{"id":"https://openalex.org/W2944372010","doi":"https://doi.org/10.1002/phar.2271","title":"Pharmacotherapy of Autism Spectrum Disorder: Results from the Randomized BAART Clinical Trial","display_name":"Pharmacotherapy of Autism Spectrum Disorder: Results from the Randomized BAART Clinical Trial","publication_year":2019,"publication_date":"2019-05-07","ids":{"openalex":"https://openalex.org/W2944372010","doi":"https://doi.org/10.1002/phar.2271","mag":"2944372010","pmid":"https://pubmed.ncbi.nlm.nih.gov/31063671","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6555676"},"language":"en","primary_location":{"id":"doi:10.1002/phar.2271","doi":"https://doi.org/10.1002/phar.2271","is_oa":true,"landing_page_url":"https://doi.org/10.1002/phar.2271","pdf_url":"https://accpjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/phar.2271","source":{"id":"https://openalex.org/S122731057","display_name":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","issn_l":"0277-0008","issn":["0277-0008","1875-9114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://accpjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/phar.2271","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079740756","display_name":"C. Lindsay DeVane","orcid":"https://orcid.org/0000-0003-1608-9911","observed_orcids":["https://orcid.org/0000-0003-1608-9911"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C. Lindsay DeVane","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0000-0003-1608-9911","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028309037","display_name":"Jane M. Charles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane M. Charles","raw_affiliation_strings":["Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111534250","display_name":"Ruth K. Abramson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth K. Abramson","raw_affiliation_strings":["Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina, Columbia, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina, Columbia, South Carolina","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032025013","display_name":"John E. Williams","orcid":"https://orcid.org/0000-0002-1353-2685","observed_orcids":["https://orcid.org/0000-0002-1353-2685"]},"institutions":[{"id":"https://openalex.org/I1283654650","display_name":"Prisma Health","ror":"https://ror.org/03n7vd314","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283654650"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Williams","raw_affiliation_strings":["Department of Developmental-Behavioral Pediatrics, Greenville Hospital System University Medical System, Greenville, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental-Behavioral Pediatrics, Greenville Hospital System University Medical System, Greenville, South Carolina","institution_ids":["https://openalex.org/I1283654650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037231847","display_name":"Laura Arnstein Carpenter","orcid":"https://orcid.org/0000-0002-6448-9242","observed_orcids":["https://orcid.org/0000-0002-6448-9242"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura A. Carpenter","raw_affiliation_strings":["Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112925257","display_name":"Sarah Raven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Raven","raw_affiliation_strings":["Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina, Columbia, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina, Columbia, South Carolina","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015448686","display_name":"McLeod Frampton Gwynette","orcid":"https://orcid.org/0000-0001-7567-1835","observed_orcids":["https://orcid.org/0000-0001-7567-1835"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frampton Gwynette","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083496829","display_name":"Craig A. Stuck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig A. Stuck","raw_affiliation_strings":["Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina, Columbia, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina, Columbia, South Carolina","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005119541","display_name":"Mark E. Geesey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark E. Geesey","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013118838","display_name":"Catherine C. Bradley","orcid":"https://orcid.org/0000-0003-4475-2805","observed_orcids":["https://orcid.org/0000-0003-4475-2805"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Bradley","raw_affiliation_strings":["Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087595155","display_name":"Jennifer L. Donovan","orcid":"https://orcid.org/0000-0002-3106-7676","observed_orcids":["https://orcid.org/0000-0002-3106-7676"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Donovan","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103848392","display_name":"Alicia G. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia G. Hall","raw_affiliation_strings":["Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina, Columbia, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina, Columbia, South Carolina","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035964222","display_name":"Shelley T. Sherk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelley T. Sherk","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nancy R. Powers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283654650","display_name":"Prisma Health","ror":"https://ror.org/03n7vd314","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283654650"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy R. Powers","raw_affiliation_strings":["Department of Developmental-Behavioral Pediatrics, Greenville Hospital System University Medical System, Greenville, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental-Behavioral Pediatrics, Greenville