{"id":"https://openalex.org/W2944580877","doi":"https://doi.org/10.1002/cmdc.201900203","title":"Development of Tetrahydroindazole\u2010Based Potent and Selective Sigma\u20102 Receptor Ligands","display_name":"Development of Tetrahydroindazole\u2010Based Potent and Selective Sigma\u20102 Receptor Ligands","publication_year":2019,"publication_date":"2019-05-09","ids":{"openalex":"https://openalex.org/W2944580877","doi":"https://doi.org/10.1002/cmdc.201900203","mag":"2944580877","pmid":"https://pubmed.ncbi.nlm.nih.gov/31071238","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6613831"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.201900203","doi":"https://doi.org/10.1002/cmdc.201900203","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201900203","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6613831","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088478112","display_name":"Iredia David Iyamu","orcid":"https://orcid.org/0000-0003-1337-1188","observed_orcids":["https://orcid.org/0000-0003-1337-1188"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iredia D. Iyamu","raw_affiliation_strings":["Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL, 60208 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL, 60208 USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Lv","raw_affiliation_strings":["Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL, 60208 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL, 60208 USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102966665","display_name":"Neha Malik","orcid":"https://orcid.org/0000-0002-8339-7546","observed_orcids":["https://orcid.org/0000-0002-8339-7546"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neha Malik","raw_affiliation_strings":["Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL, 60208 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL, 60208 USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059724338","display_name":"Rama K. Mishra","orcid":"https://orcid.org/0000-0003-3608-2602","observed_orcids":["https://orcid.org/0000-0003-3608-2602"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rama K. Mishra","raw_affiliation_strings":["Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL, 60208 USA","Department of Pharmacology, Northwestern University, Chicago, IL, 60611 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL, 60208 USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Pharmacology, Northwestern University, Chicago, IL, 60611 USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079762031","display_name":"Gary E. Schiltz","orcid":"https://orcid.org/0000-0003-4180-5051","observed_orcids":["https://orcid.org/0000-0003-4180-5051"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary E. Schiltz","raw_affiliation_strings":["Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL, 60208 USA","Department of Pharmacology, Northwestern University, Chicago, IL, 60611 USA","Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611 USA"],"raw_orcid":"https://orcid.org/0000-0003-4180-5051","affiliations":[{"raw_affiliation_string":"Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL, 60208 USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Pharmacology, Northwestern University, Chicago, IL, 60611 USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611 USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079762031"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.4099,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.53988599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":96},"biblio":{"volume":"14","issue":"13","first_page":"1248","last_page":"1256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sigma-2-receptor","display_name":"sigma-2 receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tetrahydroindazoles","display_name":"tetrahydroindazoles","score":0.9269999861717224},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9290000200271606},{"id":"https://openalex.org/keywords/pharmacophore-model","display_name":"pharmacophore model","score":0.9829999804496765},{"id":"https://openalex.org/keywords/chemical-probes","display_name":"chemical probes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/microsomal-stability","display_name":"microsomal stability","score":0.8999999761581421},{"id":"https://openalex.org/keywords/solubility","display_name":"solubility","score":0.7900000214576721},{"id":"https://openalex.org/keywords/central-nervous-system-diseases","display_name":"central nervous system disorders","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2777052854","wikidata":"https://www.wikidata.org/wiki/Q7512419","display_name":"Sigma receptor","level":3,"score":0.5800272822380066},{"id":"https://openalex.org/C103133801","wikidata":"https://www.wikidata.org/wiki/Q408572","display_name":"Sigma-1 receptor","level":4,"score":0.5308305621147156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4736572206020355},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4435601830482483},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4235593378543854},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.41525405645370483},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35512882471084595},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.34689104557037354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3235047161579132},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2508823275566101},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.1333794891834259}],"mesh":[{"descriptor_ui":"D000097605","descriptor_name":"Sigma-1 