{"id":"https://openalex.org/W2944880284","doi":"https://doi.org/10.18632/aging.101977","title":"A small molecular inhibitor of LRRK1 identified by homology modeling and virtual screening suppresses osteoclast function, but not osteoclast differentiation, in vitro","display_name":"A small molecular inhibitor of LRRK1 identified by homology modeling and virtual screening suppresses osteoclast function, but not osteoclast differentiation, in vitro","publication_year":2019,"publication_date":"2019-05-21","ids":{"openalex":"https://openalex.org/W2944880284","doi":"https://doi.org/10.18632/aging.101977","mag":"2944880284","pmid":"https://pubmed.ncbi.nlm.nih.gov/31113907","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6555463"},"language":"en","primary_location":{"id":"doi:10.18632/aging.101977","doi":"https://doi.org/10.18632/aging.101977","is_oa":false,"landing_page_url":"https://doi.org/10.18632/aging.101977","pdf_url":null,"source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6555463","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002588085","display_name":"Ming-Jue Si","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingjue Si","raw_affiliation_strings":["Department of Medicine, Loma Linda University, Loma Linda, CA 92350, USA","Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Loma Linda University, Loma Linda, CA 92350, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050528887","display_name":"Canjun Zeng","orcid":"https://orcid.org/0000-0003-3693-5900","observed_orcids":["https://orcid.org/0000-0003-3693-5900","https://orcid.org/0009-0003-1579-5838"]},"institutions":[{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Canjun Zeng","raw_affiliation_strings":["Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China","Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210088873"]},{"raw_affiliation_string":"Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Helen Goodluck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen Goodluck","raw_affiliation_strings":["Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069763323","display_name":"Sandi Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandi Shen","raw_affiliation_strings":["Department of Medicine, Loma Linda University, Loma Linda, CA 92350, USA","Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Loma Linda University, Loma Linda, CA 92350, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054497725","display_name":"Subburaman Mohan","orcid":"https://orcid.org/0000-0003-0063-986X","observed_orcids":["https://orcid.org/0000-0003-0063-986X"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subburaman Mohan","raw_affiliation_strings":["Department of Medicine, Loma Linda University, Loma Linda, CA 92350, USA","Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Loma Linda University, Loma Linda, CA 92350, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043544940","display_name":"Weirong Xing","orcid":"https://orcid.org/0000-0003-3984-2427","observed_orcids":["https://orcid.org/0000-0003-3984-2427"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Weirong Xing","raw_affiliation_strings":["Department of Medicine, Loma Linda University, Loma Linda, CA 92350, USA","Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Loma Linda University, Loma Linda, CA 92350, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA","institution_ids":["https://openalex.org/I4210116750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043544940"],"corresponding_institution_ids":["https://openalex.org/I26347476","https://openalex.org/I4210116750"],"apc_list":null,"apc_paid":null,"fwci":0.3307,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.51556038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"10","first_page":"3250","last_page":"3261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lrrk1","display_name":"LRRK1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.7080000042915344},{"id":"https://openalex.org/keywords/osteoclast-function","display_name":"osteoclast function","score":0.8930000066757202},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8339999914169312},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.972000002861023},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.7749999761581421},{"id":"https://openalex.org/keywords/sealing-zone","display_name":"sealing zone","score":0.9589999914169312},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"homology modeling","score":0.7480000257492065},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"virtual