{"id":"https://openalex.org/W2944212972","doi":"https://doi.org/10.1016/s0016-5085(19)40070-x","title":"Sa1520 \u2013 Knockdown of Stimulator of Interferon Genes (STING) Reduces Biliary Senescence and Liver Inflammation and Fibrosis in the Mdr2-/- Mouse Model of Primary Sclerosing Cholangitis (PSC)","display_name":"Sa1520 \u2013 Knockdown of Stimulator of Interferon Genes (STING) Reduces Biliary Senescence and Liver Inflammation and Fibrosis in the Mdr2-/- Mouse Model of Primary Sclerosing Cholangitis (PSC)","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2944212972","doi":"https://doi.org/10.1016/s0016-5085(19)40070-x","mag":"2944212972"},"language":"en","primary_location":{"id":"doi:10.1016/s0016-5085(19)40070-x","doi":"https://doi.org/10.1016/s0016-5085(19)40070-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(19)40070-x","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071497962","display_name":"Tianhao Zhou","orcid":"https://orcid.org/0000-0002-5722-6954","observed_orcids":["https://orcid.org/0000-0002-5722-6954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tianhao Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101888344","display_name":"Lixian Chen","orcid":"https://orcid.org/0000-0001-9413-4592","observed_orcids":["https://orcid.org/0000-0001-9413-4592"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lixian Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102732690","display_name":"Nan Wu","orcid":"https://orcid.org/0000-0003-0100-6474","observed_orcids":["https://orcid.org/0000-0003-0100-6474"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nan Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045703051","display_name":"Konstantina Kyritsi","orcid":"https://orcid.org/0000-0002-7424-2788","observed_orcids":["https://orcid.org/0000-0002-7424-2788"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantina Kyritsi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091026103","display_name":"Julie K Venter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Venter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047135599","display_name":"Ludovica Ceci","orcid":"https://orcid.org/0000-0002-2131-8494","observed_orcids":["https://orcid.org/0000-0002-2131-8494"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ludovica Ceci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008932925","display_name":"Fanyin Meng","orcid":"https://orcid.org/0000-0002-7602-9091","observed_orcids":["https://orcid.org/0000-0002-7602-9091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fanyin Meng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055423864","display_name":"Lindsey Leann Kennedy","orcid":"https://orcid.org/0000-0001-9224-8940","observed_orcids":["https://orcid.org/0000-0001-9224-8940"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lindsey Kennedy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030400303","display_name":"Heather Francis","orcid":"https://orcid.org/0000-0002-3466-3545","observed_orcids":["https://orcid.org/0000-0002-3466-3545","https://orcid.org/0000-0001-5428-641X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heather L. Francis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000327598","display_name":"David Carl Zawieja","orcid":"https://orcid.org/0000-0002-2644-6524","observed_orcids":["https://orcid.org/0000-0002-2644-6524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David C. Zawieja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084004072","display_name":"Anatoliy A. Gashev","orcid":"https://orcid.org/0000-0002-1503-5500","observed_orcids":["https://orcid.org/0000-0002-1503-5500"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anatoliy Gashev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029205234","display_name":"Gianfranco D. Alpini","orcid":"https://orcid.org/0000-0002-6658-3021","observed_orcids":["https://orcid.org/0000-0002-6658-3021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gianfranco Alpini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078136816","display_name":"Chaodong Wu","orcid":"https://orcid.org/0000-0001-8569-8070","observed_orcids":["https://orcid.org/0000-0001-8569-8070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chaodong Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045220703","display_name":"Shannon S. Glaser","orcid":"https://orcid.org/0000-0002-0749-773X","observed_orcids":["https://orcid.org/0000-0002-0749-773X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shannon Glaser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"156","issue":"6","first_page":"S","last_page":"1231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sting","display_name":"STING","score":0.8169999718666077},{"id":"https://openalex.org/keywords/primary-sclerosing-cholangitis","display_name":"primary sclerosing cholangitis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.8740000128746033},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.7889999747276306},{"id":"https://openalex.org/keywords/transepithelial-electrical-resistance","display_name":"transepithelial electrical resistance","score":0.9279999732971191},{"id":"https://openalex.org/keywords/alcoholic-liver-disease","display_name":"alcoholic liver disease","score":0.8840000033378601},{"id":"https://openalex.org/keywords/microbial-translocation","display_name":"microbial translocation","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.5419661998748779},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5343121290206909},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5306301116943359},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5126191973686218},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5112038254737854},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.47709327936172485},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.4191287159919739},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33914440870285034},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3345172703266144},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3205973505973816},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31518179178237915},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2834010720252991},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.26302722096443176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23408129811286926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11013329029083252},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0016-5085(19)40070-x","doi":"https://doi.org/10.1016/s0016-5085(19)40070-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(19)40070-x","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2944210524","https://openalex.org/W2944351083","https://openalex.org/W3213874464","https://openalex.org/W2150825242","https://openalex.org/W1966388865","https://openalex.org/W2335016701","https://openalex.org/W3137863631","https://openalex.org/W3165951582","https://openalex.org/W2081284926","https://openalex.org/W3034202276"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-05-16T00:00:00"}