{"id":"https://openalex.org/W2944522012","doi":"https://doi.org/10.1021/acsinfecdis.9b00010","title":"Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist","display_name":"Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist","publication_year":2019,"publication_date":"2019-05-06","ids":{"openalex":"https://openalex.org/W2944522012","doi":"https://doi.org/10.1021/acsinfecdis.9b00010","mag":"2944522012","pmid":"https://pubmed.ncbi.nlm.nih.gov/31060350","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7082846"},"language":"en","primary_location":{"id":"doi:10.1021/acsinfecdis.9b00010","doi":"https://doi.org/10.1021/acsinfecdis.9b00010","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.9b00010","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7082846","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071460109","display_name":"Xiaohui Zhang","orcid":"https://orcid.org/0000-0002-4746-4262","observed_orcids":["https://orcid.org/0000-0002-4746-4262"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147332","display_name":"Beijing YouAn Hospital","ror":"https://ror.org/04etaja30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147332"]},{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiaohui Zhang","raw_affiliation_strings":["Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, 8 Xitoutiao, Fengtai, Beijing 100069, China","Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, 8 Xitoutiao, Fengtai, Beijing 100069, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147332"]},{"raw_affiliation_string":"Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115603447","display_name":"Bowei Liu","orcid":"https://orcid.org/0009-0008-7603-8474","observed_orcids":["https://orcid.org/0009-0008-7603-8474","https://orcid.org/0000-0001-8013-5527"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Bowei Liu","raw_affiliation_strings":["Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","Department of Gastroenterology, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University, 7 Weiwu Road, Jinshui, Zhengzhou, Henan 450016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]},{"raw_affiliation_string":"Department of Gastroenterology, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University, 7 Weiwu Road, Jinshui, Zhengzhou, Henan 450016, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210133534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046413696","display_name":"Liudi Tang","orcid":"https://orcid.org/0000-0001-8303-3614","observed_orcids":["https://orcid.org/0000-0001-8303-3614"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liudi Tang","raw_affiliation_strings":["Microbiology and Immunology Graduate Program, Drexel University College of Medicine, 2900 West Queen Lane, Philadelphia, Pennsylvania 19129, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology Graduate Program, Drexel University College of Medicine, 2900 West Queen Lane, Philadelphia, Pennsylvania 19129, United States","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034696769","display_name":"Qing Su","orcid":"https://orcid.org/0000-0003-1462-4503","observed_orcids":["https://orcid.org/0000-0003-1462-4503"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Su","raw_affiliation_strings":["Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030998904","display_name":"Nicky Hwang","orcid":"https://orcid.org/0000-0002-0204-5267","observed_orcids":["https://orcid.org/0000-0002-0204-5267"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicky Hwang","raw_affiliation_strings":["Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024802325","display_name":"Mohit Sehgal","orcid":"https://orcid.org/0000-0001-5544-3675","observed_orcids":["https://orcid.org/0000-0001-5544-3675"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohit Sehgal","raw_affiliation_strings":["Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103100709","display_name":"Junjun Cheng","orcid":"https://orcid.org/0000-0002-3926-1481","observed_orcids":["https://orcid.org/0000-0002-3926-1481"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junjun Cheng","raw_affiliation_strings":["Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031849145","display_name":"Julia Ma","orcid":"https://orcid.org/0000-0001-7010-4970","observed_orcids":["https://orcid.org/0000-0001-7010-4970"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Ma","raw_affiliation_strings":["Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xuexiang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147332","display_name":"Beijing YouAn Hospital","ror":"https://ror.org/04etaja30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147332"]},{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xuexiang Zhang","raw_affiliation_strings":["Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, 8 Xitoutiao, Fengtai, Beijing 100069, China","Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, 8 Xitoutiao, Fengtai, Beijing 100069, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147332"]},{"raw_affiliation_string":"Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108833690","display_name":"Yinfei Tan","orcid":"https://orcid.org/0000-0002-5150-6920","observed_orcids":["https://orcid.org/0000-0002-5150-6920"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yinfei Tan","raw_affiliation_strings":["Genomics Facilities, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Facilities, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, United States","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089209583","display_name":"Yan Zhou","orcid":"https://orcid.org/0000-0002-8698-0040","observed_orcids":["https://orcid.org/0000-0002-8698-0040"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Zhou","raw_affiliation_strings":["Bioinformatics and Biostatistics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Biostatistics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, United States","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101929075","display_name":"Zhongping Duan","orcid":"https://orcid.org/0000-0003-0034-8413","observed_orcids":["https://orcid.org/0000-0003-0034-8413","https://orcid.org/0000-0001-7322-6279","https://orcid.org/0000-0002-4552-6618"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147332","display_name":"Beijing