{"id":"https://openalex.org/W2944592917","doi":"https://doi.org/10.1021/acs.macromol.9b00368","title":"Therapeutic Methacrylic Comonomers for Covalently Controlled Release from Mechanically Robust Bone Cement: Kinetics and Structure\u2013Function Relationships","display_name":"Therapeutic Methacrylic Comonomers for Covalently Controlled Release from Mechanically Robust Bone Cement: Kinetics and Structure\u2013Function Relationships","publication_year":2019,"publication_date":"2019-05-09","ids":{"openalex":"https://openalex.org/W2944592917","doi":"https://doi.org/10.1021/acs.macromol.9b00368","mag":"2944592917"},"language":"en","primary_location":{"id":"doi:10.1021/acs.macromol.9b00368","doi":"https://doi.org/10.1021/acs.macromol.9b00368","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.macromol.9b00368","pdf_url":null,"source":{"id":"https://openalex.org/S177196338","display_name":"Macromolecules","issn_l":"0024-9297","issn":["0024-9297","1520-5835"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecules","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002043421","display_name":"Zoe M. Wright","orcid":"https://orcid.org/0000-0003-2090-1538","observed_orcids":["https://orcid.org/0000-0003-2090-1538"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zoe M. Wright","raw_affiliation_strings":["Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh Pennsylvania 15213 United States"],"raw_orcid":"https://orcid.org/0000-0003-2090-1538","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh Pennsylvania 15213 United States","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068190989","display_name":"Avanti M. Pandit","orcid":"https://orcid.org/0000-0002-6816-1818","observed_orcids":["https://orcid.org/0000-0002-6816-1818"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avanti M. Pandit","raw_affiliation_strings":["Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh Pennsylvania 15213 United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh Pennsylvania 15213 United States","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042685406","display_name":"Brian D. Holt","orcid":"https://orcid.org/0000-0003-4212-4821","observed_orcids":["https://orcid.org/0000-0003-4212-4821"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian D. Holt","raw_affiliation_strings":["Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh Pennsylvania 15213 United States"],"raw_orcid":"https://orcid.org/0000-0003-4212-4821","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh Pennsylvania 15213 United States","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004974178","display_name":"Stefanie Arlene Sydlik","orcid":"https://orcid.org/0000-0001-9375-2356","observed_orcids":["https://orcid.org/0000-0001-9375-2356"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stefanie A. Sydlik","raw_affiliation_strings":["Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh Pennsylvania 15213, United States","Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh Pennsylvania 15213 United States"],"raw_orcid":"https://orcid.org/0000-0001-9375-2356","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh Pennsylvania 15213, United States","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh Pennsylvania 15213 United States","institution_ids":["https://openalex.org/I74973139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004974178"],"corresponding_institution_ids":["https://openalex.org/I74973139"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.1732,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.4010266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"52","issue":"10","first_page":"3775","last_page":"3786"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.1851000040769577,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.07720000296831131,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polymethylmethacrylate-bone-cement","display_name":"polymethylmethacrylate bone cement","score":0.9100000262260437},{"id":"https://openalex.org/keywords/copolymer-architecture","display_name":"copolymer architecture","score":0.7409999966621399},{"id":"https://openalex.org/keywords/reactivity-ratios","display_name":"reactivity ratios","score":0.8529999852180481},{"id":"https://openalex.org/keywords/compressive-strength","display_name":"compressive strength","score":0.7900000214576721},{"id":"https://openalex.org/keywords/mechanical-aging","display_name":"mechanical aging","score":0.5099999904632568},{"id":"https://openalex.org/keywords/structure-function-relationship","display_name":"structure-function relationship","score":0.7789999842643738},{"id":"https://openalex.org/keywords/orthopedic-implants","display_name":"orthopedic implants","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C2777935641","wikidata":"https://www.wikidata.org/wiki/Q382897","display_name":"Methyl methacrylate","level":4,"score":0.7723990678787231},{"id":"https://openalex.org/C132050475","wikidata":"https://www.wikidata.org/wiki/Q736232","display_name":"Methacrylate","level":4,"score":0.6364696025848389},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6081802845001221},{"id":"https://openalex.org/C523993062","wikidata":"https://www.wikidata.org/wiki/Q45190","display_name":"Cement","level":2,"score":0.6075501441955566},{"id":"https://openalex.org/C2778891590","wikidata":"https://www.wikidata.org/wiki/Q1777319","display_name":"Bone