{"id":"https://openalex.org/W2944622809","doi":"https://doi.org/10.1093/jmcb/mjz029","title":"In vitro 3D phenotypic drug screen identifies celastrol as an effectivein vivoinhibitor of polycystic kidney disease","display_name":"In vitro 3D phenotypic drug screen identifies celastrol as an effectivein vivoinhibitor of polycystic kidney disease","publication_year":2019,"publication_date":"2019-04-26","ids":{"openalex":"https://openalex.org/W2944622809","doi":"https://doi.org/10.1093/jmcb/mjz029","mag":"2944622809","pmid":"https://pubmed.ncbi.nlm.nih.gov/31065693","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7683017"},"language":"en","primary_location":{"id":"doi:10.1093/jmcb/mjz029","doi":"https://doi.org/10.1093/jmcb/mjz029","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jmcb/mjz029","pdf_url":"https://academic.oup.com/jmcb/article-pdf/doi/10.1093/jmcb/mjz029/30342809/mjz029.pdf","source":{"id":"https://openalex.org/S14311075","display_name":"Journal of Molecular Cell Biology","issn_l":"1674-2788","issn":["1674-2788","1759-4685"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/jmcb/article-pdf/doi/10.1093/jmcb/mjz029/30342809/mjz029.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008481276","display_name":"Tijmen H. Booij","orcid":"https://orcid.org/0000-0002-7478-4704","observed_orcids":["https://orcid.org/0000-0002-7478-4704"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405254007","display_name":"NEXUS Personalized Health Technologies","ror":"https://ror.org/01a83vw07","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405254007"]}],"countries":["CH","NL"],"is_corresponding":false,"raw_author_name":"Tijmen H Booij","raw_affiliation_strings":["Division of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands","NEXUS Personalized Health Technologies, ETH Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-7478-4704","affiliations":[{"raw_affiliation_string":"Division of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"NEXUS Personalized Health Technologies, ETH Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405254007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053368569","display_name":"Wouter N. Leonhard","orcid":"https://orcid.org/0000-0002-6286-4424","observed_orcids":["https://orcid.org/0000-0002-6286-4424"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wouter N Leonhard","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040844297","display_name":"Hester Bange","orcid":"https://orcid.org/0009-0003-9750-5186","observed_orcids":["https://orcid.org/0009-0003-9750-5186"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hester Bange","raw_affiliation_strings":["OcellO B.V., Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OcellO B.V., Leiden, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088282459","display_name":"Kuan Yan","orcid":"https://orcid.org/0000-0003-4143-3569","observed_orcids":["https://orcid.org/0000-0003-4143-3569"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kuan Yan","raw_affiliation_strings":["OcellO B.V., Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OcellO B.V., Leiden, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079548712","display_name":"Michiel Fokkelman","orcid":"https://orcid.org/0000-0002-6937-9384","observed_orcids":["https://orcid.org/0000-0002-6937-9384"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michiel Fokkelman","raw_affiliation_strings":["Division of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043281955","display_name":"Anna J. Plugge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anna J Plugge","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108237703","display_name":"Kimberley Veraar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Kimberley A M Veraar","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111742074","display_name":"Johannes G. Dauwerse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Johannes G Dauwerse","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088996741","display_name":"Gerard J. P. van Westen","orcid":"https://orcid.org/0000-0003-0717-1817","observed_orcids":["https://orcid.org/0000-0003-0717-1817"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gerard J P van Westen","raw_affiliation_strings":["Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081295579","display_name":"Bob van de Water","orcid":"https://orcid.org/0000-0002-5839-2380","observed_orcids":["https://orcid.org/0000-0002-5839-2380"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bob van de Water","raw_affiliation_strings":["Division of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000581416","display_name":"Leo Price","orcid":"https://orcid.org/0000-0002-4562-9086","observed_orcids":["https://orcid.org/0000-0002-4562-9086"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Leo S Price","raw_affiliation_strings":["Division of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands","OcellO B.V., Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"OcellO B.V., Leiden, The Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013947762","display_name":"Dorien J.M. Peters","orcid":"https://orcid.org/0000-0001-6974-7143","observed_orcids":["https://orcid.org/0000-0001-6974-7143"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Dorien J M Peters","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5013947762"],"corresponding_institution_ids":["https://openalex.org/I2800006345"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":{"value":2900,"currency":"USD","value_usd":2900},"fwci":1.0295,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.73643805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"8","first_page":"644","last_page":"653"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-kidney-disease","display_name":"polycystic