YouAn Hospital","ror":"https://ror.org/04etaja30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147332"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongping Duan","raw_affiliation_strings":["Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, 8 Xitoutiao, Fengtai, Beijing 100069, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, 8 Xitoutiao, Fengtai, Beijing 100069, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061712356","display_name":"Victor R. DeFilippis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738146","display_name":"Vaccine and Gene Therapy Institute","ror":"https://ror.org/00d4pqn65","country_code":"US","type":"facility","lineage":["https://openalex.org/I165690674","https://openalex.org/I4392738146"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor R. DeFilippis","raw_affiliation_strings":["Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, United States","institution_ids":["https://openalex.org/I4392738146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069904508","display_name":"Usha Viswanathan","orcid":"https://orcid.org/0000-0002-6946-2890","observed_orcids":["https://orcid.org/0000-0002-6946-2890"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Usha Viswanathan","raw_affiliation_strings":["Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086082140","display_name":"John L. Kulp","orcid":"https://orcid.org/0000-0003-2586-9207","observed_orcids":["https://orcid.org/0000-0003-2586-9207"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Kulp","raw_affiliation_strings":["Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102730146","display_name":"Yanming Du","orcid":"https://orcid.org/0000-0002-4665-8348","observed_orcids":["https://orcid.org/0000-0002-4665-8348"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanming Du","raw_affiliation_strings":["Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":"https://orcid.org/0000-0002-4665-8348","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076597546","display_name":"Ju\u2010Tao Guo","orcid":"https://orcid.org/0000-0001-5335-2788","observed_orcids":["https://orcid.org/0000-0001-5335-2788"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ju-Tao Guo","raw_affiliation_strings":["Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":"https://orcid.org/0000-0001-5335-2788","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023737081","display_name":"Jinhong Chang","orcid":"https://orcid.org/0000-0002-6723-494X","observed_orcids":["https://orcid.org/0000-0002-6723-494X"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jinhong Chang","raw_affiliation_strings":["Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":"https://orcid.org/0000-0002-6723-494X","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5023737081","https://openalex.org/A5076597546"],"corresponding_institution_ids":["https://openalex.org/I4210157427"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":3.5894,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.93907047,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"5","issue":"7","first_page":"1139","last_page":"1149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sting-agonist","display_name":"STING agonist","score":0.9580000042915344},{"id":"https://openalex.org/keywords/sting","display_name":"STING","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cgas-sting-pathway","display_name":"cGAS-STING pathway","score":0.9599999785423279},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8119999766349792},{"id":"https://openalex.org/keywords/interferon-lambda","display_name":"interferon lambda","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7480000257492065},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.878000020980835},{"id":"https://openalex.org/keywords/flavivirus-infection","display_name":"flavivirus infection","score":0.8840000033378601},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6801904439926147},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5787574052810669},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.505099356174469},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49763253331184387},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4879131019115448},{"id":"https://openalex.org/C2777349159","wikidata":"https://www.wikidata.org/wiki/Q18055374","display_name":"Stimulator of interferon genes","level":4,"score":0.4398009181022644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42956069111824036},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3930967152118683},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.353263258934021},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32110047340393066},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.320256769657135},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3033711314201355},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2746712267398834},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21881264448165894},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.17751702666282654},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.15859919786453247}],"mesh":[{"descriptor_ui":"D000099197","descriptor_name":"STING Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018177","descriptor_name":"Flavivirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D052117","descriptor_name":"Benzodioxoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D052117","descriptor_name":"Benzodioxoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D052117","descriptor_name":"Benzodioxoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acsinfecdis.9b00010","doi":"https://doi.org/10.1021/acsinfecdis.9b00010","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.9b00010","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:31060350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31060350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7082846","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7082846","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7082846","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7082846","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Infect