{"id":"https://openalex.org/W2944358985","doi":"https://doi.org/10.1016/j.pnpbp.2019.109644","title":"The Notch signaling pathway inhibitor Dapt alleviates autism-like behavior, autophagy and dendritic spine density abnormalities in a valproic acid-induced animal model of autism","display_name":"The Notch signaling pathway inhibitor Dapt alleviates autism-like behavior, autophagy and dendritic spine density abnormalities in a valproic acid-induced animal model of autism","publication_year":2019,"publication_date":"2019-05-07","ids":{"openalex":"https://openalex.org/W2944358985","doi":"https://doi.org/10.1016/j.pnpbp.2019.109644","mag":"2944358985","pmid":"https://pubmed.ncbi.nlm.nih.gov/31075347"},"language":"en","primary_location":{"id":"doi:10.1016/j.pnpbp.2019.109644","doi":"https://doi.org/10.1016/j.pnpbp.2019.109644","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pnpbp.2019.109644","pdf_url":null,"source":{"id":"https://openalex.org/S142279999","display_name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","issn_l":"0278-5846","issn":["0278-5846","1878-4216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100648510","display_name":"Ying\u2010Hua Zhang","orcid":"https://orcid.org/0000-0002-3904-8381","observed_orcids":["https://orcid.org/0000-0002-3904-8381","https://orcid.org/0000-0003-1129-6938"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yinghua Zhang","raw_affiliation_strings":["Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China; Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China. Electronic address: zyhflo2013@163.com","Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China","Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China; Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China. Electronic address: zyhflo2013@163.com","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhe Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Xiang","raw_affiliation_strings":["Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China; Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China","Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China; Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yunjie Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunjie Jia","raw_affiliation_strings":["Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China; Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China","Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China; Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051600231","display_name":"HE Xue-ling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueling He","raw_affiliation_strings":["Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China; Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China","Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China; Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318867","display_name":"Lijun Wang","orcid":"https://orcid.org/0000-0002-0074-518X","observed_orcids":["https://orcid.org/0000-0002-0074-518X"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijun Wang","raw_affiliation_strings":["Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China; Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China","Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China; Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041088271","display_name":"Weigang Cui","orcid":"https://orcid.org/0000-0002-3318-6708","observed_orcids":["https://orcid.org/0000-0002-3318-6708"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weigang Cui","raw_affiliation_strings":["Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China; Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China","Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China; Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"Department of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan 453003, PR China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100648510"],"corresponding_institution_ids":["https://openalex.org/I80626142"],"apc_list":{"value":2400,"currency":"USD","value_usd":2400},"apc_paid":null,"fwci":3.5449,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.93174299,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"94","issue":null,"first_page":"109644","last_page":"109644"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.05689999833703041,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9330000281333923},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/dapt","display_name":"DAPT","score":0.7699999809265137},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9139999747276306},{"id":"https://openalex.org/keywords/prenatal-valproic-acid-exposure","display_name":"prenatal valproic acid exposure","score":0.878000020980835},{"id":"https://openalex.org/keywords/autism-like-behavior","display_name":"autism-like behavior","score":0.8360000252723694},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dendritic-spine-density","display_name":"dendritic spine density","score":0.9139999747276306},{"id":"https://openalex.org/keywords/notch1","display_name":"Notch1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.8600000143051147},{"id":"https://openalex.org/keywords/lc3b","display_name":"LC3B","score":0.8230000138282776},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.8389999866485596},{"id":"https://openalex.org/keywords/psd-95","display_name":"PSD-95","score":0.9649999737739563},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.7500408887863159},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.7415319681167603},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.6887640953063965},{"id":"https://openalex.org/C187541742","wikidata":"https://www.wikidata.org/wiki/Q4374336","display_name":"Postsynaptic density","level":4,"score":0.6397661566734314},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.586364209651947},{"id":"https://openalex.org/C2780283210","wikidata":"https://www.wikidata.org/wiki/Q18027301","display_name":"HES1","level":4,"score":0.5670160055160522},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.5313155055046082},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.46583500504493713},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4581749141216278},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.45499852299690247},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.44671911001205444},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4374578297138214},{"id":"https://openalex.org/C65114990","wikidata":"https://www.wikidata.org/wiki/Q5745269","display_name":"Hes3 signaling axis","level":4,"score":0.4217309057712555},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.4208466708660126},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.4031631350517273},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.399925172328949},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3908066153526306},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3782428503036499},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35497838258743286},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3336658477783203},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.2929695248603821},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23479211330413818},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18536239862442017},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.16466346383094788},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1439201831817627},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1411324143409729},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0762769877910614},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06442171335220337},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071186","descriptor_name":"Beclin-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000071456","descriptor_name":"Sequestosome-1 Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000076122","descriptor_name":"Disks Large Homolog 4 Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.pnpbp.2019.109644","doi":"https://doi.org/10.1016/j.pnpbp.2019.109644","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pnpbp.2019.109644","pdf_url":null,"source":{"id":"https://openalex.org/S142279999","display_name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","issn_l":"0278-5846","issn":["0278-5846","1878-4216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","raw_type":"journal-article"},{"id":"pmid:31075347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31075347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in neuro-psychopharmacology & biological psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6565677893","display_name":null,"funder_award_id":"81301174","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7444871786","display_name":null,"funder_award_id":"U1804185","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1482174726","https://openalex.org/W1934687656","https://openalex.org/W1966765276","https://openalex.org/W1974876046","https://openalex.org/W1977206884","https://openalex.org/W1978385061","https://openalex.org/W1985647352","https://openalex.org/W1997801717","https://openalex.org/W2001029428","https://openalex.org/W2005613383","https://openalex.org/W2009130750","https://openalex.org/W2043414030","https://openalex.org/W2048283976","https://openalex.org/W2049380496","https://openalex.org/W2053909439","https://openalex.org/W2067486032","https://openalex.org/W2075026706","https://openalex.org/W2099705390","https://openalex.org/W2101110943","https://openalex.org/W2104582585","https://openalex.org/W2106870542","https://openalex.org/W2119639352","https://openalex.org/W2133470905","https://openalex.org/W2137395087","https://openalex.org/W2143309726","https://openalex.org/W2160038617","https://openalex.org/W2165144227","https://openalex.org/W2165236867","https://openalex.org/W2169871407","https://openalex.org/W2180234284","https://openalex.org/W2228196161","https://openalex.org/W2311599414","https://openalex.org/W2410661399","https://openalex.org/W2462925203","https://openalex.org/W2540426790","https://openalex.org/W2550096096","https://openalex.org/W2587508305","https://openalex.org/W2593638387","https://openalex.org/W2605411260","https://openalex.org/W2726089911","https://openalex.org/W2747530261","https://openalex.org/W2750308702","https://openalex.org/W2767035585","https://openalex.org/W2768911594","https://openalex.org/W2769163989","https://openalex.org/W2778440734","https://openalex.org/W2801451179","https://openalex.org/W2806803349","https://openalex.org/W2809176836","https://openalex.org/W2810453228","https://openalex.org/W2811102313","https://openalex.org/W2883393270","https://openalex.org/W2891540763","https://openalex.org/W2950427622"],"related_works":["https://openalex.org/W4385519022","https://openalex.org/W4390941694","https://openalex.org/W2467352702","https://openalex.org/W4382344395","https://openalex.org/W4220747661","https://openalex.org/W2750308702","https://openalex.org/W7143442819","https://openalex.org/W4406336402","https://openalex.org/W2033856668","https://openalex.org/W4254626828"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-05-16T00:00:00"}