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017480","descriptor_name":"Receptors, sigma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017480","descriptor_name":"Receptors, sigma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/cmdc.201900203","doi":"https://doi.org/10.1002/cmdc.201900203","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201900203","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},{"id":"pmid:31071238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31071238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6613831","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6613831","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ChemMedChem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6613831","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6613831","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ChemMedChem","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1360415472","display_name":"Small molecule CXCR4 modulators as molecular probes for studying AML","funder_award_id":"R01CA189074","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1382277591","display_name":null,"funder_award_id":"CA 060553","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1915163810","display_name":null,"funder_award_id":"HHSN-271-2013-00017-C","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7727698067","display_name":null,"funder_award_id":"CA189074","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000891045","display_name":"The Robert H. Lurie Comprehensive Cancer Center","funder_award_id":"P30CA060553","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1579542460","https://openalex.org/W1581236234","https://openalex.org/W1657714454","https://openalex.org/W1948622783","https://openalex.org/W1951533674","https://openalex.org/W1975201747","https://openalex.org/W1995986012","https://openalex.org/W1999491936","https://openalex.org/W2001369831","https://openalex.org/W2008752021","https://openalex.org/W2039274171","https://openalex.org/W2040599474","https://openalex.org/W2042334642","https://openalex.org/W2044256586","https://openalex.org/W2055045760","https://openalex.org/W2060303675","https://openalex.org/W2060972405","https://openalex.org/W2063333882","https://openalex.org/W2067936231","https://openalex.org/W2072419277","https://openalex.org/W2079508555","https://openalex.org/W2084282108","https://openalex.org/W2085826360","https://openalex.org/W2085858083","https://openalex.org/W2087422921","https://openalex.org/W2100944793","https://openalex.org/W2107979600","https://openalex.org/W2116319355","https://openalex.org/W2143582802","https://openalex.org/W2161463814","https://openalex.org/W2196847493","https://openalex.org/W2274538329","https://openalex.org/W2282510442","https://openalex.org/W2328952638","https://openalex.org/W2477952912","https://openalex.org/W2504150820","https://openalex.org/W2560084727","https://openalex.org/W2597717383","https://openalex.org/W2605639532","https://openalex.org/W2606075321","https://openalex.org/W2618221287","https://openalex.org/W2669040921","https://openalex.org/W2767723643","https://openalex.org/W2768022080","https://openalex.org/W2787503105","https://openalex.org/W2800940990","https://openalex.org/W2921548303"],"related_works":["https://openalex.org/W2921548303","https://openalex.org/W2041788290","https://openalex.org/W2328952638","https://openalex.org/W1594307854","https://openalex.org/W2161919881","https://openalex.org/W2620785280","https://openalex.org/W2768022080","https://openalex.org/W1970647129","https://openalex.org/W2573972992","https://openalex.org/W2909892968"],"abstract_inverted_index":{"The":[0,35],"sigma-2":[1,28,39],"receptor":[2],"has":[3],"been":[4],"shown":[5],"to":[6,30,45,87],"play":[7],"important":[8,14],"roles":[9],"in":[10,98],"a":[11,69,89],"number":[12],"of":[13,37,49,60,68,71,112,122],"diseases,":[15],"including":[16],"central":[17],"nervous":[18],"system":[19],"(CNS)":[20],"disorders":[21],"and":[22,52,78,105],"cancer.":[23],"However,":[24],"mechanisms":[25],"by":[26],"which":[27],"contributes":[29],"these":[31],"diseases":[32],"remain":[33],"unclear.":[34],"development":[36,67,121],"new":[38],"ligands":[40],"that":[41,74,92,109],"can":[42],"be":[43],"used":[44,86],"probe":[46],"the":[47,66,94,99],"function":[48],"this":[50,113],"protein":[51],"potentially":[53],"as":[54],"drug":[55,127],"discovery":[56,128],"leads":[57],"is":[58],"therefore":[59],"great":[61],"importance.":[62],"Herein":[63],"we":[64],"report":[65],"series":[70,115],"tetrahydroindazole":[72],"compounds":[73],"are":[75],"highly":[76],"potent":[77,100],"selective":[79],"for":[80,103,119],"sigma-2.":[81],"Structure-activity":[82],"relationship":[83],"data":[84],"were":[85],"generate":[88],"pharmacophore":[90],"model":[91],"summarizes":[93],"common":[95],"features":[96],"present":[97],"ligands.":[101],"Assays":[102],"solubility":[104],"microsomal":[106],"stability":[107],"showed":[108],"several":[110],"members":[111],"compound":[114],"possess":[116],"promising":[117],"characteristics":[118],"further":[120],"useful":[123],"chemical":[124],"probes":[125],"or":[126],"leads.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-05-16T00:00:00"}