cement","level":3,"score":0.5483766198158264},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.5012736320495605},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.46954473853111267},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.4629092812538147},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.4580577313899994},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.4444081783294678},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.43577373027801514},{"id":"https://openalex.org/C2775968528","wikidata":"https://www.wikidata.org/wiki/Q165949","display_name":"Methacrylic acid","level":4,"score":0.43390509486198425},{"id":"https://openalex.org/C2780718992","wikidata":"https://www.wikidata.org/wiki/Q146123","display_name":"Poly(methyl methacrylate)","level":5,"score":0.4289018511772156},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.3948233127593994},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.28125447034835815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27223312854766846},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16997170448303223},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.10351058840751648},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.macromol.9b00368","doi":"https://doi.org/10.1021/acs.macromol.9b00368","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.macromol.9b00368","pdf_url":null,"source":{"id":"https://openalex.org/S177196338","display_name":"Macromolecules","issn_l":"0024-9297","issn":["0024-9297","1520-5835"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecules","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310207","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W155930765","https://openalex.org/W1495482938","https://openalex.org/W1862589716","https://openalex.org/W1970314947","https://openalex.org/W1971705951","https://openalex.org/W1974092471","https://openalex.org/W1979430872","https://openalex.org/W1984756014","https://openalex.org/W1991912550","https://openalex.org/W2001144005","https://openalex.org/W2001179756","https://openalex.org/W2011853713","https://openalex.org/W2013666713","https://openalex.org/W2013673975","https://openalex.org/W2024714448","https://openalex.org/W2026844957","https://openalex.org/W2031046599","https://openalex.org/W2034483260","https://openalex.org/W2035277171","https://openalex.org/W2046696958","https://openalex.org/W2055294114","https://openalex.org/W2060544560","https://openalex.org/W2064270971","https://openalex.org/W2065333990","https://openalex.org/W2067665563","https://openalex.org/W2071943702","https://openalex.org/W2077844474","https://openalex.org/W2082151266","https://openalex.org/W2085817574","https://openalex.org/W2094562739","https://openalex.org/W2101421355","https://openalex.org/W2110861042","https://openalex.org/W2112845808","https://openalex.org/W2132218609","https://openalex.org/W2136691001","https://openalex.org/W2143993272","https://openalex.org/W2168695568","https://openalex.org/W2197718265","https://openalex.org/W2288312232","https://openalex.org/W2292600666","https://openalex.org/W2342773503","https://openalex.org/W2553782111","https://openalex.org/W2624698886","https://openalex.org/W2751761234","https://openalex.org/W2773634534","https://openalex.org/W2801859295","https://openalex.org/W4235476133","https://openalex.org/W4236123178","https://openalex.org/W4238358640"],"related_works":["https://openalex.org/W1977313152","https://openalex.org/W2351866706","https://openalex.org/W4401427268","https://openalex.org/W2073724406","https://openalex.org/W101699356","https://openalex.org/W2083739257","https://openalex.org/W2901836349","https://openalex.org/W2991546812","https://openalex.org/W2969262283","https://openalex.org/W1918188047"],"abstract_inverted_index":{"To":[0],"transform":[1],"biologically":[2],"inert":[3],"poly(methyl":[4],"methacrylate)":[5],"(PMMA)":[6],"bone":[7,141],"cement":[8,125,142],"into":[9],"a":[10,29,130,145],"tunable":[11],"drug-eluting":[12,60],"biomaterial,":[13],"we":[14],"have":[15],"employed":[16],"polymerizable":[17],"therapeutic":[18],"methacrylic":[19,25],"(TMA)":[20],"comonomers":[21,128],"that":[22,93],"use":[23],"the":[24,37,40,100,135,150],"carbonyl":[26],"bond":[27,42],"as":[28],"platform":[30],"for":[31,133],"hydrolytically":[32],"controlled":[33,104],"drug":[34,77],"release.":[35],"Changing":[36],"identity":[38],"of":[39,102,140,147],"tether":[41],"allows":[43],"us":[44],"to":[45,54,66,143],"select":[46],"release":[47,52,105],"patterns":[48,101],"ranging":[49],"from":[50,106],"rapid":[51],"(up":[53],"6.5":[55],"times":[56],"more":[57],"efficient":[58],"than":[59],"cements":[61,71,84],"based":[62],"on":[63,99],"passive":[64],"diffusion)":[65],"long-term":[67],"anchorage.":[68],"Further,":[69],"TMA":[70,107,127],"retain":[72],"their":[73],"mechanical":[74],"strength":[75,87],"throughout":[76],"release,":[78],"outperforming":[79],"both":[80],"PMMA":[81],"and":[82,124,137],"diffusion-based":[83],"in":[85,149],"compressive":[86],"after":[88],"aging.":[89],"We":[90],"also":[91],"found":[92],"certain":[94],"factors":[95],"exert":[96],"secondary":[97],"effects":[98],"covalently":[103],"cements,":[108],"including":[109],"TMA/methyl":[110],"methacrylate":[111],"(MMA)":[112],"copolymer":[113],"architecture":[114],"(created":[115],"by":[116],"different":[117],"reactivity":[118],"ratios":[119],"between":[120],"each":[121],"TMA/MMA":[122],"pairing)":[123],"hydrophilicity.":[126],"represent":[129],"valuable":[131],"tool":[132],"tuning":[134],"bioactivity":[136],"cure":[138],"behavior":[139],"meet":[144],"range":[146],"demands":[148],"operating":[151],"room.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2019-05-16T00:00:00"}
