{"id":"https://openalex.org/W2944349554","doi":"https://doi.org/10.3389/fimmu.2019.01009","title":"Organ-Specific Expression of IL-1 Receptor Results in Severe Liver Injury in Type I Interferon Receptor Deficient Mice","display_name":"Organ-Specific Expression of IL-1 Receptor Results in Severe Liver Injury in Type I Interferon Receptor Deficient Mice","publication_year":2019,"publication_date":"2019-05-09","ids":{"openalex":"https://openalex.org/W2944349554","doi":"https://doi.org/10.3389/fimmu.2019.01009","mag":"2944349554","pmid":"https://pubmed.ncbi.nlm.nih.gov/31143178","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6521796"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2019.01009","doi":"https://doi.org/10.3389/fimmu.2019.01009","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.01009","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.01009/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.01009/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024435015","display_name":"Martina Anzaghe","orcid":"https://orcid.org/0000-0002-7983-3835","observed_orcids":["https://orcid.org/0000-0002-7983-3835"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martina Anzaghe","raw_affiliation_strings":["Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021971210","display_name":"Theresa K. Bessey","orcid":"https://orcid.org/0000-0002-2950-1365","observed_orcids":["https://orcid.org/0000-0002-2950-1365"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Theresa Resch","raw_affiliation_strings":["Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076424618","display_name":"Elea Schaser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elea Schaser","raw_affiliation_strings":["Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016090024","display_name":"Stefanie Kronhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie Kronhart","raw_affiliation_strings":["Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Clara Diez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Clara Diez","raw_affiliation_strings":["Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072532054","display_name":"Marc A. Niles","orcid":"https://orcid.org/0000-0002-5791-1644","observed_orcids":["https://orcid.org/0000-0002-5791-1644"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marc A. Niles","raw_affiliation_strings":["Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058414707","display_name":"Eugenia Korotkova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eugenia Korotkova","raw_affiliation_strings":["Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039122343","display_name":"Stefan Sch\u00fclke","orcid":"https://orcid.org/0000-0002-9674-5116","observed_orcids":["https://orcid.org/0000-0002-9674-5116"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Sch\u00fclke","raw_affiliation_strings":["Vice President's Research Group 1 \"Molecular Allergology\", Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vice President's Research Group 1 \"Molecular Allergology\", Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040999588","display_name":"Sonja Wolfheimer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sonja Wolfheimer","raw_affiliation_strings":["Vice President's Research Group 1 \"Molecular Allergology\", Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vice President's Research Group 1 \"Molecular Allergology\", Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082075523","display_name":"Dorothea Kreuz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dorothea Kreuz","raw_affiliation_strings":["Section 3/3 \"Morphology\", Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section 3/3 \"Morphology\", Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052144527","display_name":"Marion Wingerter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marion Wingerter","raw_affiliation_strings":["Division of Veterinary Medicine, Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Veterinary Medicine, Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mar\u00eda Matilde Bartolom\u00e9 Rodr\u00edguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Matilde Bartolom\u00e9 Rodr\u00edguez","raw_affiliation_strings":["Institute for Internal Medicine University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Internal Medicine University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051811775","display_name":"Zoe Waibler","orcid":"https://orcid.org/0000-0001-5758-2652","observed_orcids":["https://orcid.org/0000-0001-5758-2652"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Zoe Waibler","raw_affiliation_strings":["Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section 3/1 \"Product Testing of Immunological Biomedicines\", Paul-Ehrlich-Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051811775"],"corresponding_institution_ids":["https://openalex.org/I884002606"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.1958,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.45756721,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"10","issue":null,"first_page":"1009","last_page":"1009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.051600001752376556,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-1-receptor-1","display_name":"IL-1 receptor 1","score":0.781000018119812},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7360000014305115},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.7609999775886536},{"id":"https://openalex.org/keywords/poly-i-c","display_name":"poly(I:C)","score":0.7200000286102295},{"id":"https://openalex.org/keywords/double-stranded-rna","display_name":"double-stranded RNA","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.5299999713897705},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.8479999899864197},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.5960000157356262},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.6840000152587891},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.6340000033378601},{"id":"https://openalex.org/keywords/il-22","display_name":"IL-22","score":0.890999972820282},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.7139999866485596},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6692339181900024},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.6552631855010986},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.5878663659095764},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.585107147693634},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5271061658859253},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.5012912750244141},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43516650795936584},{"id":"https://openalex.org/C2993002077","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Receptor