{"id":"https://openalex.org/W2944497366","doi":"https://doi.org/10.1111/jpi.12586","title":"Epigenetic inhibition of the tumor suppressor ARHI by light at night\u2010induced circadian melatonin disruption mediates STAT3\u2010driven paclitaxel resistance in breast cancer","display_name":"Epigenetic inhibition of the tumor suppressor ARHI by light at night\u2010induced circadian melatonin disruption mediates STAT3\u2010driven paclitaxel resistance in breast cancer","publication_year":2019,"publication_date":"2019-05-11","ids":{"openalex":"https://openalex.org/W2944497366","doi":"https://doi.org/10.1111/jpi.12586","mag":"2944497366","pmid":"https://pubmed.ncbi.nlm.nih.gov/31077613","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6750268"},"language":"en","primary_location":{"id":"doi:10.1111/jpi.12586","doi":"https://doi.org/10.1111/jpi.12586","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jpi.12586","pdf_url":null,"source":{"id":"https://openalex.org/S114728194","display_name":"Journal of Pineal Research","issn_l":"0742-3098","issn":["0742-3098","1600-079X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pineal Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6750268/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102242095","display_name":"Shulin Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I4405258087","display_name":"Louisiana Cancer Research Consortium","ror":"https://ror.org/0034k2773","country_code":"US","type":"other","lineage":["https://openalex.org/I114832834","https://openalex.org/I169251466","https://openalex.org/I4405258087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shulin Xiang","raw_affiliation_strings":["Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana","Tulane Cancer Center and Louisiana Cancer Research Consortium, New Orleans, Louisiana","Tulane Center for Circadian Biology, Tulane University School of Medicine, New Orleans, Louisiana","Tulane Circadian Cancer Biology Group, New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Tulane Cancer Center and Louisiana Cancer Research Consortium, New Orleans, Louisiana","institution_ids":["https://openalex.org/I4405258087"]},{"raw_affiliation_string":"Tulane Center for Circadian Biology, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Tulane Circadian Cancer Biology Group, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108445496","display_name":"Robert T. Dauchy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I4405258087","display_name":"Louisiana Cancer Research Consortium","ror":"https://ror.org/0034k2773","country_code":"US","type":"other","lineage":["https://openalex.org/I114832834","https://openalex.org/I169251466","https://openalex.org/I4405258087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert T. Dauchy","raw_affiliation_strings":["Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana","Tulane Cancer Center and Louisiana Cancer Research Consortium, New Orleans, Louisiana","Tulane Center for Circadian Biology, Tulane University School of Medicine, New Orleans, Louisiana","Tulane Circadian Cancer Biology Group, New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Tulane Cancer Center and Louisiana Cancer Research Consortium, New Orleans, Louisiana","institution_ids":["https://openalex.org/I4405258087"]},{"raw_affiliation_string":"Tulane Center for Circadian Biology, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Tulane Circadian Cancer Biology Group, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033174111","display_name":"Aaron E. Hoffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I4405258087","display_name":"Louisiana Cancer Research Consortium","ror":"https://ror.org/0034k2773","country_code":"US","type":"other","lineage":["https://openalex.org/I114832834","https://openalex.org/I169251466","https://openalex.org/I4405258087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron E. Hoffman","raw_affiliation_strings":["Department of Epidemiology, Tulane School of Public Health, New Orleans, Louisiana","Tulane Cancer Center and Louisiana Cancer Research Consortium, New Orleans, Louisiana","Tulane Center for Circadian Biology, Tulane University School of Medicine, New Orleans, Louisiana","Tulane Circadian Cancer Biology Group, New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Tulane School of Public Health, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Tulane Cancer Center and Louisiana Cancer Research Consortium, New Orleans, Louisiana","institution_ids":["https://openalex.org/I4405258087"]},{"raw_affiliation_string":"Tulane Center for Circadian Biology, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Tulane Circadian Cancer Biology Group, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079244519","display_name":"David T. Pointer","orcid":"https://orcid.org/0000-0002-0174-981X","observed_orcids":["https://orcid.org/0000-0002-0174-981X"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Pointer","raw_affiliation_strings":["Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027252737","display_name":"Tripp Frasch","orcid":"https://orcid.org/0000-0003-3354-4349","observed_orcids":["https://orcid.org/0000-0003-3354-4349"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tripp Frasch","raw_affiliation_strings":["Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana","Tulane Center for Circadian Biology, Tulane University School of Medicine, New Orleans, Louisiana"],"raw_orcid":"https://orcid.org/0000-0003-3354-4349","affiliations":[{"raw_affiliation_string":"Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Tulane Center for Circadian Biology, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016402426","display_name":"David