kidney disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/celastrol","display_name":"celastrol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phenotypic-screening","display_name":"phenotypic screening","score":0.8999999761581421},{"id":"https://openalex.org/keywords/high-throughput-microscopy","display_name":"high-throughput imaging","score":0.5680000185966492},{"id":"https://openalex.org/keywords/pkd1","display_name":"PKD1","score":0.6019999980926514},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2780145431","wikidata":"https://www.wikidata.org/wiki/Q15443105","display_name":"Polycystic kidney disease","level":3,"score":0.7568753957748413},{"id":"https://openalex.org/C2777228702","wikidata":"https://www.wikidata.org/wiki/Q5057534","display_name":"Celastrol","level":3,"score":0.739605188369751},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7050138711929321},{"id":"https://openalex.org/C2776266639","wikidata":"https://www.wikidata.org/wiki/Q2732398","display_name":"Autosomal dominant polycystic kidney disease","level":3,"score":0.6479690074920654},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5735904574394226},{"id":"https://openalex.org/C2780597408","wikidata":"https://www.wikidata.org/wiki/Q193211","display_name":"Cyst","level":2,"score":0.5400652885437012},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49604472517967224},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.47905978560447693},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4765637218952179},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4760591685771942},{"id":"https://openalex.org/C6555983","wikidata":"https://www.wikidata.org/wiki/Q7181398","display_name":"Phenotypic screening","level":4,"score":0.46842753887176514},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4155217707157135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3225666284561157},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2895190119743347},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23590511083602905},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1517362892627716},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11331713199615479},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07550287246704102},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007690","descriptor_name":"Polycystic Kidney Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007690","descriptor_name":"Polycystic Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007690","descriptor_name":"Polycystic Kidney Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053978","descriptor_name":"Pentacyclic Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053978","descriptor_name":"Pentacyclic Triterpenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1093/jmcb/mjz029","doi":"https://doi.org/10.1093/jmcb/mjz029","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jmcb/mjz029","pdf_url":"https://academic.oup.com/jmcb/article-pdf/doi/10.1093/jmcb/mjz029/30342809/mjz029.pdf","source":{"id":"https://openalex.org/S14311075","display_name":"Journal of Molecular Cell Biology","issn_l":"1674-2788","issn":["1674-2788","1759-4685"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7683017","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7683017","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Mol Cell Biol","raw_type":"Text"},{"id":"pmid:31065693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31065693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:alma.31UKB_LEU:9940743875702711","doi":null,"is_oa":true,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/75262","pdf_url":"https://scholarlypublications.universiteitleiden.nl/download/1887/75262/1?col=81522199380002711","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Cell Biology, Vol. 12, no. 8, p. 644-653","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3184586","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1887/3184586","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Cell Biology, 12(8), 644 - 653. OXFORD UNIV PRESS","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:alma.31UKB_LEU:9940743446302711","doi":null,"is_oa":true,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/3184586","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Cell Biology, Vol. 12, no. 8, p. 644-653","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/75262","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1887/75262","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Cell Biology","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2910817","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1887/75262","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Cell Biology","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_3184586","doi":null,"is_oa":true,"landing_page_url":"https://academic.oup.com/jmcb/article/12/8/644/5486613","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Cell Biology","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/454499","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/454499","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of molecular cell biology, 12 (8)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:ul:oai:scholarlypublications.universiteitleiden.nl:item_2910817","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1887/75262","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Cell Biology, 12(8), 644 - 653","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-b-000454499","doi":"https://doi.org/10.3929/ethz-b-000454499","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000454499","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1093/jmcb/mjz029","doi":"https://doi.org/10.1093/jmcb/mjz029","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jmcb/mjz029","pdf_url":"https://academic.oup.com/jmcb/article-pdf/doi/10.1093/jmcb/mjz029/30342809/mjz029.pdf","source":{"id":"https://openalex.org/S14311075","display_name":"Journal