{"id":"https://openalex.org/W2944584167","doi":"https://doi.org/10.1055/s-0039-1683996","title":"Pathogenesis of Acute Respiratory Distress Syndrome","display_name":"Pathogenesis of Acute Respiratory Distress Syndrome","publication_year":2019,"publication_date":"2019-02-01","ids":{"openalex":"https://openalex.org/W2944584167","doi":"https://doi.org/10.1055/s-0039-1683996","mag":"2944584167","pmid":"https://pubmed.ncbi.nlm.nih.gov/31060086","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7060969"},"language":"en","primary_location":{"id":"doi:10.1055/s-0039-1683996","doi":"https://doi.org/10.1055/s-0039-1683996","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0039-1683996","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1683996.pdf","source":{"id":"https://openalex.org/S193428046","display_name":"Seminars in Respiratory and Critical Care Medicine","issn_l":"1069-3424","issn":["1069-3424","1098-9048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1683996.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016418865","display_name":"Laura Ann Huppert","orcid":"https://orcid.org/0000-0002-8512-5608","observed_orcids":["https://orcid.org/0000-0002-8512-5608"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Huppert","raw_affiliation_strings":["Department of Medicine, University of California, San Francisco, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052576862","display_name":"Michael A. Matthay","orcid":"https://orcid.org/0000-0003-3039-8155","observed_orcids":["https://orcid.org/0000-0003-3039-8155"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Matthay","raw_affiliation_strings":["Department of Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California","Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017253129","display_name":"Lorraine B. Ware","orcid":"https://orcid.org/0000-0002-9429-4702","observed_orcids":["https://orcid.org/0000-0002-9429-4702"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lorraine Ware","raw_affiliation_strings":["Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017253129"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":8.4747,"has_fulltext":true,"cited_by_count":459,"citation_normalized_percentile":{"value":0.98969506,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"40","issue":"01","first_page":"031","last_page":"039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":1.0},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.8920000195503235},{"id":"https://openalex.org/keywords/non-cardiogenic-pulmonary-edema","display_name":"non-cardiogenic pulmonary edema","score":0.9829999804496765},{"id":"https://openalex.org/keywords/acute-respiratory-failure","display_name":"acute respiratory failure","score":0.8560000061988831},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/alveolar-permeability","display_name":"alveolar permeability","score":0.8970000147819519},{"id":"https://openalex.org/keywords/alveolar-epithelial-permeability","display_name":"alveolar epithelial permeability","score":0.75},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/ards-therapy","display_name":"ARDS therapy","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.9513579607009888},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9210869073867798},{"id":"https://openalex.org/C2776468924","wikidata":"https://www.wikidata.org/wiki/Q857667","display_name":"Pulmonary edema","level":3,"score":0.7095011472702026},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.636953592300415},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4745134711265564},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.4573580026626587},{"id":"https://openalex.org/C9418649","wikidata":"https://www.wikidata.org/wiki/Q5275407","display_name":"Diffuse alveolar damage","level":4,"score":0.4549420177936554},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4470311999320984},{"id":"https://openalex.org/C2909621147","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"Acute respiratory distress","level":3,"score":0.36986014246940613},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27575135231018066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17254340648651123}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1055/s-0039-1683996","doi":"https://doi.org/10.1055/s-0039-1683996","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0039-1683996","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1683996.pdf","source":{"id":"https://openalex.org/S193428046","display_name":"Seminars in Respiratory and Critical Care Medicine","issn_l":"1069-3424","issn":["1069-3424","1098-9048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:31060086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31060086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in respiratory and critical care medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7060969","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7060969","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Semin Respir Crit Care Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1055/s-0039-1683996","doi":"https://doi.org/10.1055/s-0039-1683996","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0039-1683996","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1683996.pdf","source":{"id":"https://openalex.org/S193428046","display_name":"Seminars in Respiratory and Critical Care Medicine","issn_l":"1069-3424","issn":["1069-3424","1098-9048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Respiratory and Critical Care Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1408196680","display_name":"Allogeneic Human Mesenchymal Stem Cells for the Treatment of Acute Lung Injury","funder_award_id":"U01HL108713","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2392155623","display_name":null,"funder_award_id":"HL108713","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G284455767","display_name":"Midcareer Investigator Award in Patient-Oriented Research in Acute Lung Injury","funder_award_id":"K24HL103836","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3422402278","display_name":null,"funder_award_id":"HL103836","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3429402575","display_name":null,"funder_award_id":"HL-51856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G375247153","display_name":"RESOLUTION OF CLINICAL LUNG INJURY","funder_award_id":"R01HL051856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6752351227","display_name":null,"funder_award_id":"NHLBI HL51856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000161121","display_name":null,"funder_award_id":"HL51856","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G904655290","display_name":"Resolution of Clinical Lung Injury","funder_award_id":"R37HL051856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2944584167.pdf","grobid_xml":"https://content.openalex.org/works/W2944584167.grobid-xml"},"referenced_works_count":146,"referenced_works":["https://openalex.org/W3521815","https://openalex.org/W586213563","https://openalex.org/W586637899","https://openalex.org/W1479842253","https://openalex.org/W1482266658","https://openalex.org/W1816622697","https://openalex.org/W1842750594","https://openalex.org/W1874662098","https://openalex.org/W1965737875","https://openalex.org/W1967429254","https://openalex.org/W1968413280","https://openalex.org/W1970225644","https://openalex.org/W1971696195","https://openalex.org/W1976830450","https://openalex.org/W1983881370","https://openalex.org/W1985422736","https://openalex.org/W1989796399","https://openalex.org/W1990940065","https://openalex.org/W1991120802","https://openalex.org/W1991940875","https://openalex.org/W1992974015","https://openalex.org/W1993384569","https://openalex.org/W1997255681","https://openalex.org/W1997470313","https://openalex.org/W1997991819","https://openalex.org/W1999319544","https://openalex.org/W2012329129","https://openalex.org/W2019549413","https://openalex.org/W2021163726","https://openalex.org/W2024224130","https://openalex.org/W2027222805","https://openalex.org/W2028460153","https://openalex.org/W2029844302","https://openalex.org/W2030927418","https://openalex.org/W2033075194","https://openalex.org/W2037459166","https://openalex.org/W2039251191","https://openalex.org/W2043112660","https://openalex.org/W2044217893","https://openalex.org/W2045574035","https://openalex.org/W2046237540","https://openalex.org/W2050959645","https://openalex.org/W2058864165","https://openalex.org/W2068854215","https://openalex.org/W2073264366","https://openalex.org/W2074488392","https://openalex.org/W2075430896","https://openalex.org/W2076515621","https://openalex.org/W2077726738","https://openalex.org/W2077930526","https://openalex.org/W2079874473","https://openalex.org/W2080138182","https://openalex.org/W2081127058","https://openalex.org/W2081608699","https://openalex.org/W2081994681","https://openalex.org/W2086110723","https://openalex.org/W2087499467","https://openalex.org/W2087957246","https://openalex.org/W2092892225","https://openalex.org/W2093852073","https://openalex.org/W2102840915","https://openalex.org/W2105902643","https://openalex.org/W2106410542","https://openalex.org/W2108396254","https://openalex.org/W2110707896","https://openalex.org/W2111727066","https://openalex.org/W2115672224","https://openalex.org/W2118044708","https://openalex.org/W2120310214","https://openalex.org/W2120699390","https://openalex.org/W2123417019","https://openalex.org/W2124056092","https://openalex.org/W2124318512","https://openalex.org/W2124519382","https://openalex.org/W2127148145","https://openalex.org/W2129339954","https://openalex.org/W2131135495","https://openalex.