"https://openalex.org/W2945355374","doi":null,"title":"Generation of reporter cell lines by genome editing to probe p53 activity","display_name":"Generation of reporter cell lines by genome editing to probe p53 activity","publication_year":2018,"publication_date":"2018-07-24","ids":{"openalex":"https://openalex.org/W2945355374","mag":"2945355374"},"language":"en","primary_location":{"id":"pmh:oai:research.sabanciuniv.edu:36630","doi":null,"is_oa":true,"landing_page_url":"https://research.sabanciuniv.edu/id/eprint/36630/1/10207827_NazifeTolay.pdf","pdf_url":"http://research.sabanciuniv.edu/36630/1/10207827_NazifeTolay.pdf","source":{"id":"https://openalex.org/S4306402254","display_name":"Sabanci University","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134235054","host_organization_name":"Sabanc\u0131 \u00dcniversitesi","host_organization_lineage":["https://openalex.org/I134235054"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://research.sabanciuniv.edu/36630/1/10207827_NazifeTolay.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064790692","display_name":"Nazife Tolay","orcid":"https://orcid.org/0000-0002-3295-4082","observed_orcids":["https://orcid.org/0000-0002-3295-4082"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nazife Tolay","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3295-4082","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5064790692"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9789999723434448},{"id":"https://openalex.org/keywords/reporter-cell-lines","display_name":"reporter cell lines","score":0.6809999942779541},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.7979999780654907},{"id":"https://openalex.org/keywords/transcription-activator-like-effector-nucleases","display_name":"TALEN","score":0.9950000047683716},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.8040000200271606},{"id":"https://openalex.org/keywords/p53-stabilization","display_name":"p53 stabilization","score":0.8579999804496765},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.9779999852180481},{"id":"https://openalex.org/keywords/p53-independent-cell-death","display_name":"p53-independent cell death","score":0.6740000247955322},{"id":"https://openalex.org/keywords/compound-screening","display_name":"compound screening","score":0.4779999852180481},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.7440000176429749},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.7015753388404846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5866301655769348},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5803425312042236},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.5510637164115906},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.44332951307296753},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.44124525785446167},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.415483295917511},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.41279205679893494},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.41215255856513977},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40307939052581787},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3793824315071106},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3713991045951843},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35696226358413696},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3562314510345459},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33628273010253906},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.325470507144928},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23511835932731628}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:research.sabanciuniv.edu:36630","doi":null,"is_oa":true,"landing_page_url":"https://research.sabanciuniv.edu/id/eprint/36630/1/10207827_NazifeTolay.pdf","pdf_url":"http://research.sabanciuniv.edu/36630/1/10207827_NazifeTolay.pdf","source":{"id":"https://openalex.org/S4306402254","display_name":"Sabanci University","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134235054","host_organization_name":"Sabanc\u0131 \u00dcniversitesi","host_organization_lineage":["https://openalex.org/I134235054"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2945355374","doi":null,"is_oa":false,"landing_page_url":"https://research.sabanciuniv.edu/36630/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:research.sabanciuniv.edu:36630","doi":null,"is_oa":true,"landing_page_url":"https://research.sabanciuniv.edu/id/eprint/36630/1/10207827_NazifeTolay.pdf","pdf_url":"http://research.sabanciuniv.edu/36630/1/10207827_NazifeTolay.pdf","source":{"id":"https://openalex.org/S4306402254","display_name":"Sabanci University","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134235054","host_organization_name":"Sabanc\u0131 \u00dcniversitesi","host_organization_lineage":["https://openalex.org/I134235054"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2945355374.pdf","grobid_xml":"https://content.openalex.org/works/W2945355374.