of Molecular Cell Biology","issn_l":"1674-2788","issn":["1674-2788","1759-4685"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Cell Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3347196485","display_name":null,"funder_award_id":"4OIP12","funder_id":"https://openalex.org/F4320321643","funder_display_name":"Nierstichting"},{"id":"https://openalex.org/G3759882581","display_name":null,"funder_award_id":"14410","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5667310833","display_name":null,"funder_award_id":"11823","funder_id":"https://openalex.org/F4320334893","funder_display_name":"Stichting voor de Technische Wetenschappen"},{"id":"https://openalex.org/G7608991046","display_name":null,"funder_award_id":"14410","funder_id":"https://openalex.org/F4320334893","funder_display_name":"Stichting voor de Technische Wetenschappen"},{"id":"https://openalex.org/G8090809263","display_name":null,"funder_award_id":"EU-FP7","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321643","display_name":"Nierstichting","ror":"https://ror.org/020k6v967"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320334893","display_name":"Stichting voor de Technische Wetenschappen","ror":"https://ror.org/057tq3593"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2944622809.pdf","grobid_xml":"https://content.openalex.org/works/W2944622809.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W42149881","https://openalex.org/W1509405108","https://openalex.org/W1559356085","https://openalex.org/W1968118266","https://openalex.org/W1968162861","https://openalex.org/W1988963406","https://openalex.org/W1990515559","https://openalex.org/W2000178617","https://openalex.org/W2013614403","https://openalex.org/W2016799157","https://openalex.org/W2027844138","https://openalex.org/W2029437539","https://openalex.org/W2034373020","https://openalex.org/W2035988147","https://openalex.org/W2039606101","https://openalex.org/W2054328754","https://openalex.org/W2057881558","https://openalex.org/W2062868705","https://openalex.org/W2067648338","https://openalex.org/W2085868009","https://openalex.org/W2095356257","https://openalex.org/W2096541584","https://openalex.org/W2100704215","https://openalex.org/W2107890949","https://openalex.org/W2112643254","https://openalex.org/W2113799345","https://openalex.org/W2115962978","https://openalex.org/W2124122523","https://openalex.org/W2138888192","https://openalex.org/W2143108257","https://openalex.org/W2152180560","https://openalex.org/W2156319424","https://openalex.org/W2190376035","https://openalex.org/W2282053767","https://openalex.org/W2330008013","https://openalex.org/W2342039626","https://openalex.org/W2433595988","https://openalex.org/W2471520128","https://openalex.org/W2553705497","https://openalex.org/W2574659094","https://openalex.org/W2579804224","https://openalex.org/W2585855774","https://openalex.org/W2613145009","https://openalex.org/W2723541404","https://openalex.org/W2735959923","https://openalex.org/W2803979390","https://openalex.org/W2884509042","https://openalex.org/W2893428477"],"related_works":["https://openalex.org/W2723541404","https://openalex.org/W4380626457","https://openalex.org/W2160942206","https://openalex.org/W4383709846","https://openalex.org/W4409919867","https://openalex.org/W1007664100","https://openalex.org/W1964043319","https://openalex.org/W2028097749","https://openalex.org/W7028293125","https://openalex.org/W2119529392"],"abstract_inverted_index":{"Polycystic":[0],"kidney":[1,14,20,171],"disease":[2],"(PKD)":[3],"is":[4,27,52],"a":[5,37,60,74,137,145],"prevalent":[6],"genetic":[7],"disorder,":[8],"characterized":[9],"by":[10,31],"the":[11,62,119,164],"formation":[12,51],"of":[13,64,84,118,148,166],"cysts":[15,124,168],"that":[16,48,111,127],"progressively":[17],"lead":[18],"to":[19,69],"failure.":[21],"The":[22,43],"currently":[23],"available":[24],"drug":[25],"tolvaptan":[26],"not":[28,56],"well":[29],"tolerated":[30],"all":[32],"patients":[33],"and":[34,55,97,169],"there":[35],"remains":[36],"strong":[38],"need":[39],"for":[40,81,160],"alternative":[41],"treatments.":[42],"signaling":[44],"rewiring":[45],"in":[46,151,155],"PKD":[47],"drives":[49],"cyst":[50,86,93,113,149],"highly":[53],"complex":[54],"fully":[57],"understood.":[58],"As":[59],"consequence,":[61],"effects":[63,120,131],"drugs":[65],"are":[66],"sometimes":[67],"difficult":[68],"predict.":[70],"We":[71,106],"previously":[72],"established":[73],"high":[75],"throughput":[76],"microscopy":[77],"phenotypic":[78,95,116],"screening":[79],"method":[80],"quantitative":[82],"assessment":[83],"renal":[85,167],"growth.":[87,114],"Here,":[88],"we":[89],"applied":[90],"this":[91],"3D":[92,122],"growth":[94,150,165],"assay":[96],"screened":[98],"2320":[99],"small":[100],"drug-like":[101],"molecules,":[102],"including":[103],"approved":[104],"drugs.":[105],"identified":[107,143],"81":[108],"active":[109],"molecules":[110,126],"inhibit":[112],"Multi-parametric":[115],"profiling":[117],"on":[121],"cultured":[123],"discriminated":[125],"showed":[128],"preferred":[129],"pharmacological":[130],"above":[132],"genuine":[133],"toxicological":[134],"properties.":[135],"Celastrol,":[136],"triterpenoid":[138],"from":[139],"Tripterygium":[140],"Wilfordii,":[141],"was":[142],"as":[144],"potent":[146],"inhibitor":[147],"vitro.":[152],"In":[153],"an":[154],"vivo":[156],"iKspCre-Pkd1lox,lox":[157],"mouse":[158],"model":[159],"PKD,":[161],"celastrol":[162],"inhibited":[163],"maintained":[170],"function.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-05-16T00:00:00"}