E. Blask","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I4405258087","display_name":"Louisiana Cancer Research Consortium","ror":"https://ror.org/0034k2773","country_code":"US","type":"other","lineage":["https://openalex.org/I114832834","https://openalex.org/I169251466","https://openalex.org/I4405258087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Blask","raw_affiliation_strings":["Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana","Tulane Cancer Center and Louisiana Cancer Research Consortium, New Orleans, Louisiana","Tulane Center for Circadian Biology, Tulane University School of Medicine, New Orleans, Louisiana","Tulane Circadian Cancer Biology Group, New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Tulane Cancer Center and Louisiana Cancer Research Consortium, New Orleans, Louisiana","institution_ids":["https://openalex.org/I4405258087"]},{"raw_affiliation_string":"Tulane Center for Circadian Biology, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Tulane Circadian Cancer Biology Group, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046305632","display_name":"Steven M. Hill","orcid":"https://orcid.org/0000-0002-5909-692X","observed_orcids":["https://orcid.org/0000-0002-5909-692X"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I4405258087","display_name":"Louisiana Cancer Research Consortium","ror":"https://ror.org/0034k2773","country_code":"US","type":"other","lineage":["https://openalex.org/I114832834","https://openalex.org/I169251466","https://openalex.org/I4405258087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M. Hill","raw_affiliation_strings":["Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana","Tulane Cancer Center and Louisiana Cancer Research Consortium, New Orleans, Louisiana","Tulane Center for Circadian Biology, Tulane University School of Medicine, New Orleans, Louisiana","Tulane Circadian Cancer Biology Group, New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Tulane Cancer Center and Louisiana Cancer Research Consortium, New Orleans, Louisiana","institution_ids":["https://openalex.org/I4405258087"]},{"raw_affiliation_string":"Tulane Center for Circadian Biology, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Tulane Circadian Cancer Biology Group, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027252737"],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":7.0211,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.98075365,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"67","issue":"2","first_page":"e12586","last_page":"e12586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dim-light-at-night","display_name":"dim light at night","score":0.9509999752044678},{"id":"https://openalex.org/keywords/circadian-rhythm-disruption","display_name":"circadian rhythm disruption","score":0.8519999980926514},{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.675000011920929},{"id":"https://openalex.org/keywords/paclitaxel-resistance","display_name":"paclitaxel resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9390000104904175},{"id":"https://openalex.org/keywords/arhi","display_name":"ARHI","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.8669999837875366},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.8090000152587891},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.7680000066757202},{"id":"https://openalex.org/keywords/stat3-acetylation","display_name":"STAT3 acetylation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mt1-melatonin-receptor","display_name":"MT1 receptor","score":0.8730000257492065},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6779999732971191},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.753000020980835},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.605217456817627},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.5698232054710388},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.551294207572937},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5287442207336426},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.48256435990333557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4798847734928131},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4385311007499695},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35677051544189453},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25959187746047974}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011923","descriptor_name":"Rats, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/jpi.12586","doi":"https://doi.org/10.1111/jpi.12586","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jpi.12586","pdf_url":null,"source":{"id":"https://openalex.org/S114728194","display_name":"Journal of Pineal Research","issn_l":"0742-3098","issn":["0742-3098","1600-079X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pineal Research","raw_type":"journal-article"},{"id":"pmid:31077613","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31077613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pineal research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6750268","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6750268/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Pineal Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6750268","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6750268/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Pineal Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8326587754","display_name":"Circadian Disruption by Light at Night Induces Intrinsic Tamoxifen Resistant Breast