Hospital System University Medical System, Greenville, South Carolina","institution_ids":["https://openalex.org/I1283654650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068034195","display_name":"Eve Garlington Spratt","orcid":"https://orcid.org/0000-0002-9634-4005","observed_orcids":["https://orcid.org/0000-0002-9634-4005"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eve Spratt","raw_affiliation_strings":["Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina","Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015604627","display_name":"Anne M. Kinsman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283654650","display_name":"Prisma Health","ror":"https://ror.org/03n7vd314","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283654650"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Kinsman","raw_affiliation_strings":["Department of Developmental-Behavioral Pediatrics, Greenville Hospital System University Medical System, Greenville, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental-Behavioral Pediatrics, Greenville Hospital System University Medical System, Greenville, South Carolina","institution_ids":["https://openalex.org/I1283654650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059041300","display_name":"Markus J.P. Kruesi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus J. Kruesi","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050517525","display_name":"John E. Bragg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Bragg","raw_affiliation_strings":["Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina, Columbia, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina, Columbia, South Carolina","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079740756"],"corresponding_institution_ids":["https://openalex.org/I153297377"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":3.2823,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.9238203,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"39","issue":"6","first_page":"626","last_page":"635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aripiprazole","display_name":"aripiprazole","score":0.9729999899864197},{"id":"https://openalex.org/keywords/risperidone","display_name":"risperidone","score":1.0},{"id":"https://openalex.org/keywords/antipsychotic-pharmacotherapy","display_name":"antipsychotic pharmacotherapy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/irritability","display_name":"irritability","score":0.9580000042915344},{"id":"https://openalex.org/keywords/aberrant-behavior-checklist","display_name":"Aberrant Behavior Checklist","score":0.8820000290870667},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.6439999938011169},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.4650000035762787},{"id":"https://openalex.org/keywords/predictors-of-treatment-response","display_name":"predictors of treatment response","score":0.3919999897480011},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.800000011920929},{"id":"https://openalex.org/keywords/placebo-response","display_name":"placebo response","score":0.5649999976158142},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.8420000076293945},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.6359999775886536},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.39100000262260437},{"id":"https://openalex.org/keywords/stimulants","display_name":"stimulants","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C2780211496","wikidata":"https://www.wikidata.org/wiki/Q411188","display_name":"Aripiprazole","level":3,"score":0.9196974039077759},{"id":"https://openalex.org/C2780057945","wikidata":"https://www.wikidata.org/wiki/Q412443","display_name":"Risperidone","level":3,"score":0.8923078775405884},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6951876878738403},{"id":"https://openalex.org/C2780820931","wikidata":"https://www.wikidata.org/wiki/Q29299","display_name":"Irritability","level":3,"score":0.6578947901725769},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.5955439805984497},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5876840353012085},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5720887780189514},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.5096690654754639},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.4804615378379822},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47791561484336853},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.4474199712276459},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4154145121574402},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4113057553768158},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.34849464893341064},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3482933044433594},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.21708649396896362},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000068180","descriptor_name":"Aripiprazole","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000068180","descriptor_name":"Aripiprazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018967","descriptor_name":"Risperidone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018967","descriptor_name":"Risperidone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/phar.2271","doi":"https://doi.org/10.1002/phar.2271","is_oa":true,"landing_page_url":"https://doi.org/10.1002/phar.2271","pdf_url":"https://accpjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/phar.2271","source":{"id":"https://openalex.org/S122731057","display_name":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","issn_l":"0277-0008","issn":["0277-0008","1875-9114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","raw_type":"journal-article"},{"id":"pmid:31063671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31063671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6555676","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6555676","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pharmacotherapy","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/phar.2271","doi":"https://doi.org/10.1002/phar.2271","is_oa":true,"landing_page_url":"https://doi.org/10.1002/phar.2271","pdf_url":"https://accpjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/phar.2271","source":{"id":"https://openalex.org/S122731057","display_name":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","issn_l":"0277-0008","issn":["0277-0008","1875-9114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G6872303246","display_name":"Biomarkers in Autism of Aripiprazole and Risperidone Treatment (BAART)","funder_award_id":"R01HD062550","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2944372010.pdf","grobid_xml":"https://content.openalex.org/works/W2944372010.