expression","level":3,"score":0.42772048711776733},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4186049997806549},{"id":"https://openalex.org/C149892131","wikidata":"https://www.wikidata.org/wiki/Q14914156","display_name":"Interleukin 1 receptor antagonist","level":5,"score":0.4104728698730469},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3949128985404968},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.3936326503753662},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3821770250797272},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3775433599948883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36370187997817993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28122901916503906}],"mesh":[{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011070","descriptor_name":"Poly I-C","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053633","descriptor_name":"Receptor, Interferon alpha-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053633","descriptor_name":"Receptor, Interferon alpha-beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2019.01009","doi":"https://doi.org/10.3389/fimmu.2019.01009","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.01009","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.01009/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6521796","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6521796","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:31143178","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31143178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b643c4839cd14e8abf38257589ce4676","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b643c4839cd14e8abf38257589ce4676","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 10 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2019.01009","doi":"https://doi.org/10.3389/fimmu.2019.01009","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.01009","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.01009/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2944349554.pdf","grobid_xml":"https://content.openalex.org/works/W2944349554.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1491655932","https://openalex.org/W1501457950","https://openalex.org/W1767585587","https://openalex.org/W1967139098","https://openalex.org/W1971209372","https://openalex.org/W1974549940","https://openalex.org/W1975752601","https://openalex.org/W1981983308","https://openalex.org/W1993026721","https://openalex.org/W1997616974","https://openalex.org/W2004762902","https://openalex.org/W2004829503","https://openalex.org/W2018289835","https://openalex.org/W2027411595","https://openalex.org/W2031721046","https://openalex.org/W2032015767","https://openalex.org/W2033856426","https://openalex.org/W2042673910","https://openalex.org/W2043897509","https://openalex.org/W2052178041","https://openalex.org/W2053806896","https://openalex.org/W2055253557","https://openalex.org/W2061129733","https://openalex.org/W2062564526","https://openalex.org/W2062879350","https://openalex.org/W2063082801","https://openalex.org/W2065677491","https://openalex.org/W2079295092","https://openalex.org/W2083988704","https://openalex.org/W2085237060","https://openalex.org/W2091129202","https://openalex.org/W2094197406","https://openalex.org/W2096947328","https://openalex.org/W2100837269","https://openalex.org/W2112762190","https://openalex.org/W2124291771","https://openalex.org/W2136442269","https://openalex.org/W2145866317","https://openalex.org/W2154762892","https://openalex.org/W2154882161","https://openalex.org/W2166702711","https://openalex.org/W2471828796","https://openalex.org/W2556729289","https://openalex.org/W2595963502","https://openalex.org/W2610536898","https://openalex.org/W2616675556","https://openalex.org/W2785817960","https://openalex.org/W2910755672","https://openalex.org/W2912040117","https://openalex.org/W2912569238"],"related_works":["https://openalex.org/W2043897509","https://openalex.org/W2110090126","https://openalex.org/W1971209372","https://openalex.org/W1989949469","https://openalex.org/W2069489395","https://openalex.org/W1970810460","https://openalex.org/W2055656686","https://openalex.org/W1967192015","https://openalex.org/W2022121957","https://openalex.org/W2053817910"],"abstract_inverted_index":{"Upon":[0],"treatment":[1,206],"with":[2],"polyinosinic:polycytidylic":[3],"acid":[4],"(poly(I:C)),":[5],"an":[6,48],"artificial":[7],"double-stranded":[8],"RNA,":[9],"type":[10,64],"I":[11,65],"interferon":[12,124],"receptor-deficient":[13],"(IFNAR-/-)":[14],"mice":[15,85,145,194],"develop":[16],"severe":[17],"liver":[18,43,118,202,218],"injury":[19,44,203,219],"seen":[20],"by":[21,47,222],"enhanced":[22],"alanine":[23],"aminotransferase":[24],"(ALT)":[25],"activity":[26],"in":[27,34,60,77,114,141,160,183,228],"the":[28,61,154,175,223,229],"serum":[29],"that":[30,42,70,99,153,174],"is":[31,45,180,220],"not":[32,165,186],"observed":[33],"their":[35],"wildtype":[36],"(WT)":[37],"counterparts.":[38],"Recently,":[39],"we":[40,68,172],"showed":[41,152,208],"mediated":[46,221],"imbalanced":[49],"expression":[50,73,109,225],"of":[51,63,75,82,89,94,111,156,169,188,214,226],"interleukin":[52],"(IL)-1\uf062":[53],"and":[54,79,96,134,143,162,190,198,207],"its":[55],"receptor":[56,176],"antagonist":[57],"(IL1":[58],"RA)":[59],"absence":[62],"IFN.":[66],"Here":[67],"show":[69,86],"despite":[71],"comparable":[72,137,211],"levels":[74,110],"IL-1\uf062":[76],"livers":[78,161,184],"spleens,":[80],"spleens":[81,163,187],"poly(I:C)-treated":[83],"IFNAR-/-":[84,144,191],"no":[87,102,201],"signs":[88],"injury.":[90],"In":[91],"vitro":[92],"analyses":[93,151],"hepatocytes":[95],"splenocytes":[97],"revealed":[98],"poly(I:C)":[100,205],"had":[101],"direct":[103],"toxic":[104],"effect":[105],"on":[106],"hepatocytes.":[107],"Furthermore,":[108],"cytokines":[112],"involved":[113],"other":[115],"models":[116],"for":[117,138,196],"damage":[119],"or":[120],"protection":[121],"such":[122],"as":[123],"(IFN)-\uf067,":[125],"transforming":[126],"growth":[127],"factor":[128],"(TGF)-\uf062,":[129],"IL-6,":[130],"IL":[131],"10,":[132],"IL-17,":[133],"IL-22":[135],"were":[136,164],"both":[139],"organs":[140],"WT":[142,189,215],"upon":[146,167,204],"treatment.":[147],"Moreover,":[148],"flow":[149],"cytometric":[150],"composition":[155],"different":[157],"immune":[158],"cells":[159],"altered":[166],"injection":[168],"poly(I:C).":[170],"Finally,":[171],"demonstrated":[173],"binding":[177],"IL-1\uf062,":[178],"IL1R1,":[179],"specifically":[181],"expressed":[182],"but":[185],"mice.":[192,216],"Accordingly,":[193],"double-deficient":[195],"IFNAR":[197],"IL1R1":[199,227],"developed":[200],"ALT":[209],"activities":[210],"to":[212],"those":[213],"Collectively,":[217],"organ-specific":[224],"liver.":[230]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-05-16T00:00:00"}