Dis","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G36680115","display_name":"Evaluation of therapeutic benefits of HBV nucleocapsid assembly inhibitors","funder_award_id":"R01AI113267","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4430174889","display_name":null,"funder_award_id":"AI113267","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4701184538","display_name":"Development of Benzodiazepine YFV NS4B inhibitors as therapeutic agents for Yellow Fever","funder_award_id":"R01AI134732","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G964314536","display_name":null,"funder_award_id":"AI134732","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F1797151961","display_name":"Commonwealth of Pennsylvania","ror":"https://ror.org/047x97m51"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1797768250","https://openalex.org/W1898887656","https://openalex.org/W1980923315","https://openalex.org/W1993860509","https://openalex.org/W1994826332","https://openalex.org/W1995744610","https://openalex.org/W1998976744","https://openalex.org/W2004004350","https://openalex.org/W2015879727","https://openalex.org/W2016131266","https://openalex.org/W2022337477","https://openalex.org/W2026134797","https://openalex.org/W2027315920","https://openalex.org/W2035858672","https://openalex.org/W2041345682","https://openalex.org/W2044757050","https://openalex.org/W2066818317","https://openalex.org/W2083147016","https://openalex.org/W2096286209","https://openalex.org/W2097065948","https://openalex.org/W2099610218","https://openalex.org/W2099979820","https://openalex.org/W2112400160","https://openalex.org/W2116527093","https://openalex.org/W2141458291","https://openalex.org/W2148482462","https://openalex.org/W2154171253","https://openalex.org/W2165805168","https://openalex.org/W2166820820","https://openalex.org/W2169908694","https://openalex.org/W2190388875","https://openalex.org/W2260285999","https://openalex.org/W2289389546","https://openalex.org/W2409989593","https://openalex.org/W2466965232","https://openalex.org/W2522054472","https://openalex.org/W2522300837","https://openalex.org/W2546292426","https://openalex.org/W2560541542","https://openalex.org/W2580868078","https://openalex.org/W2583676372","https://openalex.org/W2608403896","https://openalex.org/W2611565672","https://openalex.org/W2612363400","https://openalex.org/W2626019299","https://openalex.org/W2733154631","https://openalex.org/W2754087313","https://openalex.org/W2760560147","https://openalex.org/W2761906648","https://openalex.org/W2766890000","https://openalex.org/W2775210943","https://openalex.org/W2778959568","https://openalex.org/W2788480107","https://openalex.org/W2796395918","https://openalex.org/W2798153162","https://openalex.org/W2809375742","https://openalex.org/W2810612816","https://openalex.org/W2884264032","https://openalex.org/W2886331019","https://openalex.org/W2886389978","https://openalex.org/W2887504899","https://openalex.org/W2887571017","https://openalex.org/W2889372876","https://openalex.org/W2900220188"],"related_works":["https://openalex.org/W2761906648","https://openalex.org/W2995280007","https://openalex.org/W2785380693","https://openalex.org/W4417438279","https://openalex.org/W2738537281","https://openalex.org/W4387580907","https://openalex.org/W3116126415","https://openalex.org/W4327609264","https://openalex.org/W3104859533","https://openalex.org/W2809963452"],"abstract_inverted_index":{"Stimulator":[0],"of":[1,26,45,70,141,150,165,168,192,200,210],"interferon":[2,31],"genes":[3],"(STING)":[4],"is":[5,177,205],"an":[6,52,158],"integral":[7],"ER-membrane":[8],"protein":[9],"that":[10,66,85,98,133,161,175,181],"can":[11],"be":[12],"activated":[13],"by":[14,17,41],"2\u20323\u2032-cGAMP":[15],"synthesized":[16],"cyclic":[18],"guanosine":[19],"monophosphate\u2013adenosine":[20],"monophosphate":[21],"synthase":[22],"(cGAS)":[23],"upon":[24],"binding":[25],"double-stranded":[27],"DNA.":[28],"It":[29],"activates":[30],"(IFN)":[32],"and":[33,55,103,113,128,143,214],"inflammatory":[34],"cytokine":[35,89,107,121],"responses":[36,108],"to":[37,50],"defend":[38],"against":[39,188],"infection":[40,164],"microorganisms.":[42],"Pharmacologic":[43],"activation":[44,140,199],"STING":[46],"has":[47],"been":[48],"demonstrated":[49],"induce":[51],"antiviral":[53,159,186],"state":[54,160],"boost":[56],"antitumor":[57],"immunity.":[58],"We":[59,74],"previously":[60],"reported":[61],"a":[62,77,87,92,178,189],"cell-based":[63],"high-throughput-screening":[64],"assay":[65],"allowed":[67],"for":[68,207],"identification":[69],"small-molecule":[71],"cGAS\u2013STING-pathway":[72],"agonists.":[73],"report":[75],"herein":[76],"compound,":[78],"6-bromo-":[79],"N":[80],"-(naphthalen-1-yl)benzo[":[81],"d":[82],"][1,3]dioxole-5-carboxamide":[83],"(BNBC),":[84],"induces":[86,184],"proinflammatory":[88],"response":[90,122],"in":[91,109,123],"human-STING-dependent":[93],"manner.":[94],"Specifically,":[95],"we":[96],"showed":[97],"BNBC":[99,118,156,176],"induced":[100,120,157],"type":[101],"I":[102],"III":[104],"IFN":[105],"dominant":[106],"primary":[110,151],"human":[111,152],"fibroblasts":[112],"peripheral-blood":[114],"mononuclear":[115],"cells":[116,127,154],"(PBMCs).":[117],"also":[119,196],"PBMC-derived":[124],"myeloid":[125],"dendritic":[126],"promoted":[129],"their":[130],"maturation,":[131],"suggesting":[132],"STING-agonist":[134],"treatment":[135,149,209],"could":[136],"potentially":[137],"regulate":[138],"the":[139,163,198,208],"CD4+":[142],"CD8+":[144],"T":[145],"lymphocytes.":[146],"As":[147],"anticipated,":[148],"fibroblast":[153],"with":[155],"inhibited":[162],"several":[166],"kinds":[167],"flaviviruses.":[169],"Taken":[170],"together,":[171],"our":[172],"results":[173],"indicate":[174],"human-STING":[179],"agonist":[180],"not":[182],"only":[183],"innate":[185],"immunity":[187],"broad":[190],"spectrum":[191],"viruses":[193],"but":[194],"may":[195],"stimulate":[197],"adaptive":[201],"immune":[202],"responses,":[203],"which":[204],"important":[206],"chronic":[211],"viral":[212],"infections":[213],"tumors.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-05-16T00:00:00"}