screening","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.7751345634460449},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7448284029960632},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6667788624763489},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5171146392822266},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4914759397506714},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4680333435535431},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.4467146396636963},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4046025574207306},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34302768111228943},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31639981269836426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17543843388557434}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.18632/aging.101977","doi":"https://doi.org/10.18632/aging.101977","is_oa":false,"landing_page_url":"https://doi.org/10.18632/aging.101977","pdf_url":null,"source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6555463","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6555463","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"},{"id":"pmid:31113907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31113907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6555463","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6555463","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7327659168","display_name":"Mechanisms of Lrrk1 Regulation of Osteoclast Function","funder_award_id":"R21AR066831","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8654601881","display_name":"Development of Small Molecular Weight Inhibitors of Lrrk1 for Treatment of Osteoporosis.","funder_award_id":"R21AR072831","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320311429","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1550981108","https://openalex.org/W1649237061","https://openalex.org/W1974976392","https://openalex.org/W1987057890","https://openalex.org/W1989306241","https://openalex.org/W2001881294","https://openalex.org/W2002022697","https://openalex.org/W2014582878","https://openalex.org/W2025506781","https://openalex.org/W2036508612","https://openalex.org/W2039712973","https://openalex.org/W2049219019","https://openalex.org/W2053586178","https://openalex.org/W2054976402","https://openalex.org/W2056727307","https://openalex.org/W2061043362","https://openalex.org/W2069079627","https://openalex.org/W2074407062","https://openalex.org/W2076174549","https://openalex.org/W2084966484","https://openalex.org/W2096023552","https://openalex.org/W2097855124","https://openalex.org/W2102450254","https://openalex.org/W2117227053","https://openalex.org/W2124681346","https://openalex.org/W2135327653","https://openalex.org/W2137901394","https://openalex.org/W2138315303","https://openalex.org/W2152301430","https://openalex.org/W2162175212","https://openalex.org/W2165355919","https://openalex.org/W2166569849","https://openalex.org/W2327919514","https://openalex.org/W2466125837","https://openalex.org/W2606690009","https://openalex.org/W2647171660","https://openalex.org/W4298861265"],"related_works":["https://openalex.org/W2042546270","https://openalex.org/W3142341337","https://openalex.org/W2048694243","https://openalex.org/W2036876657","https://openalex.org/W2598121181","https://openalex.org/W2534042392","https://openalex.org/W2356577521","https://openalex.org/W3119435459","https://openalex.org/W2112216791","https://openalex.org/W2518221906"],"abstract_inverted_index":{"pulldown":[0],"assay.":[1],"In":[2],"differentiation":[3],"and":[4,22,49,62,74,91],"pit":[5],"assays,":[6],"while":[7],"the":[8,89],"number":[9],"of":[10,26,37,125],"OCs":[11,18,27,69,84],"on":[12,39,99,107,113,133],"bone":[13,40,100],"slices":[14,41],"were":[15],"comparable":[16],"for":[17],"treated":[19],"with":[20,130],"IN04":[21,24,102,120],"DMSO,":[23],"treatment":[25,103],"significantly":[28],"impaired":[29],"their":[30],"ability":[31],"to":[32,56,94],"resorb":[33],"bone.":[34],"The":[35],"area":[36],"pits":[38,59],"was":[42],"reduced":[43],"by":[44],"43%":[45],"at":[46,51],"5":[47],"\u03bcM":[48,53],"83%":[50],"10":[52],"as":[54],"compared":[55],"DMSO.":[57],"Individual":[58],"appeared":[60],"smaller":[61],"shallower.":[63],"F-actin":[64,75,87,92],"staining":[65],"revealed":[66],"that":[67],"DMSO-treated":[68],"displayed":[70],"clear":[71],"actin":[72],"rings,":[73],"forms":[76],"a":[77,96,122],"peripheral":[78],"sealing":[79,97],"zone.":[80],"By":[81],"contrast,":[82],"IN04-treated":[83],"showed":[85],"disarranged":[86],"in":[88],"cytoplasm,":[90],"failed":[93],"form":[95],"zone":[98],"slices.":[101],"had":[104],"no":[105,131],"effects":[106],"OC-derived":[108],"coupling":[109],"factor":[110],"production":[111],"nor":[112],"osteoblast":[114],"nodule":[115],"formation.":[116,135],"Our":[117],"data":[118],"indicate":[119],"is":[121],"potent":[123],"inhibitor":[124],"LRRK1,":[126],"suppressing":[127],"OC":[128,134],"function":[129],"effect":[132]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-05-29T00:00:00"}
