{"id":"https://openalex.org/W2945276172","doi":null,"title":"THE ROLE OF PARAOXONASE-1 AND APOLIPOPROTEIN J IN GLUCOSE AND LIPID METABOLISM","display_name":"THE ROLE OF PARAOXONASE-1 AND APOLIPOPROTEIN J IN GLUCOSE AND LIPID METABOLISM","publication_year":2018,"publication_date":"2018-12-18","ids":{"openalex":"https://openalex.org/W2945276172","mag":"2945276172"},"language":"en","primary_location":{"id":"pmh:oai:run.unl.pt:10362/58214","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/58214","pdf_url":"http://hdl.handle.net/10362/58214","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10362/58214","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026759866","display_name":"Regina Diogo Silvestre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Regina Diogo Silvestre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5026759866"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paraoxonase-1","display_name":"paraoxonase 1","score":0.996999979019165},{"id":"https://openalex.org/keywords/clusterin","display_name":"clusterin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7300000190734863},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":1.0},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.800000011920929},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.734000027179718},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9739999771118164},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7369999885559082},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.8610000014305115},{"id":"https://openalex.org/keywords/oleic-acid","display_name":"oleic acid","score":0.925000011920929},{"id":"https://openalex.org/keywords/linoleic-acid","display_name":"linoleic acid","score":0.9089999794960022},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C2776509667","wikidata":"https://www.wikidata.org/wiki/Q7135605","display_name":"Paraoxonase","level":3,"score":0.8213456273078918},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.6592311859130859},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5425918102264404},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3934251070022583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3681119680404663},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35971927642822266},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35467880964279175},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29274892807006836},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1860204041004181},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.16180169582366943}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:run.unl.pt:10362/58214","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/58214","pdf_url":"http://hdl.handle.net/10362/58214","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:2945276172","doi":null,"is_oa":false,"landing_page_url":"https://run.unl.pt/handle/10362/58214","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:run.unl.pt:10362/58214","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/58214","pdf_url":"http://hdl.handle.net/10362/58214","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2945276172.pdf","grobid_xml":"https://content.openalex.org/works/W2945276172.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W90736706","https://openalex.org/W122221630","https://openalex.org/W140840762","https://openalex.org/W261298389","https://openalex.org/W1503760388","https://openalex.org/W1549241464","https://openalex.org/W1560417199","https://openalex.org/W1578820077","https://openalex.org/W1869060308","https://openalex.org/W1965470405","https://openalex.org/W1965712234","https://openalex.org/W1966902937","https://openalex.org/W1968380136","https://openalex.org/W1971256051","https://openalex.org/W1973358400","https://openalex.org/W1976945780","https://openalex.org/W1981463133","https://openalex.org/W1992304595","https://openalex.org/W1993618969","https://openalex.org/W1997004368","https://openalex.org/W1997425045","https://openalex.org/W2000054651","https://openalex.org/W2000977514","https://openalex.org/W2002209677","https://openalex.org/W2009399634","https://openalex.org/W2010220662","https://openalex.org/W2019906171","https://openalex.org/W2020659754","https://openalex.org/W2025679035","https://openalex.org/W2028376971","https://openalex.org/W2029195391","https://openalex.org/W2029532167","https://openalex.org/W2030218056","https://openalex.org/W2031084334","https://openalex.org/W2035648934","https://openalex.org/W2038961236","https://openalex.org/W2044349160","https://openalex.org/W2054877510","https://openalex.org/W2055787050","https://openalex.org/W2057505049","https://openalex.org/W2061717797","https://openalex.org/W2061979642","https://openalex.org/W2065537179","https://openalex.org/W2065612971