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W183484377","https://openalex.org/W1758325167","https://openalex.org/W1968430210","https://openalex.org/W1969516074","https://openalex.org/W2000624544","https://openalex.org/W2007445647","https://openalex.org/W2018998808","https://openalex.org/W2037835401","https://openalex.org/W2096202887","https://openalex.org/W2116795013","https://openalex.org/W2121150539","https://openalex.org/W2123247267","https://openalex.org/W2130514663","https://openalex.org/W2141464904","https://openalex.org/W2160438215","https://openalex.org/W2614349964"],"related_works":["https://openalex.org/W1969516074","https://openalex.org/W1999630630","https://openalex.org/W4235481922","https://openalex.org/W4414579327","https://openalex.org/W4296031148","https://openalex.org/W2902296103","https://openalex.org/W10102445","https://openalex.org/W2280843891","https://openalex.org/W2078913169","https://openalex.org/W2018998808"],"abstract_inverted_index":{"The":[0],"objective":[1],"of":[2,8,29,39,107,181,306,345,353],"this":[3],"trial,":[4,90],"Biomarkers":[5],"in":[6,32,51,179,220,235,257,266,313,358],"Autism":[7],"Aripiprazole":[9],"and":[10,18,27,42,56,74,91,138,143,166,186,206,213,228,242,278,319,356,367],"Risperidone":[11],"Treatment":[12],"(BAART),":[13],"was":[14,49,218,229,261],"to":[15,79,112,328],"provide":[16],"support":[17,371],"guidance":[19],"for":[20,24,121,160,208,291,372,377,380],"an":[21,94,374],"evidence-based":[22,370],"approach":[23],"the":[25,80,88,184,198,209,214,221,236,251,258,267,287,292,296,338,343,346,369],"selection":[26],"monitoring":[28],"initial":[30,378],"pharmacotherapy":[31,379],"patients":[33,76,101,152,194,294,307,359],"with":[34,69,104,308,332,360],"autism":[35,309,361,381],"by":[36,342],"assessing":[37],"predictors":[38],"efficacy,":[40],"tolerability,":[41],"safety.":[43],"This":[44],"randomized":[45,78],"double-blind":[46],"parallel-group":[47],"study":[48,81],"conducted":[50],"three":[52],"academic":[53],"medical":[54],"centers":[55],"a":[57,157,329],"single":[58],"private":[59],"pediatric":[60],"practice.":[61],"Eighty":[62],"children":[63],"or":[64,117,172],"adolescents":[65],"(aged":[66],"6-17":[67],"yrs)":[68],"autistic":[70],"disorder":[71,311,363],"were":[72,77,102,128,147,153,169,189],"enrolled,":[73],"61":[75],"drug.":[82],"Of":[83],"those":[84],"patients,":[85],"51":[86],"completed":[87,93],"10-week":[89],"31":[92,293],"optional":[95],"12-week":[96],"blinded":[97],"extension":[98,215,298],"phase.":[99,216],"All":[100,193],"treated":[103],"2":[105,174],"weeks":[106,212,240],"placebo":[108,125],"before":[109],"random":[110],"assignment":[111],"receive":[113],"aripiprazole":[114,185,237,259,335],"(31":[115],"patients)":[116,120],"risperidone":[118,187,222,268,333],"(30":[119],"10":[122,280],"weeks.":[123,163,175,324],"Sixteen":[124],"responders":[126],"(20%)":[127],"excluded":[129],"from":[130,364],"further":[131],"analysis.":[132],"Drug":[133,139],"dosing":[134],"followed":[135],"U.S.":[136],"Food":[137],"Administration":[140],"(FDA)":[141],"labeling,":[142],"weekly":[144,171],"dosage":[145],"adjustments":[146],"allowed":[148],"until":[149],"week":[150,205,271,279,318],"4;":[151],"then":[154],"maintained":[155],"on":[156,197],"fixed":[158],"dose":[159],"6":[161,243],"additional":[162],"Safety,":[164],"physical,":[165],"psychological":[167],"assessments":[168],"recorded":[170],"every":[173,225],"No":[176,245],"significant":[177],"differences":[178,339],"severity":[180],"illness":[182],"between":[183],"groups":[188],"noted":[190],"at":[191,224,239,270,321],"baseline.":[192],"significantly":[195,231,262],"improved":[196],"Aberrant":[199],"Behavior":[200],"Checklist-Irritability":[201],"subscale":[202],"after":[203],"1":[204,317],"continued":[207],"remaining":[210],"9":[211],"Improvement":[217],"greatest":[219],"group":[223,238,260,269],"assessment":[226],"period":[227],"statistically":[230],"better":[232],"than":[233,264,334],"that":[234,265],"3":[241],"(p<0.05).":[244],"dose-limiting":[246],"adverse":[247],"events":[248],"occurred":[249,327],"during":[250],"dose-titration":[252],"period.":[253],"Mean":[254],"weight":[255],"gain":[256,326],"less":[263],"4":[272],"(0.62":[273],"vs":[274,282,301],"1.38":[275],"kg,":[276,284,303],"p=0.033)":[277],"(1.61":[281],"3.31":[283],"p<0.001),":[285],"but":[286,337],"difference":[288],"became":[289,340],"nonsignificant":[290,341],"completing":[295],"3-month":[297],"phase":[299],"(4.36":[300],"5.55":[302],"p=0.26).":[304],"Pharmacotherapy":[305],"spectrum":[310,362,382],"resulted":[312],"behavioral":[314],"improvement":[315],"within":[316],"lasted":[320],"least":[322],"22":[323],"Weight":[325],"greater":[330],"degree":[331],"initially,":[336],"end":[344],"trial.":[347],"Our":[348],"trial":[349],"supports":[350],"previous":[351],"results":[352],"drug":[354,376],"efficacy":[355],"safety":[357],"other":[365],"trials":[366],"extends":[368],"choosing":[373],"FDA-approved":[375],"disorder.":[383]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-05-16T00:00:00"}