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W25654050","https://openalex.org/W170859630","https://openalex.org/W1576330810","https://openalex.org/W1591281137","https://openalex.org/W1592021885","https://openalex.org/W1650797637","https://openalex.org/W1726030378","https://openalex.org/W1749960549","https://openalex.org/W1845461494","https://openalex.org/W1868102126","https://openalex.org/W1965086052","https://openalex.org/W1965296739","https://openalex.org/W1970540492","https://openalex.org/W1976261939","https://openalex.org/W1977393886","https://openalex.org/W1977686001","https://openalex.org/W1981702438","https://openalex.org/W1981890026","https://openalex.org/W1982259691","https://openalex.org/W1982545065","https://openalex.org/W1988877971","https://openalex.org/W1990479033","https://openalex.org/W1991494214","https://openalex.org/W1994394502","https://openalex.org/W1997557358","https://openalex.org/W1999843211","https://openalex.org/W2003634176","https://openalex.org/W2003971548","https://openalex.org/W2004311983","https://openalex.org/W2008553597","https://openalex.org/W2009668465","https://openalex.org/W2011361940","https://openalex.org/W2017168362","https://openalex.org/W2018385269","https://openalex.org/W2018614905","https://openalex.org/W2022416218","https://openalex.org/W2023486531","https://openalex.org/W2025722611","https://openalex.org/W2028553570","https://openalex.org/W2028704866","https://openalex.org/W2030430397","https://openalex.org/W2030738890","https://openalex.org/W2031135203","https://openalex.org/W2036632122","https://openalex.org/W2040068538","https://openalex.org/W2042119456","https://openalex.org/W2046241945","https://openalex.org/W2046780997","https://openalex.org/W2055595037","https://openalex.org/W2056530510","https://openalex.org/W2064330613","https://openalex.org/W2064645340","https://openalex.org/W2067368732","https://openalex.org/W2072951864","https://openalex.org/W2078308455","https://openalex.org/W2079852484","https://openalex.org/W2082979850","https://openalex.org/W2083731850","https://openalex.org/W2084481314","https://openalex.org/W2084831115","https://openalex.org/W2092675732","https://openalex.org/W2092722802","https://openalex.org/W2093775600","https://openalex.org/W2097616194","https://openalex.org/W2097933346","https://openalex.org/W2099907467","https://openalex.org/W2110143309","https://openalex.org/W2112006537","https://openalex.org/W2116755440","https://openalex.org/W2122563582","https://openalex.org/W2126679757","https://openalex.org/W2126832141","https://openalex.org/W2128060680","https://openalex.org/W2128680272","https://openalex.org/W2129905381","https://openalex.org/W2132291850","https://openalex.org/W2141529421","https://openalex.org/W2150206531","https://openalex.org/W2150583263","https://openalex.org/W2155782154","https://openalex.org/W2159907048","https://openalex.org/W2162527129","https://openalex.org/W2163565167","https://openalex.org/W2166475106","https://openalex.org/W2170494099","https://openalex.org/W2170622332","https://openalex.org/W2179681966","https://openalex.org/W2207370113","https://openalex.org/W2239370303","https://openalex.org/W2267596434","https://openalex.org/W2317877638","https://openalex.org/W2335459725","https://openalex.org/W2387064725","https://openalex.org/W2528458398","https://openalex.org/W2560306568","https://openalex.org/W2605051147"],"related_works":["https://openalex.org/W2035046405","https://openalex.org/W2005219014","https://openalex.org/W2948891087","https://openalex.org/W6989242614","https://openalex.org/W4308695860","https://openalex.org/W2039013619","https://openalex.org/W2050477636","https://openalex.org/W2107513289","https://openalex.org/W2026932801","https://openalex.org/W2059399904"],"abstract_inverted_index":{"The":[0,17,36],"p53":[1,18,39,49,63,76,164,202,223,228],"protein":[2,19,224],"is":[3,20,40,137],"defined":[4],"as":[5,12,95],"a":[6,13,104,143,147],"sequence-specific":[7],"transcription":[8],"factor":[9],"and":[10,34,50,57,71,108,171,203,257,263],"functions":[11,77],"tumor":[14,68],"suppressor":[15],"protein.":[16],"involved":[21],"in":[22,53,59,195,225],"diverse":[23],"cellular":[24],"processes":[25],"which":[26],"are":[27,64],"important":[28],"for":[29,86],"controlling":[30],"cell":[31,81,116,169,193,210],"cycle":[32],"arrest":[33],"apoptosis.":[35],"regulation":[37,61],"of":[38,62,75,106,128,156,163,175,182,189,201,213,238,242,270],"governed":[41],"by":[42,118,165],"an":[43,96,138],"autoregulatory":[44],"negative":[45],"feedback":[46],"loop":[47],"between":[48,255],"MDM2.":[51],"Mutations":[52],"the":[54,60,125,154,160,179,187,190,197,222,253],"TP53":[55],"gene":[56,105,145],"defects":[58],"mostly":[65],"associated":[66],"with":[67],"initiation,":[69],"invasion,":[70],"metastasis.":[72],"Therefore,":[73],"restoration":[74],"to":[78,99,102,109,123,141,267],"target":[79],"cancer":[80,87],"viability":[82,194],"has":[83],"been":[84,93],"used":[85,94],"therapy.":[88],"Genome":[89],"editing":[90,121,136],"techniques":[91],"have":[92],"effective":[97,139],"method":[98,140],"correct":[100],"mutations,":[101],"integrate":[103,142],"interest,":[107],"knock":[110],"out":[111],"genes.":[112],"We":[113,130,152,184,231],"generated":[114],"reporter":[115,144,168],"lines":[117,170],"using":[119,166],"genome":[120,135],"methods":[122],"probe":[124],"transcriptional":[126,161,180],"activation":[127],"p53.":[129,183,214,243,258,271],"showed":[131,205,232,246],"that":[132,173,206,218,233,247],"TALEN":[133],"induced":[134],"into":[146],"targeted":[148],"safe":[149],"harbor":[150],"site.":[151],"investigated":[153],"effects":[155,188],"various":[157],"compounds":[158,177,191,208,220,249],"on":[159,192],"activity":[162,181],"these":[167,176,207,248],"found":[172],"some":[174],"increased":[178],"also":[185],"analyzed":[186],"either":[196],"presence":[198],"or":[199],"absence":[200],"we":[204,216,245,261],"caused":[209],"death":[211],"independent":[212],"Additionally,":[215],"identified":[217],"all":[219],"stabilized":[221],"HCT":[226],"116":[227],"WT":[229],"cells.":[230],"this":[234],"stabilization":[235],"was":[236],"because":[237],"damage-induced":[239],"post-translational":[240],"modification":[241],"Lastly,":[244],"did":[250],"not":[251],"block":[252],"interaction":[254],"MDM2":[256],"In":[259],"summary,":[260],"developed":[262],"tested":[264],"screening":[265],"tools":[266],"identify":[268],"modifiers":[269]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-05-29T00:00:00"}