","https://openalex.org/W2072754176","https://openalex.org/W2076921335","https://openalex.org/W2085181720","https://openalex.org/W2085339189","https://openalex.org/W2088720117","https://openalex.org/W2090778569","https://openalex.org/W2092913820","https://openalex.org/W2096979086","https://openalex.org/W2099040294","https://openalex.org/W2101154649","https://openalex.org/W2103116278","https://openalex.org/W2105359426","https://openalex.org/W2107568348","https://openalex.org/W2112291880","https://openalex.org/W2113939070","https://openalex.org/W2122751858","https://openalex.org/W2123094796","https://openalex.org/W2123960992","https://openalex.org/W2126998088","https://openalex.org/W2128171635","https://openalex.org/W2133472518","https://openalex.org/W2135943330","https://openalex.org/W2140434971","https://openalex.org/W2145329746","https://openalex.org/W2146561547","https://openalex.org/W2149946290","https://openalex.org/W2153997209","https://openalex.org/W2198349818","https://openalex.org/W2278793656","https://openalex.org/W2396563432","https://openalex.org/W2405907603","https://openalex.org/W2528211973","https://openalex.org/W2582042944","https://openalex.org/W2604219750","https://openalex.org/W2604465176","https://openalex.org/W2607266784","https://openalex.org/W2763977964","https://openalex.org/W4318471892"],"related_works":["https://openalex.org/W2969936136","https://openalex.org/W2109620299","https://openalex.org/W4416042759","https://openalex.org/W2571532757","https://openalex.org/W2158953418","https://openalex.org/W2529878147","https://openalex.org/W2088069985","https://openalex.org/W2138262220","https://openalex.org/W7167571194","https://openalex.org/W2087531586"],"abstract_inverted_index":{"In":[0],"the":[1,93,103,126,166,189],"last":[2],"decades,":[3],"some":[4,99,175],"metabolic":[5,62,74,90,199,273],"diseases":[6,63,91,109],"became":[7],"a":[8,120,147,152,171,205],"serious":[9],"problem":[10],"worldwide":[11],"whose":[12],"prevalence":[13],"has":[14],"been":[15],"growth":[16],"at":[17],"an":[18],"alarming":[19],"rate.":[20],"The":[21,180,225],"exponential":[22],"increase":[23],"of":[24,27,38,59,89,95,98,105,108,155,174,182,194,207,211,219],"this":[25,106,183],"type":[26,107],"disease":[28,55],"is":[29,119,146,159,186],"highly":[30],"related":[31],"with":[32,72,151],"globalization,":[33],"sedentarism":[34],"and":[35,45,51,67,82,86,114,128,143,168,191,196,241,269],"high":[36],"intake":[37],"processed":[39],"food":[40],"rich":[41],"in":[42,64,102,125,162,198,216,237,260,272],"saturated":[43],"fat":[44],"cholesterol.":[46],"Obesity,":[47],"diabetes":[48],"mellitus":[49],"(DM)":[50],"non-alcoholic":[52],"fatty":[53],"liver":[54,127,167],"(NAFLD)":[56],"are":[57,264],"examples":[58],"more":[60],"common":[61],"actual":[65],"society":[66],"appear":[68],"to":[69,187,234,239,258,266],"be":[70,130,223,235],"associated":[71],"severe":[73],"complications":[75],"such":[76,110],"as":[77,111,204],"hyperglycemia,":[78],"insulin":[79,220],"resistance":[80,221],"(IR)":[81],"dyslipidemia.":[83],"Inflammatory":[84],"status":[85],"oxidation":[87],"characteristic":[88],"highlights":[92],"importance":[94],"antioxidant":[96,190],"properties":[97],"endogenous":[100],"enzymes":[101],"progression":[104],"paraoxonase-1":[112],"(PON1)":[113],"apolipoprotein":[115],"J":[116],"(ApoJ).":[117],"PON1":[118,195,245,270],"43":[121],"kDa":[122],"glycoprotein":[123],"express":[124],"can":[129,202],"modulated":[131],"by":[132],"various":[133,163],"external":[134],"factors":[135],"including":[136,165],"diet":[137],"increasing":[138],"or":[139],"attenuating":[140],"its":[141],"activity":[142],"expression.":[144],"ApoJ":[145,158,197,230,254,268],"sulfated":[148],"heterodimeric":[149],"protein":[150,231,255],"molecular":[153],"weight":[154],"75-80":[156],"kDa.":[157],"ubiquitously":[160],"expressed":[161],"tissues":[164],"acts":[169],"like":[170],"cytoprotective":[172],"chaperone":[173],"antioxidants":[176],"enzyme":[177],"named":[178],"PON1.":[179],"objective":[181],"experimental":[184],"work":[185],"elucidate":[188,267],"anti-inflammatory":[192],"role":[193],"diseases,":[200],"that":[201,229,253],"act":[203],"form":[206],"diagnostic":[208],"and/or":[209],"treatment":[210],"inflammatory":[212],"diseases.":[213,274],"For":[214],"this,":[215],"vitro":[217],"models":[218],"will":[222],"used.":[224],"obtained":[226],"results":[227],"suggest":[228],"levels":[232,246,256],"seems":[233],"increased":[236],"response":[238],"oleic":[240],"linoleic":[242],"acid,":[243],"while":[244],"were":[247],"unchanged.":[248],"Furthermore,":[249],"it":[250],"was":[251],"observed":[252],"tend":[257],"decrease":[259],"hyperglycemia.":[261],"Further":[262],"works":[263],"needed":[265],"roles":[271]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-05-29T00:00:00"}