Cancer","funder_award_id":"R56CA193518","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W126944972","https://openalex.org/W181556572","https://openalex.org/W1133137246","https://openalex.org/W1563819414","https://openalex.org/W1592217318","https://openalex.org/W1607794022","https://openalex.org/W1821858011","https://openalex.org/W1885439970","https://openalex.org/W1940754997","https://openalex.org/W1966605094","https://openalex.org/W1992882573","https://openalex.org/W1994049744","https://openalex.org/W2004914674","https://openalex.org/W2015127357","https://openalex.org/W2017290745","https://openalex.org/W2018802500","https://openalex.org/W2020238484","https://openalex.org/W2024282024","https://openalex.org/W2024533570","https://openalex.org/W2025689023","https://openalex.org/W2031018710","https://openalex.org/W2038061816","https://openalex.org/W2040108806","https://openalex.org/W2042619042","https://openalex.org/W2044505153","https://openalex.org/W2045987911","https://openalex.org/W2055397209","https://openalex.org/W2059127283","https://openalex.org/W2060142295","https://openalex.org/W2069834221","https://openalex.org/W2070512478","https://openalex.org/W2070747775","https://openalex.org/W2074356752","https://openalex.org/W2078390666","https://openalex.org/W2078655231","https://openalex.org/W2081673273","https://openalex.org/W2083802827","https://openalex.org/W2087366979","https://openalex.org/W2088338909","https://openalex.org/W2093155739","https://openalex.org/W2098613950","https://openalex.org/W2103315206","https://openalex.org/W2106787323","https://openalex.org/W2110024452","https://openalex.org/W2111152582","https://openalex.org/W2111424964","https://openalex.org/W2113231588","https://openalex.org/W2116401711","https://openalex.org/W2125538105","https://openalex.org/W2132195064","https://openalex.org/W2141056749","https://openalex.org/W2141393790","https://openalex.org/W2147989715","https://openalex.org/W2152181862","https://openalex.org/W2153086428","https://openalex.org/W2158229562","https://openalex.org/W2159268679","https://openalex.org/W2159407899","https://openalex.org/W2160711420","https://openalex.org/W2165316668","https://openalex.org/W2167191662","https://openalex.org/W2270468128","https://openalex.org/W2285791739","https://openalex.org/W2415164681","https://openalex.org/W2512653609","https://openalex.org/W2517965114","https://openalex.org/W2519876786","https://openalex.org/W2773147665"],"related_works":["https://openalex.org/W2478155540","https://openalex.org/W2015127357","https://openalex.org/W2045987911","https://openalex.org/W2287337778","https://openalex.org/W2090740247","https://openalex.org/W2741194624","https://openalex.org/W2058824847","https://openalex.org/W2944139145","https://openalex.org/W6908156483","https://openalex.org/W1525288721"],"abstract_inverted_index":{"Abstract":[0],"Disruption":[1],"of":[2,8,39,50,59,64,81,97,107,144,168,173,187,221,243],"circadian":[3,9,138,219],"time":[4],"structure":[5],"and":[6,42,46,62,66,79,87,137,146,156,170,236,248],"suppression":[7,58],"nocturnal":[10],"melatonin":[11],"(MLT)":[12],"production":[13],"by":[14,223],"exposure":[15],"to":[16,44,102,122,135,175,217,228,246],"dim":[17],"light":[18],"at":[19],"night":[20,25],"(dLAN),":[21],"as":[22],"occurs":[23],"with":[24,34,201],"shift":[26],"work":[27],"and/or":[28,160],"disturbed":[29],"sleep\u2010wake":[30],"cycles,":[31],"is":[32,198,213],"associated":[33],"a":[35],"significantly":[36,199],"increased":[37,149],"risk":[38],"breast":[40,52,75,92,129,182,209,244],"cancer":[41,53,183,210],"resistance":[43,227],"tamoxifen":[45],"doxorubicin.":[47],"Melatonin":[48],"inhibition":[49,63],"human":[51],"chemoresistance":[54],"involves":[55],"mechanisms":[56,232],"including":[57],"tumor":[60,108,130,250],"metabolism":[61],"kinases":[65],"transcription":[67,82,106],"factors":[68],"which":[69,115],"are":[70],"often":[71],"activated":[72,88],"in":[73,89,119,132,180,208],"drug\u2010resistant":[74],"cancer.":[76],"Signal":[77],"transducer":[78],"activator":[80],"3":[83],"(STAT3),":[84],"frequently":[85],"overexpressed":[86],"paclitaxel":[90],"(PTX)\u2010resistant":[91],"cancer,":[93],"promotes":[94],"the":[95,105,120,188,214],"expression":[96,179,197,235],"DNA":[98],"methyltransferase":[99],"one":[100,113],"(DNMT1)":[101],"epigenetically":[103],"suppress":[104],"suppressor":[109],"Aplasia":[110],"Ras":[111],"homolog":[112],"(ARHI)":[114],"can":[116,240],"sequester":[117],"STAT3":[118,169,234],"cytoplasm":[121],"block":[123],"PTX":[124,229,247],"resistance.":[125],"We":[126],"demonstrate":[127,192,218],"that":[128,193,237],"xenografts":[131],"rats":[133],"exposed":[134],"dLAN":[136,224],"MLT":[139,159,222,238],"disrupted":[140],"express":[141],"elevated":[142,194],"levels":[143],"phosphorylated":[145],"acetylated":[147],"STAT3,":[148],"DNMT1,":[150],"but":[151],"reduced":[152],"sirtuin":[153],"1":[154,190],"(SIRT1)":[155],"ARHI.":[157],"Furthermore,":[158],"SIRT1":[161],"administration":[162,239],"blocked/reversed":[163],"interleukin":[164],"6":[165],"(IL\u20106)\u2010induced":[166],"acetylation":[167],"its":[171],"methylation":[172],"ARH1":[174,177],"increase":[176],"mRNA":[178],"MCF\u20107":[181],"cells.":[184],"Finally,":[185],"analyses":[186],"I\u2010SPY":[189],"trial":[191],"MT1":[195],"receptor":[196],"correlated":[200],"pathologic":[202],"complete":[203],"response":[204],"following":[205],"neo\u2010adjuvant":[206],"therapy":[207],"patients.":[211],"This":[212],"first":[215],"study":[216],"disruption":[220],"driving":[225],"intrinsic":[226],"via":[230],"epigenetic":[231],"increasing":[233],"reestablish":[241],"sensitivity":[242],"tumors":[245],"drive":[249],"regression.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-05-16T00:00:00"}