org/W2132040583","https://openalex.org/W2133375451","https://openalex.org/W2133449810","https://openalex.org/W2134906082","https://openalex.org/W2138694950","https://openalex.org/W2138946470","https://openalex.org/W2139350281","https://openalex.org/W2140749892","https://openalex.org/W2141818933","https://openalex.org/W2143748013","https://openalex.org/W2143766390","https://openalex.org/W2144304154","https://openalex.org/W2149162919","https://openalex.org/W2150086428","https://openalex.org/W2152198508","https://openalex.org/W2152280553","https://openalex.org/W2153156760","https://openalex.org/W2153331362","https://openalex.org/W2153339769","https://openalex.org/W2155842880","https://openalex.org/W2156613610","https://openalex.org/W2158310716","https://openalex.org/W2158580948","https://openalex.org/W2159052610","https://openalex.org/W2159400425","https://openalex.org/W2159913536","https://openalex.org/W2163053457","https://openalex.org/W2163240112","https://openalex.org/W2165073735","https://openalex.org/W2165537330","https://openalex.org/W2166019746","https://openalex.org/W2166746332","https://openalex.org/W2169732472","https://openalex.org/W2178894591","https://openalex.org/W2190171834","https://openalex.org/W2204697639","https://openalex.org/W2212188123","https://openalex.org/W2314787815","https://openalex.org/W2316287299","https://openalex.org/W2317277886","https://openalex.org/W2317705795","https://openalex.org/W2320873518","https://openalex.org/W2322669631","https://openalex.org/W2336025467","https://openalex.org/W2340094078","https://openalex.org/W2396870668","https://openalex.org/W2416701231","https://openalex.org/W2465242076","https://openalex.org/W2515625652","https://openalex.org/W2548097234","https://openalex.org/W2552618355","https://openalex.org/W2586389729","https://openalex.org/W2593892363","https://openalex.org/W2596348429","https://openalex.org/W2597070792","https://openalex.org/W2620241325","https://openalex.org/W2623687009","https://openalex.org/W2885426958","https://openalex.org/W2885500852","https://openalex.org/W2901220228","https://openalex.org/W3020992950","https://openalex.org/W4234304531","https://openalex.org/W4235932673","https://openalex.org/W4241494310","https://openalex.org/W4244976753","https://openalex.org/W4245739111","https://openalex.org/W4292330637","https://openalex.org/W6674131947","https://openalex.org/W6677308222"],"related_works":["https://openalex.org/W2604264722","https://openalex.org/W2297960835","https://openalex.org/W2159763561","https://openalex.org/W98223208","https://openalex.org/W3027508680","https://openalex.org/W3044529551","https://openalex.org/W3024613654","https://openalex.org/W2989877521","https://openalex.org/W4390838116","https://openalex.org/W2069056995"],"abstract_inverted_index":{"Acute":[0],"respiratory":[1,10],"distress":[2],"syndrome":[3,7,59],"(ARDS)":[4],"is":[5,26,41,68,111],"a":[6],"of":[8,20,57,65,74,79,137,146,154,161],"acute":[9],"failure":[11],"caused":[12],"by":[13],"noncardiogenic":[14],"pulmonary":[15,86,108],"edema.":[16],"Despite":[17],"five":[18],"decades":[19],"basic":[21],"and":[22,34,47,60,77,96,100,118,134],"clinical":[23,132],"research,":[24],"there":[25],"still":[27],"no":[28],"effective":[29],"pharmacotherapy":[30],"for":[31],"this":[32,58,66,147],"condition":[33],"the":[35,45,75,115,152,159],"treatment":[36,160],"remains":[37],"primarily":[38],"supportive.":[39],"It":[40],"critical":[42],"to":[43,53,69,93],"study":[44,153],"molecular":[46],"physiologic":[48],"mechanisms":[49],"that":[50],"cause":[51],"ARDS":[52,91],"improve":[54],"our":[55,71,144],"understanding":[56,73,145],"reduce":[61],"mortality.":[62],"The":[63],"goal":[64],"review":[67,106],"describe":[70,84,119],"current":[72],"pathogenesis":[76],"pathophysiology":[78],"ARDS.":[80,126,162],"First,":[81],"we":[82,104,128],"will":[83,105,129],"how":[85,107,120,131],"edema":[87,109],"fluid":[88,110],"accumulates":[89],"in":[90,114,125,150,158],"due":[92],"lung":[94],"inflammation":[95],"increased":[97],"alveolar":[98],"endothelial":[99],"epithelial":[101],"permeabilities.":[102],"Next,":[103],"normally":[112],"cleared":[113],"uninjured":[116],"lung,":[117],"these":[121],"pathways":[122],"are":[123],"disrupted":[124],"Finally,":[127],"explain":[130],"trials":[133],"preclinical":[135],"studies":[136],"novel":[138],"therapeutic":[139],"agents":[140],"have":[141],"further":[142],"refined":[143],"condition,":[148],"highlighting,":[149],"particular,":[151],"mesenchymal":[155],"stromal":[156],"cells":[157]},"counts_by_year":[{"year":2026,"cited_by_count":29},{"year":2025,"cited_by_count":55},{"year":2024,"cited_by_count":84},{"year":2023,"cited_by_count":88},{"year":2022,"cited_by_count":90},{"year":2021,"cited_by_count":77},{"year":2020,"cited_by_count":33},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-05-16T00:00:00"}
